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Plasma Cell Neoplasms, Clinicopathological Characteristics and Immunophenotype of 21 Patients

Open Journal of Pathology 2012年第4期2卷 127-132页

作者： mónica belinda romero-guadarrama Cinthia Adriana meza medina Elvira Aguilar martínez Facultad de medicina Universidad Autónoma de Nayarit Tepic Mexico Unidad de Hematología del Hospital General de méxico Mexico City Mexico Unidad de Patología del Hospital General de méxico Mexico City Mexico

Introduction: Plasma cell neoplasms are monoclonal proliferations characterized by the secretion of an immunoglobulin product known as component "m" or monoclonal. The World Health Organization (WHO 2008) defines as plasma cell neoplasms the following: plasma cell myeloma, plasmacytoma and those syndromes defined by immunoglobulin deposits and primary amyloidosis, The objective of the present work was to correlate their clinical, morphological and phenotype characteristics in 21 patients. material and methods: A 2-year retrospective review was performed of the files of the surgical pathology laboratory and of the hematology service of the General Hospital of mexico, searching for patients with a diagnosis of plasma cell neoplasm. We analyzed the following variables: age, gender, clinical symptoms, evolution, localization, laboratory tests, morphology, and expression of immunohistochemical markers. Of the 21 patients, 12 (57.1%) corresponded to plasma cell myelomas and 9 (42.8%) were plasmacytomas (seven extraosseous and two solitary bone plasmacytoma);women predominated with 61.4% and age ranged between 22 and 84 years. mass and epistaxis were observed in the patients with plasmacytomas, and symptoms of medullary compression and anemia were observed in those patients with plasma cell myeloma. The time of symptomatology varied from 3 to 12 months. Laboratory tests revealed that lactate dehydrogenase (LDH), beta 2 microglobulin, C-reactive protein were altered and that hypercalcemia and anemia were present more in the systemic form of the disease. Treatment depended on the clinical staging and laboratory data. mature forms predominated morphologically. Immunohistochemical stain revealed a constant expression for CD 138, six patients expressed CD 56, and expression of the Kappa and Lambda light chains was while.

关键词： Plasma Cell Neoplasms

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Diffuse Large B-Cell Lymphoma with Anaplastic Clear Cells: A Rare Variant

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Open Journal of Pathology 2012年第4期2卷 150-154页

作者： mónica belinda romero-guadarrama Leslie Elizmara Aguilar-Ayala German Ott Jorge Pérez-Espinosa Department of Clinical Pathology Robert-Bosch-Hospital Stuttgart Germany Unit Pathology Hospital General de México OD and Medicine School Autonomous National University of Mexico Mexico City Mexico

Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms;it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The existence of DLBCL with anaplastic morphology and expression of CD30 without t (2;5) translocation is rare. The aim of the present article is to describe this morphologic variant in a 54-year-old woman and a 74-year-old man, respectively. materials and methods: Patients diagnosed with DLBCL with anaplastic variant were identified from the surgical pathology records. Results: Out of 357 biopsies with this diagnosis, 11 (3%) corresponded to the anaplastic variant, 2 presented morphological clear cells;they became visible because of an increase in volume in the cervical area of 4 months of evolution, usually associated to diaphoresis and weight loss with clinical fulminating progression. An autopsy study was performed to one patient and it showed infiltration in supraclavicular lymph nodes, thyroid, and lung. The neoplastic cells presented abundant clear cytoplasm and pleomorphic nuclei that expressed CD20, CD30 and CD45. Conclusion: This variation is rare. The clinical presentation and prognosis are controversial;we present the morphological and immunophenotype changes of this variant. The differential diagnosis from other clear cell neoplasms should be made.

关键词： B-Cell Anaplastic Lymphoma with Clear Cells

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Diffuse Large B-Cell Lymphoma of the Central Nervous System. Immunophenotype, Clinicopathological Features and Differential Diagnosis

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Open Journal of Pathology 2012年第4期2卷 133-139页

作者： mónica belinda romero-guadarrama maría Esther Gutiérrez Díaz-Ceballos Fiacro Jiménez-Ponce Samantha Thingen-Velarde Hemathology Service Hospital General de México Mexico City Mexico mónica belinda romero-guadarrama Neurosurgery Unit Hospital General de méxico Mexico City Mexico Unit Pathology Hospital General de méxico Medicine School Autonomous University of Mexico Mexico City Mexico

Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache, blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the right thalamus. morphologically, large lymphoid cells with a diffuse growth pattern and necrosis were observed. Immunohistochemical markers, such as CD 20 and bcl2 were positive, one was positive to CD3. Expression of bcl6 and CD 10 was positive in one case, and mUm-1 was positive in three cases. All the cases were negative for Epstein-Barr virus. Conclusions: The diffuse large-B cell lymphoma of the central nervous system is rare. Its average age of presentation is at 60 years or older. The localization is in the pineal, frontal, parietal and thalamic regions. Three cases were originated by activated B lymphocyte (mUm-1 expression) and other from the Germinal Center (GC) (CD 10 expression). The clinical course was bad. The four patients died shortly after the diagnosis.

关键词： Primary Lymphoma Central Nervous System

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Association of morphology and Immunophenotype in Diffuse Large B-Cell Lymphomas with Bone marrow Infiltration in a Sample mexican Population

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Open Journal of Pathology 2012年第2期2卷 29-37页

作者： mónica-belinda romero-guadarrama Fiacro Jiménez Ponce Armando medina Cruz Elsa Lorena Durán Ramírez Icela Palma Lara molecular and Celular morphology Laboratory Escuela Superior de Medicina Instituto Politécnico Nacional and Morphology Department Facultad de Medicina Veterinaria y Zootecnia (UNAM) México City México Unidad de Patología del Hospital General de méxico Facultad de Medicina Universidad Nacional Autónoma de México (UNAM) México City México

Introduction: Diffuse large B-cell lymphoma (DLBCL), not otherwise specified, is a large B-cell lymphoma with a diffuse growth pattern and aggressive clinical course. It is divided in subgroups according to its morphology, immunophenotype, and primary site. Dissemination to bone marrow occurs in 11% to 35% of cases and can be of concordant or discordant morphology. Objective: To examine the association, the type of bone marrow involvement in relation to the primary site, morphology, immunohistochemistry of DLBCLs and to determine the cases of Epstein-Barr virus positive DLBCLs. materials and methods: We reviewed lymph node and extranodal biopsies as well as the respective bone marrow biopsies in all cases of DLBCL diagnosed in the Hospital General de méxico during the period from 2002 to 2010. We used immunohystochemistry for immunophenotype identification (Hans’s algorithm) and an in-situ hybridization technique to detect presence of Epstein Barr encoded RNA (EBER). Results: We included 108 patients with a mean age of 51.9 years, 59 (55%) were men. DLBCL involved lymph nodes in 60% of cases and palatine tonsils in 13%. The centroblastic variant predominated (80%) and 58% originated from activated B-cells. Infiltration of bone marrow was present in 30% of cases and was discordant in 55% of these cases. Correlation between morphology and bone marrow infiltration was statistically significant (P = 0.0003). Presence of Epstein-Barr virus was demonstrated in 15% of patients older than 50 years. Conclusions: Dissemination to bone marrow occurred in 30% of cases and discordant involvement was most common. DLBCL originating from activated B-lymphocytes predominated and the most common extranodal sites were palatine tonsils, suggesting that our population has a clinical behavior similar to Asiatic populations.

关键词： Dissemination to Bone marrow Diffuse Large B-Cell Lymphoma Immunophenotype

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Kikuchi-Fujimoto Disease Associated to the Epstein-Barr Virus. A Type of Rare Necrotizing Lymphadenitis and Its Differential Diagnosis

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Open Journal of Pathology 2013年第4期3卷 186-192页

作者： mónica belinda romero guadarrama Oscar Daniel Guzmán-Aguilar Adriana Carolina López-Ugalde José Samuel Almeida Navarro Humberto Cruz-Ortíz Unidad de Patología Hospital General de México “Dr. Eduardo Liceaga” México D.F. México

Introduction: Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a specific and self-limited disease;its etiology is unknown. Some causal microorganisms have been proposed. The objective of the present article is to emphasize the clinicopathological characteristics of this disease that has been associated to the Epstein-Barr virus and to compare the histological changes with other types of necrotizing lymphadenopathies. material and methods: We studied 32 patients of the Surgical Pathology Service with necrotizing lymphadenitis, diagnosed in the years from 2004 to 2012 to found more cases of this rare disease in our Institution. Patients were 18 women and 14 men with an average age of 37 years. Results: The lymph nodes were cervical and axillary ones, some were associated to autoimmune diseases and no cause was identified in others. One of the cases, was diagnosed as KFD, presented morphological changes characteristic of this disease, such as subcapsular lymphoid follicles, zones with cell debris, epithelioid macrophages, clear-cytoplasm histiocytes, and immunoblast-reactive lymphocytes. Immunohistochemical markers were determined, such as CD20, CD2, CD4, CD8, CD68, lysozyme, CD56, granzyme B and EBER, which demonstrated the presence of B, T lymphocytes, histiocytes and cells positive to EBER. Histological changes in KFD occurred in three stages: proliferative stage, necrotizing, and xanthomatous. It is important to identify the histological stages of the disease because a differential diagnosis must be performed in regard to lymphadenopathies with necrosis and diverse types of lymphomas. Conclusion: We present a case of necrotizing lymphadenitis (KFD) associated to the Epstein-Barr virus and in some cases it is not possible to render a specific diagnosis based on morphologic findings, alone, and a diagnosis of necrotizing lymphadenitis may be used.

关键词： Kikuchi-Fujimoto Disease Epstein Barr Virus

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mechanochemical preparation and structural characterization of Ta-doped chlorapatite nanopowders

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Progress in Natural Science:materials International 2016年第6期26卷 546-554页

作者： Bahman Nasiri-Tabrizi Wan Jefrey Basirun belinda Pingguan-murphy Advanced materials Research Center Materials Engineering DepartmentNajafabad BranchIslamic Azad University Department of Chemistry Faculty of ScienceUniversity of Malaya Department of Biomedical Engineering Faculty of EngineeringUniversity of Malaya

Nanocrystalline tantalum-doped chlorapatite（Ta-doped ClA） was successfully synthesized using a facile mechanochemical method. In the absence of the dopant, milling for 3 h led to the formation of a poorly crystalline hydroxyapatite, while in its presence of the Ta dopant, Ta-doped ClA nanopowders were produced as a result of an oncoming reaction. The results indicated that lattice micro-strain, crystallite size, crystallinity level, phase percentage and hexagonal lattice constants of the substituted apatite nanopowders were dramatically affected by the doping concentration. The a-axis and unit cell volume increased with the increase in the doping concentration, owing to the ionic radius difference of Cl;and OH;ions. From the TEm observations, the doped powders consisted of nanoneedles with a mean size of 60 ± 20 nm in length and 14 ±4 nm in width.

关键词： mechano-synthesis Structural features Lattice constants XRD-Rietveld refinement Ta-doped ClA

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Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： belinda Sánchez-Pérez Josém Ramia Department of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of Surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAS)programs have been widely applied in liver surgery since the publication of the first ERAS guidelines in 2016 and the new recommendations in *** surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAS programs in oncological outcomes is not clearly *** advantages of ERAS programs are:ERAS decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving ***,ERAS could be another way to improve our oncological *** will discuss the literature about liver surgery ERAS focusing on its oncological implications and future investigations projects.

关键词： Enhanced recovery after surgery programs Liver surgery Key components Long-term oncological outcomes Enhanced recovery after surgery compliance

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Fabrication of three-dimensional islet models by geometry-controlled hanging drop method

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Acta mechanica Sinica 2019年第2期35卷 329-337页

作者： Bin Gao Ce Jing Kelvin Ng belinda Pingguan-murphy Qingzhen Yang Department of Endocrinology and metabolism The First Affiliated Hospital Air Force Military Medical University Xi’an 710032 China Outpatient Department of Lanzhou military Region 940 Hospital Joint Logistics Support Force of the People's Liberation Army of China Lanzhou 730000 China Department of Biomedical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Key Laboratory of Biomedical Information Engineering of ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 China Bioinspired Engineering and Biomechanics Center (BEBC) Xi’an Jiaotong University Xi’an 710049 China

Hanging-drop method has been widely used to fabricate three-dimensional (3D) in vitro tissue models due to its advantages such as being easy to perform, inexpensive, and permitting precise control of cell spheroid formation. The geometry of hanging drop may play a critical role on the formation of cell spheroids, which, however, has not been explored. In this study, we developed a modified hanging-drop platform that enables the production of cell spheroids in a high-throughput manner by controlling hanging drop geometry with defined spreading ring. The surface tension force is proportional to the spreading ring and gravitational force is determined by the droplet volume, and the geometry can be determined by the balance between surface tension and gravity.β-TC-6 cell spheroids with optimized diameters were fabricated as 3D in vitro islet models. The models show morphology similar to primary islets and have functionality that more closely resembles primary islets than two-dimensional cell culture. The developed platform holds great potential for engineering well-controlled in vitro tissue models for various applications such as physiological and pathological studies, drug screening, as well as transplantation for treatment purpose.

关键词： Hanging drop cell culture mechanical microenvironment Drop geometry 3D islet spheroids

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ADAm12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation

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Cellular & molecular Immunology 2021年第8期18卷 1904-1919页

作者： Yawei Liu Robert Bockermann mahdieh Hadi Iman Safari belinda Carrion marie Kveiborg Shohreh Issazadeh-Navikas Neuroinflammation Unit Biotech Research&Innovation Centre(BRIC)Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark BRIC Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark

A disintegrin and metalloproteinase(ADAm)12 was previously found to be expressed in T cells in the inflamed ***,the function of ADAm12 in T-cell responses in general and in tissue inflammation has not been ***,we studied the role of ADAm12 in T-cell responses,fate determination on activation,and its functions in T cells to mediate tissue *** identified ADAm12 as a costimulatory molecule that is expressed on naive T cells and downregulated on ***12 mimics CD28 costimulatory signaling to activate and induce the proliferation of T-helper 1(Th1)*** ADAm12 Fab antibodies trigger T-cell activation by amplifying TCR signaling to stimulate T-bet-mediated IFNγ*** of genomic ADAm12 and its knockdown in T cells diminished T-bet and IFNγproduction in Th1 cells,whereas other T cells,including Th17 cells,were ***12 had similar functions in vivo on myelin antigen(mOG_(35-55))-induced T-cell *** found that genetic loss of ADAm12 profoundly alleviated Th1-mediated neuroinflammation and thus disease severity in experimental autoimmune encephalomyelitis,a model of multiple *** profiling of mOG_(35-55)-specific ADAm12^(−/−)T cells revealed differentially expressed genes that are important for T-cell activation,proliferation,and costimulatory signaling and Th1 pathogenicity,consistent with their inability to cause T-cell-mediated skin inflammation in a model of adoptive delayed-type *** conclude that ADAm12 is a T-cell costimulatory molecule that contributes to the pathogenesis of tissue inflammation and a potential target for the treatment of Th1-mediated diseases.

关键词： T cells T-bet Th17 EAE DTH Gm-CSF

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Impact of China-Nigeria Relations in Nigeria from1997-2009

Impact of China-Nigeria Relations in Nigeria from1997-2009

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作者： belinda Bridget Brown（柏琳娜）山东大学

学位级别：硕士

论文是研究中国和尼日利亚贸易关系对1997到2009年的尼日利亚的影响。今天我们的世界是一个“地球村”,它使经济的内在联系达到了一个高峰。中国和尼日利亚及国际间的贸易方面取得了进一步发展和增长。论文观察全球环境是一个不断加深,... 详细信息

论文是研究中国和尼日利亚贸易关系对1997到2009年的尼日利亚的影响。今天我们的世界是一个“地球村”,它使经济的内在联系达到了一个高峰。中国和尼日利亚及国际间的贸易方面取得了进一步发展和增长。论文观察全球环境是一个不断加深,互相依存的现象存在,并且对尼日利亚减少在全球化方面的不利影响是很有必要的,同时也对国家发展和治理有着益处。中国和尼日利亚贸易关系有着逐年增长的趋势。更多的生产商表明尼日利亚是他们商品的主要市场出口地,同时其中的一些也表明国外市场其中包括中国。在相当大比例的生产商中指出来自多样市场的竞争(包括尼日利亚国内外)已经打击了他们的积极性。根据上述发现,一些建议是从多样利益相关者的方面提出的,包括政府,消费者和制造业者/出口商等。中国从尼日利亚获取石油资源并且这项贸易促进尼日利亚GDP的增长。建议尼日利亚彻底重新修改对中国的政策,原因是为了从相互的贸易关系中得到更多的利益。尼日利亚人还没有完全的重视其潜在的好处。更多的需求需要解决并用来发展政策的创建,政府大楼,人力资本,企业和文化及领导能力的最大化获取。最重要的是,尼日利亚需要运用综合策略来更有效地平衡与中国的合作和平衡西方影响其实力并创造一个同样适合其公民的发展模式。论文努力尝试去讨论中国与尼日利亚在经济结构和发展上的角色。作为一个前言,这种中国与尼日利亚的发展表现称为实际产出和人均产出。中国和尼日利亚正在搭建一个在非洲大地上最大的自由贸易带,这就是经济中心——尼日利亚。中国的公司会用设备来生产可以通过非洲出口的商品。尼日利亚和中国正在建立一个16,000公顷的自由贸易区来发展当地制造业和缩减尼日利亚的制造。自从1971年当中国和尼日利亚开始了他们的双边关系直到目前,已经继续对尼日利亚进行原料进口,因为能负担得起的商品和对于零售商,他们可以从销售中国产品中获得理想收入。尼日利亚从中国进口许多产品,由于这点,尼日利亚已经正在面对一系列的贸易赤字。贸易赤字是一个衡量贸易不平衡,也就是一个国家的进口超过其出口的标准。贸易赤字表示国内货币到国外市场的流出。尼日利亚在面对着一系列贸易赤字并开始限制一些从中国进口的商品,原因是为了庇护当地经济。这项政策导致中国走私商品到尼日利亚。能够让中国和尼日利亚双赢的问题需要结合其他的问题一起考虑。尼日利亚的零售商对中国产品质量的许多抱怨还有抱怨中国把尼日利亚当成低档品和次品的倾销地,但事实上,尼日利亚人仍在持续的维护中国的产品,由于其低廉的价格。尼日利亚的消费者和政府从中国进口产品中获利不少,因为从另一方面来说增加了税收。如果特别是大多数的进口是进口的只能选择其一的最终中国的产品,这样产尼日利亚生产者和工人们应该会输。这就表明尼日利亚生产者市场份额会缩水并且导致生产力的减少和裁员。

关键词： imports 贸易赤字贸易关系贸易不平衡 goods 中国产品质量 nations 石油资源 modernization sector

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