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Preparation of water-soluble tantalum nanoparticles and their radiosensitization application

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Tungsten 2024年第4期6卷 748-758页

作者： Wang Zhang Shuang-Long Du Zhi-Guo Zhang Tao Wang chun-jian Su Xing-Hua Dong Shuang Zhu Zhan-Jun Gu College of Mechanical and Electronic Engineering Shandong University of Science and Technology CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Science GBA Research Innovation Institute for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Chinese Academy of Sciences

Radiation therapy(RT) that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment ***,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the *** high atom number(Z) element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma *** nanoparticles(Ta NPs) exhibit good radiotherapy sensitization ***,achieving the water solubility of Ta NPs is *** study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP) for radiotherapy sensitization *** results showed that the water solubility of Ta NPs modified with SHMP was significantly *** biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.

关键词： Mechanochemical method Radiotherapy sensitization Sodium hexametaphosphate Tantalum nanoparticles

Progress and prospects of graphene-based materials in lithium batteries

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Rare Metals 2024年第5期43卷 1886-1905页

作者： Shen Lai Tao Huang Pei Liu Hong-Bin Wang Shi-chun Yang Xin-Hua Liu Kai Yang Qian-Ling Zhang jian-Hong Liu jiang-Tao Hu Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen518060China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Department of Electrical and Electronic Engineering Advanced Technology InstituteUniversity of SurreyGuildfordSurrey GU27XHUK

Reasonable design and applications of graphene-based materials are supposed to be promising ways to tackle many fundamental problems emerging in lithium batteries,including suppression of electrode/electrolyte side reactions,stabilization of electrode architecture,and improvement of conductive ***,extensive fundamental research on this aspect has been performed so ***,when it comes to large-scale industrial applications,the utilization of graphene-based materials progresses at a very slow ***,there presents a severe technological decoupling between academic research and industrial application,and there is an urgent need to link ***,in order to address current issues of graphene-based materials used in lithium batteries,we present their latest advancements with stateof-the-art *** applications of graphenebased materials in practical lithium batteries are highlighted and predicted to bridge the gap between the academic progress and industrial manufacture,thereby paving the way for accelerating the development of graphenebased material as well as lithium battery industry.

关键词： Lithium batteries Graphene-based materials Academic research Industrial application Development direction

Copper-Free Click Chemistry-Mediated Assembly of Single Quantum Dot Nanosensor for Accurately Monitoring Locus-Specific m^(6)A in Cancer Cells

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Chinese Journal of Chemistry 2024年第5期42卷 499-504页

作者： Yue-Ying Li Ning-Ning Zhao Yi-Xuan Geng Qian Han jian-Ge Qiu Bing-Hua jiang Zi-Yue Wang chun-Yang Zhang Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityThe Academy of Medical SciencesHenan Institute of Medical and Pharmaceutical Sciences BGI CollegeZhengzhou UniversityZhengzhouHenan450052 China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinanShandong250014 China School of Chemistry and Chemical Engineering Southeast UniversityNanjingJiangsu211189 China

N6-methyladenosine(m^(6)A)plays an important role in embryogenesis,nuclear export,transcription splicing,and protein translation ***,we demonstrate a copper-free click chemistry-mediated assembly of single quantum dot(QD)nanosensor for accurately monitoring locus-specific m^(6)A in cancer *** m^(6)A-sensitive endoribonuclease MazF can digest the unmethylated A-RNA,and the intact m^(6)A-RNA then hybridizes with DNA probes a and b to produce a sandwich hybrid,initiating the click chemistry to generate probe a–b ligation product via first tandem ligation detection reaction(LDR)***,DNA probes c and d can hybridize with the probe a–b ligation product to generate the probe c–d ligation product via second LDR *** LDR cycles can be repeated through denaturation and annealing reaction to generate abundant biotin-/fluorophore-modified probe c–d ligation products that can easily assemble on the QD surface to induce distinct fluorescence resonance energy transfer(FRET)between QD and *** assay can be homogenously performed without the involvement of copper catalyst,m^(6)A-specific antibody,radioactive labeling,ligase enzyme,enzymatic reverse transcription,and next-generation ***,it can discriminate even 0.01% m^(6)A level in complex samples and accurately measure cellular m^(6)A-RNA expression,providing a promising avenue for clinical diagnostics and biomedical research.

关键词： RNA methylation Click chemistry Förster resonance energy transfer Biosensor Cancer

Clinical analysis of secondary penile cancer:a case series at a tertiary referral center in China

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Asian Journal of Andrology 2024年第2期26卷 225-226页

作者： Xiao-Yu Li chun-Ru Xu Xing Ji Zhen-Peng Zhu Zhen-Ke Guo Tian-Yu Cai jian Lin Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China

Dear Editor,Secondary penile cancer is an extremely rare condition that refers to the metastasis of other malignancies to the *** are limited reports on secondary penile cancer in Asian populations,and perceptions about this disease are extremely *** reviewed and analyzed the data of patients diagnosed with secondary penile cancer based on the pathological findings at Peking University First Hospital in Beijing,China,aiming to expand the clinical reference for this rare disease.

关键词： cancer rare finding

Animal models of hepatitis E infection: Advances and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He Chuan-Wu Zhu Jia-Jia Yang Lan Huang chun jiang jian Wu Chinese Consortium for the Study of Hepatitis E(CCSHE) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis E virus(HEV)is one of the leading causes of acute viral hepatitis *** most of HEV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HEV infection can also cause several extrahepatic *** exists in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HEV can be used as *** establishment of animal models is of great significance for studying HEV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HEV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HEV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HEV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HEV animal models.

关键词： Hepatitis E virus Animal models Pathogenesis Prevention Treatment

Correction to:Assembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uranium

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Nuclear Science and Techniques 2024年第2期35卷 234-235页

作者： Xiao-Xiao Li De-Yang Cui chun-Yan Zou jian-Hui Wu Xiang-Zhou Cai Jin-Gen Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academy in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Following publication of the original article,the authors observed that both Fig.5 and Fig.4 depict the same *** 5 was inaccurately referenced and *** correct Fig.5 is copied below:The original article has been updated.

关键词： fuel enriched reactivity

Mechanical and damping performances of TPMS lattice metamaterials fabricated by laser powder bed fusion

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China Foundry 2024年第4期21卷 327-333页

作者： Yan-peng Wei Huai-qian Li Jing-jing Han Ying-chun Ma Hao-ran Zhou Jing-chang Cheng jian Shi Zhi-quan Miao Bo Yu Feng Lin National Key Laboratory of Advanced Casting Technologies Shenyang Research Institute of Foundry Co.Ltd.CAMShenyang 110022China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory of Space Physics Beijing 100076China

Lattice metamaterials based on three-period minimum surface(TPMS)are an effective means to achieve lightweight and high-strength materials which are widely used in various fields such as aerospace and ***,its vibration and noise reduction,and damping properties have not been fully ***,in this study,the TPMS structures with parameterization were designed by the method of surface migration,and the TPMS structures with high forming quality was manufactured by laser powder bed fusion(LPBF).The mechanical properties and energy absorption characteristics of the beam and TPMS structures were studied and compared by quasi-static *** modal shapes of the beam lattice structures and TPMS structures were obtained by the free modal analysis,and the damping properties of two structures were obtained by modal *** the two structures after heat treatment with the same porosity of 70%,the yield strength of the beam lattice structure reaches 40.76 MPa,elastic modulus is 20.38 GPa,the energy absorption value is 32.23 MJ·m^(-3),the damping ratio is 0.52%.The yield strength,elastic modulus,energy absorption value,and damping ratio of the TPMS structure are 50.74 MPa,25.37 GPa,47.34 MJ·m^(-3),and 0.99%,*** results show that TPMS structures exhibit more excellent mechanical properties and energy absorption,better damping performance,and obvious advantages in structural load and vibration and noise reduction compared with the beam lattice structures under the same porosity.

关键词： lattice metamaterials TPMS energy absorption damping laser powder bed fusion

Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng Shuang Zhou Yi-Fang Zhang Ya-Ping Wang chun-Yan Fu jian-Wen Li Yuan-Lang Wan Zhi-Jia Zhang Yong jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

Uncovering Chemical Interactions between Danshen and Danggui Using Liquid Chromatography–Mass Spectrometry and Network Pharmacology-Based Research on Stroke

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 230-243页

作者： Han-Qing Pang Jia-Xiu Guo Xiao-Yu Shang jian Wang Hui Liu Jing Tian Lu Zhang jian-Bin Wang Wei Shi Bing-chun Yan Liang Liu Department of Pharmacy School of MedicineInstitute of Translational MedicineYangzhou UniversityYangzhouChina School of Medicine Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile DiseasesYangzhou UniversityYangzhouChina School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)GuilingChina Yangzhou Food and Drug Inspection and Testing Center YangzhouChina

Objective: The objective of this study was to decipher chemical interactions between Danshen and Danggui using liquid chromatography–mass spectrometry(LC-MS) and explore the mechanisms of Danshen–Danggui against stroke using network pharmacology and molecular docking. Materials and Methods: First, the chemical compounds of Danshen–Danggui were profiled using ultra-high-performance liquid chromatography(HPLC)-quadrupole time-of-flight MS. Accurately characterized compounds in various proportions of Danshen–Danggui were quantified using HPLC combined with triple quadrupole electrospray tandem MS. Network pharmacology was used to uncover the essential mechanisms of action of Danshen–Danggui against stroke. Discovery Studio Software was used for the molecular docking verification of key active chemicals and stroke-related targets. Results: A total of 53 compounds were characterized, and 22 accurately identified constituents(10 phenolic acids, 8 phthalides, and 4 tanshinones) were quantified in 15 proportions of Danshen–Danggui. The quantification results showed that Danggui significantly increased the dissolution of most phenolic acids(compounds from Danshen), whereas Danshen promoted the dissolution of most phthalides(compounds from Danggui). Overall, the combination of Danshen and Danggui at a 1:1 ratio resulted in the maximum total dissolution rate. Further network pharmacology and molecular docking results indicated that Danshen–Danggui exerted anti-stroke effects mainly by regulating inflammation-related(tumor necrosis factor, hypoxia-inducible factor, and toll-like receptor) signaling pathways, which ranked among the top three pathways based on Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Conclusion: The chemical compounds in Danshen–Danggui could interact with each other to increase the dissolution of the most active compounds, which could provide a solid basis for uncovering the compatibility mechanisms of Danshen–Danggui and Danshen–Danggu

关键词： Chemical interactions Danggui Danshen liquid chromatography–mass spectrometry network pharmacology