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Characteristics of gully bed scour and siltation between check dams

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Journal of Mountain Science 2023年第1期20卷 49-64页

作者： lyu Xiao-bo YOU Yong WANG Zhuang LIU Jin-feng SUN Hao ZHAO Wan-yu Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of SciencesChengdu610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China

Check dams are the most commonly used engineering measure for debris flow control *** scour and siltation characteristics between dams are important factors affecting dam *** this study,classical dimensional analysis of the variables that influence the development of gully bed scour and siltation was carried *** experiments were conducted to examine the influence characteristics of opening width,flume slope,debris flow density,and opening rate on the characteristics of gully bed scour and *** influential characteristics of variables on the dimensionless scour depth,scour length,siltation length,scour volume and siltation volume were *** experiments showed that,with an increase in the relative opening from 1.5 to 2.5,scour depth increased by 7.4%,scour length decreased by 11.2%,siltation length increased by 22.0%,scour volume decreased by 4.7%and siltation volume increased by 22.0%.With an increase in flume gradient from 0.105 to 0.213,scour depth,siltation length and siltation volume increased by 40.0%,65.9%and 65.9%,respectively,and scour length decreased by 20.1%.With an increase in sediment concentration from 0.303 to 0.545,siltation length and siltation volume increased by 15.4%and 15.4%,respectively,and scour depth,scour length and scour volume decreased by 9.6%,9.1%and 17.8%,*** opening rate increased from 0.08 to 0.32,siltation length and siltation volume increased by 33.3%and 33.3%,respectively,and scour depth,scour length and scour volume decreased by 5.4%,13.7%and 18.4%,*** results showed that the flume gradient was the most influential factor on scour depth,scour length,siltation length and siltation volume,and the sediment concentration was the most influential factor on scour ***,according to the experimental data,some empirical formulas predicting scour depth,scour length,siltation length,scour volume and siltation volume were *** error between the computed values accord

关键词： Debris flow Gully bed scour Gully bed siltation Window dam

Deterioration of Antioxidant Competence in Barley Lesion Mimic Mutant 194

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Phyton-International Journal of Experimental botany 2019年第2期88卷 109-117页

作者： Qunqun Hao bo lyu Yuhan Tang Deya Wang Yuanyuan Li Qingliang Li Yuhai Wang Wenqiang Wang College of Life Sciences Zaozhuang UniversityZaozhuang277000China State Key Laboratory of Crop Biology College of AgronomyShandong Agricultural UniversityTai’an271018China.

A barley mutant,194,was observed to exhibit a leaf spot phenotype over the whole course of its growing *** this study,the phenotype and antioxidant competence were studied in the lesion mimic mutant *** height was slightly higher in mutant 194 than in the wild type(WT).In addition,leaf spot per plant in mutant 194 was significantly higher than in *** competence,as indicated by reactive oxygen species(ROS)accumulation,antioxidant enzyme activity,and the expression of antioxidant enzyme-encoding genes was also assessed in mutant *** to the WT,mutant 194 displayed a relatively higher accumulation of ROS,accompanied by lower activities of some antioxidant enzymes and downregulation of antioxidant enzyme-encoding *** demonstrated reduced antioxidant competence in mutant *** results suggested that this lower antioxidant competence of mutant 194 could lead to the accumulation of excessive *** excess of ROS could induce programmed cell death and has the potential to promote disease resistance in mutant 194.

关键词： Lesion mimic mutant ROS accumulation antioxidant enzymes barley

Phosphorylation of Cofilin-1 Enhances Paclitaxel Resistance of Epithelial Ovarian Cancer Cells by Inhibiting Apoptosis

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Biomedical and Environmental Sciences 2021年第6期34卷 465-477页

作者： LI Min DONG Xu Dong lyu Qiu bo ZHANG Wei HUANG Shuai YANG Chun Xue CUI Di LAI Hui Ying Department of Obstetrics and Gynecology Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Obstetrics the First People's Hospital of Yunnan ProvinceKunming 650032YunnanChina Department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking University Health Science Center Beijing 100069China Clinical Laboratory Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective To investigate the molecular mechanism of high phosphorylation levels of cofilin-1(p-CFL-1)associated with paclitaxel resistance in epithelial ovarian cancer(EOC)*** Cells displaying varying levels of p-CFL-1 and CFL-1 were created by plasmid transfection and shRNA *** inhibition rate indicating paclitaxel efficacy was assessed by Cell Counting Kit-8(CCK-8)*** was assessed by flow cytometry and protein levels were detected by western *** real-time polymerase chain reaction(qRT-PCR)was used to measure the expression levels of phosphokinases and phosphatases of *** analysis evaluated the correlation between the prognosis of EOC patients and the levels of p-CFL-1 and slingshot-1(SSH-1).Results High levels of p-CFL-1 were observed in EOC cells that survived treatment with high doses of ***3 cell mutants with upregulated p-CFL-1 showed impaired paclitaxel efficacy,as well as decreased apoptosis rates and pro-survival patterns of apoptosis-specific protein *** accumulation of p-CFL-1 inhibited paclitaxel-induced mitochondrial ***-1 silencing mediated CFL-1 phosphorylation in paclitaxel-resistant SKOV3 ***,the high level of p-CFL-1 and the low level of SSH-1 in EOC tissues were closely related to chemotherapy resistance and poor prognosis in EOC *** The SSH-1/p-CFL-1 signaling pathway mediates paclitaxel resistance by apoptosis inhibition in EOC and is expected to be a potential prognostic predictor.

关键词： Cofilin-1 Slingshot-1 Epithelial ovarian cancer Chemo-resistance Apoptosis

Buyang Huanwu Decoction Ameliorates Damage of Erectile Tissue and Function Following Bilateral Cavernous Nerve Injury

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Chinese Journal of Integrative Medicine 2023年第9期29卷 791-800页

作者： YE Miao-yong ZHAO Fan MA Ke YAO Li-juan ZHOU Kang MA Jian-xiong lyu bo-dong XU Zeng-bao Department of Urology the First People’s Hospital of WenlingWenlingZhejiang Province317500China Department of Urology Affiliated Hospital of Nantong UniversityNantongJiangsu Province226001China The Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou310053China Department of Urology Huzhou Hospital of Traditional Chinese MedicineHuzhouZhejiang Province313000China Andrology Laboratory on Integration of Chinese and Western Medicine Zhejiang Provincial Key Laboratory of Traditional Chinese MedicineHangzhou310053China

Objective To verify the effect of Buyang Huanwu Decoction(BHD)in ameliorating erectile dysfunction(ED)after radical prostatectomy(RP).Methods The composition of BHD was verified by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry(UPLC-QTOF-MS/MS)*** cavernous nerve crush injury(BCNI)in rats was used to mimic the neurovascular injury occurring after *** the envelope method,forty rats were randomly divided into 4 groups as follows:sham(cavernous nerves exposed only),model(BCNI),low-dosage BHD[LBHD,12.8 g/(kg·d)],and high-dosage BHD[HBHD,51.2 g/(kg·d)]groups,10 rats in each group,feeding for 3 weeks *** function was evaluated by measuring intracavernosal pressure(ICP).Changes in the histopathology of corpus cavernosum(CC)were examined by hematoxylin-eosin ***,the fibrosis of CC was measured by Masson’s trichrome staining and Western blot was used to detect the expressions of collagen I,transforming growth factor beta 1(TGF-β1)andα-smooth muscle actin(α-SMA).Apoptosis index was detected by terminal-deoxynucleoitidyl transferase mediated nick end labeling(TUNEL)and Western blot for determining the expressions of B-cell lymphoma 2(Bcl-2)and Bcl-2-associated X(Bax).The oxidative stress in the CC were assessed by the superoxide dismutase(SOD),malondialdehyde(MDA)and reactive oxygen species(ROS)*** proteins expression of c-Jun N-terminal kinase(JNK)and c-Jun were detected by Western *** addition,the expression ofα-SMA and p-c-Jun in the CC was observed by double immunofluorescence *** The UPLC-QTOF-MS/MS analysis showed that BHD contained calycosin-7-O-β-D-glucoside,ononin,calycosin and *** with the model group,LBHD and HBHD treatment improved the ICP and the circumference,area,and weight of CC(P<0.05 or P<0.01).Furthermore,LBHD and HBHD treatments increased CC smooth muscle content and decreased apoptosis index(P<0.05 or P<0.01).LBHD and HBHD also e

关键词： Buyang Huanwu Decoction erectile dysfunction cavernous nerve injury Chinese medicine Jun N-terminal kinase

Characteristics of debris flow impact on a double-row slit dam

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Journal of Mountain Science 2023年第2期20卷 415-428页

作者： WANG Zhuang LIU Dao-chuan YOU Yong lyu Xiao-bo LIU Jin-feng ZHAO Wan-yu SUN Hao WANG Dong-wei LIU Yang Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China Sichuan Highway Planning SurveyDesign and Research Institute Ltd.Chengdu 610041China Sichuan Tongchuan Engineering Technology Development Co. Ltd.Chengdu 610041China State Grid Sichuan Electric Power Transmission&Transformation Construction Co. Ltd.Chengdu 610051China

To accurately predict impact loads can ensure the safe operation of debris flow control *** instantaneous impact process is usually considered in the calculation of the debris flow impact force;however,the redistribution of an impact load after structural regulation is *** this study we deduced the theoretical calculation of a debris flow impact on a double-row slit dam,and carried out a verification experiment on the debris flow *** calculation model considers the influence of the debris flow properties,dam arrangement and pile *** results show that the impact force of the debris flow is obviously affected by the bulk *** the bulk density is 21 kg/m^(3),the maximum impact force on the pile dam is 1.15 times that when the bulk density is 15 kg/m^(3),but the time it takes for the debris flow to pass through the dam body is reduced by 60%.The larger the relative pile spacing,the more sufficient the flow space and the lower the maximum impact *** maximum impact force of relative pile spacing of 0.8 is 12%less than that of elative pile spacing of *** horizontal distribution of the impact force in the mud depth range is *** maximum impact force on the centre pier is 1.3 times that of a side pier,and the maximum impact force on the dam body appears at the top of the mud depth *** the vertical distribution of the impact force,the maximum impact force at the highest mud mark is approximately 70%of that of the *** the increase in the relative pile spacing,the longitudinal maximum impact force distribution first decreases and then increases.

关键词： Debris flow force Slit dam Fluctuations Flume model test

ACC/AHA risk score for predicting the presence and severity of coronary artery disease in a Chinese population:a cross-sectional Study

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Chinese Medical Journal 2020年第22期133卷 2753-2755页

作者： Yao Wang Jie-Fang Zhang Song-Zan Chen Qing-bo lyu Xue lyu Wen-Bin Zhang Department of Cardiology Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang ProvinceSir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310016.China

Coronary artery disease(CAD),the most common type of cardiovascular disease(CVD),remains the leading cause of mortality in both developing and developed countries,accounting for approximately 17.3 million deaths in 2013,higher than the data in 1990.111 The American College of Cardiology(ACC)/American Heart Association(AHA)score is one of the typical and accurate model to evaluate the 10-year risk of a first hard atherosclerotic cardiovascular disease(ASCVD)event based on a sex-and-race large Pooled Cohort ***,the present study aimed to investigate the association between the ACC/AHA risk score and the Gensini Score(GS)system,and determine whether ACC/AHA score could predict the presence and severity of CAD.

关键词： severity cardiovascular mortality

Application of kombucha combined with fructo-oligosaccharides in soy milk: Colony composition, antioxidant capacity, and flavor relationship

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FOOD BIOSCIENCE 2023年第3期53卷 378-389页

作者： Peng, Xinhui Yang, Sai Liu, Yanwei Ren, Kunyu Tian, Tian Tong, Xiaohong Dai, Shicheng lyu, bo Yu, Aihua Wang, Huan Jiang, Lianzhou Northeast Agr Univ Coll Food Sci Harbin 150030 Heilongjiang Peoples R China Heilongjiang Beidahuang Green Hlth Food Co Ltd Jiamusi 154000 Heilongjiang Peoples R China Heilongjiang Farmland Longwang Food Co Ltd Suihua 152000 Heilongjiang Peoples R China Hainan Univ Coll Food Sci & Engn Haikou 570228 Peoples R China

Plant-based milk is considered a healthy and environmentally sustainable option. In order to solve the physical and chemical instability problem of most plant milk and increase the chance of consumer acceptance of the flavor, this experiment used soybean as raw material, fructo-oligosaccharides (FOS) as prebiotics, and added kombucha for fermentation. The microbial composition, functional components, antioxidant capacity, physico-chemical properties and flavor relationship of fermented soy milk at different fermentation times (up to 96 h) were studied by high-throughput sequencing, laser confocal scanning imaging, and gas chromatography-mass spectrometry. According to the results, the synbiotic interaction of FOS and kombucha consortium promoted the growth of yeast and lactic acid bacteria in soy milk. The ideal fermentation time was 84 h. At this time, fer-mented soy milk added with FOS displayed increased beta-glucosidase activity (by 68.10 mU/mL), isoflavones mainly represented by genistein content (by 612.41%), and DPPH radical scavenging activity (by 25.02%). Furthermore, the addition of FOS intensified the sour taste of the 84 h-fermented soy milk. The content of hexanal was reduced, while favorable flavor substances, such as citric acid and linalool, were also produced. Soymilk fermented with kombucha and FOS provides an opportunity to explore the physical and chemical characteristics and the mechanism of flavor formation in multi-strain co-fermentation systems and to develop commercial plant-based fermentation products.

关键词： Kombucha Fructo-oligosaccharide Gene sequencing Antioxidant capacity Flavour substance

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《七录序》与阮孝绪的知识、思想世界

学术月刊 2020年第9期52卷 159-172页

作者：吕博武汉大学历史学院湖北武汉430072

南朝时期,由于纸的普及,相比于使用简牍的时代,获取知识的途径已大为便捷。在这种背景下,私家藏书兴盛。家有文史、拥书万卷者,也不罕见。“知识下移”成为一种趋势。因此,带有“博”的词汇,如“渊博综广”等,常常被用来形容当时的知识... 详细信息

南朝时期,由于纸的普及,相比于使用简牍的时代,获取知识的途径已大为便捷。在这种背景下,私家藏书兴盛。家有文史、拥书万卷者,也不罕见。“知识下移”成为一种趋势。因此,带有“博”的词汇,如“渊博综广”等,常常被用来形容当时的知识人。阮孝绪阅读量惊人,号称“博极群书”。保留在《广弘明集》中的《七录序》就对阮孝绪的阅读过程、知识构成有所记录。从《七录序》可知,书籍总目《七录》因其穷“天下之遗书秘记”的性质,在某种程度上反映了梁武帝大同二年(536)以前,整个南朝的藏书规模。从私人阅读的角度来讲,《七录》是阮孝绪个人“阅读史”的总结,包含了他自身的“知识轮廓”。不过,阮孝绪博极群书,“阅读领域”几乎涉及了当时各个学术门类。因此,探讨阮孝绪私人阅读的历程以及《七录》的目录构成,也就具备了更大的意义。阮孝绪个人的“阅读史”与精神前进的历程,其实也是整个南朝学术文化、精神世界变化的缩影。

关键词：阮孝绪《七录序》佛道变迁南朝文化

磷酸功能化空心二氧化硅的制备及其对Cd^(2+)的吸附

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材料导报 2022年第9期36卷 38-44页

作者：吕博陈连喜武汉理工大学化学化工与生命科学学院武汉430070

在水溶液中,分别以2-氰乙基三乙氧基硅烷(CTES)、3-脲丙基三甲氧基硅烷(UDPTMS)为内核与外壳前驱体,氨水为催化剂,通过一步法及官能团差异性刻蚀法合成了脲基功能化空心二氧化硅纳米球(UD-HSNs),并通过后磷酸化将功能化二氧化硅转化为... 详细信息

在水溶液中,分别以2-氰乙基三乙氧基硅烷(CTES)、3-脲丙基三甲氧基硅烷(UDPTMS)为内核与外壳前驱体,氨水为催化剂,通过一步法及官能团差异性刻蚀法合成了脲基功能化空心二氧化硅纳米球(UD-HSNs),并通过后磷酸化将功能化二氧化硅转化为磷酸基功能化空心二氧化硅纳米球(H_(2)O_(3)P-HSNs)。通过扫描电子显微镜(SEM)、场发射透射电子显微镜(TEM)、傅里叶变换红外光谱(FTIR)、X射线光电子能谱仪和热重(TG)分析对所得微球的形貌、结构及性能进行了表征。研究结果表明,UD-HSNs与H_(2)O_(3)P-HSNs的粒径分布在450~650 nm范围内,壳层厚度在70~100 nm范围内,磷酸基团修饰前后纳米粒子的形貌和粒径变化不大。从比表面积和孔径分析可知,含脲基或磷酸基团的空心二氧化硅材料均具有一定的比表面积,FTIR、EDS、XPS和TG等表明,磷酸基团被成功地接枝到了二氧化硅材料上,改性后的材料含有一定量的P元素,其含量在5%左右。吸附实验表明,UD-HSNs与H_(2)O_(3)P-HSNs在120 min后逐渐能接近饱和吸附量,pH值为6左右、初始Cd^(2+)浓度在100~180 mg/L时两种材料具有较好的吸附性能,UD-HSNs的最大吸附量达152.63 mg/g,H_(2)O_(3)P-HSNs的最大吸附量达171.81 mg/g。在经过五次循环使用后,两种材料对Cd^(2+)的吸附性能仍然是第一次的65%~70%。

关键词：磷酸空心二氧化硅吸附