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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane mazzarella Karina Canon‑Beltran Yulia N.Cajas meriem Hamdi Encina m.gonzalez Juliano C.da Silveira Claudia l.V.leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of Biochemistry and molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de Ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of Veterinary medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(lmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within EVs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-EVs from the early luteal phase and UF-EVs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on lmGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-EVs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-EVs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-EVs from the early luteal phase and UF-EVs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes mammalian Preimplantation Reproductive fluids

Vertical Displacement measurement in a Slow-moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVIllANO Javier PRECIADO-GARBAYO Jorge SEVIl Francisco GUTIERREZ Juan JmARTiNEZ Sonia mARTiN-lOPEZ miguel gonzAlez-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

Implementation of a New Solution for the Preservation of Anatomical Specimens made of Non-Toxic Substances

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Open Journal of Veterinary medicine 2024年第3期14卷 56-67页

作者： ma Reyes Pichardo-molinero Samantha Jardon-Xicotencatl misael R. Oliver-gonzález Carlos G. García-Tovar laboratorio de Apoyo Técnico a la Anatomía Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Estado de México Mexico Unidad de Investigación multidisciplinaria l4 (morfología Veterinaria y Biología Celular) Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Estado de México Mexico

The preservation of anatomical pieces in Veterinary Anatomy is essential since it is not possible to dissect all domestic species. most techniques use reagents with high levels of toxicity such as formaldehyde. The objective of this work was to develop a new preservation technique that uses reagents with zero toxicity and that allows obtaining preserved pieces suitable for anatomical studies. The alcohol propylene glycol technique was developed, the method of which uses a fixation step with alcohol, sodium chloride, commercial vinegar and subsequently the impregnation of the preservation solution made from propylene glycol and commercial vinegar, which are non-toxic. As a result of this work, adequately preserved sheep hearts were obtained that preserved their morphology with slight changes in size and weight, which did not affect their external and internal anatomical structure. Its coloration was not substantially affected, remaining a little lighter. The pieces obtained showed flexibility which allowed dissections to be carried out. The time to develop the technique was 20 days. A comparative study was carried out with the phenolated glycerin technique that uses toxic reagents (formaldehyde and phenol) and the pieces obtained with the alcohol propylene glycol technique were of better quality, observing that the pieces with phenolated glycerin tend to darken and are more rigid. And the time to develop the technique is 24 days. In conclusion, a preservation technique for anatomical pieces was developed that allowed the preservation of the organs under study, which allow their use for anatomical studies, and which have been preserved without changes until the time of this publication (8 months) and there are pieces preserved with this technique for 2 years.

关键词： Veterinary Anatomy Heart Preservation Techniques Alcohol Propylene Glycol Technique Fixation Necropsy Toxic chemicals

Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo l.Peri Juan Gaitán matías mastrangelo marcelo Nosetto Pablo E.Villagra Ezequiel Balducci martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia marina gonzález Polo Silvina manrique Pablo A.meglioli Julián Rodríguez-Souilla martín mónaco Jimena E.chaves Ariel medina Ignacio Gasparri Eugenio Alvarez Arnesi maría Paula Barral Axel von müller Norberto m.Pahr Josefina Uribe Echevarria Pedro Fernández marina morsucci Dardo lópez Juan manuel Cellini leandro Alvarez Ignacio Barberis Hernán Colomb ludmila la manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco laura Cavallero Gualberto Zalazar Guillermo martínez Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y medioambiente (INIBIOmA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) laboratorio de Investigaciones en maderas (lImAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（lST） images from landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation modelling Resilience

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.morassuti A.P.l Silva l.A.O.Nunes S.m.lima l.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

Corrosion and tribocorrosion behavior of Ti6Al4V/xTiN composites for biomedical applications

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Transactions of Nonferrous metals Society of china 2022年第2期32卷 540-558页

作者： J.chÁvez O.JImÉNEZ D.BRAVO-BARCENAS l.OlmOS F.AlVARADO-HERNÁNDEZ m.A.gonzÁlez A.BEDOllA-JACUINDE m.FlORES Departamento de Ingeniería mecánica Eléctrica CUCEIUniversidad de GuadalajaraBlvd.Marcelino García Barragán#1421GuadalajaraC.P.44430México Departamento de Ingeniería de Proyectos CUCEIUniversidad de GuadalajaraJoséGuadalupe Zuno#48Los BelenesZapopanC.P.45150México Departamento de Ingeniería de Proyectos CUCEIUniversidad de Guadalajara-CONACyTBlvd.Marcelino García Barragán#1421GuadalajaraC.P.44430México Instituto de Investigaciones en Ciencias de la Tierra INICITUniversidad Michoacana de San Nicolás de HidalgoAv.Francisco J.Mujica S/NCiudad UniversitariaMoreliaMichoacánC.P.58030México Unidad Académica de Ingeniería I Universidad Autónoma de ZacatecasAv.López Valverde 801ZacatecasZacatecasC.P.98060México Instituto de Investigaciones metalúrgicas IIMMUniversidad Michoacana de San Nicolás de HidalgoEdificio‘‘U-5’’Ciudad UniversitariaMoreliaMichoacánC.P.58030México

The corrosion and tribocorrosion behavior of Ti6Al4V/xTiN(x=0,5,10 and 15,vol.%)composites fabricated by solid-state sintering and their relationship with the microstructure and microhardness were *** body conditions such as a temperature of 37℃ and a simulated body fluid were *** main results demonstrated a microstructural.change caused by theα-Ti stabilization due to solid-solution of nitrogen(N)into the titanium(Ti)lattice,producing a maximum hardening effect up to 109%for the Ti64 matrix by using 15 vol.%*** potentials of composites changed to more noble values with the TiN particle addition,while corrosion current density of samples increased as an effect of the remaining porosity,decreasing the corrosion resistance of ***,changes to a less passive behavior were observed for samples with 15 vol.%*** non-passive behavior of composites resulted in the reduction of the potential drops during rubbing in tribocorrosion ***,an improvement of up to 88%of the wear rate of composites was seen from the solid-solution *** results allowed to understand the relationship between composition and sintering parameters with the improved tribocorrosion performance of materials.

关键词： Ti64 alloy composites powder metallurgy microstructure corrosion tribocorrosion

Spark Plasma Sintering of mg-based Alloys:microstructure,mechanical Properties,Corrosion Behavior,and Tribological Performance

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Journal of magnesium and Alloys 2024年第2期12卷 405-442页

作者： Alessandro m.Ralls mohammadreza Daroonparvar Pradeep l.menezes Department of mechanical Engineering University of Nevada RenoRenoNV89557United States

Within the past ten years,spark plasma sintering(SPS)has become an increasingly popular process for mg *** the SPS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule *** to traditional and additive manufacturing(Am)techniques,SPS gives unique control of the structural and microstructural features of mg *** doing so,their mechanical,tribological,and corrosion properties can be *** great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single *** motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SPS manufacturing for *** do so,the existing body of SPS mg literature was first surveyed,with a focus on their structural formation and degradation *** was found that successful mg SPS fabrication highly depended on the processing temperature,particle size,and particle *** addition of metal and ceramic composites also affected their microstructural features due to the Zener pinning *** degradative environments,their performance depends on their structural features and whether they have secondary phased *** industrial applications,SPS'd mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling *** prospects to advance the field include using mg as a doping agent for crystallite size refinement and using bulk metallic mg-based glass powders for amorphous SPS *** these findings,the interactions of multi-composites on the processing-structure-property relationships of SPS mg is not well *** total,this work will provide a useful direction in the SPS field and serve as a milestone for future mg-based SPS manufacturing.

关键词： Spark plasma sintering magnesium alloys Nanocrystalline Tribology mechanical properties Corrosion

A comprehensive review on the processing-property relationships of laser strengthened magnesium

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Journal of magnesium and Alloys 2024年第1期12卷 1-34页

作者： Alessandro m.Ralls Aaksheta Agnel Pradeep l.menezes Department of mechanical Engineering University of Nevada RenoRenoNV 89557United States

Among the existing series of softer metals,magnesium(mg)has attracted much attention due to its impressive strength-to-weight ***,due to its ease of deformability,mg tends to suffer from rapid degradation in a wide variety of abrasive and electrochemical *** method of improving its surface properties is through surface modification *** the existing techniques,laser shock peening(lSP)has been one of the most widely utilized processes due to its surface-hardening-like *** this understanding,a comprehensive review has yet to exist that encapsulates the strengthening mechanism of lSP for mg and its influence in degradation *** review aims to encapsulate the existing research around the lSP field for ***,an understanding of the surface-strengthening effects in relation to its mechanical,tribological,corrosion,and tribo-corrosion characteristics is ***,the feasibility of lSP for mg materials in critical industries is also *** this work,a novel understanding of lSP for mg can be understood,which can provide a future direction for research in this field.

关键词： laser shock peening magnesium Surface deformation Tribology microstructure

A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah l.Apostolou Ian m.mcDonough Department of Psychology The University of AlabamaTuscaloosaALUSA Department of Psychology Binghamton UniversityBinghamtonNYUSA

loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(Perlman and Peplau,1984).lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil