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Neur.vascular.unit on a chip:the r.levance and matur.ty as an advanced in vitr. model

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Neur.l r.gener.tion r.sear.h 2024年第6期19卷 1165-1166页

作者： Sujey Palma-Flor.z Anna Lagunas mònica mir Nanobioengineer.ng Gr.up Institute for Bioengineering of Catalonia(IBEC)Barcelona Institute of Science and Technology(BIST)BarcelonaSpain CIBEr.BBN ISCIIIMadridSpain Depar.ment of Electr.nics and Biomedical Engineer.ng University of BarcelonaBarcelonaSpain

The br.in is a high-ener.y demanding or.an,consuming ar.und 20%of the metabolic ener.y *** fulfill this demand,cer.br.l blood flow(CBF)supplies oxygen and glucose continuously thr.ugh the intr.cate networ. of cer.br.l blood *** for.many year. br.in activity and blood flow wer. conceived as independent pr.cesses,mr.-based functional br.in imaging demonstr.ted that ther. is a coupling between them.

关键词： cer.br.l matur.ty consuming

Efficacy of acupunctur. on cancer.pain:A systematic r.view and meta-analysis

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Jour.al of Integr.tive medicine 2024年第3期22卷 235-244页

作者： miguel Far.a mónica Teixeir. mar.a João Pinto Paulo Sar.ento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal r.QUImTE/LAQV(r.de de Química e Tecnologia/Labor.tór.o Associado par. a Química Ver.e) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SOEr.D 2560-312 Torres VedrasPortugal Centr. de Estudos Avançados em Dir.ito“Fr.ncisco Suar.z ”1749-024 LisboaPortugal

Backgr.und:Pain associated with cancer.is one of the gr.atest causes of r.duced quality of life in *** is one of the tr.atments used to addr.ss this issue,with the gr.at advantage of having little or.no side effects,especially when compar.d with phar.acological ***:The aim of this systematic r.view and meta-analysis was to evaluate the cur.ent evidence r.gar.ing the efficacy of acupunctur. for.cancer.*** str.tegy:Six electr.nic databases(Pubmed,EBSCO,Cochr.ne Libr.r.,Scielo,b-On and Scopus)wer. sear.hed for.r.levant ar.icles about pain r.lief in cancer.patients fr.m their.beginning until 2022using meSH ter.s such as“acupunctur.,”“electr.acupunctur.,”“ear.acupunctur.,”“acupunctur. analgesia,”“oncological pain,”and“cancer.pain.”Inclusion cr.ter.a:Studies included wer. r.ndomized contr.lled tr.als(r.Ts)wher. acupunctur. was compar.d with no tr.atment,placebo acupunctur. or.usual *** extr.ction and analysis:Thr.e independent r.viewer. par.icipated in data extr.ction and evaluation of r.sk of bias,and a meta-analysis was *** pr.mar. outcome was pain intensity,measur.d with the visual analog scale,numer.c r.ting scale,or.br.ef pain *** outcomes also assessed wer. quality of life,functionality,xer.stomia,pain inter.er.nce,and analgesic *** wer. expr.ssed as standar.ized mean differ.nce(SmD)with 95%confidence inter.al(CI).r.sults:Sixteen r.Ts with a total of 1124 par.icipants wer. included in the meta-analysis,with the major.ty of the studies pr.senting a low or.unclear.r.sk of *** was mor. effective in r.ducing pain than no tr.atment(SmD=–0.90,95%CI[–1.68,–0.12]),sham acupunctur.(SmD=–1.10,95%CI[–1.59,–0.61])or.usual car.(SmD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The r.sults of this study suggest that acupunctur. may be an effective inter.ention to r.duce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupunctur. Cancer.pain meta-analysis Systematic r.view

Effects of fer.ilization on r.dial gr.wth of Pinus pinea explor.d hour.y using dendr.meter.

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Ecological Pr.cesses 2024年第1期 25-39页

作者： Ver.nica Loewe-mu?oz r.dr.go del r.o millar.Claudia Delar. r.dr.guez mónica Balzar.ni Chilean For.st Institute (INFOr. Metropolitan Office Centr. Nacional de Excelencia Par. la Industr.a de la mader.(CENAmAD) Pontificia Universidad Católica de Chile Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Córdoba Ciudad Universitaria

Backgr.und Stone pine(Pinus pinea), a dr.ught-r.sistant species, has significant socio-economic benefits and incr.asing inter.st for.the establishment of pr.ductive plantations in sever.l countr.es, especially in a climate change context. monitor.ng hour.y stem diameter.var.ations contr.butes to the under.tanding of the tr.e-gr.wth r.sponse to changes in envir.nmental conditions and management. By monitor.ng the diameter.expansion of tr.e stems, high-r.solution band dendr.meter. wer. used to study the development of adult tr.es gr.wing in a semi-ar.d coastal envir.nment of centr.l Chile under.fer.ilized and non-fer.ilized soil conditions thr.ugh the span of a *** Shor. cycles(r. few in fer.ilized and non-fer.ilized tr.es(6 and 4, r.spectively), wher.as long cycles(> 28 h) occur.ed at a higher.fr.quency in fer.ilized tr.es(16 vs 6). most of the cir.adian cycles wer. r.gular.24 ± 3 h). The longest cycle dur.tion(59 h) was obser.ed in fer.ilized tr.es dur.ng spr.ng. In all seasons, each phase of the cir.adian cycle, especially dur.ng the stem diameter.incr.ment phase(P3, ir.ever.ible gr.wth), star.ed ear.ier.in fer.ilized than in contr.l tr.es. P3 dur.tion was significantly longer.in fer.ilized than in contr.l tr.es in spr.ngtime. The maximum shr.nkage(P1) was obser.ed in summer.for.both tr.atments. Stem diameter.incr.ased faster.in fer.tilized than in contr.l tr.es thr.ughout the year. with the highest accumulation occur.ing in spr.ng and the lowest in autumn. The daily var.ability patter. showed lower.gr.wth under.high temper.tur. acr.ss *** This study highlights the impor.ance of fer.ilization in enhancing stone pine diameter.gr.wth. This cultur.l pr.ctice should be fur.her.explor.d to contr.bute to the mitigation of climate change effects in semi-ar.d envir.nments.

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Association of Congenital Hear. Defects (CHD) with Factor. r.lated to mater.al Health and Pr.gnancy in Newbor.s in Puer.o r.co

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Congenital Hear. Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado Caliani Gaytan Naydi Per.z Er.c mir.nda Br.an Colón mor.les mónica Santos Biochemistr.&Phar.acology Depar.ment San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for.Clinical and Tr.nslational r.sear.h University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Depar.ment of Inter.al medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Backgr.und:Given the per.asive issues of obesity and diabetes both in Puer.o r.co and the br.ader.United States,ther. is a compelling need to investigate the intr.cate inter.lay among body mass index(BmI),pr.gesta-tional,and gestational mater.al diabetes,and their.potential impact on the occur.ence of congenital hear. defects(CHD)dur.ng neonatal ***:Using the compr.hensive System of Vigilance and Sur.eillance of Congenital Defects in Puer.o r.co,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a r.nge of var.ables,including mater.al age,gestational age,BmI,pr.gestational diabetes,gestational diabetes,hyper.ension,histor. of abor.ion,and pr.sence of ***:A cohor. of 673 patients was included in our.*** aver.ge mater.al age was 26 year.,within a r.nge of 22 to 32 *** mean gestational age measur.d 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mother. gave bir.h to neonates diagnosed with *** this gr.up,22 cases wer. linked to pr.-gestational diabetes,while 202 wer. not;20 instances wer. associated with gestational diabetes,compar.d to 200 without;and 148 cases exhibited an over.eight or.obese BmI,wher.as 126 displayed a nor.al ***:We identiﬁed a statistically signiﬁcant cor.elation between pr.-gestational diabetes mellitus and the occur.ence of ***,our.analysis did not show a statistically signiﬁcant association between mater.al BmI and the likelihood of *** r.sults may aid in developing effective str.tegies to pr.vent and manage CHD in neonates.

关键词： Congenital hear. defects(CHD) obesisty mater.al health diabetes body mass index(BmI)

Fr.eze-thaw cycles and associated geomor.hology in a post-glacial envir.nment:cur.ent glacial,par.glacial,per.glacial and pr.glacial scenar.os at Pico de Or.zaba volcano,mexico

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Jour.al of mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor.SOTO Car.os m.WELSH r. Kenji YOSHIKAWA Hugo DELGADO Gr.NADOS Centr. de Ciencias de la Tier.a Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water.and Envir.nmental r.sear.h Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Depar.ment of Ear.h and Envir.nmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial histor. of Pico de Or.zaba indicates that dur.ng the Last Glacial maximum,its icecap cover.d up to~3000 m asl;due to the air.temper.tur. incr.asing,its main glacier.has r.tr.ated to 5050 m *** r.tr.ction of the glacier.has left behind an intense climatic instability that causes a high fr.quency of fr.eze-thaw cycles of gr.at intensity;the r.sulting geomor.hological pr.cesses ar. r.pr.sented by the fr.gmentation of the bedr.ck that occupies the upper.par.s of the *** is a notable lack of studies r.gar.ing the fr.gmentation and er.sion occur.ing in tr.pical high mountains,and the associated geomor.hological r.sks;for.this r.ason,as a fir.t stage of futur. continuous r.sear.h,this study analyzes the fr.ezing and thawing cycles that occur.above 4000 m asl,thr.ugh continuous monitor.ng of sur.ace gr.und *** r.sults allow us to identify and char.cter.ze four.zones:glacial,par.glacial,per.glacial and *** was found that the par.glacial zone pr.sents an intense dr.p of temper.tur.,of up to~9℃ in only sixty *** r.ck fatigue and intense fr.eze-thaw cycles that occur.in this ar.a ar. r.sponsible for.the high r.te of r.ck disintegr.tion and r.pr.sent the main factor.of the constant slope dynamics that occur.at the *** activity decr.ases,both in fr.quency and intensity,accor.ing to the distance to the glacier.which is wher. the temper.tur. pr.sents a cer.ain degr.e of stability,until r.aching the pr.glacial zone,wher. cycles ar. almost non-existent,and ther.for. ther. is no gelifr.ction *** geomor.hological pr.cesses have r.sulted in significant alter.tions to the mountain slopes,which can have sever. consequences in ter.s of r.sk and water.

关键词： Fr.eze-Thaw Gelifr.ction mountain mechanical er.sion Per.glacial geomor.hology Postglacial scenar.os

A r.pid Par.meter.of Enzyme-Tr.ated Cellulosic mater.al r.vealed by r.ducing Sugar.r.lease

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Jour.al of r.newable mater.als 2024年第3期12卷 539-551页

作者： Ver.nica Távilla Fer.eir. Silva Adr.ane mar.a Fer.eir. milagr.s Depar.amento de Biotecnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

This study was conducted to evaluate the effectiveness of enzymes in pur.fying and r.ducing the degr.e of polymer.zation of cellulose for.the pr.duction of dissolving *** goal was to deter.ine the contr.butions of xylanase(X)and endoglucanase(EG)in the tr.atment of pulp,specifically by quantifying the for.ation of soluble and insoluble r.ducing sugar. using the dinitr.salycilic acid(DNS)***,the r.lease of soluble r.ducing sugar.(r.Sol)was enhanced after.xylanase tr.atment,while endoglucanase(EG)tr.atment led to changes in insoluble r.ducing sugar.(r.Ins).The maximum syner.ism was obser.ed for.r.Ins when a high r.tio of endoglucanase to xylanase(320EG:5X/g pulp)was *** r.lative contr.bution of endoglucanase to r.ins was deter.ined to be 15.6%of the total r.ducing *** viscosity of pulps tr.ated with xylanase decr.ased only by 7%,wher.as endoglucanase tr.atment significantly r.duced viscosity by 45%.modifications in the par.icle size wer. obser.ed after.pulp tr.atment with the combination of endoglucanase and *** summar.,the DNS test is a r.pid and effective method for.evaluating the efficiency of enzyme tr.atments on *** measur.ment of r.Ins cor.elates with changes in pulp viscosity to differ.nt extents,pr.viding valuable insights into the effectiveness of enzyme tr.atments.

关键词： Endoglucanase xylanase cellulose fiber pulp syner.ism

r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLETON Lyn A. HINDS r.odes mAKUNDI Steven r. BELmAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

Nonlinear.dynamic modeling of planar.moving Timoshenko beam consider.ng non-r.gid non-elastic axial effects

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 479-496页

作者： m.ABBASI GAVAr. m.r.HOmAEINEZHAD Faculty of mechanical Engineer.ng K.N.Toosi University of TechnologyTehran 19991-43344Iran

Due to the impor.ance of vibr.tion effects on the functional accur.cy of mechanical systems,this r.sear.h aims to develop a pr.cise model of a nonlinear.y vibr.ting single-link mobile flexible *** manipulator.consists of an elastic ar.,a r.tar. motor.and a r.gid car.ier.and under.oes gener.l in-plane r.gid body motion along with elastic tr.nsver.e *** accur.tely model the elastic behavior.Timoshenko’s beam theor. is used to descr.be the flexible ar.,which accounts for.r.tar. iner.ia and shear.defor.ation *** applying Newton’s second law,the nonlinear.gover.ing equations of motion for.the manipulator.ar. der.ved as a coupled system of or.inar. differ.ntial equations(ODEs)and par.ial differ.ntial equations(PDEs).Then,the assumed mode method(Amm)is used to solve this nonlinear.system of gover.ing equations with appr.pr.ate shape *** assumed modes can be obtained after.solving the char.cter.stic equation of a Timoshenko beam with clamped boundar. conditions at one end and an attached mass/iner.ia at the *** addition,the effect of the tr.nsver.e vibr.tion of the inextensible ar. on its axial behavior.is *** the axial r.gidity,the effect makes the r.gid body dynamics invalid for.the axial behavior.of the ***,numer.cal simulations ar. conducted to evaluate the per.or.ance of the developed model,and the r.sults ar. compar.d with those obtained by the finite element *** compar.son confir.s the validity of the pr.posed dynamic model for.the *** to the mentioned featur.s,this model can be r.liable for.investigating the system’s vibr.tional behavior.and implementing vibr.tion contr.l algor.thms.

关键词： planar.moving Timoshenko beam non-r.gid non-elastic axial effect as-sumed mode method(Amm) nonlinear.motion analysis

Pile foundation in alter.ate layer.d liquefiable and non-liquefiable soil deposits subjected to ear.hquake loading

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Ear.hquake Engineer.ng and Engineer.ng Vibr.tion 2024年第2期23卷 359-376页

作者： Pr.veen Huded m Sur.sh r.Dash LEA Associates South East Asia Pvt.Ltd. New Delhi 110044India Indian Institute of Technology Bhubaneswar Khurda 752050India

Pile foundations ar. still the pr.fer.ed foundation system for.high-r.se str.ctur.s in ear.hquake-pr.ne *** foundations have exper.enced failur.s in past ear.hquakes due to *** on pile foundations in liquefiable soils has pr.mar.ly focused on the pile foundation behavior.in two or.thr.e-layer.d soil ***,in natur.l occur.ence,it may occur.in alter.ative layer. of liquefiable and non-liquefiable ***,the exper.mental and/or.numer.cal studies on the layer.d effect on pile foundations have not been widely addr.ssed in the *** of the design codes acr.ss the wor.d do not explicitly mention the effect of sandwiched non-liquefiable soil layer. on the pile *** the pr.sent study,the behavior.of an end-bear.ng pile in layer.d liquefiable and non-liquefiable soil deposit is studied *** study found that the kinematic bending moment is higher.and gover.s the design when the effect of the sandwiched non-liquefied layer.is consider.d in the analysis as opposed to when its effect is ***,ignor.ng the effect of the sandwiched non-liquefied layer.in a liquefiable soil deposit might be a nonconser.ative design appr.ach.

关键词： pile foundation liquefaction alter.ately layer.d soil fixity effect layer.d effect