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Unusual breast metastasis of gastrointestinal stromal tumor:A case report and literature review

World Journal of Clinical Oncology 2023年第3期14卷 131-137页

作者： Daria Filonenko Nikolay Karnaukhov Gurami Kvetenadze lyudmila zhukova Department of Oncology Chemotherapy SBIH Moscow Clinical Scientific and Practical Center Named After A.S.Loginov of DHM MoscowMoscow 111123Russia Department of Pathomorphology SBIH"Moscow Clinical Scientific and Practical Center Named After A.S.Loginov''DHMMoscow 111123Russia Department of Surgery SBIH"Moscow Clinical Scientific and Practical Center Named After A.S.Loginov''DHMMoscow 111123Russia Department of Oncology SBIH"Moscow Clinical Scientific and Practical Center Named After A.S.Loginov''DHMMoscow 111123Russia

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most frequent mesenchymal tumors of gastrointestinal *** most common sites of metastases are the liver and the peritoneum,whereas breast metastases from GIST are extremely *** present a second case of GIST breast *** SUMMARY We found a case of breast metastasis from rectum GIST.A 55-year-old female patient presented with rectum tumor with multiply liver lesions and metastasis in the right ***-perineal extirpation of rectum was performed,histology and immunohistochemistry study showed GIST,mixed type with CD117 and DOG-1 positive *** patient was taking imatinib 400 mg for 22 mo with stable *** of growth of the breast metastasis the treatment was changed twice:The dose of imatinib was doubled with further progression in the breast lesion and then the patient was receiving sunitinib for 26 mo with partial response in the right breast and stable disease in the liver *** breast lesion increased and right breast resection was done–surgery on local progression,the liver metastases were *** and immunohistochemistry studies revealed GIST metastasis,CD 117 and DOG 1 positive with KIT exon 11 *** surgery the patient resumed *** now the patient has been taking imatinib 400 mg for 19 mo without progression,last follow up was in November *** GISTs breast metastases are extremely rare,we described the second *** the same time second primary tumors have been reported frequently in patients diagnosed with GISTs and breast cancer is one of the most common second primary tumors in patients with *** is why it is very important to distinguish primary from metastatic breast *** on local progression made it possible to resume less toxic treatment.

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