检索结果-南通市图书馆

Bone Mineral Density Reporting Underestimates Fracture Risk in Ontario

Health 2015年第5期7卷 566-571页

作者： Joanna E. M. Sale Earl Bogoch lynn meadows Monique Gignac Lucy Frankel Taucha Inrig Dorcas Beaton Ravi Jain Musculoskeletal Health and Outcomes Research Li Ka Shing Knowledge Institute St. Michael’s Hospital Toronto Canada Institute of Health Policy Management & Evaluation University of Toronto Toronto Canada Mobility Program St. Michael’s Hospital Toronto Canada Department of Surgery University of Toronto Toronto Canada Community Health Sciences University of Calgary Calgary Canada Toronto Western Research Institute University Health Network Toronto Canada Dalla Lana School of Public Health University of Toronto Toronto Canada Osteoporosis Canada Toronto Canada

Objective: Analysis of clinical documents such as bone mineral density (BMD) reports is an important component of program evaluation because it can provide insights into the accuracy of assessment of fracture risk communicated to patients and practitioners. Our objective was to compare fracture risk calculations from BMD test reports to those based on the 2010 Canadian guidelines. Methods: We retrieved BMD reports from fragility fracture patients screened through a community hospital fracture clinic participating in Ontario’s Fracture Clinic Screening Program. Fracture risk was determined according to the 2010 Canadian guidelines using age, sex, and T-score at the femoral neck, in addition to three clinical factors. Three researchers classified patients’ fracture risk until consensus was achieved. Results: We retrieved reports for 17 patients from nine different BMD clinics in the Greater Toronto Area. Each patient had a different primary care physician and all BMD tests were conducted after the 2010 Canadian guidelines were published. The fracture risk of 10 patients was misclassified with 9 of the 10 reports underestimating fracture risk. Nine reports acknowledged that the prevalence of a fragility fracture raised the risk category by one level but only four of these reports acknowledged that the patient had, or may have sustained, a fragility fracture. When we raised fracture risk by one level according to these reports, eight patients were still misclassified. Fracture risk in the majority of these patients remained underestimated. Inconsistent classification was found in the majority of cases where reports came from the same clinic. Four reports described risk levels for two different types of risk. Conclusions: More than half of patients received BMD reports which underestimated fracture risk. Bone health management recommendations based on falsely low fracture risk are likely to be sub-optimal.

关键词： Fracture Risk Bone Densitometry Reports Fragility Fracture Ontario

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging glacier forelands alter carbon dynamics on the Tibetan Plateau

引用

Journal of Mountain Science 2024年第9期21卷 2871-2875页

作者： GAO Tanguang ZHANG Yulan meadows Michael Edward College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Geography and Ocean Sciences Nanjing UniversityNanjing 210023China Department of Environmental&Geographical Science University of Cape TownRondebosch 7701South Africa

The critical challenge of ongoing climate warming is resulting in glacier melting globally,a process accompanied by the formation of substantial glacier *** phenomenon emerges as a pivotal area of study,especially in the Tibetan Plateau(TP),known as the Third Pole and the Asian Water *** particular,the rapid retreat of temperate glaciers in the southeastern TP has led to the formation of expansive glacier *** forelands are not merely evidence of climate shifts but are also key areas for transformative carbon ***,the newly exposed land surface actively adjusts the balance of dissolved organic carbon,especially in meltwater,and influences the release of greenhouse gases from a range of sources including glacial lakes,subglacial sediments,and supraglacial/proglacial *** processes play a crucial role in the dynamics of atmospheric carbon *** from our intensive and detailed observations over several years,this perspective not only emphasizes the importance of the underexplored impact of glacier forelands on carbon cycles but also opens a window into understanding potential future trajectories in a warming world.

关键词： Glacier Climate warming Carbon release Tibetan Plateau

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乡村地理学新视野:通过地理空间数据融合模拟乡村地域系统

引用

Science Bulletin 2024年第11期69卷 1590-1592页

作者： Michael E.meadows School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Department of Environmental and Geographical Science University of Cape TownRondebosch 7701South Africa

As nations worldwide strive to bridge the ever-expanding urban-rural divide,the rapid pace of urbanization has precipitated dramatic shifts in land use,population demographics,and the economy of rural areas[1,2].

关键词：乡村地理学 expanding 空间数据融合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

引用

Protein & Cell 2024年第9期15卷 661-685页

作者： Sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good Amanda Huang Hailey lynn Wrona Jody Liu Chuan-ju Liu Department of Orthopedic Surgery New York University Grossman School of MedicineNew YorkNY 10016United States Department of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cornell University IthacaNew YorkNYUnited States Department of Biomedical Engineering University of North Carolina Chapel HillChapel HillNC 27599United States New York University NY 14853United States Department of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Department of Orthopedics&Rehabilitation Yale University School of MedicineNew HavenCT 06510United States

Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation,known as *** state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver *** is a glycolytic metabolite and a crucial node in various metabolic ***,its role and molecular mechanism in obesity and associated complications are *** this study,we reported that pyruvate substantially inhibited adipogenic differentiation in vitro and its administration significantly prevented HFD-induced weight gain,white adipose tissue inflammation,and metabolic *** identify the target proteins of pyruvate,drug affinity responsive target stability was employed with proteomics,cellular thermal shift assay,and isothermal drug response to detect the interactions between pyruvate and its molecular ***,we identified cytosolic phospholipase A2(cPLA2)as a novel molecular target of pyruvate and demonstrated that pyruvate restrained diet-induced obesity,white adipose tissue inflammation,and hepatic steatosis in a cPLA2-dependent *** with global ablation of cPLA2 in mice showed that the protective effects of pyruvate were largely abrogated,confirming the importance of pyruvate/cPLA2 interaction in pyruvate attenuation of inflammation and ***,our study not only establishes pyruvate as an antagonist of cPLA2 signaling and a potential therapeutic option for obesity but it also sheds light on the mechanism of its ***’s prior clinical use indicates that it can be considered a safe and viable alternative for obesity,whether consumed as a dietary supplement or as part of a regular diet.

关键词： metabolic disease pyruvate cytosolic phospholipase obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Decadal Forecasts of Large Earthquakes along the Northern San Andreas Fault System, California: Increased Activity on Regional Creeping Faults Prior to Major and Great Events

引用

International Journal of Geosciences 2024年第2期15卷 204-230页

作者： lynn R. Sykes Lamont-Doherty Earth Observatory of Columbia University Palisades New York USA

The three largest earthquakes in northern California since 1849 were preceded by increased decadal activity for moderate-size shocks along surrounding nearby faults. Increased seismicity, double-difference precise locations of earthquakes since 1968, geodetic data and fault offsets for the 1906 great shock are used to re-examine the timing and locations of possible future large earthquakes. The physical mechanisms of regional faults like the Calaveras, Hayward and Sargent, which exhibit creep, differ from those of the northern San Andreas, which is currently locked and is not creeping. Much decadal forerunning activity occurred on creeping faults. Moderate-size earthquakes along those faults became more frequent as stresses in the region increased in the latter part of the cycle of stress restoration for major and great earthquakes along the San Andreas. They may be useful for decadal forecasts. Yearly to decadal forecasts, however, are based on only a few major to great events. Activity along closer faults like that in the two years prior to the 1989 Loma Prieta shock needs to be examined for possible yearly forerunning changes to large plate boundary earthquakes. Geodetic observations are needed to focus on identifying creeping faults close to the San Andreas. The distribution of moderate-size earthquakes increased significantly since 1990 along the Hayward fault but not adjacent to the San Andreas fault to the south of San Francisco compared to what took place in the decades prior to the three major historic earthquakes in the region. It is now clear from a re-examination of the 1989 mainshock that the increased level of moderate-size shocks in the one to two preceding decades occurred on nearby East Bay faults. Double-difference locations of small earthquakes provide structural information about faults in the region, especially their depths. The northern San Andreas fault is divided into several strongly coupled segments based on differences in seismicity.

关键词： San Andreas and Hayward Faults California Fault Creep Forecasts Double-Difference Relocations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Still elusive: Developments in the accurate diagnosis of indeterminate biliary strictures

引用

World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 297-304页

作者： lynn Affarah Philip Berry Sreelakshmi Kotha Department of Hepatology Guy's and St Thomas'HospitalLondon SE17EHUnited Kingdom

Indeterminate biliary strictures pose a significant diagnostic dilemma for *** advances in endoscopic techniques and instruments,it is difficult to differentiate between benign and malignant pathology.A positive histological diagnosis is always preferred prior to high risk hepatobiliary surgery,or to inform other types of *** retrograde cholangiopancreato-graphy with brushings has low sensitivity and despite significant improvements in instruments there is still an unacceptably high false negative *** methods such as endoscopic ultrasound and cholangioscopy have improved diagnostic *** this review we explore the techniques available to aid accurate diagnosis of indeterminate biliary strictures and obtain accurate histology to facilitate clinical management.

关键词： Indeterminate biliary stricture Benign biliary stricture Malignant biliary stricture Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound Primary sclerosing cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Creating large EMS populations for functional genomics and breeding in wheat

引用

Journal of Integrative Agriculture 2024年第2期23卷 484-493页

作者： Wenqiang Wang Xizhen Guan Yong Gan Guojun Liu Chunhao Zou Weikang Wang Jifa Zhang Huifei Zhang Qunqun Hao Fei Ni Jiajie Wu lynn Epstein Daolin Fu Spring Valley Agriscience Co. Ltd.Jinan 250300China College of Life Sciences Zaozhuang UniversityZaozhuang 277160China National Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China Department of Plant Pathology University of CaliforniaDavisCA 95616USA

Wheat germplasm is a fundamental resource for basic research,applied studies,and wheat breeding,which can be enriched normally by several paths,such as collecting natural lines,accumulating breeding lines,and introducing mutagenesis *** methane sulfonate(EMS)is an alkylating agent that can effectively introduce genetic variations in a wide variety of plant *** this study,we created a million-scale EMS population(MEP)that started with the Chinese wheat cultivars‘Luyan 128’,‘Jimai 38’,‘Jimai 44’,and‘Shannong 30’.In the M1 generation,the MEP had numerous phenotypical variations,such as>3,000 chlorophyll-deficient mutants,2,519 compact spikes,and 1,692 male sterile *** were also rare mutations,including 30 independent tillers each with double *** M1 variations of chlorophyll-deficiency and compact spikes were inheritable,appearing in the M2 or M3 *** advance the entire MEP to higher generations,we adopted a single-seed descendent(SSD)*** other seed composites of M2 were used to screen other agronomically important traits,such as the tolerance to herbicide *** MEP is available for collaborative projects,and provides a valuable toolbox for wheat genetics and breeding for sustainable agriculture.

关键词： wheat germplasm ethyl methane sulfonate genetics and breeding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

构建教育家精神引领下的教师专业素养体系——OECD教师核心素养框架的经验与启示

引用

中小学管理 2024年第9期 24-27页

作者：王兴洲 lynn Paine 廖伟教育部普通高校人文社会科学重点研究基地北京师范大学教师教育研究中心密歇根州立大学教育学院

构建以教育家精神为引领的教师专业素养体系，是建设教育强国、推进中国式现代化进程的重要环节。经济合作与发展组织（OECD）围绕教师的知识、技能、态度和价值观等要素，构建全球视野和多元理念下的教师核心素养框架，为我国构建面向... 详细信息

构建以教育家精神为引领的教师专业素养体系，是建设教育强国、推进中国式现代化进程的重要环节。经济合作与发展组织（OECD）围绕教师的知识、技能、态度和价值观等要素，构建全球视野和多元理念下的教师核心素养框架，为我国构建面向未来的教师专业素养体系提供了一定启示。在研究立场上，要坚守教师专业素养的本土属性；在研究内容上，要关注教师专业素养的多维层次；在研究路径上，要考量素养体系构建的纵横向度，从而为我国教师专业素养体系构建提供重要保障。

关键词：教育家精神教师专业素养教师知识教师能动性 OECD教师核心素养框架

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

书迷的旅游行程

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第6期 24-25,45,46页

作者： lynn O'Rourke Hayes 不详

一本好书可以带我们进入到各种奇幻之地以下五个来自文学世界的建议,或许可以激发你自己前去探险1.亚伦·亚历山大·米尔恩的小熊维尼,马尼托巴省温尼伯市一个世纪以前,一位加拿大士兵收养了一头小黑熊,并以家乡温尼伯的名字为它命名为... 详细信息

一本好书可以带我们进入到各种奇幻之地以下五个来自文学世界的建议,或许可以激发你自己前去探险1.亚伦·亚历山大·米尔恩的小熊维尼,马尼托巴省温尼伯市一个世纪以前,一位加拿大士兵收养了一头小黑熊,并以家乡温尼伯的名字为它命名为维尼。

关键词：米尔恩温尼伯旅游行程亚历山大加拿大

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

D^0~0 mixing and other recent charm results from BABAR

引用

Chinese Physics C 2010年第6期34卷 780-787页

作者： B.meadows University of Cincinnati Department of Physics

Studies in which BABAR data have shown evidence for mixing in the neutral charm meson system are presented. A new measurement of the lifetime difference parameter ycp = （1.16±0.22±0.18）% is described. Results are also presented from a systematic study of DK and D＊K invariant mass distributions from a 470 fb^-1 sample of asymmetric e^＋e^- interactions recorded by the BABAR detector at the PEP-Ⅱ storage rings. A new charmed-strange meson has been observed with mass [3044 ± 8stat （-5^＋30 ）syst] MeV/c^2 and width [239± 35stat （-42^＋46）syst]MeV/c^2.

关键词： mixing oscillations charm meson spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：