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Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3964-3982页

作者： Bao, Weilian lyu, jiaren Feng, Guize Guo, Linfeng Zhao, Dian You, Keyuan Liu, Yang Li, Haidong Du, Peng Chen, Daofeng Shen, Xiaoyan Fudan Univ Sch Pharm Dept Pharmacol Minist Educ Shanghai 201210 Peoples R China Fudan Univ Sch Pharm Key Lab Smart Drug Delivery Minist Educ Shanghai 201210 Peoples R China Fudan Univ Sch Pharm Dept Nat Med Shanghai 201210 Peoples R China Shanghai Jiao Tong Univ Xinhua Hosp Dept Colorectal & Anal Surg Sch Med Shanghai 200092 Peoples R China Shanghai Colorectal Canc Res Ctr Shanghai 200092 Peoples R China

The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post injury. Label retaining cells (LRCs) expressing SRY-box transcription factor 9 (SOX9) promote epithelial repair by replenishing LGR5+ intestinal stem cells (ISCs). While, LRCs are also considered precursor cells for enteroendocrine cells (EECs) which exacerbate mucosal damage in inflammatory bowel disease (IBD). The factors that determine LRC-EEC differentiation and the effect of intervening in LRC-EEC differentiation on IBD remain unclear. In this study, we investigated the effects of a natural anthraquinone called aloe emodin (derived from the Chinese herb rhubarb) on mucosal healing in IBD models. Our findings demonstrated that aloe emodin effectively interfered with the differentiation to EECs and preserved a higher number of SOX9+ LRCs, thereby promoting mucosal healing. Furthermore, we discovered that aloe emodin acted as an antagonist of free fatty acid receptors (FFAR1), suppressing the FFAR1-mediated Gbg/serine/threonine-protein kinase (AKT) pathway and promoting the translo cation of forkhead box protein O1 (FOXO1) into the nucleus,ultimately resulting in the intervention of differentiation fate. These findings reveal the effect of free fatty acid accessibility on EEC differentiation and introduce a strategy for promoting mucosal healing in IBD by regulating the FFAR1/AKT/FOXO1 signaling pathway.

关键词： LRCs ISCs EECs IBD SOX9 Aloe emodin FFAR1 FOXO1 CHRONIC ULCERATIVE-COLITIS EVIDENCE-BASED CONSENSUS INSULIN-SECRETION GRANULE RELEASE DNA-BINDING FOXO1 INDUCTION RECEPTOR DISEASE BETA

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Geochemical Characteristics and Hydrocarbon Generation Modeling of the Paleocene Source Rocks in the Jiaojiang Sag,East China Sea Basin

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Journal of Earth Science 2024年第2期35卷 642-654页

作者： Chuang Lei Shiyan Yin jiaren Ye Jingfu Wu Zhaosheng Wang Bin Gao Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources North China University of Science and TechnologyTangshan063210China Key Laboratory of Tectonics and Petroleum Resources China University of GeosciencesMinistry of EducationWuhan430074China CNOOC Research Institute Ltd Beijing100028China

Jiaojiang sag in the East China Sea Basin is at the earlier exploration stage,where characterizing hydrocarbon generation of source rocks is important to understand oil-gas exploration *** geochemical and basin modeling analysis,hydrocarbon generation capacity and process of the Paleocene E_(1)y,E_(1)l and E_(1)m formations were *** show that E_(1)y and E_(1)l mudstones are high-quality source rocks with Type Ⅱ kerogen,which is dominated by both aquatic organisms and terrestrial higher plants deposited in sub-reduced environment.E_(1)m mudstone interbedded with thin carbonaceous mudstone and coal is poor-quality source rock with Type Ⅲ kerogen,whose organic matter was originated from terrestrial higher plants under oxidized *** by burial and maturity histories,E_(1)y and E_(1)l source rocks experienced two hydrocarbon generation stages,which took place in the Late Paleocene and in the Middle to Late Eocene,respectively,and had high hydrocarbon generation capacity with cumulative hydrocarbon volume of 363 and 328 mg/g,respectively.E_(1)m source rock only had one hydrocarbon generation process in the Late Eocene,which had low hydrocarbon generation capacity with cumulative hydrocarbon volume of only 24 mg/*** future oil-gas exploration in the Jiaojiang sag should focus on hydrocarbon generation center and select targets in the central uplift formed before the Miocene with high-quality traps.

关键词： East China Sea Basin Jiaojiang sag source rock geochemical characteristics hydrocarbon generation basin modeling petroleum geology

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A Constrained Local Neighborhood Approach for Efficient Markov Blanket Discovery in Undirected Independent Graphs

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Computers, Materials & Continua 2024年第8期80卷 2535-2555页

作者： Kun Liu Peiran Li Yu Zhang jiaren Ming Li Xianyu Wang Cong Li School of Information and Communication Engineering Hainan UniversityHaikou570228China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space Technology Xi’anXi’an710100China Strategic Emerging Industries Department CRSC Communication&Information Group Co.Ltd.Beijing100070China Military Representative Bureau of the Army Equipment Department in Xi’an Xi’an710032China

When learning the structure of a Bayesian network,the search space expands significantly as the network size and the number of nodes increase,leading to a noticeable decrease in algorithm *** constraint-based methods typically rely on the results of conditional independence ***,excessive reliance on these test results can lead to a series of problems,including increased computational complexity and inaccurate results,especially when dealing with large-scale networks where performance bottlenecks are particularly *** overcome these challenges,we propose a Markov blanket discovery algorithm based on constrained local neighborhoods for constructing undirected independence *** method uses the Markov blanket discovery algorithm to refine the constraints in the initial search space,sets an appropriate constraint radius,thereby reducing the initial computational cost of the algorithm and effectively narrowing the initial solution ***,the method first determines the local neighborhood space to limit the search range,thereby reducing the number of possible graph structures that need to be *** process not only improves the accuracy of the search space constraints but also significantly reduces the number of conditional independence *** performing conditional independence tests within the local neighborhood of each node,the method avoids comprehensive tests across the entire network,greatly reducing computational *** the same time,the setting of the constraint radius further improves computational efficiency while ensuring *** to other algorithms,this method can quickly and efficiently construct undirected independence graphs while maintaining high *** simulation results show that,this method has significant advantages in obtaining the structure of undirected independence graphs,not only maintaining an accuracy of over 96%but also reducing the number of conditi

关键词： Bayesian network structure learning Markov blanket conditional independence

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Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： Liang Zhou Youyou Li jiaren Li Hanyu Yao Jin Huang Cheng Li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

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Achieving Seconds-to-Hours Duration-Tunable Organic Long Persistent Luminescence from Carbon Dots-Based Exciplex Systems by Energy Gaps Regulation

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Chinese Journal of Chemistry 2024年第12期42卷 1407-1417页

作者： Yixuan Xu Kai Jiang Linger Feng Xinyuan Tong Zuxu Zhou Fengshi Li Yi Zhang jiaren Du Hengwei Lin International Joint Research Center for Photo-responsive Molecules and Materials School of Chemical and Material EngineeringJiangnan UniversityWuxiJiangsu214122China State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxiJiangsu 214122China

Comprehensive Summary Duration-tunable afterglow materials have garnered considerable attention in various ***,carbon dots(CDs)-based long persistent luminescence(LPL)composites with a tunable duration in an ultrawide range of seconds-to-hours levels were designed and prepared for the first *** contrast to the established CD-based afterglow materials,we reported that CD-based composites exhibit LPL in the form of exciplexes and long-lived charge-separated states,enabling the LPL to be prolonged from several seconds to over one hour,exceeding the typical regulation range(limited to 1 min).Further studies revealed that the relationship between the excited and charge-transfer states of CDs plays a pivotal role in activating the LPL and regulating its ***,these composites exhibited high photoluminescence(PL)quantum yields of up to 60.63%,and their LPL was robust under ambient conditions,even in aqueous *** robust and superior LPL performance endows these composites with a strong competitive advantage in dynamic display systems,such as tags for time-resolved data encryption and displays of the remaining time of *** study offers an approach to preparing CDs-based LPL composites with tunable durations and may provide new insights for the development of rare-earth-free LPL materials.

关键词： Carbon dots Composites Charge separation Exciplex Persistent luminescence

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恒温振荡培养箱校准方法的研究

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现代科学仪器 2024年第1期41卷 147-149,211页

作者：张佳仁上海市质量监督检验技术研究院上海201114

研究建立了恒温振荡培养箱的校准方法。通过对生产厂家和用户的调研,参考相关的国家标准、行业标准和校准规范,提出一种采用多通道温度计、转速表和位移传感器作为校准装置,校准恒温振荡培养箱的温度偏差、温度波动度、温度均匀度、振... 详细信息

研究建立了恒温振荡培养箱的校准方法。通过对生产厂家和用户的调研,参考相关的国家标准、行业标准和校准规范,提出一种采用多通道温度计、转速表和位移传感器作为校准装置,校准恒温振荡培养箱的温度偏差、温度波动度、温度均匀度、振荡频率误差和振荡幅度误差的方法。选择代表性的恒温振荡培养箱,依据该校准方法对计量特性进行实验验证,验证结果符合指标要求。该方法促进了恒温振荡培养箱量值溯源的标准化和规范化,推动其校准规范的制定。

关键词：恒温振荡培养箱溯源校准验证

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Recent Advance in Low-Dielectric-Constant Organosilicon Polymers

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Chinese Journal of Chemistry 2023年第18期41卷 2371-2381页

作者： jiaren Hou Jing Sun Qiang Fang Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of Sciences345Lingling RoadShanghai 200032China Center for Excellence in Molecular Synthesis Shonghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoodShanghai 200032China University of Chinese Academy of Sciences 19 Yuquan RoadShijinshan DistrictBeijing 100049China

Comprehensive Summary,Low dielectric(low-k)organosilicon polymers have received extensive interests from industry and academia due to good electrical insulation,high temperature resistance,flame retardancy and *** attractive properties enable them to be utilized as low-k materials in fabrication of electronic devices in high-frequency communication *** review summarizes recent progress in developing low-k organosilicon polymers,including the synthetic methods and properties of different organosilicon polymers classified according to the chemical *** may provide some inspiration to design new low-k organosilicon polymers for application in the.

关键词： Organosilicon polymers Low dielectric materials Thermosetting resins Functional polymers Monomers Resins

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片区化推进乡村振兴--苏州市吴中区澄湖甪直乡村振兴示范片区规划

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城市建筑空间 2024年第1期31卷 89-91页

作者：徐佳仁吴蔚苏州科技大学建筑与城市规划学院

片区化推进乡村振兴、组团式开展乡村建设是苏州市创新性提出的乡村振兴工作推进方式。以片区化推进乡村振兴为指引,以苏州市吴中区澄湖甪直片区为例,从总体定位、空间结构、产业振兴、文化振兴、人居环境5个维度提出规划策略,以期为乡... 详细信息

片区化推进乡村振兴、组团式开展乡村建设是苏州市创新性提出的乡村振兴工作推进方式。以片区化推进乡村振兴为指引,以苏州市吴中区澄湖甪直片区为例,从总体定位、空间结构、产业振兴、文化振兴、人居环境5个维度提出规划策略,以期为乡村振兴工作提供新思路。

关键词：乡村振兴片区规划

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WU’S SOLITON IN A SLOPING TROUGH

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Chinese Physics Letters 1990年第9期7卷 406-409页

作者： YAN jiaren YOU Jianqiang Department of Physics Xiangtan UniversityXiangtan 411105

The expression of Wu’s hydrodynamic soliton in a sloping trough was derived wing the perturbation method of multiple *** showed that the soliton slowly moves toward the shallow end with uniform acceleration,which is ... 详细信息

关键词： shallow trough scales

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涂膜、腻子膜打磨性测定仪校准方法的研究

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现代科学仪器 2024年第2期41卷 31-33页

作者：张佳仁吴成新上海市质量监督检验技术研究院上海201114

研究建立了涂膜、腻子膜打磨性测定仪的校准方法。通过对生产厂家和用户的调研,参考相关的国家标准和校准规范,提出一种采用电子秒表、钢直尺、电子天平作为校准设备,校准涂膜、腻子膜打磨性测定仪的摩擦速度示值误差、摩擦行程、打磨... 详细信息

研究建立了涂膜、腻子膜打磨性测定仪的校准方法。通过对生产厂家和用户的调研,参考相关的国家标准和校准规范,提出一种采用电子秒表、钢直尺、电子天平作为校准设备,校准涂膜、腻子膜打磨性测定仪的摩擦速度示值误差、摩擦行程、打磨头质量、附加砝码质量的方法。选择代表性的涂膜、腻子膜打磨性测定仪,依据该校准方法对计量特性进行实验验证,验证结果符合指标要求。该方法促进了涂膜、腻子膜打磨性测定仪量值溯源的标准化和规范化,推动其校准规范的制定。

关键词：涂膜、腻子膜打磨性测定仪溯源校准验证

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