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基于触觉感知的简化模型研究寸口处脉象差异

Digital Chinese medicine 2024年第1期7卷 29-39页

作者：史宇兵杨洪义 YEO Joon hock 陕西中医药大学整合医学研究院陕西咸阳712046 Department of mechanical Materials&Manufacturing EngineeringUniversity of Nottingham Malaysia Campus43500 SemenyihSelangor Darul EhsanMalaysia School of mechanical and Aerospace Engineering Nanyang Technological University639798Singapore

目的中医脉诊理论认为腕部桡动脉处(称为寸口)的脉象表征着人体不同脏腑器官的生理病理状况。然而,研究人员对于脉诊技术的客观性存在不同看法,部分研究人员提到在不同的寸口部位未观察到显著的脉象差异,通过寸口脉象辨别不同器官的状... 详细信息

目的中医脉诊理论认为腕部桡动脉处(称为寸口)的脉象表征着人体不同脏腑器官的生理病理状况。然而,研究人员对于脉诊技术的客观性存在不同看法,部分研究人员提到在不同的寸口部位未观察到显著的脉象差异,通过寸口脉象辨别不同器官的状态可能存在一定难度。本研究通过对触觉感知特性的简化数学建模来分析寸口处的脉象,从而对上述问题进行探讨。方法基于Weber-Fechner定律,将诊脉过程中的触觉感知变化描述为带宽随不同取脉压力而变化的低通信号滤波器。应用该模型分析本研究组此前采集的临床数据,对14例介入测量得到的主动脉缩窄患者的动脉血压数据进行处理,以模拟不同取脉压力作用于寸关尺部所形成的脉象差异。结果考虑触觉感知特性时,伴随取脉压力的变化诊脉中寸口处不同脉深的脉象存在显著差异;而采用传感器测量时由于不存在触觉感知特性的影响,所得到的脉象则没有这种随脉深的变化。这就解释了为什么中医直接诊脉与现代脉诊学使用传感器测量会对脉象形成不同的理解。此外,采用本研究中建立的触觉感知模型所计算出的寸口处浮中沉不同脉深的脉象特征,与中医脉搏理论中的相关描述一致。结论本研究通过建立触觉感知模型,初步解释了中医脉诊理论中的脉象随取脉压力变化现象。将触觉感知建模引入中医脉诊研究,开启了图象化表达脉象以对其进行定量分析的新的探索窗口,这不仅有效扩展了脉诊研究的范畴,也为现有脉诊仪的技术升级和功能优化提供了科学依据。

关键词：脉象中医寸口触觉感知数学模型

不同民族传统医学脉诊术的比较及血流动力学分析

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医用生物力学 2024年第S1期 270-270页

作者：史宇兵杨洪义 Yeo Joon hock 陕西中医药大学整合医学研究院 School of mechanical and Aerospace Engineering Nanyang Technological University

目的古时候受限于诊疗手段,不同的民族传统医学都发展出通过诊脉了解患者身体状况的技术。从血流动力学的角度比较这些脉诊术的技术内容,对于中医的脉诊研究具有重要借鉴意义。方法整理国内外各民族传统医学包括中医、印度阿育吠陀、...

目的古时候受限于诊疗手段,不同的民族传统医学都发展出通过诊脉了解患者身体状况的技术。从血流动力学的角度比较这些脉诊术的技术内容,对于中医的脉诊研究具有重要借鉴意义。方法整理国内外各民族传统医学包括中医、印度阿育吠陀、藏医、蒙医、玛雅医学、伊斯兰医学等的脉诊术资料,从诊脉部位和脏腑配位关系等方面对它们的异同点进行分析比较,从血流动力学的角度分析和评价其对临床诊断的影响。结果各民族传统医学的脉诊术存在形式上的相似性,但在技术内容上存在较大差异,主要表现在对诊脉部位与脏腑的配位关系的认识方面。仅从操作的角度看这些差异会造成彼此在技术上相互抵触并影响诊断结论,但实际上各脉诊术都能对患者做出正确诊断。从血流动力学角度分析这种矛盾现象,本文认为诊脉位置并非天然和不同脏腑存在配位关系;各民族传统医学根据自己的习惯选择了腕部脉搏的不同位置,通过大量学习和训练建立起各自的诊脉部位脉象与脏腑疾病状况的对应关系,就像采用同类数据集的不同样本训练人工神经网络,都能得到适合应用的人工智能系统一样。结论广泛比较多方面信息和采用血流动力学分析有助于对传统脉诊理论和技术形成新的深层次认识。

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Numerical Simulations of a Florida Sea Breeze and Its Interactions with Associated Convection:Effects of Geophysical Representation and model Resolution

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Advances in Atmospheric Sciences 2022年第5期39卷 697-713页

作者： Nessa hock Feimin ZHANG Zhaoxia PU Department of Atmospheric Sciences University of UtahSalt Lake CityUtah 84112USA Air Force Institute of Technology Wright-Patterson Air Force BaseOhio 45433USA Lanzhou University Lanzhou 730000China

The Florida peninsula in the USA has a frequent occurrence of sea breeze(SB)*** this study,the numerical simulation of a Florida SB and its associated convective initiation(CI)is simulated using the mesoscale community Weather Research and Forecasting(WRF)model in one-way nested domains at different horizontal *** are compared with observations to examine the accuracy of model-simulated SB convection and factors that influence SB CI within the *** is found that the WRF model can realistically reproduce the observed SB *** are found in the timing,location,and intensity of the convective cells at different domains with various spatial *** increasing spatial resolution,the simulation improvements are manifested mainly in the timing of CI and the orientation of the convection after the sea breeze front(SBF)merger into the squall line over the *** indicate that accurate representation of geophysical variables(e.g.,coastline and bay shape,small lakes measuring 10-30 km2),better resolved by the high resolution,play a significant role in improving the *** geophysical variables,together with the high resolution,impact the location and timing of SB CI due to changes in low-level atmospheric convergence and surface sensible *** importantly,they enable Florida lakes(30 km2 and larger)to produce noticeable lake breezes(LBs)that collide with the SBFs to produce ***,they also help the model reproduce a stronger convective squall line caused by merging SBs,leading to more accurate locations of postfrontal convective systems.

关键词： sea breeze convective initiation lake breeze numerical simulation

The role of aggression in range expansion and biological invasions

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Current Zoology 2014年第3期60卷 401-409页

作者： Sandra HUDINA Karlo hock Kresimir ZGANEC Faculty of Science University of Zagreb Rooseveltov trg 6 10000 Zagreb Croatia School of Biological Sciences University of Queensland Brisbane Australia Department of Teachers' Education in Gospie University of Zadar Croatia

Traits that aid in the invasion process should exhibit a gradient across the expansion range in response to changing selection pressures. Aggression has been repeatedly associated with invasion success in many taxa, as it may help invaders to wrestle the resources from other species which enhances their success in a novel environment. However, aggression primarily al lows individuals to overcome conspecific rivals, providing advantages in competition over resources. Agonistic prowess could therefore increase fitness at both ends of the expansion gradient. Here we review the role of aggression in range expansion of in vasive species, and its potential role as a driver of range expansion. We analyze how these different mechanisms could affect trait variation in expanding and invasive populations. Specifically, we look at how aggression could help dilate the edges of a popula tion through niche competition, as well as lead to exclusion from the center （Le. areas of high population density） by the conspe cities. Both of these processes will result in a characteristic spatial distribution of phenotypes related to aggression that could provide insights into the ecological pressures and dynamics of expanding populations, potentially providing clues to their success as niche competitors and invasive species

关键词： Aggression Trait variation Invasion success Invasive species

The rapid determination of volatile fatty acid number in para rubber latex using fourier transform-near infrared spectroscopy based on quantification and discrimination model

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 107-115页

作者： Sureeporn Narongwongwattana Ronnarit Rittiron Chin hock Lim Department of Food Engineering Faculty of Engineering at Kamphaengsaen Kasetsart University NakhonpathomThailand Thai Rubber Latex Corporation(Thailand)Public Company Limited ChonburiThailand

Volatile Fatty Acid number(VFA no.)is one of the parameters indicating the state of quality of Para rubber latex at that particular *** factories analyze this parameter using standard analytical method as in ISO 506:1992(E).Nevertheless,this procedure is complicated,chemical and time consuming,as well as skilled analyst ***,near infrared(NIR)spectroscopy which is rapid,accurate and nonchemicals method was applied to determine the VFA *** latex and concentrated latex based on quantification and discriminant *** best calibration equation was obtained from standard normal variate(SNV)spectra in the region of 6109.7–5770.3,4613.1–4242.9 cm^(-1) with R?0:832,SECV?0:036 and no *** the performance check,statistically it was found that SECV and bias were low enough for practical acceptance and the predicted VFA *** not di®erent significantly from actual VFA *** 95% confidence *** addition,discriminant model was developed to separate good quality latex from the deteriorated latex using VFA *** 0.06 as standard as in ISO 2004:2010(E).The discriminant model can be used to screen the latex with overall accuracy of 91.86%in validation set.

关键词： Hevea brasiliensis latex quality polyisoprene ISO 12099:2010(E)

Shape correspondence for cel animation based on a shape association graph and spectral matching

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Computational Visual media 2023年第3期9卷 633-656页

作者： Shaolong Liu Xingce Wang Xiangyuan Liu Zhongke Wu hock Soon Seah Beijing Normal University Beijing 100875China Nanyang Technological University Singapore 639798Singapore

We present an effective spectral matching method based on a shape association graph for finding region correspondences between two cel animation *** formulate the correspondence problem as an adapted quadratic assignment problem,which comprehensively considers both the intrinsic geometric and topology of regions to find the globally optimal *** simultaneously represent the geometric and topological similarities between regions,we propose a shape association graph(SAG),whose node attributes indicate the geometric distance between regions,and whose edge attributes indicate the topological distance between combined region *** convert topological distance to geometric distance between geometric objects with topological features of the pairs,and introduce Kendall shape space to calculate the intrinsic geometric *** utilizing the spectral properties of the affinity matrix induced by the SAG,our approach can efficiently extract globally optimal region correspondences,even if shapes have inconsistent topology and severe *** is also robust to shapes undergoing similarity transformations,and compatible with parallel computing techniques.

关键词： cel animation shape correspondence shape association graph(SAG) spectral matching quadratic assignment Kendall shape space

The Future of Gas to Liquids as a Gas monetisation Option

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Journal of Natural Gas Chemistry 2004年第2期13卷 63-70页

作者： hock Cheng Heng Suhaili Idrus

The paper introduces gas to liquids (GTL) as a monetising option from a technology, marketing and project perspective. GTL is complementary to LNG and pipelines. At the same time, using natural gas as a source for fuels in the form of GTL helps countries around the world to diversify their energy supplies. Furthermore, gas-based products are inherently cleaner than oil products. Shell's proprietary GTL technology or SmDS (Shell middle Distillates Synthesis), is discussed in some detail. The paper also covers the challenges for successful implementation of GTL projects and why Shell is well positioned to take a lead in the industry on the basis of its long standing and broad experience in GTL research, plant operations, marketing and excellent track record in mega projects in the last thirty years. Shell's commitment to GTL is best demonstrated by the recent signing of a Heads of Agreement with Qatar Petroleum for the construction of the world's largest GTL plant. A key success factor is Shell's experience with marketing quantities of high quality GTL products from its 12,500 barrels per day plant at Bintulu, malaysia since 1993. Further marketing opportunities will arise when new GTL capacity comes on-stream in the middle east when more quantities will become available to bulk users. Amongst the most interesting market will be automotive transportation, where clean GTL fuels can be positioned as an 'alternative fuel beyond oil' providing energy security to host countries. Shell is actively engaging with a number of regulators, automotive companies and governments worldwide including China, to demonstrate the performance of GTL and its cost effectiveness in reducing local emissions. An added benefit is that GTL can use existing infrastructure and requires no investment. Finally, the paper briefly discusses the coal to liquids (CTL) process as an alternative route to produce high quality GTL products and the key issues relating to the process.

关键词： gas to liquids (GTL) coal to liquids (CTL) liquefied natural gas (LNG)

modes of action of fraxinellone against the tobacco budworm, Heliothis virescens

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Insect Science 2009年第2期16卷 147-155页

作者： Zhi Long Liu Shuit Hung Ho Swee hock Goh Department of Entomology China Agricultural University Beijing China Department of Biological Sciences National University of Singapore Singapore

Fraxinellone significantly reduced the relative growth rate, food consumption rate as well as the efficiency of conversion of ingested food into biomass of Heliothis virescens when incorporated into artificial diets at concentrations of 4.31 x 10.5 mol/L and above. After being fed with fraxinellone-treated diets for 24 h, the larval midguts of H. vb＇escens possess significantly lower activities of α-amylase and non-specific proteases and higher activities of cytochrome P450s. In vitro, the compound did not inhibit the activities of u-amylase and non-specific proteases extracted from the larval midguts. Clear evidence of post-ingestive toxicity of fraxinellone to midgut cells was observed under an electron microscope. The modes of action of the compound against insects were discussed.

关键词： amylase detoxification enzyme digestive enzyme fraxinellone Heliothisvirescens protease

Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C＞T mutation in CLCN7

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Bone Research 2016年第4期4卷 232-240页

作者： Xiang Chen Kun Zhang Janet hock Chunyu Wang Xijie Yu Laboratory of Endocrinology and metabolism Department of Endocrinology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China The Polis Center Indiana University-Purdue University Indianapolis Indianapolis IN USA

Type II autosomal dominant osteopetrosis(ADO2), which is the most common form of osteopetrosis, is caused by heterozygous mutations in the chloride channel 7(CLCN7) gene. The osteopetrosis of ADO2 has been attributed to hypofunctional osteoclasts. The mechanism underlying the abnormality in osteoclast function remains largely unknown. This study was designed to investigate gene mutations and osteoclast function in a case that was clinically diagnosed as ADO2. Genomic DNA was extracted from blood samples of this patient, and the 25 exons of CLCN7 were amplified. Peripheral blood from the ADO2 subject and a healthy age- and sex-matched control was used to evaluate osteoclastogenesis, osteoclast morphology, and bone resorption. Analysis of DNA from the patient showed a germline heterozygous missense mutation,c.1856C>T(p.P619L), in exon 20 of CLCN7. A similar homozygous mutation at this site was previously reported in a patient with autosomal recessive osteopetrosis. When cultured, the peripheral blood mononuclear cells(PBmCs) from the ADO2 patient spontaneously differentiated into mature osteoclasts in vitro. The ADO2 patient’s PBmCs formed enhanced, but heterogeneous, osteoclasts in both the presence and absence of macrophage-colony stimulating factor, and nuclear factor-?B ligand. Bone resorption was reduced in the ADO2 patient’s osteoclasts, which exhibited aberrant morphology and abnormal distribution of integrin avβ3. Gene analysis found increased c-fos expression and reduced Rho A and integrin beta 3expression in ADO2 cells. In conclusion, our data suggest that enhanced, heterogeneous osteoclast induction may be an intrinsic characteristic of ADO2.

关键词： ADO T mutation in CLCN7 Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C case type II