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中华结核和呼吸杂志 2015年第10期38卷 797-797页

作者：蔡珊 Li Qin lynn tanoue 胡安美贾秀杰罗红陈燕陈平彭红中南大学湘雅二医院呼吸内科长沙410011 Yale University School of Medicine

慢性阻塞性肺疾病（慢阻肺）是呼吸系统常见疾病，我国针对40岁以上人群的大样本调查结果显示慢阻肺患病率为8．2％。慢阻肺起病隐匿，早期多无临床症状或症状轻微，临床医生（尤其是非呼吸专科医生）对其认识和重视不够，患者早期常被... 详细信息

慢性阻塞性肺疾病（慢阻肺）是呼吸系统常见疾病，我国针对40岁以上人群的大样本调查结果显示慢阻肺患病率为8．2％。慢阻肺起病隐匿，早期多无临床症状或症状轻微，临床医生（尤其是非呼吸专科医生）对其认识和重视不够，患者早期常被漏诊，就医时往往已是中重度，因此我国慢阻肺的诊治情况不容乐观。既往报道，湖南省不同等级医院肺功能仪配备率及吸入制剂普及率存在显著差异，各级医院对慢阻肺患者的健康教育均重视不足，基层医院医生普遍缺乏慢阻肺诊治的基本知识，医生对慢阻肺诊治知识的掌握程度与其学历有密切关系。

关键词：慢性阻塞性肺疾病临床医生肺功能仪配备治疗诊断培训基层医院医生

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肺癌分期分类相关的解剖学、生物学及理念

中国肺癌杂志 2010年第1期13卷 1-8页

作者： Frank C. DETTERBECK lynn T. tanoue Daniel J. BOFFA 杨永波李志刚 Thoracic Oncology Program Yale Cancer Center Division of Thoracic Surgery Department of Surgery Yale University Division of Pulmonary and Critical Care Medicine Department of Medicine Yale University 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

尽管用于此修订本的大样本量患者数据库已极大地拓宽了我们的知识面,但最新提出的肺癌分期系统仍以解剖学特征为基础。可以预见,由于所鉴定出的患者亚群数目不断增加,肺癌分期系统变得愈加复杂。表述这些亚组的临床特征有可能为我们提... 详细信息

尽管用于此修订本的大样本量患者数据库已极大地拓宽了我们的知识面,但最新提出的肺癌分期系统仍以解剖学特征为基础。可以预见,由于所鉴定出的患者亚群数目不断增加,肺癌分期系统变得愈加复杂。表述这些亚组的临床特征有可能为我们提供肿瘤亚组特殊的生物学行为特性的线索。本文探索了可用于以解剖学为基础的新分期系统的肿瘤生物学相关观念。

关键词：肺癌解剖学生物学概念分期

Still elusive: Developments in the accurate diagnosis of indeterminate biliary strictures

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 297-304页

作者： lynn Affarah Philip Berry Sreelakshmi Kotha Department of Hepatology Guy's and St Thomas'HospitalLondon SE17EHUnited Kingdom

Indeterminate biliary strictures pose a significant diagnostic dilemma for gastroenterologists.Despite advances in endoscopic techniques and instruments,it is difficult to differentiate between benign and malignant pathology.A positive histological diagnosis is always preferred prior to high risk hepatobiliary surgery,or to inform other types of therapy.Endoscopic retrograde cholangiopancreato-graphy with brushings has low sensitivity and despite significant improvements in instruments there is still an unacceptably high false negative rate.Other methods such as endoscopic ultrasound and cholangioscopy have improved diagnostic quality.In this review we explore the techniques available to aid accurate diagnosis of indeterminate biliary strictures and obtain accurate hist-ology to facilitate clinical management.

关键词： Indeterminate biliary stricture Benign biliary stricture Malignant biliary stricture Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound Primary sclerosing cholangitis

Decadal Forecasts of Large Earthquakes along the Northern San Andreas Fault System, California: Increased Activity on Regional Creeping Faults Prior to Major and Great Events

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International Journal of Geosciences 2024年第2期15卷 204-230页

作者： lynn R. Sykes Lamont-Doherty Earth Observatory of Columbia University Palisades New York USA

The three largest earthquakes in northern California since 1849 were preceded by increased decadal activity for moderate-size shocks along surrounding nearby faults. Increased seismicity, double-difference precise locations of earthquakes since 1968, geodetic data and fault offsets for the 1906 great shock are used to re-examine the timing and locations of possible future large earthquakes. The physical mechanisms of regional faults like the Calaveras, Hayward and Sargent, which exhibit creep, differ from those of the northern San Andreas, which is currently locked and is not creeping. Much decadal forerunning activity occurred on creeping faults. Moderate-size earthquakes along those faults became more frequent as stresses in the region increased in the latter part of the cycle of stress restoration for major and great earthquakes along the San Andreas. They may be useful for decadal forecasts. Yearly to decadal forecasts, however, are based on only a few major to great events. Activity along closer faults like that in the two years prior to the 1989 Loma Prieta shock needs to be examined for possible yearly forerunning changes to large plate boundary earthquakes. Geodetic observations are needed to focus on identifying creeping faults close to the San Andreas. The distribution of moderate-size earthquakes increased significantly since 1990 along the Hayward fault but not adjacent to the San Andreas fault to the south of San Francisco compared to what took place in the decades prior to the three major historic earthquakes in the region. It is now clear from a re-examination of the 1989 mainshock that the increased level of moderate-size shocks in the one to two preceding decades occurred on nearby East Bay faults. Double-difference locations of small earthquakes provide structural information about faults in the region, especially their depths. The northern San Andreas fault is divided into several strongly coupled segments based on differences in seismicity.

关键词： San Andreas and Hayward Faults California Fault Creep Forecasts Double-Difference Relocations

Creating large EMS populations for functional genomics and breeding in wheat

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Journal of Integrative Agriculture 2024年第2期23卷 484-493页

作者： Wenqiang Wang Xizhen Guan Yong Gan Guojun Liu Chunhao Zou Weikang Wang Jifa Zhang Huifei Zhang Qunqun Hao Fei Ni Jiajie Wu lynn Epstein Daolin Fu Spring Valley Agriscience Co. Ltd.Jinan 250300China College of Life Sciences Zaozhuang UniversityZaozhuang 277160China National Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China Department of Plant Pathology University of CaliforniaDavisCA 95616USA

Wheat germplasm is a fundamental resource for basic research,applied studies,and wheat breeding,which can be enriched normally by several paths,such as collecting natural lines,accumulating breeding lines,and introducing mutagenesis materials.Ethyl methane sulfonate(EMS)is an alkylating agent that can effectively introduce genetic variations in a wide variety of plant species.In this study,we created a million-scale EMS population(MEP)that started with the Chinese wheat cultivars‘Luyan 128’,‘Jimai 38’,‘Jimai 44’,and‘Shannong 30’.In the M1 generation,the MEP had numerous phenotypical variations,such as>3,000 chlorophyll-deficient mutants,2,519 compact spikes,and 1,692 male sterile spikes.There were also rare mutations,including 30 independent tillers each with double heads.Some M1 variations of chlorophyll-deficiency and compact spikes were inheritable,appearing in the M2 or M3 generations.To advance the entire MEP to higher generations,we adopted a single-seed descendent(SSD)approach.All other seed composites of M2 were used to screen other agronomically important traits,such as the tolerance to herbicide quizalofop-P-methyl.The MEP is available for collaborative projects,and provides a valuable toolbox for wheat genetics and breeding for sustainable agriculture.

关键词： wheat germplasm ethyl methane sulfonate genetics and breeding

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书迷的旅游行程

空中英语教室（高级版．彭蒙惠英语） 2024年第6期 24-25,45,46页

作者： lynn O'Rourke Hayes 不详

一本好书可以带我们进入到各种奇幻之地以下五个来自文学世界的建议,或许可以激发你自己前去探险1.亚伦·亚历山大·米尔恩的小熊维尼,马尼托巴省温尼伯市一个世纪以前,一位加拿大士兵收养了一头小黑熊,并以家乡温尼伯的名字为它命名为... 详细信息

一本好书可以带我们进入到各种奇幻之地以下五个来自文学世界的建议,或许可以激发你自己前去探险1.亚伦·亚历山大·米尔恩的小熊维尼,马尼托巴省温尼伯市一个世纪以前,一位加拿大士兵收养了一头小黑熊,并以家乡温尼伯的名字为它命名为维尼。

关键词：米尔恩温尼伯旅游行程亚历山大加拿大

Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： Yuki Ishikawa-Kakiya Hirotsugu Maruyama Kojiro tanoue Shusei Fukunaga Yasuaki Nagami Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely occurs.It was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

Integrating genomic and morphological data into bamboo taxonomicand evolutionary studies

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Plant Diversity 2023年第2期45卷 123-124页

作者： lynn G.Clark Department of Ecology Evolutionand Organismal BiologyIowa State University251 BesseyAmesIA5001-4009USA

The Bambusoideae (bamboos),with over 1700 described species,is the third largest subfamily of the Poaceae (grasses),native to all continents except Antarctica and Europe (Clark et al.,2015;Soreng et al.,2022).Within the Bambusoideae,three tribes representing the three major lineages are recognized.The Olyreae comprise the ca.130 species of herbaceous bamboos,which are smaller and much less lignified than their woody cousins.

关键词： bamboo evolutionary Bambusoideae

Improving cell transplantation by understanding and manipulating the phagocytic activity of peripheral glia

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Neural Regeneration Research 2022年第2期17卷 313-314页

作者： lynn Nazareth James St John Jenny Ekberg Menzies Health Institute Queensland Griffith UniversitySouthportAustralia Clem Jones Centre for Neurobiology and Stem Cell Research Griffith UniversityNathanAustralia Griffith Institute for Drug Discovery Griffith UniversityNathanAustralia

One of the key challenges in neuroscience is that the central nervous system(CNS;the brain and spinal cord), is largely unable to regene rate after injury. One factor contributing to this lack of repair is the accumulation of cellular and myelin debris at the site of injury. The debris is not efficiently phagocytosed and can persist for years after the initial injury, resulting in an inflammatory environment which inhibits axonal regrowth(Lutz and Barres, 2014).

关键词： debris contributing injury