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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanic.(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanic.l Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression

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World Journal of Gastroenterology 2015年第21期21卷 6526-6542页

作者： Kathy Saraiva-Pava Nazanin Navabi Emma C Skoog Sara K Lindén mónic. Oleastro mónic. roxo-rosa Faculdade de Engenharia Universidade Católica PortuguesaCampus de Sintra2635-631 Rio de MouroPortugal Department of medical Biochemistry and Cell Biology Institute of BiomedicineUniversity of Gothenburg Departamento de Doen?as Infeciosas Instituto Nacional Saúde Dr.Ricardo Jorge1649-016 LisboaPortugal Chronic.Diseases Research Center CEDOCNova Medical SchoolCampo Mártires da Pátria1169-056 LisboaPortugal

AIm:To establish a cellular model correctly mimicking the gastric epithelium to overcome the limitation in the study of Helicobacter pylori(***) ***:Aiming to overcome this limitation,clones of the heterogenic.cancer-derived NCI-N87 cell line were isolated,by stably-transducing it with the human telomerase reverse-transcriptase(h TERT) catalytic subunit *** clones were first characterized regarding their cell growth pattern and *** that we measured the clones' adherence properties,expression of cell-cell junctions' markers(ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical *** gastric properties of the clones,concerning expression of mucins,zymogens and glycan contents,were then evaluated by haematoxylin and eosin staining,Periodic acid Schiff(PAS) and PAS/Alcian Blue-staining,immunocytochemistry and Western *** addition,we assessed the usefulness of the h TERT-expressing gastric cell line for *** research,by performing co-culture assays and measuring the IL-8 secretion,by ELISA,upon infection with two *** strains differing in ***:Compared with the parental cell line,themost promising NCI-hT ERT-derived clones(CL5 and CL6) were composed of cells with homogenous phenotype,presented higher relative telomerase activities,better adhesion properties,ability to be maintained in culture for longer periods after confluency,and were more efficient in PAS-reactive mucins *** clones were shown to produce high amounts of mUC1,mUC2 and ***-hT ERT-CL5 mucins were shown to be decorated with blood group H type 2(BG-H),Lewis-x(Lex),Ley and Lea and,in a less extent,with BG-A antigens,but the former two antigens were not detected in the NCI-h *** of the clones exhibited detectable levels of mUC6 nor sialylated Lex and Lea *** good gastric properties,both NCIhT ERT-clones were found to produce pepsinogen-5 and human gastric *** progen

关键词： Helicobacter pylori infection Pathogenesis Human gastric epithelium Cellular model NCI-N87cells

micro-computed tomography utility for estimation of intraparenchymal spinal cord cystic lesions in small animals

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Neural Regeneration Research 2021年第11期16卷 2293-2298页

作者： mahmoud Farrag Dipak D.Pukale nic.D.Leipzig Integrated Bioscience Program The University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringThe University of AkronAkronOHUSA Department of Chemical Biomolecularand Corrosion EngineeringIntegrated Bioscience ProgramThe University of AkronAkronOHUSA

Precise assessment of spinal cord cystic lesions is crucial to formulate effective therapeutic strategies,yet histological assessment of the lesion remains the primary method despite numerous studies showing inconsistent results regarding estimation of lesion size via *** the other hand,despite numerous advances in micro-computed tomography(micro-CT)imaging and analysis that have allowed precise measurements of lesion size,there is not enough published data on its application to estimate intraspinal lesion size in laboratory animal *** work attempts to show that micro-CT can be valuable for spinal cord injury research by demonstrating accurate estimation of syrinx size and compares between micro-CT and traditional histological *** used a post-traumatic syringomyelia rat model to compare micro-CT analysis to conventional histological *** study showed that micro-CT can detect lesions within the spinal cord very similar to ***,micro-CT appears to provide more accurate estimates of the lesions with more measures(e.g.,surface area),can detect compounds within the cord,and can be done with the tissue of interest(spinal cord)*** summary,the experimental work presented here provides one of the first investigations of the use of micro-CT for estimating the size of intraparenchymal cysts and detecting materials within the spinal *** animal procedures were approved by the University of Akron Institutional Animal Care and Use Committee(IACUC)(protocol#LRE 16-05-09 approved on may 14,2016).

关键词： cyst size histology intraparenchymal cysts lesion size estimate micro-CT post-traumatic syringomyelia spinal cord imaging spinal cord injury spinal cystic lesion syrinx

Bandpass transmission spectra of a whisperinggallery microcavity coupled to an ultrathin fiber

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Photonic. Research 2017年第4期5卷 362-366页

作者： FUCHUAN LEI RAFINO m.J.mURPHY JONATHAN m.WARD YONG YANG SíLE nic.CHORmAIC Light-matter Interactions Unit Okinawa Institute of Science and Technology Graduate University

Tapered fibers with diameters ranging from 1 to 4 μm are widely used to excite the whispering-gallery(WG)modes of microcavities. Typically, the transmission spectrum of a WG cavity coupled to a waveguide around a resonance assumes a Lorentzian dip morphology due to resonant absorption of the light within the cavity. In this paper, we demonstrate that the transmission spectra of a WG cavity coupled with an ultrathin fiber(500–700 nm)may exhibit both Lorentzian dips and peaks, depending on the gap between the fiber and the microcavity. By considering the large scattering loss of off-resonant light from the fiber within the coupling region, this phenomenon can be attributed to partially resonant light bypassing the lossy scattering region via WG modes, allowing it to be coupled both to and from the cavity, then manifesting as Lorentzian peaks within the transmission *** implies the system could be implemented within a bandpass filter framework.

关键词： WG Bandpass transmission spectra of a whisperinggallery microcavity coupled to an ultrathin fiber mode

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communic.tion olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

用ELISA对自然感染鼠伤寒沙门氏菌雏鸡的血清学检查

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国外兽医学（畜禽传染病） 1993年第2期13卷 33-34页

作者： nic.,RAJ 李维东

Kinetics and mechanism of oxidation for nic.el-containing pyrrhotite tailings

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International Journal of minerals,metallurgy and materials 2021年第9期28卷 1469-1477页

作者： Alexander m.Klyushnikov rosa I.Gulyaeva Evgeniy N.Selivanov Sergey m.Pikalov Institute of metallurgy of the Ural branch of the Russian Academy of Sciences Yekaterinburg 620016Russia

X-ray powder diffraction,scanning electron microscopy,energy dispersive spectroscopy,thermogravimetry,differential scanning calorimetry,and mass spectrometry have been used to study the products of nic.el-containing pyrrhotite tailings oxidation by oxygen in the *** kinetic triplets of oxidation,namely,activation energy(E_(a)),pre-exponential factor(A),and reaction model(f(α))being a function of the conversion degree(α),were adjusted by regression *** case of a two-stage process representation,the first step proceeds under autocatalysis control and ends atα=*** kinetic triplet in the first step is E_(a)=262.2 kJ/mol,lg A=14.53 s^(−1),and f(α)=(1-α)^(4.11)(1+1.51×10^(-4)α).For the second step,the process is controlled by the two-dimensional diffusion of the reactants in the layer of oxidation *** kinetic triplet in the second step isЕa=215.0 kJ/mol,lg A=10.28 s^(−1),and f(α)=(-ln(1-α))^(-1).The obtained empirical formulae for the rate of pyrrhotite tailings oxidation reliably describe the macro-mechanism of the process and can be used to design automatization systems for roast-ing these materials.

关键词： pyrrhotite tailings oxidation thermogravimetry kinetics mechanism

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanic.(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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