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new trends in diagnosis and management of gallbladder carcinoma

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： efstathios t Pavlidis Ioannis n Galanis theodoros e Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(Pet)-Ct or ^(18)F-FDG Pet-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(t1a)to extended resections and including extended cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

Management of obstructed colorectal carcinoma in an emergency setting:An update

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 598-613页

作者： efstathios t Pavlidis Ioannis n Galanis theodoros e Pavlidis 2nd Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colorectal carcinoma is common,particularly on the left *** 20%of patients,obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced(stage II,III or even IV).Diagnosis is based on clinical presentation,plain abdominal radiogram,computed tomography(Ct),Ct colonography and positron emission tomography/*** best management strategy in terms of short-term operative or interventional and long-term oncological outcomes re-mains *** the most common left-sided obstruction,the first choice should be either emergency surgery or endoscopic decompression by self-expen-dable metal stents or *** operative plan should be either one-stage or two-stage ***-stage resection with on-table bowel decompression and irrigation can be accompanied or not accompanied by proximal defunctioning stoma(colostomy or ileostomy).Primary anastomosis is more convenient but has increased risks of anastomotic leakage and ***-stage resection(Hart-mann’s procedure)is safer and the most widely used despite temporally affecting quality of *** control surgery in high-risk frail patients is less frequently performed since it can be successfully substituted with endoscopic stenting or *** the less common right-sided obstruction,one-stage surgical resection is more beneficial than endoscopic *** role of minimally invasive surgery(laparoscopic or robotic)is a subject of *** laparoscopic-assisted management is advantageous to some extent but requires much expertise due to inherent difficulties in dissecting the distended colon and the risk of rup-ture and subsequent septic *** decompressing stent as a bridge to elective surgery more substantially decreases the risks of morbidity and mortality than emergency surgery for decompression and has equivalent medium-term overall survival and disease-free survival *** combination with neoadjuvant chemotherapy or radiation may have a p

关键词： Acute abdomen Obstructive ileus Colorectal carcinoma emergency surgery Colectomy Intraluminal metal stents

Current considerations on intraductal papillary neoplasms of the bile duct and pancreatic duct

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World Journal of Gastroenterology 2024年第10期30卷 1461-1465页

作者： efstathios t Pavlidis Ioannis n Galanis theodoros e Pavlidis 2^(nd) Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancreatobiliary intraductal papillary neoplasms(IPns)represent precursors of pancreatic cancer or bile duct cholangiocarcinoma that can be detected and *** advances in diagnostic methods,identifying these premalignant lesions is still challenging for treatment *** imaging,biomarkers and molecular tests for genomic alterations can be used for diagnosis and *** intervention in combination with new chemotherapeutic agents is considered the optimal treatment for malignant *** balance between the risk of malignancy and any risk of resection guides management policy;therefore,treatment should be individualized based on a meticulous preoperative assessment of high-risk *** of the bile duct is more aggressive;thus,early diagnosis and surgery are *** conservative management of low-risk pancreatic branch-duct lesions is safe and effective.

关键词： Biliary tree diseases Pancreatic cystic neoplasms Biliary tract neoplasms extrahepatic cholangiocarcinoma Pancreatic adenocarcinoma

Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied Mathematics and Mechanics(english edition) 2024年第5期45卷 891-910页

作者： n.D.nGUyen t.n.nGUyen Faculty of Civil engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of engineering and technology Kien Giang UniversityChau Thanh 92000Viet Nam

this study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(tD)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBt)

Current considerations for the surgical management of gallbladder adenomas

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1507-1512页

作者： efstathios t Pavlidis Ioannis n Galanis theodoros e Pavlidis the Second Department of Propaedeutic Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder adenomas are rare lesions(0.5%)associated with potential malignant transformation,particularly with gallbladder adenomas that are≥1 cm in *** detection and management are crucial for preventing lethal carcinoma *** polyps can often be distinguished from the more often nonneo-plastic cholesterol pseudopolyps(5%-10%),which are *** is the first-line tool for initial diagnosis and follow-up when *** question is whether cholecystectomy is always necessary for all *** manage-ment of gallbladder adenomas is determined according to the size of the tumor,the growth rate of the tumor,the patient’s symptoms and whether risk factors for malignancy are ***≥1 cm in size,an age>50 years and a familial history of gallbladder carcinoma are indications for immediate laparoscopic ***,ultrasound follow-up is *** adenomas 6-9 mm in size,the absence of≥2 mm growth at 6 months,one year,and two years,as well as an adenoma sizedthout existing risk factors indicates that no further surveillance is ***,it would be preferable to individualize the management in doubtful *** interventional modalities for preserving the gallbladder need further evaluation,especially to determine the long-term outcomes.

关键词： Biliary diseases true neoplastic polyps Gallbladder adenomas Benign bi-liary tumors Gallbladder polyps extrahepatic biliary neoplasms

First results of turbulence investigation on Globus-M2 using radial correlation Doppler reflectometry

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Plasma Science and technology 2024年第10期26卷 49-55页

作者： A.POnOMARenKO A.yASHIn V.GUSeV e.KISeLeV G.KURSKIeV V.MInAeV y.PetROV n.SAKHAROV P.SHCHeGOLeV e.tKACHenKO n.ZHILtSOV Peter the Great St.Petersburg Polytechnic University St.Petersburg 195251Russia Ioffe Institute St.Petersburg 194064Russia

the first results of investigation of the turbulence structure using Doppler backscattering(DBS)on the Globus-M2 tokamak are presented.A one-channel DBS system with a variable probing frequency within the 18–26 GHz range was installed to investigate the edge plasma at normalized minor radiiρ=0.9–*** correlation Doppler reflectometry was used to study the changes in turbulence eddies after the LH *** analysis was applied to the phase derivative of complex in-phase and quadrature(IQ)signals of the DBS diagnostic as it contains information about the poloidal plasma rotation *** L-mode,the radial correlation length L_(r)is estimated to be 3 cm and after transition to H-mode reduces to approximately 2 *** modelling in a linear local approximation using code Gene indicates that the instability with positive growth rate at the normalized minor radiusρ=0.75 in L-mode and H-mode on Globus-M2 was the ion temperature gradient(ItG)mode.

关键词： tokamak turbulence Doppler backscattering correlation reflectometry

Deploying Hybrid ensembleMachine Learning techniques for effective Cross-Site Scripting (XSS) Attack Detection

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Computers, Materials and Continua 2024年第1期81卷 707-748页

作者： Bacha n.U. Lu S. Ur Rehman A. Idrees M. Ghadi y.y. Alahmadi t.J. School of Cyber Science and engineering Huazhong University of Science and Technology Wuhan 430073 China Department of Computer Science and engineering University of Engineering and Technology Lahore 54000 Pakistan Department of Computer Science and Software engineering Al Ain University Al Ain Abu Abu Dhabi 12555 United Arab Emirates Department of Information Systems College of Computer and Information Sciences Princess Nourah bint Abdulrahman University Riyadh 84428 Saudi Arabia

Cross-Site Scripting (XSS) remains a significant threat to web application security, exploiting vulnerabilities to hijack user sessions and steal sensitive data. traditional detection methods often fail to keep pace with the evolving sophistication of cyber threats. this paper introduces a novel hybrid ensemble learning framework that leverages a combination of advanced machine learning algorithms-Logistic Regression (LR), Support Vector Machines (SVM), eXtreme Gradient Boosting (XGBoost), Categorical Boosting (CatBoost), and Deep neural networks (Dnn). Utilizing the XSS-Attacks-2021 dataset, which comprises 460 instances across various real-world trafficrelated scenarios, this framework significantly enhances XSS attack detection. Our approach, which includes rigorous feature engineering and model tuning, not only optimizes accuracy but also effectively minimizes false positives (FP) (0.13%) and false negatives (Fn) (0.19%). this comprehensive methodology has been rigorously validated, achieving an unprecedented accuracy of 99.87%. the proposed system is scalable and efficient, capable of adapting to the increasing number of web applications and user demands without a decline in performance. It demonstrates exceptional real-time capabilities, with the ability to detect XSS attacks dynamically, maintaining high accuracy and low latency even under significant loads. Furthermore, despite the computational complexity introduced by the hybrid ensemble approach, strategic use of parallel processing and algorithmtuning ensures that the system remains scalable and performs robustly in real-time applications. Designed for easy integration with existing web security systems, our framework supports adaptable Application Programming Interfaces (APIs) and a modular design, facilitating seamless augmentation of current defenses. this innovation represents a significant advancement in cybersecurity, offering a scalable and effective solution for securing modern web applications a

关键词： Cross-site scripting hybrid learning machine learning stacking ensemble learning XSS detection

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On B(5,20)2-Groups

Algebra Colloquium 2024年第3期31卷 429-440页

作者： e.A.Alhassan y.L.tan y.Li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by several *** this paper,we give a complete characterization of B(5,20)2-groups by showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

Distinct electrical and Mechanical Responses of a Cu-10Fe Composite Prepared by Hot-Pressed Sintering and Post treatment

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Acta Metallurgica Sinica(english Letters) 2024年第2期37卷 255-265页

作者： X.y.yue S.y.Peng X.Zhang C.n.He y.Z.tian Key Laboratory for Anisotropy and texture of Materials(Ministry of education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and engineering and tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite Hot-pressed sintering thermal stability Strength electrical conductivity