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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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mediterranean Berries as Inhibitors of Lipid Oxidation in Porcine Burger Patties Subjected to Cooking and Chilled Storage

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Journal of Integrative Agriculture 2013年第11期12卷 1982-1992页

作者： Rui Ganho mario Estévez mónica Armenteros David morcuende Food Science Department ESTMPolytechnic Institute of Leiria Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/n Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/nCáceres 10003Spain

The efifciency of extracts from Arbutus unedo L. （AU）, Crataegus monogyna L. （Cm）, Rosa canina L. （RC）, and Rubus ulmifolius Schott. （RU） to inhibit lipid oxidation in raw, cooked and cooked and chilled （2°C/12 d） porcine burger patties, was investigated. The modiifcation of the fatty acid proifle during processing treatments （cooking and chilling）, the quantitative measurements of thiobarbituric acid reactive substances （TBA-RS）, and lipid-derived volatiles, were used as indicators of lipid oxidation. Polyunsaturated fatty acids （PUFA） gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being signiifcantly greater （P〈0.05） in control patties than in those with added berry extracts. In accordance, the control patties showed signiifcantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts （P〈0.05）. Results from the present work show, for the ifrst time, that extracts from A. unedo, C. monogyna, R. canina, and R. ulmifolius are promising antioxidants which could enhance the nutritional, safety and sensory properties of porcine burger patties.

关键词： berries lipid oxidation meat pattiesm TBA-RSm polyunsaturated fatty acids lipid-derived volatiles

Predictability of Plastic Parts Behaviour made from Rapid manufacturing

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Tsinghua Science and Technology 2009年第S1期14卷 100-107页

作者： mario monzón Pedro m Hernández Antonio n Benítez maría D marrero ngel Fernández Department of mechanical Engineering Las Palmas de Gran Canaria University Las Palmas 35017 Spain AITIIP Foundation Cogullada Technologic Park Zaragoza 50014 Spain

One of the most important issues to resolve in parts manufactured from rapid manufacturing (Rm) technologies is to know their behavior working under real conditions. Total quality manufacturing (TQm) is only possible if mechanical properties are well known in the design stage depending on the processing parameters. This work is mainly focused on testing of several samples made with different selective laser sintering (SLS) parameters and technologies. This procedure is the starting point to establish a basis for designing for Rm and the standardization of Rm testing. The experiments and the analysis of variance (AnOVA) analyzed the effects of several factors on mechanical properties. The SLS technologies were 3DSystem and EOS. The results show which factor has a large effect on the variables and the interaction between them. The conclusions are very useful for developing rules for designing (designing for Rm) and creating new standard rules (ISO, AISI, and DIn) for Rm materials and parts testing. The AnOVA gives a better knowledge of the effects of these factors and eliminates unimportant parameters.

关键词： laser sintering rapid manufacturing (Rm) analysis of variance (AnOVA) rapid prototyping additive manufacturing selective laser sintering (SLS)

Phylofloristics:an example from the Lesser Antilles

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Journal of Plant Ecology 2014年第2期7卷 166-175页

作者： nathan G.Swenson maría n.Umaña Department of Plant Biology Michigan State UniversityEast LansingMichigan 48824USA

Aims The last decade has seen many plant ecologists integrating phylogenetic analysis into ecology to explain patterns of species cooccurrence and compositional similarity across *** the advances in this area,there are still some challenges that need to be *** challenge is that most of the phylogenetic studies of plant assemblages have focused only on a small proportion of all of the vascular plants that co-occur(*** plants),while much of the remaining co-occurring flora has been *** Here we introduce an analytical approach that we term phylofloristics that analyzes the compositional similarity of floras in relation to spatial and environmental gradients to understand their *** an illustration,we assembled a large phylogenetic tree for the flora of the Lesser Antilles and evaluated the patterns of floristic and phylofloristic similarity among the island-specific *** analyzed the relationship of these similarities with spatial and environmental distance and compared the results for non-endemic and endemic *** Findings The results show a major influence of environmental heterogeneity on the assembly of island floras and far less evidence for the importance of dispersal limitation of lineages and *** study highlights the importance of incorporating broader taxonomic sampling to improve our understanding of assembly processes in *** expect future phylofloristic studies will improve the approach we have taken by generating more refined phylogenetic trees and by incorporating phylogeographic information.

关键词： biogeography Caribbean flora phylogeny plant geography

Experimental bio-artificial liver:Importance of the architectural design on ammonia detoxification performance

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World Journal of Hepatology 2018年第10期10卷 719-730页

作者： maría Dolores Pizarro maría Eugenia mamprin Lucas Damián Daurelio Joaquín Valentín Rodriguez maría Gabriela mediavilla Consejo nacional de Investigaciones Científicas y Técnicas(COnICET) Rosario S2002 LRKArgentina Laboratorio de Investigaciones en Fisiología y Biología molecular Vegetal(LIFiBVe) Facultad de Ciencias AgrariasUniversidad Nacional del LitoralEsperanza 3080Argentina Facultad de Ciencias Bioquímicas y Farmacéuticas Universidad Nacional de RosarioRosario S2002 LRKArgentina Centro Binacional de Criobiología Clínica y Aplicada(CAIC) Universidad Nacional de RosarioRosario S2011 BXNArgentina Instituto de Biología molecular y Celular de Rosario(IBR CONICET-UNR)Consejo Nacional de Investigaciones Científicas y Tecnológicasy Universidad Nacional de RosarioRosario S2002 LRKArgentina

AIm To determine the influence of the construction design over the biological component's performance in an experimental bio-artificial liver(BAL) *** Two BAL models for liver microorgans(LmOs) were constructed. First, we constructed a cylindrical BAL and tested it without the biological component to establish its correct functioning. Samples of blood and biological compartment(BC) fluid were taken after 0, 60, and 120 min of perfusion. Osmolality, hematocrit, ammonia and glucose concentrations, lactate dehydrogenase(LDH) release(as a LmO viability parameter), and oxygen consumption and ammonia metabolizing capacity(as LmO functionality parameters) were determined. CPSI and OTC gene expression and function were measured. The second BAL, a "flat bottom" model, was constructed using a 25 cm2 culture flask while maintaining all other components between the models. The BC of both BALs had the same capacity(approximately 50 cm3) and both were manipulated with the same perfusion system. The performances of the two BALs were compared to show the influence of *** The cylindrical BAL showed a good exchange of fluids and metabolites between blood and the BC, reflected by the matching of osmolalities, and glucose and ammonia concentration ratios after 120 min of perfusion. no hemoconcentration was detected, the hematocrit levels remained stable during the whole study, and the minimal percentage of hemolysis(0.65% ± 0.10%) observed was due to the action of the peristaltic pump. When LmOs were used as biological component of this BAL they showed similar values to the ones obtained in a normothermic Reoxygenation System(nRS) for almost all the parameters assayed. After 120 min, the results obtained were: LDH release(%): 14.7 ± 3.1 in the BAL and 15.5 ± 3.2 in the nRS(n = 6); oxygen consumption(μmol/min?g wet tissue): 1.16 ± 0.21 in the BAL and 0.84 ± 0.15 in the nRS(n = 6); relative expression of Cps1 and Otc: 0.63 ± 0.12 and 0.67 ± 0.20, respectively,

关键词： Bio-artificial liver Ammonia detoxification Device design Ornithine Transcarbamylase Rat liver microorgans Carbamyl Phosphate SynthetaseⅠ

Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate

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Journal of Integrative Agriculture 2015年第1期14卷 131-139页

作者： Abdelfattah Z m Salem German Buendía-Rodríguez mona m m Elghandour maría A mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C V Chagoyán maría A Cerrillo miguel A Rodríguez Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico national Center of Disciplinary Research in Animal Physiology and Improvement INIFAP Ajuchitlán Institute of Agricultural Sciences Autonomous University of HidalgoEx-Hda. of Aquetzalpa Faculty of Veterinary medicine and Animal Science Juárez University of the Durango State

An in vitro gas production （GP） technique was used to investigate the effects of combining different doses of Salix babylonica extract （SB） with exogenous fibrolytic enzymes （EZ） based on xylanase （X） and cellulase （C）, or their mixture （XC; 1：1 v/v） on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture （50：50, w/w） as substrate. Four levels of SB （0, 0.6, 1.2 and 1.8 mL g-1 dry matter （Dm）） and four supplemental styles of EZ （1 μL g-1 Dm; control （no enzymes）, X, C and XC （1：1, v/v） were used in a 4×4 factorial arrangement. In vitro GP （mL g-1 Dm） were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant pH was determined, and then filtered to determine dry matter degradability （DmD）. Fermentation parameters, such as the 24 h gas yield （GY24）, in vitro organic matter digestibility （OmD）, metabolizable energy （mE）, short chain fatty acid concentrations （SCFA）, and microbial crude protein production （mCP） were also estimated. Results indicated that there was a SBxEZ interaction （P〈0.0001） for the asymptotic gas production （b）, the rate of gas production （c）, GP from 6 to 72 h, GP2 （P=0.0095）, and GP4 （P=0.02）. The SB and different combination of enzymes supplementation influenced （P〈0.001） in vitro GP parameters after 12 h of incubation; the highest doses of SB （i.e., 1.8 mL g-1 Dm）, in the absence of any EZ, quadratically increased （P〈0.05） the initial delay before GP begins （L） and GP at different incubation times, with lowering b （quadratic effect, P〈0.0001 ） and c （quadratic effect, P〈0.0001 ; linear effect, P=0.0018）. The GP was the lowest （P〈0.05） when the highest SB level was combined with cellulose. There were SBxEZ interactions （P〈0.001） for OmD, mE, the partitioning factor at 72 h of incubation （PF72）, GY24, SCFA, mCP （P=0.0143）, and pH （P=0.0008）. The OmD, mE, GY24 and SCFA with supplementation of SB extract at 1.8 mL g-1 Dm were h

关键词： cellulase degradability gas production Salix babylonica xylanase

Knowledge arising from long-term research of variable retention harvesting in Tierra del Fuego: where do we go from here?

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Ecological Processes 2019年第1期8卷 318-333页

作者： Guillermo J.martínez Pastur Yamina m.Rosas mónica Toro manríquez Alejandro Huertas Herrera Juan A.miller Juan m.Cellini marcelo D.Barrera Pablo L.Peri maría V.Lencinas Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Universidad nacional de la Plata(UnLP) Calle 7 e/47 y 48(1900)La PlataBuenos AiresArgentina Instituto nacional de Tecnología Agropecuaria(InTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)cc 332(9400)Río GallegosSanta CruzArgentina

nothofagus pumilio forests in Tierra del Fuego are the southernmost forests in the world,where extreme climate conditions represent a challenge to attain sustainable forest *** forestry was proposed as an alternative to increase the species conservation in managed ***,we synthetized results related to the implementation of a variable retention harvesting based on a combination of aggregate patches and dispersed retention during the last 18 years comparing with other silviculture proposals(e.g.,shelterwood cuts)and control treatments(primary unmanaged forests).We summarized the results for(i)sawmill operations,(ii)timber yield,(iii)overstory stability,(iv)forest structure,(v)microclimate and natural cycles,(vi)natural regeneration dynamics(flowering,seeding,foraging,recruitment,growth,and mortality),and(vii)biodiversity(mammals,understory plants,mistletoes,birds,arthropods,mosses,lichens,and fungi).In general,aggregate patches maintained forest structure and micro-environmental variables,and slightly increased biodiversity and forest reproduction variables compared to unmanaged primary *** the contrary,dispersed retention decreased forest structure variables and greatly increased biodiversity(richness and abundance)when it was compared to unmanaged primary *** conditions are influenced by variable retention harvesting,but direction and magnitude of the effect depend and differ according to retention *** this,biodiversity taxa greatly differed among groups depending on retention *** general,the species assemblages in aggregate patches were similar to those found in primary unmanaged forests,while they were significantly modified in the dispersed *** occurred due to(i)local extinction of some original species,(ii)the introduction of native species from the surrounding environments,or(iii)the invasion of exotic *** silvicultural method has been a useful tool to conserve biodiversity and ec

关键词： Aggregate patches Dispersed retention Biodiversity conservation Long-term sustainability Timber production

Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： Sheharyar S.Baig Ali n.Ali Arshad majid Sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VnS)and stroke:Stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VnS paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,STOP-AUST,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks maría F mascardi Adrián Gadano Sebastián marciano Instituto de medicina Traslacional e Ingeniería Biomédica-Consejo nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(mASLD)risk *** ability to identify patients with mASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of mASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in mASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving mASLD biomarker research.

关键词： metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

Agglutination of Helicobacter pylori coccoids by lectins

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World Journal of Gastroenterology 2000年第2期6卷 202-209页

作者： mar mar Khin Jie Song Hua Han Cong ng Torkel Wadstrm Bow Ho Departments of microbiology Faculty of MedicineNational University of Singapore5Science Drive 2Singapore 117597Republic of Singapore Department of medical microbiology Lund UniversitySolvegatan 23S 223 62 LundSweden

AIm To study the agglutination pattern ofHelicobacter pylori coccoid and spiral *** Assays of agglutination andagglutination inhibition were applied usingfifteen commercial *** Strong agglutination was observedwith mannose-specific Concanavalin A(Con A),fucose-specific Tetragonolobus purpureas(Lotus A)and n-acetyl glucosamine-specificTriticum vulgaris(WGA)*** andfucose specific lectins were reactive with allstrains of *** coccoids as compared to *** carbohydrates,glycoproteinsand mucin were shown to inhibit ***-agglutination ***-treatment ofthe bacterial cells with formalin and sulphuricacid did not alter the agglutination patterns ***,sodium periodate treatment ofbacterial cells were shown to inhibitagglutination reaction with Con A,Lotus A andWGA *** the contrary,enzymatictreatment of coccoids and spirals did not showmarked inhibition of ***,heating of *** cells at 60℃ for 1 hour was shown toaugment the agglutination with all of the *** The considerable differences inlectin agglutination patterns seen among the twodifferentiated forms of *** might beattributable to the structural changes during theevents of morphological transformation,resulting in exposing or masking some of the sugar residues on the cell *** ofvarious sugar residues on the cell wall of thecoccoids may allow them to bind to differentcarbohydrate receptors on gastric mucus andepithelial *** coccoids with adherencecharacteristics like the spirals could aid in thepathogenic process of Helicobacter *** may probably lead to different clinicaloutcome of *** associated gastroduodenaldisease.

关键词： Helicobacter pylori coccoids lectin gastric mucosa