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Postnatal development of fetuses with a single umbilical artery:differences between malformed and non-malformed infants

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World Journal of Pediatrics 2015年第1期11卷 61-66页

作者： Jose Vicente Arcos-machancoses Purificación marín-Reina Eugenia Romaguera-Salort Yolanda García-Camuñas Antonio Pérez-Aytés máximo vento Department of Pediatrics University & Polytechnic Hospital La Fe Valencia Spain Division of Neonatology University & Polytechnic Hospital La Fe Valencia Spain Department of Obstetrics & Gynecology University & Polytechnic Hospital La Fe Valencia Spain Division of Dysmorphology & Reproductive Assessment University & Polytechnic Hospital La Fe Valencia Spain

Background:The presence of a single umbilical artery(SUA)is a fetal soft marker of congenital *** the most common related malformations,there are cardiological,nephrourological and digestive anomalies,most of which are considered to have a vascular *** is an association between increased incidence of intrauterine growth retardation and adverse perinatal indicators,but whether this association is due to related anomalies or isolated SUA(SUA)is ***:We reviewed 96 cases of iSUA and non-isolated SUA(niSUA),diagnosed in a period of two years in a referral hospital for high-risk *** on prenatal explorations,including fetal ultrasonography and karyotyping,were *** was diagnosed when no malformations were found prenatally or in postnatal ***:Sixty-six newborns(68.8%)had no other anomalies and 30(31.3%)presented with a variety of malformations including heart diseases,urophaties,digestive,nervous and musculoskeletal disorders,genetic abnormalities and complex *** and nephrourological abnormalities were found to be the most frequent association with a SUA(both in 23.8%of malformed SUA newborns).Intrauterine growth restriction was not higher in iSUA newborns than in a normal *** allowed optimal prenatal diagnosis in most ***:The prognosis of the fetus with a SUA is determined by the presence of other malformations observed by an expert *** no other findings are made,only a routine physical examination should be performed in newborns,but no other complementary examinations are required.

关键词： cardiovascular abnormalities congenital abnormalities fetal growth retardation prenatal ultrasonography single umbilical artery

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metabolic dysregulation in term infants from SARS-CoV-2-infected mothers

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World Journal of Pediatrics 2023年第9期19卷 912-917页

作者： mari merce Cascant-Vilaplana Inmaculada Lara-Cantón Victoria Ramos-Garcia Alejandro Pinilla-González Álvaro Solaz-García Guillermo Quintás Purificación marín-Reina marta Aguar Laura Torrejón-Rodríguez máximo vento Julia Kuligowski maría Cernada Neonatal Research Unit Health Research Institute Hospital La FeUniversity Polytechnic Hospital La FeAvda.Fernando Abril Martorell 10646026ValenciaSpain Leitat Technological Center ValenciaSpain Analytical Unit Health Research Institute La FeValenciaSpain Division of Neonatology University and Polytechnic Hospital La FeValenciaSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a novel beta coronavirus that causes coronavirus disease 2019(COVID-19),a severe infectious respiratory *** January 2020,the World Health Organization(WHO)d... 详细信息

关键词： mother respiratory acute

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Clinical Parameters in the First 5 minutes after Birth Have a Predictive Value for Survival of Extremely Preterm Infants

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maternal-Fetal medicine 2023年第4期5卷 244-247页

作者： Laura Torrejón-Rodríguez Álvaro Solaz-García Inmaculada Lara-Cantón Alejandro Pinilla-González marta Aguar máximo vento Division of Neonatology University and Polytechnic Hospital La Fe(HULAFE)Valencia 46026Spain Neonatal Research Group Instituto de Investigación Sanitaria La Fe(IISLAFE)Valencia 46026Spain

Extreme preterm infants(60%)and lower(<30%)initial FiO_(2).Recent evidence and meta-analyses have underscored the predictive value for survival and/or relevant clinical outcomes of the Apgar score and the achievement ... 详细信息

Extreme preterm infants(mal inspired fraction of oxygen(FiO_(2))still represents a conundrum in newborn care oscillating between higher(>60%)and lower(meta-analyses have underscored the predictive value for survival and/or relevant clinical outcomes of the Apgar score and the achievement of arterial oxygen saturation measured by pulse oximetry≥85%at 5 minutes after *** clinical trials comparing higher versus lower initial FiO_(2)have been launched aiming to optimize postnatal stabilization of extreme preterm while avoiding adverse effects of hypoxemia or hyperoxemia.

关键词： Extreme preterm Postnatal stabilization Oxygen saturation Heart rate Inspired fraction of oxygen Apgar score

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Volume of Domains in Symmetric Spaces

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Chinese Annals of mathematics,Series B 2007年第5期28卷 521-526页

作者： ximo GUAL-ARNAU Antonio m.NAVEIRA Department of mathematics Universitat Jaume I 12071-CastellóSpain. Departamento de Geometría y Topología Universidad de Valencia 46100-BurjassotValenciaSpain.

The authors derive a formula for the volume of a compact domain in a symmetric space from normal sections through a special submanifold in the symmetric *** formula generalizes the volume of classical domains as tubes... 详细信息

关键词： Curvature-adapted submanifold Lie triple systematic normal bundle Root decomposable normal bundle Symmetric space Volume

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measure of Segments which Intersect a Convex Body from Rotational Formulae

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Acta mathematica Sinica,English Series 2015年第2期31卷 345-352页

作者： ximo GUAL-ARNAU Silena HEROLD-GARCA Departament de matemàtiques-INIT Universitat Jaume I. 12071-CastellSpain Departamento de Computacin Universidad de Oriente. 90900-Santiago de CubaCuba

Classical problems in integral geometry and geometric probability involve the kinematic measure of congruent segments of fixed length within a convex body in R3. We give this measure from rotational formulae; that is, from isotropic plane sections through a fixed point. From this result we also obtain a new rotational formula for the volume of a convex body; which is proved to be equivalent to the wedge formula for the volume.

关键词： Convex body flower integral geometry stereology rotational formulae segment supportset

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maize forage aptitude: Combining ability of inbred lines and stability of hybrids

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The Crop Journal 2014年第6期2卷 407-418页

作者： Luis máximo Bertoia mónica Beatriz Aulicino Department of Plant Production Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 21832 Lomas de Zamora Buenos Aires Argentina Department of Genetics Faculty of Agrosciences National University of Lomas de Zamora Camino de Cintura km 2 1832 Lomas de ZamoraBuenos Aires Argentina Santa Catalina Plant Breeding Institute National University of La Plata CC 4 1836 Llavallol Buenos Aires Argentina

Breeding of forage maize should combine improvement achieved for grain with the specific needs of forage hybrids. Production stability is important when maize is used for silage if the planting area is not in the ideal agronomic environment. The objectives of the present research were:(i) to quantify environmental and genetic and their interaction effects on maize silage traits;(ii) to identify possible heterotic groups for forage aptitude and suggest the formation of potential heterotic patterns, and(iii) to identify suitable inbred line combinations for producing hybrids with forage aptitude. Forty-five hybrids derived from diallelic crosses(without reciprocals) among ten inbred lines of maize were evaluated in this study. Combined ANOVA over environments showed differences between genotypes(G), environments(E), and their interactions(GEI). Heritability(H2), and genotypic and phenotypic correlations were estimated to evaluate the variation in and relationships between forage traits. Postdictive and predictive AmmI models were fitted to determine the importance of each source of variation, G, E, and GEI, and to select genotypes simultaneously on yield, quality and stability. A predominance of additive effects was found in the evaluated traits. The heterotic pattern Reid-BSSS × Argentine flint was confirmed for ear yield(EY) and harvest index(HI). High and broad genetic variation was found for stover and whole plant traits. Some inbred lines had genes with differential breeding aptitude for ear and stover. Stover and ear yield should be the main breeding objectives in maize forage breeding.

关键词： Zea mays L. Forage maize Combining ability GEI interaction Stover and ear digestibility

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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Defensive medicine:It is time to finally slow down an epidemic

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World Journal of Clinical Cases 2018年第11期6卷 406-409页

作者： Sandro vento Francesca Cainelli Alfredo Vallone Department of medicine Nazarbayev University University medical Center Infectious Diseases Unit G.Jazzolino Hospital

Defensive medicine is widespread and practiced the world over, with serious consequences for patients, doctors, and healthcare costs. Even students and resi-dents are exposed to defensive medicine practices and taught to take malpractice liability into consideration when making clinical decisions. Defensive medicine is generally thought to stem from physicians' perception that they can easily be sued by patients or their relatives who seek compensation for presumed medical errors. However, in our view the growth of defensive medicine should be seen in the context of larger changes in the conception of medicine that have taken place in the last few decades, undermining the patient–physician trust, which has traditionally been the main source of professional satisfaction for physicians. These changes include the following: time directly spent with patients has been overtaken by time devoted to electronic health records and desk work; family doctors have played a progressively less central role; clinical reasoning is being replaced by guidelines and algorithms; the public at large and a number of young physicians tend to believe that medicine is a perfect science rather than an imperfect art, as it continues to be; and modern societies do not tolerate the inevitable morbidity and mortality. To finally reduce the increasing defensive behavior of doctors around the world, the decriminalization of medical errors and the assurance that they can be dealt with in civil courts or by medical organizations in all countries could help but it would not suffice. Physicians and surgeons should be allowed to spend the time they need with their patients and should give clinical reasoning the importance it deserves. The institutions should support the doctors who have experienced adverse patient events, and the media should stop reporting with excessive evidence presumed medical errors and subject physicians to "public trials" before they are eventually judged in court.

关键词： Adverse event Clinical reasoning Defensive medicine Doctor-patient relationship Healthcare cost medical education medical error

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Improving fetal to neonatal transition of the very preterm infant： novel approaches

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Chinese medical Journal 2010年第20期123卷 2924-2928页

作者： maximo vento Neonatal Researcla Unit Division of Neonatology University Hospital La Fe Avenida de Campanar 21E46009 Valencia Spain

Two main issues are crucial for neonatology at present： first, the increased rate of preterm delivery （〉 10%） especially in low and middle income countries or even in industrialized countries lacking a universal a... 详细信息

关键词： newborn oxygen oxidative stress meta-analysis preterm oxygen saturation

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Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

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Acta Pharmaceutica Sinica B 2014年第5期4卷 376-383页

作者： máximo Gallignani Rebeca A.Rondón JoséF.Ovalles maría R.Brunetto Laboratorio de Espectroscopia molecular Departamento de QuímicaFacultad de CienciasUniversidad de Los AndesMérida 5101-AVenezuela Departamento de Análisis y Control Facultad de Farmacia y BioanálisisUniversidad de Los AndesMérida 5101-AVenezuela

A Fourier transform infrared derivative spectroscopy(FTIR-DS)method has been developed for determining furosemide(FUR)in pharmaceutical solid dosage *** method involves the extraction of FUR from tablets with N,N-dimethylformamide by sonication and direct measurement in liquid phase mode using a reduced path length *** general,the spectra were measured in transmission mode and the equipment was configured to collect a spectrum at 4 cm^(-1) resolution and a 13 s collection time(10 scans co-added).The spectra were collected between 1400 cm^(-1) and 450 cm^(-1).Derivative spectroscopy was used for data processing and quantitative measurement using the peak area of the second order spectrum of the major spectral band found at 1165 cm^(-1)(SO_(2) stretching of FUR)with baseline *** method fulfilled most validation requirements in the 2 mg/mL and 20 mg/mL range,with a 0.9998 coefficient of determination obtained by simple calibration model,and a general coefficient of variation mean recovery for the proposed assay method resulted within the(100±3)%over the 80%–120% range of the target *** results agree with a pharmacopoeial method and,therefore,could be considered interchangeable.

关键词： FTIR Derivative spectroscopy Furosemide Frusemide Pharmaceutical analysis

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