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Successful treatment of acute liver failure due to Wilson’s disease: Serendipity or fortuity?

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World Journal of Hepatology 2024年第8期16卷 1111-1119页

作者： Valeria Delle cave Fabiola Di Dato Pier Luigi Calvo Maria Immacolata Spagnuolo Raffaele Iorio Department of Translational Medical Science Section of PediatricsUniversity of Naples Federico IINaples 80131Italy Pediatric Gastroenterology Unit Regina Margherita Children's HospitalAzienda Ospedaliera-Universitaria Cittàdella Salute e della ScienzaTurin 10126Italy

BACKGROUND Acute liver failure(ALF)may be the first and most dramatic presentation of Wilson’s disease(WD).ALF due to WD(WD-ALF)is difficult to distinguish from other causes of liver disease and is a clear indication for liver *** is no firm recommendation on specific and supportive medical treatment for this *** To critically evaluate the diagnostic and therapeutic management of WD-ALF patients in order to improve their survival with native *** A retrospective analysis of patients with WD-ALF was conducted in two pediatric liver units from 2018 to *** During the study period,16 children(9 males)received a diagnosis of WD and 2 of them presented with *** first was successfully treated with an unconventional combination of low doses of D-penicillamine and zinc plus steroids,and survived without liver *** second,exclusively treated with supportive therapy,needed a hepatotransplant to overcome *** Successful treatment of 1 WD-ALF patient with low-dose D-penicillamine and zinc plus steroids may provide new perspectives for management of this condition,which is currently only treated with liver transplantation.

关键词： Fulminant liver failure Copper Chelator Zinc Steroids Liver transplantation Autoimmune hepatitis Prognostic score 24 hour-urinary copper excretion Native liver

Linking uplift and mineralisation at the Mount Novit Zn-Pb-Ag Deposit,Northern Australia:Evidence from geology,U-Pb geochronology and sphalerite geochemistry

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Geoscience Frontiers 2022年第2期13卷 333-350页

作者： Bradley cave William Perkins Richard Lilly Department of Earth Sciences University of AdelaideAdelaideSAAustralia Geological Survey of Queensland BrisbaneQLDAustralia

The subeconomic Mount Novit Zn-Pb-Ag deposit is located approximately 20 km south of Mount Isa,*** contrast to the nearby Mount Isa,Hilton and George Fisher Zn-Pb-Ag deposits,mineralisation at Mount Novit is situated to the west of the regional-scale Mount Isa Fault and is hosted in the Moondarra Siltstone as opposed to the Urquhart ***-grade(10 wt.%Zn+Pb)mineralisation occurs as a matrix supported breccia dominated by sphalerite and pyrrhotite with galena,pyrite,and ***-situ U-Pb geochronology was completed on apatite and two textural varieties of ***-grained(10 ppm),possibly reflecting the leaching of the metals from an underlying basement *** GGIMFis geothermometer(Frenzel et al.,2016)produced a mean formation temperature of 345±52℃.The timing and temperature of Zn-Pb-Ag mineralisation is consistent with the age and cooling temperature of apatite presented in this *** on these correlations,we

关键词： Mount Isa Mount Novit Zn-Pb-Ag mineralisation Monazite Apatite Geochronology

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Zeb2 directs EMT-like processes that underlies the glial response to injury

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Neural Regeneration Research 2021年第9期16卷 1788-1790页

作者： Ana L.Vivinetto John W.cave Burke Neurological Institute White PlainsNYUSA InVitro Cell Research EnglewoodNJUSA

In both the peripheral and central nervous systems(PNS and CNS, respectively), glial cells are critical for the wound healing response to injury. However, the glial cell types that orchestrate the response and the ext... 详细信息

关键词： healing wound injury

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Implementation of a novel train-the-trainer program for pharmacists in China

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Family Medicine and Community Health 2016年第1期4卷 60-63页

作者： Hoan Linh Banh Andrew cave Faculty of Medicine and Dentistry Department of Family MedicineUniversity of Alberta

Clinical pharmacy services in North American are well implemented both in community phar-macies and in hospital *** 2009 the Chinese government mandated the implementation of clinical pharmacy services in all secondary and tertiary hospitals by *** mandate would require adequately trained clinical ***,most pharmacy education programs in China have not yet incorporated clinical pharmacy into their *** pharmacists have been sent to countries,including the United States and Canada,to receive clinical pharmacy *** of different health care systems,medical team dynamics,and language barriers,it became difficult for the returning pharmacists to apply the skills gained from this type of *** a result,the Second Xiangya Hospital of Central South University initiated an international academic-run train-the-trainer *** objectives are to provide adequate training for phar-macists to provide pharmaceutical care to patients,conduct clinical pharmacy-related research,and engage in scholarly *** evaluation of local readiness,the course commenced in 2014,and to date four trainers have received personalized one-on-one training by an advanced pharma-cist with 15 years of experience of delivering similar curricula in North *** present the initial process evaluation and learning that will contribute to the development of clinical pharmacy courses at Central South University.

关键词： Train the trainer clinical pharmacists clinical pharmacy clinical pharmacy research China

Do PaCO2 and peripheral venous PCO2 become comparable when the peripheral venous oxygen saturation is above a certain critical value?

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World Journal of Emergency Medicine 2020年第3期11卷 191-192页

作者： Lauren McGarey Patrick Liddicoat Matthew Gaines Martyn Harvey Grant cave Intensive Care Unit Tamworth Base HospitalTamworthNew South WalesAustralia Emergency Department Tamworth Base HospitalTamworthNew South WalesAustralia Waikato Hospital HamiltonNew Zealand

Dear editor,Peripheral venous blood gas(VBG)analysis is increasingly used as an alternative to arterial sampling in Emergency Departments throughout the world.[1]There are multiple advantages using peripheral venous samples for blood gas analysis-technical ease,reduced pain and fewer *** difference in sample site chosen for blood gas analysis between European and Australian centres has been notable for members of our author group,prompting discussion and review of the literature.

关键词： venous saturation prompt

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Nucleotide sequence conservation of novel and established cis-regulatory sites within the tyrosine hydroxylase gene promoter

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Frontiers in Biology 2015年第1期10卷 74-90页

作者： Meng WANG Kasturi BANERJEE Harriet BAKER John W. cave Burke Medical Research Institute White Plains NY 10605 USA Weill Cornell Medical College Brain and Mind Research Institute NY 10065 USA

Tyrosine hydroxylase （TH） is the rate-limiting enzyme in catecholamine biosynthesis and its gene proximal promoter （〈 1 kb upstream from the transcription start site） is essential for regulating transcription in both the developing and adult nervous systems. Several putative regulatory elements within the TH proximal promoter have been reported, but evolutionary conservation of these dements has not been thoroughly investigated. Since many vertebrate species are used to model development, function and disorders of human catecholaminergic neurons, identifying evolutionarily conserved transcription regulatory mechanisms is a high priority. In this study, we align TH proximal promoter nucleotide sequences from several vertebrate species to identify evolutionarUy conserved motifs. This analysis identified three elements （a TATA box, cyclic AMP response element （CRE） and a 5＇-GGTGG-3＇ site） that constitute the core of an ancient vertebrate TH promoter. Focusing on only eutherian mammals, two regions of high conservation within the proximal promoter were identified： a -250 bp region adjacent to the transcription start site and a -85 bp region located approximately 350 bp further upstream. Within both regions, conservation of previously reported cis-regulatory motifs and human single nucleotide variants was evaluated. Transcription reporter assays in a TH-expressing cell line demonstrated the functionality of highly conserved motifs in the proximal promoter regions and electromobility shift assays showed that brain-region specific complexes assemble on these motifs. These studies also identified a non-canonical CRE binding （CREB） protein recognition element in the proximal promoter. Together, these studies provide a detailed analysis of evolutionary conservation within the TH promoter and identify potential cisregulatory motifs that underlie a core set of regulatory mechanisms in mammals.

关键词： catecholamine dopamine transcription evolution

Predicting early outcomes of liver transplantation in young children: The EARLY study

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World Journal of Hepatology 2018年第1期10卷 62-72页

作者： Rashid Alobaidi Natalie Anton Dominic cave Elham Khodayari Moez Ari R Joffe Department of Pediatrics Division of Pediatric Critical Care Medicine University of Alberta and Stollery Children’s Hospital School of Public Health University of Alberta

AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 *** This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June ***-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperat

关键词： Liver transplantation Pediatric Complications Thrombosis Antithrombin

Microscopic colitis: A review of etiology, treatment and refractory disease

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World Journal of Gastroenterology 2015年第29期21卷 8804-8810页

作者： Tina Park David cave Christopher Marshall Department of Medicine Division of Gastroenterology University of Massachusetts Worcester

Microscopic colitis is a common cause of chronic,nonbloody diarrhea. Microscopic colitis is more common in women than men and usually affects patients in their sixth and seventh decade. This article reviews the etiology and medical management of microscopic colitis. The etiology of microscopic colitis is unknown, but it is associated with autoimmune disorders, such as celiac disease, polyarthritis, and thyroid disorders. Smoking has been identified as a risk factor of mi-croscopic colitis. Exposure to medications, such as non-steroidal anti-inflammatory drugs, proton pump inhibitors, and selective serotonin reuptake inhibitors, is suspected to play a role in microscopic colitis, although their direct causal relationship has not been proven. Multiple medications, including corticosteroids, anti-diarrheals, cholestyramine, bismuth, 5-aminosalicylates, and immunomodulators, have been used to treat microscopic colitis with variable response rates. Budesonide is effective in inducing and maintaining clinical remission but relapse rate is as high as 82% when budesonide is discontinued. There is limited data on management of steroid-dependent microscopic colitis or refractory microscopic colitis. Immunomodulators seem to have low response rate 0%-56% for patients with refractory microscopic colitis. Response rate 66%-100% was observed for use of anti-tumor necrosis factor(TNF) therapy for refractory microscopic colitis. Anti-TNF and diverting ileostomy may be an option in severe or refractory microscopic colitis.

关键词： Chronic diarrhea Etiology of microscopiccolitis Collagenous colitis Refractory microscopiccolitis Microscopic colitis Lymphocytic colitis Steroiddependentmicroscopic colitis

Impacts from the implementation of a Novel Clinical Pharmacist Training Program in Changsha,Hunan Province,China

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Family Medicine and Community Health 2018年第2期6卷 89-92页

作者： Ping Xu Da Xiong Xiang Andrew J.cave Hoan Linh Banh Department of Pharmacy The Second Xiangya Hospital of Central South UniversityNo 139 Middle Renmin RoadChangshaHunanChina Department of Family Medicine Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlbertaCanadaand 6-10 University TerraceUniversity of AlbertaEdmontonAB T6G 2T4Canada

The Ministry of Health and Family Planning of the People’s Republic of China issued a mandate to all hospitals to implement clinical pharmacy services by *** of clinical pharmacy services to provide pharmaceutical care is a *** Second Xiangya Hospital of Central South University in collaboration with the University of Alberta implemented a structured train-the-trainer program to train pharmacists to provide direct patient care in collaboration with physicians,to teach/mentor other pharmacists and students from Hunan province,and to conduct clinical pharmacy *** implementation of the program,the pharmacy department increased the number of clinical pharmacists,expanded the clinical pharmacy services,made changes to hospital policies,and received a financial award of five million renminbi(one million Canadian dollars)to support the department.

关键词： Clinical pharmacy pharmaceutical care pharmacy practice in China hospital pharmacy training program pharmacy practice China