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Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy

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World Journal of Clinical Cases 2024年第12期12卷 2031-2039页

作者： Tsvetelina Velikova Georgi Vasilev Russka Shumnalieva lyubomir Chervenkov Dimitrina Georgieva Miteva Milena Gulinac Stamatios Priftis Snezhina Lazova Medical Faculty Sofia University"St.Kliment Ohridski"Sofia 1407Bulgaria Clinic of Neurology and Department of Emergency Medicine UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Rheumatology Clinic of RheumatologyUniversity Hospital"St.Ivan Rilski"Medical University-SofiaSofia 1612Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of General and Clinical Pathology Medical University of PlovdivPlovdiv 4002Bulgaria Department of Healthcare Faculty of Public Health“Prof.Tsekomir VodenicharovMDDSc”Medical University of SofiaSofia 1407Bulgaria Department of Pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria

Gluten ataxia and other central nervous system disorders could be linked to gluten enteropathy and related *** this narrative review,we focus on the various neuro-logical manifestations in patients with gluten sensitivity/celiac disease,immunological and autoimmune mechanisms of ataxia in connection to gluten sensitivity and the autoantibodies that could be used as a biomarker for diagnosing and *** focused on the anti-gliadin antibodies,antibodies to different isoforms of tissue transglutaminase(TG)(anti-TG2,3,and 6 antibodies),anti-glycine receptor antibodies,anti-glutamine acid decarboxylase antibodies,anti-deamidated gliadin peptides antibodies,*** studies found a higher prevalence of these antibodies in patients with gluten sensitivity and neurological dysfunction,presented as different neurological *** also discuss the role of a gluten-free diet on the clinical improvement of patients and also on imaging of these disorders.

关键词： Gluten ataxia Celiac disease Gluten enteropathy Autoantibodies Anti-gliadin antibodies Anti-bodies to tissue transglutaminase Anti-tissue transglutaminase antibodies Anti-transglutaminase 6 antibodies Anti-glycine receptor antibodies Anti-glutamine acid decarboxylase antibodies

Clinical issues and challenges in imaging of gastrointestinal diseases:A minireview and our experience

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World Journal of Clinical Cases 2024年第18期12卷 3304-3313页

作者： Milena Gulinac Georgi Kiprin Ivan Tsranchev Vasko Graklanov lyubomir Chervenkov Tsvetelina Velikova Department of General and Clinical Pathology Medical University of PlovdivPlovdiv 4002Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Gastroenterology MHAT EurohospitalPlovdiv 4000Bulgaria Department of Forensic Medicine and Deontology Medical University of PlovdivPlovdiv 4000Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria

Imaging techniques play a crucial role in the modern era of medicine,particularly in ***,various non-invasive and invasive imaging modalities are being routinely employed to evaluate different gastrointestinal(GI)***,many instrumental as well as clinical issues are arising in the area of modern GI *** minireview article aims to briefly overview the clinical issues and challenges encountered in imaging GI diseases while highlighting our experience in the *** also summarize the advances in clinically available diagnostic methods for evaluating different diseases of the GI tract and demonstrate our experience in the *** conclusion,almost all imaging techniques used in imaging GI diseases can also raise many challenges that necessitate careful consideration and profound expertise in this field.

关键词： Imaging methods Gastrointestinal diseases Gastrointestinal tract Radiology Tumors of the gastrointestinal tract

The Character and Formation of Elongated Depressions on the Upper Bulgarian Slope

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Journal of Ocean University of China 2018年第3期17卷 555-562页

作者： XU Cuiling GREINERT Jens HAECKEL Matthias BIALAS Jorg DIMITROV lyubomir ZHAO Guangtao College of Marine Geo-Sciences Ocean University of China Qingdao 266100 China GEOMAR Helmholtz Centre for Ocean Research Kiel Kiel 24148 Germany Institute of Oceanology Bulgarian Academy of Science Varna 9000 Bulgaria

Seafloor elongated depressions are indicators of gas seepage or slope instability. Here we report a sequence of slopeparallel elongated depressions that link to headwalls of sediment slides on upper slope. The depressions of about 250 m in width and several kilometers in length are areas of focused gas discharge indicated by bubble-release into the water column and methane enriched pore waters. Sparker seismic profiles running perpendicular and parallel to the coast, show gas migration pathways and trapped gas underneath these depressions with bright spots and seismic blanking. The data indicate that upward gas migration is the initial reason for fracturing sedimentary layers. In the top sediment where two young stages of landslides can be detected, the slopeparallel sediment weakening lengthens and deepens the surficial fractures, creating the elongated depressions in the seafloor supported by sediment erosion due to slope-parallel water currents.

关键词： methane seepage elongated depression pockmark landslide Black Sea

Applications of time series analysis in epidemiology: Literature review and our experience during COVID-19 pandemic

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World Journal of Clinical Cases 2023年第29期11卷 6974-6983页

作者： Latchezar Tomov lyubomir Chervenkov Dimitrina Georgieva Miteva Hristiana Batselova TsvetelinaVelikova Department of Informatics New Bulgarian UniversitySofia 1618Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityUniversity Hospital"St George"Plovdiv 4000Bulgaria Department of Medical Faculty Sofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria

Time series analysis is a valuable tool in epidemiology that complements the classical epidemiological models in two different ways:Prediction and *** is related to explaining past and current data based on various internal and external influences that may or may not have a causative *** is an exploration of the possible future values based on the predictive ability of the model and hypothesized future values of the external and/or internal *** time series analysis approach has the advantage of being easier to use(in the cases of more straightforward and linear models such as Auto-Regressive Integrated Moving Average).Still,it is limited in forecasting time,unlike the classical models such as *** applicability in forecasting comes from its better accuracy for short-term *** its basic form,it does not assume much theoretical knowledge of the mechanisms of spreading and mutating pathogens or the reaction of people and regulatory structures(governments,companies,etc.).Instead,it estimates from the data *** predictive ability allows testing hypotheses for different factors that positively or negatively contribute to the pandemic spread;be it school closures,emerging variants,*** can be used in mortality or hospital risk estimation from new cases,seroprevalence studies,assessing properties of emerging variants,and estimating excess mortality and its relationship with a pandemic.

关键词： Time series analysis Epidemiology COVID-19 Pandemic Auto-regressive integrated moving average Excess mortality Seroprevalence

Future of prostate imaging:Artificial intelligence in assessing prostatic magnetic resonance imaging

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World Journal of Radiology 2023年第5期15卷 136-145页

作者： lyubomir Chervenkov Nikolay Sirakov Gancho Kostov Tsvetelina Velikova George Hadjidekov Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Research Complex for Translational Neuroscience Medical University of PlovdivBul.Vasil Aprilov 15APlovdiv 4002Bulgaria Department of Diagnostic Imaging Dental Allergology and PhysiotherapyFaculty of Dental MedicineMedical University PlovdivPlovdiv 4000Bulgaria Department of Special Surgery Medical University PlovdivPlovdiv 4000Bulgaria Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria Department of Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Radiology University Hospital LozenetzSofia 1407Bulgaria Department of Physics Biophysics and RadiologyMedical FacultySofia University St.Kliment OhridskiSofia 1407Bulgaria

Prostate cancer(Pca;adenocarcinoma)is one of the most common cancers in adult males and one of the leading causes of death in both men and *** diagnosis of Pca requires substantial experience,and even then the lesions can be difficult to ***,although the diagnostic approach for this disease has improved significantly with the advent of multiparametric magnetic resonance,that technology has certain unresolved *** recent years artificial intelligence(AI)has been introduced to the field of radiology,providing new software solutions for prostate *** mapping of the prostate has become possible through AI and this has greatly improved the accuracy of *** has also allowed for certain suspicious lesions to be attributed to a given group according to the Prostate Imaging-Reporting&Data System ***,AI has facilitated the combination of data obtained from clinical,laboratory(prostate-specific antigen),imaging(magnetic resonance),and biopsy examinations,and in this way new regularities can be found which at the moment remain *** evolution of AI in this field is inevitable and it is almost certain to significantly expand the efficacy,accuracy and efficiency of diagnosis and treatment of Pca.

关键词： Artificial intelligence Deep learning Machine learning Multiparametric magnetic resonance imaging Prostate cancer Quantitative imaging

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舞动之美

现代青年 2014年第4期 F0002-F0002,1页

作者： lyubomir Sergeev

舞动之美／lyubomirSergeev，保加利亚摄影师，在这组作品中，他将人体与时尚完美融合，以镜头捕捉舞者们的靓影。她们摊动着，轻盈的步伐跃然而起，优美的身体化作一串奇异的音符，融汇成一曲华丽的乐章。

关键词：保加利亚摄影师身体化时尚

Infrared upconversion imaging in nonlinear metasurfaces

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Advanced Photonics 2021年第3期3卷 83-92页

作者： Rocio Camacho-Morales Davide Rocco Lei Xu Valerio Flavio Gili Nikolay Dimitrov lyubomir Stoyanov Zhonghua Ma Andrei Komar Mykhaylo Lysevych Fouad Karouta Alexander Dreischuh Hark Hoe Tan Giuseppe Leo Costantino De Angelis Chennupati Jagadish Andrey E.Miroshnichenko Mohsen Rahmani Dragomir N.Neshev The Australian National University Research School of PhysicsARC Centre of Excellence for Transformative Meta-Optical SystemsDepartment of Electronic Materials EngineeringCanberraACTAustralia University of Brescia Department of Information EngineeringBresciaItaly University of New South Wales School of Engineering and Information TechnologyCanberraACTAustralia Nottingham Trent University School of Science and TechnologyAdvanced Optics and Photonics LaboratoryDepartment of EngineeringNottinghamUnited Kingdom UniversitéParis Diderot Matériaux et Phénomènes QuantiquesParisFrance Friedrich Schiller University Jena Institute of Applied PhysicsAbbe Center of PhotonicsJenaGermany Sofia University Department of Quantum ElectronicsFaculty of PhysicsSofiaBulgaria

Infrared imaging is a crucial technique in a multitude of applications,including night vision,autonomous vehicle navigation,optical tomography,and food quality *** infrared imaging technologies,however,require the use of materials such as narrow bandgap semiconductors,which are sensitive to thermal noise and often require cryogenic *** demonstrate a compact all-optical alternative to perform infrared imaging in a metasurface composed of GaAs semiconductor nanoantennas,using a nonlinear wave-mixing *** experimentally show the upconversion of short-wave infrared wavelengths via the coherent parametric process of sum-frequency *** this process,an infrared image of a target is mixed inside the metasurface with a strong pump beam,translating the image from the infrared to the visible in a nanoscale ultrathin imaging *** results open up new opportunities for the development of compact infrared imaging devices with applications in infrared vision and life sciences.

关键词： metasurfaces nonlinear optical processes infrared photonics imaging.

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World Journal of Clinical Infectious Diseases 2022年第1期12卷 1-19页

作者： Elena Ilieva Alexandra Boyapati lyubomir Chervenkov Milena Gulinac Jordan Borisov Kamelia Genova Tsvetelina Velikova Department of Diagnostic Imaging University Emergency Hospital(UMHATEM)"N.I.Pirogov"Sofia 1606Bulgaria Department of Diagnostic Imaging Medical UniversityPlovdivUniversity Hospital"St George"Plovdiv 4000Bulgaria Department of General and Clinical Pathology Medical UniversityPlovdivUniversity Hospital"St George"Plovdiv 4000Bulgaria Department of Diagnostic Imaging "MBAL-Dobrich"ADDobrich 9300Bulgaria Department of Clinical Immunology University Hospital“Lozenetz”Sofia 1407Bulgaria Medical Faculty Sofia University"St.Kliment Ohridski"Sofia 1407Bulgaria

The introduction of coronavirus disease-2019(COVID-19)as a global pandemic has contributed to overall morbidity and *** a focus on understanding the immunology and pathophysiology of the disease,these features can be linked with the respective findings of imaging ***,the constellation between clinical presentation,histological,laboratory,immunological,and imaging results is crucial for the proper management of *** purpose of this article is to examine the role of imaging during the particular stages of severe acute respiratory syndrome coronavirus 2 infection–asymptomatic stage,typical and atypical COVID-19 pneumonia,acute respiratory distress syndrome,multiorgan failure,and *** use of imaging methods to assess the severity and duration of changes is crucial in patients with *** and computed tomography are among the methods that allow accurate characterization of changes.

关键词： Coronavirus disease-2019 Ultrasound Computed tomography Magnetic resonance imaging Ground-glass opacity Acute respiratory distress syndrome Cytokine storm COVID-19 reporting and data system High-resolution computed tomography Severe acute respiratory syndrome coronavirus 2