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Acellular mineralized Exoskeleton Shrimp (mES): A Natural Source of Bioactive Factors for Tissue Regeneration—Preliminary Results

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Journal of Biosciences and medicines 2022年第3期10卷 34-43页

作者： Raquel Zita Gomes Rodrigo Valdoleiros e Silva Américo Afonso maria Helena Fernandes mário vasconcelos José Cavalheiro Faculty of Dental medicine University of Porto Porto Portugal Private Practice (Raquel Zita Dental Clinic) Porto Portugal i3S—Institute for Research and Innovation in Health University of Porto Porto Portugal INEB—National Institute of Biomedical Engineering Porto Portugal ICBAS—Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal School of medicine University of Minho Braga Portugal Department of Histology Faculty of Dental Medicine University of Oporto Porto Portugal Department of Pharmacology Faculty of Dental Medicine University of Oporto Porto Portugal Department of Biomaterials Faculty of Dental Medicine University of Oporto Porto Portugal Faculty of Engineering University of Oporto Porto Portugal

Current challenges in the development of scaffolds for bone regeneration include the engineering of biomaterials that can withstand a natural dynamic physiology on the bone that provides a matrix capable of supporting cell migration and tissue ingrowth. The objective of the present work was to develop and characterize a new biomembrane—mineralized Exoskeleton Shrimp (mES) developed from the exoskeleton of paleomonetes. The integration of mES as a biomaterial for tissue regeneration relies on the growing evidence that the shrimp is characterized by a hierarchically arranged chitin fiber structure, mineralized predominately by calcium carbonate and/or calcium phosphate, bringing beneficial effects in bone regeneration. Additionally, the tridimensional mES structure, can act as a “tent” for Guided Bone Regeneration (GBR). Recently, our team has characterized the mES biomaterial by in vitro (human osteoblastic cellular cultures and immersion of the membrane in modified synthetic plasma) and in vivo (soft tissue in lab mice and hard tissue in rabbit model). The cellular growth in the mES membrane was very exuberant in cellular culture with osteoblastic colonization on its surface (histophilic and biocompatible). After the immersion in modified synthetic plasma for one week, a mass mineralization occurred throughout the membrane’s surface (bioactive). The analysis of histological samples from experimental surgery in lab mice showed that the mES membrane wasn’t toxic to soft tissues and that it caused a moderate inflammatory response (first reabsorption signs at 8 weeks). The mES could act as a cell-guiding template that contains the necessary cues and adequate three-dimensional set to facilitate cell adhesion and promote tissue regeneration upon implantation and subsequent biodegradation.

关键词： Guided Bone Regeneration Biomaterial Biocompatibility Oral Surgery

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Six-Writings multimodal processing with pictophonetic coding to enhance Chinese language models

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 84-105页

作者： Li WEIGANG mayara Chew mARINHO Denise Leyi LI Vitor vasconcelos DE OLIVEIRA Department of Computer Science University of BrasiliaBrasilia 70910-900Brazil Faculty of Economics AdministrationAccounting and ActuariesUniversity of Sao PauloSao Paulo 05508-010Brazil

While large language models(LLms)have made significant strides in natural language processing(NLP),they continue to face challenges in adequately addressing the intricacies of the Chinese language in certain *** propose a framework called Six-Writings multimodal processing(SWmP)to enable direct integration of Chinese NLP(CNLP)with morphological and semantic *** first part of SWmP,known as Six-Writings pictophonetic coding(SWPC),is introduced with a suitable level of granularity for radicals and components,enabling effective representation of Chinese characters and *** conduct several experimental scenarios,including the following:(1)We establish an experimental database consisting of images and SWPC for Chinese characters,enabling dual-mode processing and matrix generation for CNLP.(2)We characterize various generative modes of Chinese words,such as thousands of Chinese idioms,used as question-and-answer(Q&A)prompt functions,facilitating analogies by *** experiments achieve 100%accuracy in answering all questions in the Chinese morphological data set(CA8-mor-10177).(3)A fine-tuning mechanism is proposed to refine word embedding results using SWPC,resulting in an average relative error of≤25%for 39.37%of the questions in the Chinese wOrd Similarity data set(COS960).The results demonstrate that SWmP/SWPC methods effectively capture the distinctive features of Chinese and offer a promising mechanism to enhance CNLP with better efficiency.

关键词： Chinese language model Chinese natural language processing(CNLP) Generative language model multimodal processing Six-Writings

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Jacob's Room:A New Form fora New Novel

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Journal of Foreign Languages and Cultures 2024年第1期8卷 80-91页

作者： Sandra Guardini vasconcelos University of São Paulo

This article discusses the impact of the Post-Impressionist Exhibition that Roger Fry organized in London in 1910 on Virginia Woolf's ideas on the *** dissatisfaction with the state of the genre finds expression in her diary and in her criticism of the work of the Edwardian ***'s Room(1922),her first truly experimental novel,deploys some of the painterly techniques that the post-impressionist painters and vanguard movements of the 1910s *** represents a decisive step in her search for a new form for a new novel.

关键词： Jacob's Room Virginia Woolf essay experimental novel painting post-impressionism

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ZnO/CeO_(2)/carbon xerogel composites with direct Z-scheme heterojunctions:Enhancing photocatalytic remediation of 4-chlorophenol under visible light

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Journal of Rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas Perciani de moraes maite Birkett de Campos Sanmartin Robson da Silva Rocha Abner de Siervo marcos Roberto de vasconcelos Lanza D.Amaranatha Reddy Lianqing Yu Liana Alvares Rodrigues Escola de Engenharia de Lorena-EEL/USP Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of Physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto de Quimica de Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain Department of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of materials Science and Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light driven ternary photocatalysts using zinc oxide(ZnO),cerium(IV)oxide(CeO_(2)),and carbon xerogel(CX) as constituent *** use of CeO_(2) is based on the creation of direct-Z-scheme heterojunctions with the ZnO and the consequent diminishing of charge recombination,whereas the carbon xerogel inclusion is predicted to minimize bandgap energy,decrease electro n-hole reco mbination,and boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted at the development of an environmentally friendly and affordable *** existence of the hexagonal phase of zinc oxide and cubic structure of the cerium(IV) oxide in the ternary material was confirmed by X-ray diffractometry and X-ray photoelectron spectroscopy,with the latter also suggesting chemical bonding between the ZnO and the CX due to the creation of zinc oxycarbide *** inclusion of the carbon xerogel provokes a significant modification in the morphology of the ternary material,resulting in an increased surface area and smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials studied,degrading 100% of 4-chlorophenol under simulated sunlight and 68% under visible radiation,after 5 *** increased photocatalytic activity can be attributed to the formation of direct Z-scheme heterojunctions between the semiconductors,higher visible light response,and higher specific surface area,as evidenced by the results obtained by active radical scavenging,chronoamperometry,diffuse reflectance spectroscopy,and N_(2) adsorption-desorption isotherms.

关键词： Zinc oxide Cerium(Ⅳ)oxide Carbon xerogel Photocatalysis Direct Z-scheme heterojunction 4-Chlorophenol Rare earths

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Behavior of argon gas release from manganese oxide minerals as revealed by ^(40)Ar/^(39)Ar laser incremental heating analysis

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Chinese Science Bulletin 2002年第18期47卷 1502-1510页

作者： P. m. vasconcelos Faculty of Earth Resources China University of Geosciences Wuhan China Department of Earth Sciences The University of Queensland Brisbane Australia

manganese oxides in association with paleo-weathering may provide significant insights into the multiple factors affecting the formation and evolution of weathering profiles, such as temperature, precipitation, and biodiversity. Laser probe step-heating analysis of supergene hollandite and cryptomelane samples collected from central Queensland, Australia, yield well-defined plateaus and consistent isochron ages, confirming the feasibilityy dating very-fined supergene manganese oxides by 40Ar/39 Ar technique. Two distinct structural sites hosting Ar isotopes can be identified in light of their degassing behaviors obtained by incremental heating analyses. The first site, releasing its gas fraction at the laser power 0.2-0.4 W, yields primarily 40Aratm, 38Aratm, and 36Aratm(atmospheric Ar isotopes). The second sites yield predominantly 40Ar*(radiogenic 40Ar), 39Ark, and Ark (nucleogenic components), at -0.5-1.0 W. There is no significant Ar gas released at the laser power higher than 1.0 W, indicating the

关键词： hollandite cryptomelane 40Ar/39Ar laser incremental heating argon degassing tunnel site.

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Techno-functionality of fisetin-enriched yoghurt fermented with Lactobacillus acidophilus bio-capsules produced via osmoporation

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Systems microbiology and Biomanufacturing 2022年第4期2卷 743-749页

作者： Eduardo Wagner vasconcelos de Andrade Sebastien Dupont Laurent Beney Edilene Souza da Silva Roberta Targino Hoskin márcia Regina da Silva Pedrini Bioprocess Laboratory Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil Laboratory of Bioactive Compounds Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil UmR Procédés Alimentaires et microbiologiques(PAm UMR A 02.102)Univ.Bourgogne Franche-ComtéAgroSup Dijon21000 DijonFrance

Osmoporation is a novel encapsulation approach for bioactive compounds based on the osmoresistance mechanisms of microbial *** the best of our knowledge,this is the first study investigating the production of fisetin-enriched yoghurt using Lactobacillus acidophilus-based bio-capsules via osmoporation as the starter *** showed that the milk acidification with fisetin-loaded *** progressed at a slower pace due to complex mechanisms induced by osmopo-ration and internalized *** fermentation using fisetin bio-capsules reached a maximum acidification rate of 0.18 pH units/h after 23 h and pH 4.6 was achieved after 32 ***,the antioxidant activity of yoghurts produced with fisetin bio-capsules did not change during cold storage,while the antioxidant activity of yoghurt produced with non-encapsulated fisetin was reduced by 2.5-fold after 28 ***,this study shows that fisetin osmoporation using *** is a versatile encapsulation bioprocess that enables the delivery of preserved phytoactives into fermented foods like *** strategy has the potential to be extended to other applications in the dairy industry using lactic acid bacteria as both the encapsulation matrix and fermentation agent.

关键词： Cell-based carriers Probiotic bacteria Dairy fermented products Food biotechnology Functional foods

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Erbium photoluminescence response related to nanoscale heterogeneities in sol-gel silicates

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Journal of Rare Earths 2013年第1期31卷 18-26页

作者： H.C.vasconcelos m.G.meirelles F.Rivera-López Department of Technological Sciences and Development Azores University CEFITEC-Centre of Physics and Technological Research Physics Department of FCT/UNL Department of Fundamental and Experimental Physics Electronics and SystemsUniversity of La Laguna

Sol-gel glassy films of the SiO2-TiO2-PO2.5-ErO2.5 system containing nanocrystallites of ErPO4, were obtained through suitable heat treatments. Variations in the shape and intensity of the Er3＋ photoluminescent signal around 1500 nm were linked to the nature of the host environment of the active ions; the specific features of the photoluminescent emission spectrum of the erbium 4113/2 metastable level were interpreted in terms of structural changes in the glassy films. The photoluminescent spectrum was found to be sensitive to the order （crystalline） or disorder （amorphous） of the Er3＋ ions neighbour within the glassy matrix. An amorphous envi- ronment led to a broadening of Er3＋ PL emission band while a crystalline one was responsible for a drastic photoluminescent band- width narrowing. The presence of nanoscale heterogeneities caused a drastic photoluminescence intensity decrease. Changes in the shape of the decay curve of fluorescence lifetime were found also structurally dependent on volumetric defects, occurrence of phase separation and Er3＋-Er3＋ clustering effects as well.

关键词： sol-gel Er3+ optical probe nanoscale heterogeneities photoluminescence ErPO4 rare earths

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Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors

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World Journal of Clinical Cases 2022年第31期10卷 11283-11291页

作者： Fabrício Freire de melo Hanna Santos marques Fabian Fellipe Bueno Lemos marcel Silva Luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza márcio vasconcelos Oliveira Institution multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene *** function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory RNAs Nickel-regulated small RNA Virulence factors Cytotoxin associated antigen A Gastric cancer

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Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries:A Systematic Review

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maternal-Fetal medicine 2023年第2期5卷 97-103页

作者： marta maria Silva Érica Alcântara Silva Caline Novais Teixeira Oliveira maria Luísa Cordeiro Santos Cláudio Lima Souza Fabrício Freire de melo márcio vasconcelos Oliveira Instituto multidisciplinar em Saúde Universidade Federal da BahiaBahia 45.029-094Brazil

Objective:This review aimed to compile scientific data on the distribution and prevalence of group BStreptococcus (GBS) serotypes isolated from pregnant women across 30 countries from 2010 to ***:This was a systematic review that addresses the distribution and prevalence of GBS in pregnant *** search included studies published between January 2010 and December 2019 in Pubmed,Virtual Health Library (BVS),ScienceDirect,Scientific Electronic Library Online (SciELO),and LILACS *** also surveyed relevant articles published in English,Spanish,and Portuguese between February and April *** articles,communication,short report,theses,and dissertations were *** prevalence of GBS colonization,method for capsular serotyping,antimicrobial resistance,distribution and prevalence of serotypes were extracted from each ***:In all,795 publications were *** applying the eligibility criteria,48 articles were included for the final systematic analysis;most articles were from Asia and were published during the years 2014 to *** the identification of serotypes,most studies used the polymerase chain reaction *** were records of all 10 GBS serotypes,namely,Ia,Ib,and II–IX,among the countries *** susceptibility and resistance to antibiotics were addressed in 37.5% of the publications ***:This review showed that GBS serotypes are distributed differently in the 30 analyzed countries,with serotypes Ia,Ib,and II to V being the most ***,our results highlighted the relationship of GBS with maternal colonization,implications for neonates,and antibiotic resistance.

关键词： Streptococcus agalactiae Serotype Pregnant women

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Genomic Perspectives on the Emerging SARS-CoV-2 Omicron Variant

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 60-69页

作者： Wentai ma Jing Yang Haoyi Fu Chao Su Caixia Yu Qihui Wang Ana Tereza Ribeiro de vasconcelos Georgii A.Bazykin Yiming Bao mingkun Li CAS Key Laboratory of Genomic and Precision medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Pathogenic microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Laboratorio de Bioinformatica Laboratorio Nacional de Computacao CientıficaPetropolis 25651-075Brazil Skolkovo Institute of Science and Technology Moscow 121205Russia Kharkevich Institute for Information Transmission Problems of the Russian Academy of Sciences Moscow 127051Russia Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

A new variant of concern for SARS-CoV-2,Omicron(B.1.1.529),was designated by the World Health Organization on November 26,*** study analyzed the viral genome sequencing data of 108 samples collected from patients infected with ***,we found that the enrichment efficiency of viral nucleic acids was reduced due to mutations in the region where the primers anneal ***,the Omicron variant possesses an excessive number of mutations compared to other variants circulating at the same time(median:62 vs.45),especially in the Spike *** in the Spike gene confer alterations in 32 amino acid residues,more than those observed in other SARS-CoV-2 ***,a large number of nonsynonymous mutations occur in the codons for the amino acid residues located on the surface of the Spike protein,which could potentially affect the replication,infectivity,and antigenicity of ***,there are 53 mutations between the Omicron variant and its closest sequences available in public *** of these mutations were rarely observed in public databases and had a low mutation *** addition,the linkage disequilibrium between these mutations was low,with a limited number of mutations concurrently observed in the same genome,suggesting that the Omicron variant would be in a different evolutionary branch from the currently prevalent *** improve our ability to detect and track the source of new variants rapidly,it is imperative to further strengthen genomic surveillance and data sharing globally in a timely manner.

关键词： Omicron Genomics mutation Variant of concern SARS-CoV-2

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