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Hepatocellular carcinoma: a new hope?

Hepatoma Research 2019年第7期5卷 26-28页

作者： lynn G.feun Department of Medicine University of MiamiMiller School of MedicineMiamiFL USA

In this special issue of Hepatoma Research,we highlight certain Novel Approaches to Hepatocellular *** the article"Stereotactic ablative radiotherapy for hepatocellular carcinoma"Dr Spieler and Dr Portelance discussed the development of improved toxicity models and highly conformal radiation delivery systems which allows for stereotactic radiosurgery to ablate liver tumors in few fractions and spare noncancerous liver tissue[1].

关键词： liver carcinoma radiotherapy

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Stereotactic ablative radiotherapy for hepatocellular carcinoma

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Hepatoma Research 2019年第1期5卷 36-48页

作者： Benjamin Spieler Eric A.Mellon Patricia D.Jones Huan Giap lynn feun Shree Venkat LorrainePortelance Department of Radiation Oncology Sylvester Comprehensive Cancer CenterUniversity of MiamiMiamiFL 33136USA Department of Medicine Division of HepatologyUniversity of MiamiMiamiFL 33136USA Department of Medical Oncology Sylvester Comprehensive Cancer CenterUniversity of MiamiMiamiFL 33136USA Department of Radiation Sylvester Comprehensive Cancer CenterUniversity of MiamiMiamiFL 33136USA

Patients with hepatocellular carcinoma(HCC)often present with underlying liver disease and significant comorbidities,limiting treatment *** the development of improved toxicity models and highly conformal radiation delivery systems,external beam radiotherapy has become a valuable treatment option for liver *** cutting edge technology,stereotactic ablative radiotherapy(SABR)allows for the delivery of ablative doses in few fractions while sparing uninvolved liver *** approach permits dose escalation and precise tumor targeting with minimal risk of radiation induced liver *** review clarifies SABR's role alongside liver-directed treatments such as radiofrequency ablation,transarterial radioembolization,and transarterial chemoembolization in the management of *** also examines the promising potential of SABR combined with immunotherapy to treat advanced HCC.

关键词： Hepatocellular carcinoma stereotactic ablative body radiation therapy image guided radiation therapy adaptive radiation therapy radiation toxicity multidisciplinary cancer treatment

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Immunotherapy for hepatocellular carcinoma: the force awakens in HCC?

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Hepatoma Research 2017年第3期3卷 43-51页

作者： lynn G.feun Ying-Ying Li Medhi Wangpaichitr Chun-Jing Wu Niramol Savaraj Sylvester Comprehensive Cancer Center University of MiamiMiamiFL 33136USA.

Systemic therapy for hepatocellular carcinoma (HCC) has been disappointing. The only drug approved by Food and Drug Administration recently has been sorafenib. Sorafenib has modest benefits with a low response rate and an improvement in time to progression of only 2-3 months. Multiple randomized trials, which compare the new agent to sorafenib as either first line or second line therapy, have been negative, showing no improved clinical benefit. Recently, in a large phase Ⅲ randomized trial, regorafenib has shown superiority to placebo as a second line treatment for HCC. However, this drug has multiple side effects and is not well tolerated by many patients. The clinical benefit is also modest. Clearly, new approaches to treat advanced HCC are still needed. There is data showing that HCC is immunogenic and the immune system can be stimulated to attack these cancer cells. This article will briefly review immunotherapy as a promising treatment for HCC.

关键词： Immunotherapy hepatocellular carcinoma sorafenib new approaches

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