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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Cellular & molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia maría Trujillo-Rodriguez Ana Serna-Gallego Esperanza muñoz-muela maría de los Reyes Jiménez-Leon mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-mateos Josémiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-martínez Carmen Infante-Domínguez marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo márquez Josémanuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero maría Dolores Avilés maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba máximo bernabeu-wittel Candela Caballero-Eraso macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa michelle Espinoza Carmen Ferrándiz-millón marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-mancera Emilio García Horacio García-Delgado manuel García-Gutiérrez maría Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-melero marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-márquez Daniel macías-García Guillermo martín-Gutiérrez Luis martín-Villén Josémolina Aurora morillo maría Dolores Navarro-Amuedo Dolores Nieto-martín Francisco Ortega maría Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports

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World Journal of Clinical Cases 2020年第1期8卷 103-109页

作者： Sophia Chikhladze Ann-Kathrin Lederer Stefan Fichtner-Feigl Uwe A wittel martin Werner Konrad Aumann Department of General and Visceral Surgery Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Center for Complementary medicine Department of Infection Prevention and Hospital EpidemiologyMedical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Surgical Pathology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany

BACKGROUND Sclerosing angiomatoid nodular transformation(SANT)is a rare benign disease of the spleen with unknown *** symptoms are inhomogeneous,and suspicious splenic lesion often found incidentally,leading to splenectomy,as malignancy cannot securely be ruled *** is made histologically after *** SUmmARY Two cases of German,white,non-smoking,and non-drinking patients of normal weight are *** first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 *** second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery,suffering from a lasting feeling of abdominal *** showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical *** diagnoses of SANT were made ***-up went well,and both were treated according to the recommendation for asplenic *** SANT is a rare cause of splenectomy and an incidental histological *** research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.

关键词： Splenectomy Sclerosing angiomatoid nodular transformation Spleen Abdominal discomfort Gastrointestinal dysfunction Case report

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口服纳多洛尔治疗婴幼儿血管瘤及普萘洛尔引起的睡眠障碍

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中国口腔颌面外科杂志 2015年第6期 529-529页

作者： bernabeu-wittel J Narváez-moreno B de la Torre-García Jm

口服普萘洛治疗婴幼儿血管瘤(IH)已被证明安全有效,其副作用包括睡眠障碍等。该文对普萘洛尔治疗过程中出现睡眠障碍导致治疗中断的部分患儿改用口服纳多洛尔治疗,并对该药的疗效及安全性进行评估。对三级儿童医院2008年7月-2013年3月... 详细信息

口服普萘洛治疗婴幼儿血管瘤(IH)已被证明安全有效,其副作用包括睡眠障碍等。该文对普萘洛尔治疗过程中出现睡眠障碍导致治疗中断的部分患儿改用口服纳多洛尔治疗,并对该药的疗效及安全性进行评估。对三级儿童医院2008年7月-2013年3月间接受普萘洛尔治疗的97例IH患儿进行回顾分析。结果:9(9.3%)例患儿出现睡眠障碍,7例中断治疗,改服纳多洛尔,5(71%)例患儿症状缓解,1例4个月后再次出现睡眠障碍。结论:由于样本量过小,

关键词：普萘洛尔纳多洛尔婴幼儿血管瘤睡眠障碍

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