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内蒙古大学蒙古语文研究所六十年历程

中国蒙古学（蒙文） 2024年第2期52卷 129-135页

作者：斯钦巴图不详

sedimentology and Chronology of Paleogene Coarse Clastic Rocks in East-Central Tibet and Their Relationship to Early Tectonic Uplift

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Acta Geologica sinica(English Edition) 2007年第3期81卷 398-408页

作者： ZHOU Jiangyu WANG Jianghai K. H. BRIAN A. YIN m. s. mATTHEW Faculty of Earth and Resources China University of Geosciences Wuhan Hubei 430074 China Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou Guangdong 510640 China Food Engineering Research Center of the ministry of Education/state Key Laboratory of Biocontrol College of Life Sciences Sun Yat-Sen University Guangzhou Guangdong 510275 China Department of Earth and space sciences University of California Los Angeles CA 90095 USA

A systematic sedimentological and chronological study of typical Paleogene basins in eastcentral Tibet suggests that the depositional characteristics of extensively developed huge-bedded, purplish-red coarse clastic rocks formed in a tectonic setting of regional thrusting and strike-slipping represent a typical dry and hot subaerial alluvial fan environment formed in a proximal and rapidaccumulating sediment body in debris flows and a fan-surface braided river. Combining results from basin-fill sequences, sequences of coarse clastic rocks, fauna and sporo-pollen associations and thermochronological data, it is conduded that the coarse clastic rocks formed in the period of 54.2- 24.1 ma, nearly coeval with the formation of Paleogene basins in the northern （Nangqen-Yushu thrust belt）, middle （Batang-Lijiang fault belt）, and disintegration of large basins in the southern （Lanpingsimao fold belt） segments of Tibet. The widespread massive-bedded coarse clastic rocks, fold thrusting and strike-slip, thrust shortening, and igneous activities in the Paleogene basins of eastcentral Tibet indicate that an early diachronous tectonic uplift might have occurred in the Tibetan Plateau from middle Eocene to Oligocene, related to the initial stage of collision of the Indian and Asian plates.

关键词： Paleogene clastic rocks tectonic uplift chronology east-central Tibet

Effects of base analogues 5-bromouracil and 6-aminopurine on development of zebrafish Danio Rerio

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Chinese Journal of Oceanology and Limnology 2005年第1期23卷 54-59页

作者： sAWANT m. s. 张士璀王清印 College of marine Life sciences Ocean University of China Qingdao 266003 China Yellow sea Fisheries Research Institute Qingdao 266071 China

Zebrafish (Danio rerio) genetic screens allow isolation of a wide array of problems in vertebrate biology. The effects of base analogues 5-bromouracil and 6-aminopurine on the development of zebrafish embryos are reported for the first time in this study. The early development of the zebrafish embryos was little affected by 5-bromouracil and 6-aminopurine, while the late development (organogenesis) was significantly impaired. Embryos exposed to 5-bromouracil mainly showed curled tail, wavy body, golden pigmentation and the mouth with protruding lower jaw. 6-aminopurine-treated embryos had defective anterior structures, curled tails and wavy body. RAPD analysis showed that the majority of 5-bromouracil- and 6-aminopurine-treated larvae and fish shared banding patterns in common with the control, suggesting that most mutagenesis induced by these agents are point mutations. However, some fish derived from 5-bromouracil-treated embryos had golden (gol) pigmentation; and RAPD analysis revealed that their band patterns differed from those of the control. Possibly, 5-bromouracil can occasionally cause relatively extensive changes in the fish genome. The results of this study may provide valuable help for detailed studies of mutagenesis.

关键词： zebrafish Danio rerio 5-bromouracil 6-aminopurine mutagenesis

massive neutron stars and A-hypernuclei in relativistic mean field models

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Chinese Physics C 2018年第2期42卷 136-143页

作者：孙亭亭夏铖君张时声 m.s.smith school of Physics and Engineering and Henan Key Laboratory of Ion Beam Bioengineering Zhengzhou University Zhengzhou 450001 China school of Information science and Engineering Ningbo Institute of Technology Zhejiang University Ningbo 315100 China CAs Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China school of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China Physics Division Oak Ridge National Laboratory Oak Ridge Tennessee 37831-6354 USA

Based on relativistic mean field（RmF） models, we study finite A-hypernuclei and massive neutron stars. The effective N-N interactions PK1 and Tm1 are adopted, while the N-A interactions are constrained by reproducing the binding energy of A-hyperon at 1 s orbit of Λ^40Ca. It is found that the A-meson couplings follow a simple relation, indicating a fixed A potential well for symmetric nuclear matter at saturation densities, i.e., around VΛ=-29.786 meV. With those interactions, a large mass range of Λ-hypernuclei can be described well. Furthermore,the masses of PsR J1614-2230 and PsR J0348＋0432 can be attained adopting the Λ-meson couplings gσΛ/gσN≥0.73,gωΛ/gωN≥0.80 for PK1 and gσΛ/gσN≥0.81,gωΛ/gωN≥0.90 for Tm1, respectively. This resolves the hyperon puzzle without introducing any additional degrees of freedom.

关键词： massive neutron stars A-hypernuclei relativistic mean field theory

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我们有可能用“经济”之外的语言理解世界吗

教师博览（上旬刊） 2024年第5期 48-51页

作者： [加]F.s.迈克尔斯黄煜文(译) 不详

为什么要摆脱经济语言的单一文化单一文化使我们的经验与期待向经济故事靠拢,生活面临的风险也随之增加。正如生物多样性反映了许多生命形式与生态系统的健康,价值多样性也反映了我们各种生活“方式”与社会系统的健康。以经济语言来讲... 详细信息

为什么要摆脱经济语言的单一文化单一文化使我们的经验与期待向经济故事靠拢,生活面临的风险也随之增加。正如生物多样性反映了许多生命形式与生态系统的健康,价值多样性也反映了我们各种生活“方式”与社会系统的健康。以经济语言来讲述我们所有的故事,最终将改变故事本身的意义。正如语言建构了我们的思想,而我们的思想影响了我们的行为,单一文化也开始改变我们的决定与生活方式。

关键词：语言建构单一文化语言理解生态系统生物多样性故事健康生活

melatonin and schistosomal antigens ameliorate the anti-oxidative and biochemical response to schistosoma mansoni infection in hamster

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Current Zoology 2009年第2期55卷 165-172页

作者： Nahla s. El-sHENAWY maha F. m. sOLImAN shimaa E. Abel-RAHmAN Zoology Department Faculty of ScienceSuez Canal University

The present study was designed to investigate the potential protective effect of melatonin as an antioxidant separately or in combination with antigens （cerearial; CAP or soluble worm; sWAP） against schistosoma mansoni infection in hamsters. Each hamster was sensitized with an initial immunization of 0.6 ml of the extracted antigen （30μg protein/mL）. After four days, a second injection of 0.4 mL was given （20μg protein/mL）. Then, each hamster was exposed to 260 ± 20 s. mansoni cercariae followed with melatonin treatment （3.5 mg/kg） for thirty days from the 1st day of post infection. Levels of lipid peroxidation （LPO） products, eatalase （CAT） activity, hepatic glutathione （GsH） and biochemical changes in the liver and kidneys functions were investigated. The results revealed a high significant increasing of LPO and decreasing of CAT and GsH in liver of infected hamsters. Biochemical observations showed severe damage in the liver enzyme activities and increasing cholesterol level in infected animals. melatonin co-treatment with antigen to the infeeted-hamster attenuated the increase of LPO and restored the activity of CAT and levels of hepatic GsH. Also, the biochemical damages in the liver and kidneys funetions were reduced. The present study suggests that melatonin may be useful in combating free radical-induced damage due to infection toxicity. The immunization with previous antigens resulted in a remarkable improvement on the liver enzyme activities, which were increased after infection. Thus, vaccination of hamsters with antigens （both CAP and sWAP） and melatonin treatment has more potent effect on the enhancement of antioxidant and biochemical of s. mansoni infected-hamster than each treatment separately. Immunization of the hamster with sWAP followed by melatonin was the best way among the other regime treatments to improve the biochemical and antioxidant parameters of the infected-hamsters.

关键词： Lipid peroxidation Catalase Glutathione Cholesterol Uric acid Creatinine Enzymes activity melatonin Antigen schistosoma mansoni

Dexamethasone intravitreal implant(Ozurdex) in diabetic macular edema: real-world data versus clinical trials outcomes

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1571-1580页

作者： Pedro Neves mário Ornelas Inês matias João Rodrigues margarida santos marco Dutramedeiros David martins Department of Ophthalmology Centro Hospitalar de SetúbalSetúbal 2910-549Portugal Department of Ophthalmology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Ophthalmology Hospital da Luz SetúbalSetúbal 2900-722Portugal Department of Ophthalmology Centro Hospitalar Lisboa CentralFaculdade de Ciências MédicasNOVA University of LisbonLisbon 1990-237Portugal

AIm: To investigate the safety and efficacy of intravitreal dexamethasone implants(Ozurdex?/DEX) in patients with diabetic macular edema(DmE) either na?ve or nonna?ve to anti-VEGF therapies who switched to DEX implant independent of response to anti-vascular endothelial growth factors(anti-VEGFs).mETHODs: This was an audit retrospective review of medical records of patients with DmE who switched to the DEX intravitreal implant. Patients were divided into 2 groups: patients na?ve to antiangiogenic therapy and patients who were previously treated with anti-VEGFs. Data regarding demographics, changes in mean best-corrected visual acuity(BCVA), central macular thickness(CmT), and intraocular pressure(IOP) was collected over 6 mo. The demographic data mean changes in BCVA, CmT, and IOP were compared. six-month follow-up data of 47 patients(57 eyes), who either switched to DEX implant irrespective of response to previous treatments or were treatment na?ve before receiving DEX implant, was ***: Improvement in mean BCVA was observed from 1-4 mo after injection with a decreased effect at month 6 as expected, with better outcomes in na?ve compared to non-na?ve patients. A statistically relevant decrease in mean CmT was observed during the follow-up period. An increase in mean IOP was observed in the first 2 mo after DEX therapy. The mean number of injections of the overall population during the 6 mo was 1.3. A subgroup analysis showed no relevant difference between phakic versus pseudophakic patients relative to measured outcomes. There was no cataract progression during the follow-up period and no adverse events ***: This real-life setting study shows that intravitreal DEX implant is effective and safe. The timings of greater therapeutic impact are concordant with previous studies and suggest that earlier treatment with corticosteroids may have an additional benefit in na?ve patients.

关键词： anti-VEGF therapy diabetic macular edema dexamethasone intravitreal implant na?ve eyes steroids

Non-Canonical Functions of the E2F/DP Pathway with Emphasis in Plants

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 307-330页

作者： Víctor A.sánchez-Camargo samantha Romero-Rodríguez Jorge m.Vázquez-Ramos Facultad de Química Departamento de BioquímicaUniversidad Nacional Autónoma de MéxicoAvenida Universidad y CopilcoCiudad de México04510México Plant Development and(Epi)Genetics Group Swammerdam Institute for Life SciencesUniversiteit van AmsterdamAmsterdam1098XHNetherlands

The E2F/DP pathway is a widely conserved regulatory mechanism in pluricellular *** family of E2F and DP transcription factors was originally described having a role in the transition from the G1 to the s phase of the cell ***,the discovery of hundreds of possible gene targets and their involvement in many other biochemical processes,soon showed that they participated in cell development and differentiation,chromatin remodeling,DNA repair and *** E2F/DP transcription factors can act as either activators or repressors of transcription depending on their association to other regulatory proteins,particularly the retinoblastoma protein,or even depending to their protein structure that can define their *** plants the E2F/DP pathway also regulates endoreduplication,a process present along the life cycle,from organ elongation to root differentiation and *** transcription factors also help plant cells to respond to environmental disturbances such as those caused by different types of radiation,or by *** review focuses on the“so called”non-canonical functions of the E2F/DP family proteins in animal and plant cells,that are in fact essential activities that connect regulatory circuits among multiple metabolic pathways by means of their atypical functions.

关键词： E2F DP transcription factors atypical functions plant cells

Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma

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Genes & Diseases 2017年第4期4卷 215-221页

作者： Khalda s.Amr Hanan Abd Elmawgoud Atia Rehab Abd Elazeem Elbnhawy Wafaa m.Ezzat medical molecular Genetics Department National Research CentreCairoEgypt Biochemistry Department Faculty of Pharmacy(Girls)Al-Azhar UniversityCairoEgypt Urology and Nephrology Center Mansoura UniversityMansouraEgypt Internal medicine Department National Research CenterCairoEgypt

Hepatocellular carcinoma(HCC)is one of the common lethal types of tumor all over the *** lethality of HCC accounts for many *** of them,the lack of reliable diagnostic markers at the early stage,in this context,serum miRNAs became promising diagnostic ***,we aimed to identify the predictive value of two miRNAs(miR-122 and miR-224)in plasma of patients with HCC preceded by chronic HCV *** miRNA assays specific for hsa-miR-122 and hsa-miR-224 were used to assess the expression levels of the chosen miRNAs in plasma samples collected from three groups;40 patients with HCC related to HCV,40 with CHC patients and 20 healthy *** study revealed that the mean plasma values of miRNA-122 were significantly lower among HCC group when compared to CHC and control groups(Ps,miR-224 mean plasma values were significantly higher among HCC group when compared to both CHC group and control ***,it was found that miR-122 can predict development of HCC at cut-off values regards miR-224,it can predict development of HCC at cut-off value>1.2(RQ)and(AUC Z 0.93,Pse HCC was(AUC:0.619;P Z 0.06).In conclusion,the expression plasma of miR-122 and miR-224 could be used as noninvasive biomarkers for the early prediction of developing HCC at the early stage.

关键词： Diagnosis Hepatocellular carcinoma miR-122 miR-224 sensitivity