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Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 298-304页

作者： Qi-Feng Chen Song Chen Minshan Chen Ning lyu Ming Zhao Department of Minimally Invasive Interventional Therapy Liver Cancer Study and Service GroupSun Yat-sen University Cancer CenterGuangzhouGuangdongChina State Key Laboratory of Oncology in South China GuangzhouGuangdongChina Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdongChina

The high mortality rate in hepatocellular carcinoma(HCC)is partially due to the fact that a significant number of patients are diagnosed at an intermediate or advanced stage,with surgical treatment options *** therapy,which involves both locoregional and systemic treatments,has the potential to downstage tumors in selected patients with initially unresectable HCC,thereby making surgical treatment a possibility and potentially increasing long-term *** optimize the conversion rate,it is necessary to maximize successful conversions and clearly define the target population for conversion treatment through a collaborative *** this review article,we summarize the clinical experience and evidence for conversion therapy in patients with‘potentially resectable’HCC from four perspectives:1)defining the target population for conversion therapy,2)selecting the appropriate conversion strategy,placing emphasis on the utilization of combination therapy that exhibits a significant objective response rate,3)determining the timing and urgency of surgical resection,4)promoting the adoption of a multidisciplinary team *** authors are optimistic that with the continuous progress in treatment and a deeper understanding of HCC,the success rate of HCC conversion therapy will increase,and the overall survival of HCC patients will be prolonged.

关键词： Hepatocellular carcinoma Conversion therapy Conversion rate Targeted population Combination therapy

The degradation of cathodic Fe/N/C catalyst in PEMFCs:The evolution of remanent active sites after demetallation

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Journal of Materials Science & Technology 2024年第6期173卷 100-106页

作者： Xiaohua Yang Wentao Sun Jiatang Chen Yang Gao Rongxian Zhang Qun Luo Tao lyu Lei Du Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications J3X 1P7 VarennesQCCanada School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory of Advanced Special Steels&Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Huangpu Hydrogen Energy Innovation Center School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China

The state-of-the-art Fe/N/C catalyst has presented comparable initial cathode performance to the benchmark Pt/C catalyst in proton exchange membrane fuel cells(PEMFCs).However,the major bottleneck is its significant activity decay in real-world PEMFC *** superposed“fast decay”and“slow decay”have been well documented to describe the degradation process of Fe/N/C catalysts during PEMFC *** fast decay has been well understood in close relation to the demetallation at the initial 15-h stability ***,it is still unclear how the remanent active sites evolve after *** this end,the catalyst performance and evolution of a typical Fe/N/C active site were herein investigated through postmortem characterizations of the membrane electrode assemblies(MEAs)after different *** is presented that 1 bar pressure and 80℃ temperature are the optimized conditions for Fe/N/C ***,the“fast decay”in the initial 15 h is immune to the various operating parameters,while the“slow decay”highly depends on the applied temperature and *** to the X-ray absorption spectra(XAS)analysis and stability test of MEA,the gradual evolution of Fe-N coordination to Fe-O is found correlated with the“slow decay”and accounts for the catalyst decay after the demetallation process.

关键词： Fe/N/C Stability Decay mechanism Metal oxidation PEMFCs

Application of machine learning models in groundwater quality assessment and prediction:progress and challenges

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 25-55页

作者： Yanpeng Huang Chao Wang Yuanhao Wang Guangfeng lyu Sijie Lin Weijiang Liu Haobo Niu Qing Hu School of Environment Harbin Institute of TechnologyHarbin 150090China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Engineering Innovation Center of SUSTech(Beijing) Southern University of Science and TechnologyBeijing 100083China Technical Center for Soil Agriculture and Rural Ecology and EnvironmentMinistry of Ecology and EnvironmentBeijing 100012China Chinese Academy of Environmental Planning Beijing 100043China

Groundwater quality assessment and prediction(GQAP)is vital for protecting groundwater *** GQAP methods can not adequately capture the complex relationships among attributes and have the disadvantage of being computationally ***,the application of machine learning(ML)in GAQP(GQAPxML)has been widely studied due to ML’s reliability and *** many GQAPxML publications exist,a thorough review is *** review provides a comprehensive summary of the development of ML applications in the field of ***,the workflow of ML modeling is briefly introduced,as are data preparation,model development,model evaluation,and model ***,299 publications related to the topic are filtered,mainly through ML ***,many aspects of GQAPxML,such as publication trends,the spatial distribution of study areas,the size of data sets,and ML algorithms,are discussed from a bibliometric *** addition,we review in detail the well-established applications and recent findings for several subtopics,including groundwater quality assessment,groundwater quality modeling using groundwater quality parameters,groundwater quality spatial mapping,probability estimation of exceeding the groundwater quality threshold,groundwater quality temporal prediction,and the hybrid use of ML and physics-based ***,the development of GQAPxML is explored from three perspectives:data collection and preprocessing,model building and evaluation,and the broadening of model *** review provides a reference for environmental scientists to better understand GQAPxML and promotes the development of innovative methods and improvements in modeling quality.

关键词： Groundwater quality assessment Groundwater quality prediction Machine learning Groundwater modeling

Classification and reconstructive algorithm for nasal alar defect in Asians

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 22-27页

作者： Renpeng Zhou Dongze lyu Chen Wang Danru Wang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background:The nasal alar defect in Asians remains a challenging issue,as do clear classification and algorithm guidance,despite numerous previously described surgical *** aim of this study is to propose a surgical algorithm that addresses the appropriate surgical procedures for different types of nasal alar defects in Asian ***:A retrospective case note review was conducted on 32 patients with nasal alar defect who underwent reconstruction between 2008 and *** on careful analysis and our clinical experience,we proposed a classification system for nasal alar defects and presented a reconstructive *** data,including age,sex,diagnosis,surgical options,and complications,were *** extent of surgical scar formation was evaluated using standard photography based on a 4-grade scar ***:Among the 32 patients,there were 20 males and 12 females with nasal alar *** predominant cause of trauma in China was industrial *** majority of alar defects were classified as type Ⅰ C(n=8,25%),comprising 18 cases(56.2%);there were 5 cases(15.6%)of type Ⅱ defect,7(21.9%)of type Ⅲ defect,and 2(6.3%)of type Ⅳ *** most common surgical option was auricular composite graft(n=8,25%),followed by bilobed flap(n=6,18.8%),free auricular composite flap(n=4,12.5%),and primary closure(n=3,9.4%).Satisfactory improvements were observed ***:Factors contributing to classifications were analyzed and defined,providing a framework for the proposed classification *** reconstructive algorithm offers surgeons appropriate procedures for treating nasal alar defect in Asians.

关键词： Nasal alar Defect Classification Algorithm Surgical methods

Ultra-low reflection electromagnetic interference shielding nanofiber film with effective solar harvesting and self-cleaning

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Collagen and Leather 2024年第1期6卷 47-60页

作者： Bin lyu Yunchuan Wang Dangge Gao Shihao Guo Yingying Zhou Jianzhong Ma College of Bioresources Chemical and Materials Engineering Shaanxi University of Science and Technology National Demonstration Center for Experimental Light Chemistry and Engineering Education (Shaanxi University of Science and Technology) Xi'an Key Laboratory of Green Chemicals and Functional Materials

It is urgent to develop low-reflection electromagnetic interference shielding material to shield electromagnetic waves(EMW) and reduce their secondary radiation ***,an electromagnetic interference shielding nanofiber film is composed of ZnO and carbon nanofiber(CNF) via electrospinning and carbonization approachs,and subsequently coating perfuorooctyltriethoxysilane as a protective *** the one hand,ZnO coated by porous carbon,which is derived from ZIF-8,endows the nanofiber film low reflection property through optimizing impedance matching between free space and the nanofiber *** the other hand,the nanofiber film possesses high electromagnetic interference shielding efficiency,which is beneficial by excellent electrical conductivity of CNF derived from waste leather ***,the nanofiber film involves abundant interface,which contributes to high interfacial polarization ***,the nanofiber film with a thickness of 250 μm has electrical conductivity of 53 S/m and shielding efficiency of 50 *** reflection coefficient of the nanofiber film is inferior to 0.4 indicates that most of EMW are absorbed inside the materials and the nanofiber film is effective in reducing secondary radiation contamination of electromagnetic ***,the nanofiber film exhibits outstanding solar harvesting performance(106℃ at 1 sun density) and good self-cleaning performance,which ensure that the nanofiber film can work in harsh *** work supplies a credible reference for fabricating low-reflection electromagnetic shielding nanofiber film to reduce secondary radiation pollution and facilitates the upcycling of waste leather scraps.

关键词： Electromagnetic interference shielding Nanofiber film Solar harvesting Self-cleaning

Effect of temperature on tribofilm growth and the lubrication of the piston ring-cylinder liner system in two-stroke marine engines

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Friction 2024年第8期12卷 1858-1881页

作者： Xiuyi lyu Jiang HU Yunchuan WANG Jinlu SHENG Xuan MA Tongyang LI Chang GE Xiqun LU Chongqing Jiaotong University Chongqing 400074China Chongqing Metropolitan College of Science and Technology Chongqing 402167China Harbin Engineering University Harbin 150001China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

This study is an optimized extension based on the authors’previous research on the tribo-chemical reaction under constant temperature field of two-stroke internal combustion engines(ICEs).It establishes a coupled analysis model that considers the tribo-chemical reactions,dynamic contact,and interface lubrication of the piston ring-cylinder liner(PRCL)system under transient temperature *** this study,for the first time,the prediction of the tribofilm thickness and its influence on the surface micro-topography(the comprehensive roughness)are coupled in the working temperature field of the PRCL system,forming an effective model framework and providing a model basis and analytical basis for subsequent *** study findings reveal that by incorporating temperature and tribofilm into the simulation model,the average friction deviation throughout the stroke decreases from 8.92%to 0.93%when compared to experimental ***,the deviation during the combustion regime reduces from 39.56%to 7.34%.The proposed coupled model provides a valuable tool for the evaluation of lubrication performance of the PRCL system and supports the analysis software forward design in two-stroke ICEs.

关键词： tribofilm piston ring-cylinder liner(PRCL)system temperature comprehensive roughness two-stroke internal combustion engines(ICEs)

On the Shallowing of Antarctic Low-Level Temperature Inversions Projected by CESM-LE under RCP8.5

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Journal of Meteorological Research 2024年第3期38卷 586-599页

作者： Minghu DING Lin ZHANG Tingfeng DOU Yi HUANG Yingyan LUO Junmei lyu Cunde XIAO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China Key Laboratory of Meteorology and Ecological Environment of Hebei Province Hebei Provincial Institute of Meteorological SciencesShijiazhuang050021China College of Resources and Environment University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing100875China

Temperature inversions are frequently observed in the boundary layer and lower troposphere of polar *** variations of the low-level temperature inversions in these regions,especially the Antarctic,are still poorly *** to the scarcity of observations in the Antarctic,reanalysis data and numerical simulations are often used in the study of Antarctic climate *** on ERA-Interim,ERA5,JRA-55,and NCEP-NCAR reanalysis products,this study examines temporal and spatial variations of Antarctic inversion depth in austral autumn and winter during *** inversions are found to occur over the high plateau areas of the Antarctic *** on the Mann-Kendall test,ERA-Interim and ERA5 data reveal that the Antarctic inversion depth in austral autumn and winter increased during 1992-2007,roughly maintained afterwards,and then significantly decreased since around *** decrease trend is more obvious in the last two months of ***,JRA-55 better represents the spatial distribution of inversion depth,and ERA-Interim has better interannual *** Community Earth System Model Large Ensemble(CESM-LE)30-member simulations in 1979-2005 were first verified against JRA-55,showing reasonable consistency,and were then used to project the future changes of Antarctic low-level inversion depth over 2031-2050 under *** CESM-LE projection results reveal that the temperature inversion will shallow in the Antarctic at the end of the 21st century,and the decrease in depth in autumn will be more pronounced than that in *** particular,the temperature inversion will weaken over the ice-free ocean,while it will remain stable over the ice sheet,showing certain spatial heterogeneity and seasonal dependence on the underlying cryospheric surface *** addition,the decrease of inversion depth is found closely linked with the reduction in sea ice,suggesting the strong effect of global warming on the thermal structure change o

关键词： boundary layer temperature inversion Antarctic climate change Community Earth System Model Large Ensemble(CESM-LE)

Microphysical Characteristics of Rainfall Based on Long-Term Observations with a 2DVD in Yangbajain,Tibet

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Advances in Atmospheric Sciences 2024年第9期41卷 1721-1734页

作者： Ming LI Yongheng BI Yonghai SHEN Yinan WANG Ciren Nima Tianlu CHEN Daren lyu Key Laboratory for Cosmic Rays of the Ministry of Education Tibet UniversityLhasa 850000China Key Laboratory of Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of ScienceBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Raindrop size distribution(DSD)plays a crucial role in enhancing the accuracy of radar quantitative precipitation estimates in the Tibetan Plateau(TP).However,there is a notable scarcity of long-term,high-resolution observations in this *** address this issue,long-term observations from a two-dimensional video disdrometer(2DVD)were leveraged to refine the radar and satellite-based algorithms for quantifying precipitation in the hinterland of the *** was observed that weak precipitation(R<1,mm h-1)accounts for 86%of the total precipitation time,while small raindrops(D<2 mm)comprise 99%of the total raindrop ***,the average spectral width of the DSD increases with increasing rain *** DSD characteristics of convective and stratiform precipitation were discussed across five different rain rates,revealing that convective precipitation in Yangbajain(YBJ)exhibits characteristics similar to maritime-like *** constrained relationships between the slopeΛand shapeμ,D_(m)and N_(w)of gamma DSDs were ***,we established a correlation between the equivalent diameter and drop axis ratio and found that raindrops on the TP attain a nearly spherical ***,the application of the rainfall retrieval algorithms of the dual-frequency precipitation radar in the TP is improved based on the statistical results of the DSD.

关键词： Tibetan Plateau raindrop size distribution 2DVD dual frequency radar microphysical features

Raindrop Size Distributions in the Zhengzhou Extreme Rainfall Event on 20 July 2021:Temporal-Spatial Variability and Implications for Radar QPE

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Journal of Meteorological Research 2024年第3期38卷 489-503页

作者： Liman CUI Haoran LI Aifang SU Yang ZHANG Xiaona lyu Le XI Yuanmeng ZHANG Henan Key Laboratory of Agrometeorological Support and Applied Technique China Meteorological AdministrationZhengzhou450003China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing100081China Henan Meteorological Observatory Zhengzhou450003China

In this study,a regional Parsivel OTT disdrometer network covering urban Zhengzhou and adjacent areas is employed to investigate the temporal-spatial variability of raindrop size distributions(DSDs)in the Zhengzhou extreme rainfall event on 20 July *** rain rates observed by disdrometers and rain gauges from six operational sites are in good agreement,despite significant site-to-site variations of 24-h accumulated rainfall ranging from 198.3 to 624.1 *** Parsivel OTT observations show prominent temporal-spatial variations of DSDs,and the most drastic change was registered at Zhengzhou Station where the record-breaking hourly rainfall of 201.9 mm over 1500-1600 LST(local standard time)was *** hourly rainfall is characterized by fairly high concentrations of large raindrops,and the mass-weighted raindrop diameter generally increases with the rain rate before reaching the equilibrium state of DSDs with the rain rate of about 50 mm h^(−1).Besides,polarimetric radar observations show the highest differential phase shift(K_(dp))and differential reflectivity(Z_(dr))near surface over Zhengzhou Station from 1500 to 1600 *** light of the remarkable temporal-spatial variability of DSDs,a reflectivity-grouped fitting approach is proposed to optimize the reflectivity-rain rate(Z-R)parameterization for radar quantitative precipitation estimation(QPE),and the rain gauge measurements are used for *** results show an increase of mean bias ratio from 0.57 to 0.79 and a decrease of root-mean-square error from 23.69 to 18.36 for the rainfall intensity above 20.0 mm h^(−1),as compared with the fixed Z-R *** study reveals the drastic temporal-spatial variations of rain microphysics during the Zhengzhou extreme rainfall event and warrants the promise of using reflectivity-grouped fitting Z-R relationships for radar QPE of such events.

关键词： extreme rainfall raindrop size distribution radar quantitative precipitation estimation(QPE)