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One method for the bounda.y va.ue problem eigenva.ues ca.cua.ing for a.second-order differentia. equa.ion with a.fra.tiona. deriva.ive

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Interna.iona. Journa. of Modeling, Simula.ion, a.d Scientific Computing 2019年第1期10卷 44-50页

作者： Temirkha. a.eroev Hedi a.eroeva.lyudmila Kiria.ova Depa.tment of a.plied Ma.hema.ics NRU MGSU Yaroslavskoe Boulevard26MoscowRussia Depa.tment of Informa.ion Technologies Moscow Technica. University of communica.ion a.d informa.ics a.ia.otorna.a.street 8AMoscowRussia

In this pa.er,we give a.formula.for computing the eigenva.ues of the Dirichlet problem for a.differentia. equa.ion of second-order with fra.tiona. deriva.ives in the lower *** obta.ned this formula.using the perturba.ion theory for linea. *** this formula.we ca. write out the system of eigenva.ues for the problem under considera.ion.

关键词： Eigenva.ues fra.tiona. deriva.ive differentia. equa.ion

Selective sorptive remova. of Methyl Red from individua. a.d bina.y component solutions by mesoporous orga.osilica. of MCM-41 type

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Journa. of Environmenta. Sciences 2021年第1期33卷 59-71页

作者： Na.iia.V.Roik lyudmila a.Belya.ova.Ma.ina.O.Dzia.ko Chuiko Institute of Surfa.e Chemistry of Na. of Ukra.ne 17 General Naumov Str.Kyiv 03164Ukraine

Orga.osilica. with chemica.ly immobilized 3-a.inopropyl a.d Methyl Red-conta.ning surfa.e groups were prepa.ed by sol-gel condensa.ion of tetra.thyl orthosilica.e a.d(3-a.inopropyl)triethoxysila.e in the presence of dye a. pa.t of the mixed micelles or dyeconta.ning sila.e a. silica.*** hexa.ona.ly a.ra.ged mesoporous structure of synthesized ma.eria.s wa. confirmed by low-tempera.ure nitrogen a.sorption-desorption,xra. diffra.tion,a.d TEM *** composition of MCM-41-type orga.osilica. wa. esta.lished by FT-IR spectroscopy a.d chemica. a.a.ysis of surfa.e *** of Methyl Red by orga.osilica. wa. studied from diluted phospha.e buffer solutions in dependence of medium p H,dura.ion of conta.t,a.d equilibrium concentra.ion of *** wa. found tha. effective remova. of Methyl Red ta.es pla.e a. p H va.ues within a.ra.ge of *** curves of Methyl Red sorption on orga.osilica. were a.a.yzed by the La.ergren,Ho-McKey,a.d Weber-Morris kinetic *** wa. found tha. the pseudo-second-order model fits the kinetics of Methyl Red sorption on a.l synthesized ma.eria.s a.d the intra.a.ticle diffusion is not the only one mecha.ism controlling the ra.e of Methyl Red sorptive *** pa.a.eters of equilibrium sorption of Methyl Red on orga.osilica. of MCM-41 type were ca.cula.ed using La.gmuir,Freundlich,Redlich-Peterson,a.d Bruna.er-Emmett-Teller *** of a.id dyes with geometry simila. or substa.tia.ly different from Methyl Red on mesoporous silica. wa. studied from single a.d bina.y component mixtures in a.ueous solutions with p H 4.8 a.d *** wa. found tha. selective sorption process is highly dependent on the structura. cha.a.teristics a.d protolytic sta.e of silica.surfa.e a. well a. a.id dye.

关键词： MCM-41 Sol-gel synthesis Methyl Red Chemica. modifica.ion Selective sorption

Lea. Induces Different Responses of Two Subpopula.ions of Pha.ocytes in the Holothuria. Eupenta.ta.fra.da.rix

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Journa. of Ocea. University of China 2018年第6期17卷 1391-1403页

作者： DOLMa.OVa.lyudmila S. DOLMa.OV Igor Yu. La.ora.ory of Biochemistry V.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences La.ora.ory of Compa.a.ive Cytology National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Depa.tment of Cell Biology a.d Genetics Far Eastern Federal University

In view of increa.ing lea. pollution(Pb^(2+)) of coa.ta. wa.ers, the compensa.ory a.ilities of holothuria.s need to be a.sessed. The goa. of the work is to cla.ify the functiona. a.d phenotypica. differences between two types of pha.ocytes(P1 a.d P2) in Eupenta.ta.fra.da.rix exposed to Pb(NO_3)_2. It ha. been shown tha. 2 mg L^(-1) lea. exposure for 48 h increa.es the number of P2 pha.ocytes a. compa.ed to P1 cells, does not significa.tly a.fect cell via.ility in both P1 a.d P2 pha.ocyte fra.tions, a.d significa.tly enha.ces chroma.in condensa.ion in P2 but not in P1 pha.ocytes. a.lea. concentra.ion of 4 mg L^(-1) increa.es the number of P1 pha.ocytes compa.ed to tha. of P2 type, a.d does not cha.ge cell via.ility a.d chroma.in condensa.ion in P1 pha.ocytes. In the P2 type, it decrea.es cell via.ility a.d does not influence the level of a.optosis. The protection a.a.nst lea.-induced a.optosis is a.pa.ently media.ed by the a.tivities of a.tioxida.t enzymes, especia.ly gluta.hione S-tra.sfera.e. The differences in la.eling cell surfa.e receptors of P1 a.d P2 pha.ocytes by pla.t lectins a.so indica.e the specific phenotypic properties of these cells. The results cla.ify the potentia. a.d GSH-dependent mecha.isms of immune a.a.ta.ion in holothuria.s tha. ha.e been shortly exposed to lea. a. concentra.ions close to the ma.imum environmenta.ly releva.t level in coa.ta. wa.ers. a.ditiona.ly, P1 a.d P2 pha.ocytes a.e first shown to ha.e different functions a.d phenotypes during the response to lea., which indica.es the complexity of the pha.ocytic system in holothuria.s a.d contributes to understa.ding the immunity evolution.

关键词： a.oebocytes a.tioxida.t ca.a.ity a.optosis cell a.a.ta.ion lea. pla.t lectin con A DBA PNA SBA

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跳变马尔可夫系统的最大混合相关熵状态估计

电子学报 2021年第11期49卷 2225-2233页

作者：沈忱 MIHa.LOVa.lyudmila 浙江工商大学信息与电子工程学院(萨塞克斯人工智能学院) 浙江杭州310018 谢菲尔德大学自动控制与系统工程系谢菲尔德S102TN

依托于多模型框架的跳变马尔可夫系统状态估计的性能通常受限于多模型间的信息融合程度.本文以交互式多模型方法为框架,针对跳变马尔可夫系统提出了一种基于最大混合相关熵的状态估计方法.为了能有效处理模型高阶信息,在混合和融合步骤... 详细信息

依托于多模型框架的跳变马尔可夫系统状态估计的性能通常受限于多模型间的信息融合程度.本文以交互式多模型方法为框架,针对跳变马尔可夫系统提出了一种基于最大混合相关熵的状态估计方法.为了能有效处理模型高阶信息,在混合和融合步骤引入最大混合相关熵测度替代常规的二阶统计矩准则,设计了关于系统状态的代价函数,通过最优化该函数得到状态估计的迭代解.仿真实验详尽展示了所提方法的主要特征,并表明其在高斯和非高斯噪声环境下都具有较好的估计效果.

关键词：混合相关熵状态估计模型不确定

Interferon thera.y in hepa.itis Clea.ing to chronic type 1 dia.etes

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World Journa. of Ga.troenterology 2015年第1期21卷 233-239页

作者： Ta.ba.Zornitzki Stephen Ma.nick lyudmila Lysyy Hilla.Knobler Depa.tment of Dia.etes Metabolism and EndocrinologyHebrew University Medical SchoolKaplan Medical CenterRehovot 76100Israel Depa.tment of Ga.troenterology Hebrew University Medical SchoolKaplan Medical CenterRehovot 76100Israel

a.M: To review the preva.ence,clinica. da.a.a.d course of interferon-a.socia.ed type 1 dia.etes in chronic hepa.itis C virus(HCV) ***: Sea.ch of a.l interferon(INF)-rela.ed type 1dia.etes mellitus(T1DM) ca.es published in the English litera.ure from 1992 to December 2013 a.cording to the key words: chronic hepa.itis C infection,dia.etes mellitus type 1,insulin dependent dia.etes mellitus,a.d interferon *** found 107 ca.es a.d a.a.yzed their clinica. a.d la.ora.ory da.a.a.d long-term *** to the predomina.ce of ca.es described in Ja.a.ese litera.ure,we a.a.yzed sepa.a.ely ca.es of Ca.ca.ia. a.d Ja.a.ese *** a.dition we describe a.representa.ive ca.e with HCV who developed INFrela.ed T1 ***: Our da.a.show tha. INF trea.ment increa.es the risk of developing T1 DM by 10-18 fold compa.ed with the corresponding genera. popula.ion a.d the media. a.e of onset wa. 43 yea.s(ra.ge: 24-66 yea.s) in Ca.ca.ia.s a.d 52 yea.s(ra.ge: 45-63 yea.s) in *** pa.ients developed T1 DM during INF trea.ment,a.ter a.media. time-period of 4.2 a.d 5.7 mo in Ca.ca.ia. a.d Ja.a.ese groups,*** clinica. course wa. cha.a.terized by a.fulmina.t course with a.rupt severe hyperglycemia.or ketoa.idosis,a.high titer of a.ti-islet a.toa.tibodies a.d a.most a.l pa.ients(105/107) perma.ently required insulin thera.y with a.follow-up of up to 4 yea.s.a.substa.tia. number of pa.ients ha. evidence for other a.toimmune disorders ma.nly thyroid disea.es(25% a.d 31% in Ca.ca.ia. a.d Ja.a.ese groups,respectively).CONCLUSION: INF-a.socia.ed T1 DM in HCV ha. a.fulmina.t course,often a.socia.ed with other a.toimmune disea.es,a.d results a.most inevita.ly in perma.ent insulin thera.y requirement.

关键词： Interferon Hepa.itis C Type 1 dia.etes a.toimmune

Construction of RNa.na.otubes

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Na.o Resea.ch 2019年第8期12卷 1952-1958页

作者： Hui Li Sha.ying Wa.g Zhouxia.g Ji Congcong Xu lyudmila S. Shlya.htenko Peixua. Guo Center for RNa.Na.obiotechnology a.d Na.omedicine Division of Pharmaceutics and Pharmaceutical ChemistryCollege of Pharmacy/Department of Physiology & Cell BiologyCollege of Medicine/Dorothy M. Davis Heart and Lung Research Institute and James Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH43210USA UNMC Na.oima.ing Core Fa.ility Department of Pharmaceutical SciencesCollege of Pharmacy University of Nebraska Medical CenterOmahaNE68182USA Present a.dress: University of Ca.ifornia San FranciscoCA94158USA Present a.dress: P&Z Biologica. Technology NewarkNJ07103USA

Na.otubes a.e minia.ure ma.eria.s with significa.t potentia. a.plica.ions in na.otechnologica., medica., biologica. a.d ma.eria. sciences. The quest for ma.ufa.turing methods of na.o-mecha.ica. modules is in progress. For exa.ple, the a.plica.ion of ca.bon na.otubes ha. been extensively investiga.ed due to the precise width control, but the precise length control rema.ns cha.lenging. Here we report two a.proa.hes for the one-pot self-a.sembly of RNa.na.otubes. For the first a.proa.h, six RNa.stra.ds were used to a.semble the na.otube by forming a.11 nm long hollow cha.nel with the inner dia.eter of 1.7 nm a.d the outside dia.eter of 6.3 nm. For the second a.proa.h, six RNa.stra.ds were designed to hybridize with their neighboring stra.ds by complementa.y ba.e pa.ring a.d formed a.na.otube with a.six-helix hollow cha.nel simila. to the na.otube a.sembled by the first a.proa.h. The fa.rica.ed RNa.na.otubes were cha.a.terized by gel electrophoresis a.d a.omic force microscopy (a.M), confirming the forma.ion of na.otube-sha.ed RNa.na.ostructures. Cholesterol molecules were introduced into RNa.na.otubes to fa.ilita.e their incorpora.ion into lipid bila.er. Incuba.ion of RNa.na.otube complex with the free-sta.ding lipid bila.er membra.e under a.plied volta.e led to discrete current signa.ures. a.dition of peptides into the sensing cha.ber revea.ed discrete steps of current blocka.e. Polya.ginine peptides with different lengths ca. be detected by current signa.ures, suggesting tha. the RNa.cholesterol complex holds the promise of a.hieving single molecule sensing of peptides.

关键词： RNA na.otechnology peptide sensing RNA na.otube na.obiotechnology

Periodica. zona. cha.a.ter of da.a.e nea. the openings inhighly-stressed rock ma.s conditions

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2016年第2期8卷 164-169页

作者： Vla.imir VMa.a.ov Mikha.l a.uzev Vla.imir NOdintsev lyudmila SKsendzenko Fa.-Ea.tern Federa. University VladivostokRussia Russia. a.a.emy of Sciences MoscowRussia

Rock ma.s da.a.e a. grea. depths nea. underground openings is often of a.zona. ***,the cla.sica. ela.topla.tic theory fa.ls to expla.n sufficiently a.l properties of zona. fa.lure structures.a.new non-Euclidea. ma.hema.ica. model for highly-stressed rock ma.s wa. developed ba.ed on the principles of mecha.ics of defected ma.eria. a.d non-equilibrium *** were developed to determine model pa.a.eters tha. provide sa.isfa.tory correspondence between the experimenta. findings concerning fa.lted zona. structures nea. openings a. grea. depths a.d ma.hema.ica. *** mecha.ism of this phenomenon wa. discovered which consisted in a.periodica. cha.a.ter of stresses in the surrounding rock ma.s a.d development of tensile ma.rocra.ks a. zones of ma.ima. ta.gentia. *** rela.ionships between the cra.king zone width a.d rock ma.s strength were esta.lished.

关键词： Rock fa.lure Openings Zones Modeling

Efficient a.gorithm for big da.a.clustering on single ma.hine

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Ca.I Tra.sa.tions on Intelligence Technology 2020年第1期5卷 9-14页

作者： Ra.im M.a.guliyev Ra.iz M.a.iguliyev lyudmila V.Sukhosta. Institute of Informa.ion Technology Azerbaijan National Academy of Sciences9AB.Vahabzade StreetAZ1141 BakuAzerbaijan

Big da.a.a.a.ysis requires the presence of la.ge computing powers, which is not a.wa.s fea.ible. a.d so, itbeca.e necessa.y to develop new clustering a.gorithms ca.a.le of such da.a.processing. This study proposes a.newpa.a.lel clustering a.gorithm ba.ed on the k-mea.s a.gorithm. It significa.tly reduces the exponentia. growth ofcomputa.ions. The proposed a.gorithm splits a.da.a.et into ba.ches while preserving the cha.a.teristics of the initia.da.a.et a.d increa.ing the clustering speed. The idea.is to define cluster centroids, which a.e a.so clustered, for ea.hba.ch. a.cording to the obta.ned centroids, the da.a.points belong to the cluster with the nea.est centroid. Rea. la.geda.a.ets a.e used to conduct the experiments to eva.ua.e the effectiveness of the proposed a.proa.h. The proposeda.proa.h is compa.ed with k-mea.s a.d its modifica.ion. The experiments show tha. the proposed a.gorithm is a.romising tool for clustering la.ge da.a.ets in compa.ison with the k-mea.s a.gorithm.

关键词： a.gorithm. a.gorithm ba.ch

Kinetics a.d mecha.ism of na.ura. wolfra.ite intera.tions with sodium ca.bona.e

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2019年第11期26卷 1364-1371页

作者： Evgeniy Nikola.vich Seliva.ov Kirill Vla.imirovich Pikulin lyudmila Iva.ovna.Ga.kova.Roza.Iosifovna.Gulya.va.Sofia.a.eksa.drovna.Petrova Institute of Meta.lurgy of the Ura. Bra.ch of the Russia. a.a.emy of Sciences

The kinetics a.d mecha.ism of na.ura. wolfra.ite intera.tions with sodium ca.bona.e during a.r hea.ing were studied.X-ra. pha.e a.d X-ra. microa.a.ysis were used to esta.lish tha. the initia. monocrysta.line wolfra.ite consists of Fe0.5 Mn0.5 WO4 a.d Fe0.3 Mn0.7 *** therma. a.a.ysis showed tha. the intera.tion of wolfra.ite with sodium ca.bona.e begins a.ove 450°C with the forma.ion of tungsta.e,sodium ferrite,iron oxides,a.d *** experiments on sintering with the subsequent remova. of wa.er-soluble compounds(lea.hing)tra.ked the cha.ge in the structure of *** a.omic ra.io of Fe/Mn in wolfra.ite does not cha.ge up to 600°C,a.d subsequently decrea.es to 0.2 during hea.ing,which a.lows the mecha.ism of the process to be identified a.d indica.es the grea.er rea.tivity of wolfra.ites with a. increa.ed proportion of *** a.a.ysis with da.a.processing using non-isotherma. kinetics esta.lished tha. the intera.tion of wolfra.ite with sodium ca.bona.e in a. a.r strea. proceeds via.a.two-sta.e mecha.ism,wherein the first sta.e is limited by diffusion(a.tiva.ion energy,E=243 kJ/mol)a.d the second sta.e is limited by a.toca.a.ysis(a.tiva.ion energy,E=212 k J/mol)due to the forma.ion of a.Na. WO4–Na. CO3 eutectic.

关键词： wolfra.ite structure sodium ca.bona.e sintering therma. a.a.ysis kinetics