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Application of the concept of continuous dopaminergic stimulation for the management of Parkinson's disease

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Neuroscience Bulletin 2013年第5期29卷 661-669页

作者： Qing lv Baorong Zhang Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University

Continuous dopaminergic stimulation（CDS）is a prominent therapeutic concept for the treatment of Parkinson＇s disease（PD）,which proposes that continuous brain dopamine-receptor stimulation,rather than intermittent doses of oral L-dopa,prevents or manages L-dopa-induced dyskinesias（LIDs）.In the normal situation,dopaminergic neurons in the substantia nigra pars compacta fire tonically to keep the dopamine receptor stimulation at a steady-state *** when the dopaminergic pathway is impaired,the dopamine receptor stimulation becomes intermittent or *** pulsatile stimulation causes a series of gene and protein changes in striatal neurons,leading to alterations in the firing patterns of basal ganglia neurons that result in *** in animal models and clinical trials of PD have shown that approaches providing CDS,currently including patches,extended-release formulations of L-dopa or dopamine agonists,continuous delivery of apomorphine and duodenal L-dopa infusion,are associated with a decreased risk of *** this review,we summarize both preclinical and clinical evidence for the five methods that may provide CDS in theory and compare the advantages and disadvantages of these methods.

关键词： continuous dopaminergic stimulation application Parkinson's disease L-dopa-induced dyskinesias

ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury

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Neural Regeneration Research 2021年第8期16卷 1598-1605页

作者： Shi-Qin lv Wutian Wu Guangdong-Hong Kong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Re-Stem Biotechnology Co. Ltd.SuzhouJiangsu ProvinceChina

Both intracellular sigma peptide(ISP) and phosphatase and tensin homolog agonist protein(PAP4) promote nerve regeneration and motor functional recovery after spinal cord injury. However, the role of these two small peptides in peripheral nerve injury remains unclear. A rat model of brachial plexus injury was established by crush of the C6 ventral root. The rats were then treated with subcutaneous injection of PAP4(497 μg/d, twice per day) or ISP(11 μg/d, once per day) near the injury site for 21 successive days. After ISP and PAP treatment, the survival of motoneurons was increased, the number of regenerated axons and neuromuscular junctions was increased, muscle atrophy was reduced, the electrical response of the motor units was enhanced and the motor function of the injured upper limbs was greatly improved in rats with brachial plexus injury. These findings suggest that ISP and PAP4 promote the recovery of motor function after peripheral nerve injury in rats. The animal care and experimental procedures were approved by the Laboratory Animal Ethics Committee of Jinan University of China(approval No. 20111008001) in 2011.

关键词： axon brachial plexus injury crush injury intracellular sigma peptide motor function PAP4 peripheral nerve protection regeneration repair

Test studies of gas flow in rock and coal surrounding a mined coal seam

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International Journal of Mining Science and Technology 2012年第4期22卷 499-502页

作者： lv Youchang School of Safety Engineering China University of Mining&TechnologyXuzhou 221116China Energy and Chemical InstituteChina Pingmei Shenma CroupPingdingshan 467000China

An analysis of the variation rule of abutment pressure at the mining working face in a single coal seam and the mechanical behavior of surrounding rock during stoping is presented. Consideration of the elastic and plastic deformation zones that develop during the mining process allowed the determination of a relationship between horizontal stress and vertical stress. Based on this, a confined pressure unloading test was conducted by the use of the ＂gas-containing coal tbermo-fluid-solid coupling 3-axis servo seep- age＂ experimental apparatus. Thus, gas flow patterns in the elastic and plastic zones were derived from an experimental point of view. Darcy＇s law and the Klinkenberg effect were used to derive a gas flow equation for the elastic and plastic stress fields. The study of gas flow phenomena at the working face during coal mining is of great importance for the study of gas migration and enrichment patterns.

关键词： Coal seamMining-inducedGasFlow law

Fast method for spreading sequence estimation of DSSS signal based on maximum likelihood function

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Journal of Systems Engineering and Electronics 2010年第6期21卷 948-953页

作者： Yanhua Peng Bin Tang Ming lv College of Electronic Engineering University of Electronic Science and Technology of China Chengdu 610054 E R. China

To estimate the spreading sequence of the direct sequence spread spectrum (DSSS) signal, a fast algorithm based on maximum likelihood function is proposed, and the theoretical derivation of the algorithm is provided. By simplifying the objective function of maximum likelihood estimation, the algorithm can realize sequence synchronization and sequence estimation via adaptive iteration and sliding window. Since it avoids the correlation matrix computation, the algorithm significantly reduces the storage requirement and the computation complexity. Simulations show that it is a fast convergent algorithm, and can perform well in low signal to noise ratio (SNR).

关键词： direct sequence spread spectrum (DSSS) signal spreading sequence maximum likelihood estimation (MLE).

Synthesis,structure,and host-guest chemistry of a pair of isomeric selenanthrene-bridged molecular cages

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Chinese Chemical Letters 2023年第11期34卷 143-146页

作者： Wanqian lv Yunyi Song Xinyuan lv Jun Yuan Kelong Zhu School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China School of Innovation and Entrepreneurship Shaoguan UniversityShaoguan 512005China

A pair of selenanthrene-bridged molecular cages have been constructed through a one-step cyclization reaction of a tetrakis(iodo) crown ether with selenium powder. The tubular belt-shaped cage has an intrinsic cavity which can adaptively transform to accommodate electron-deficient guests forming [2]pseudorotaxane complexes. The other product was determined to be an isomeric cage featuring a Mobius strip structure, which exhibits slower twist-migration dynamics than its thianthrene counterpart. The success of using selenanthrene as joints enables an alternative way to structural design and property regulation of molecular cages.

关键词： Selenanthrene Crown ether Molecular cage Mobius strip Host-guest chemistry

^1H NMR Quantification of DHA and EPA in Fish Oil

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Journal of Ocean University of China 2020年第5期19卷 1193-1197页

作者： lv Jinxiao WANG Cong ZHANG Xiuli lv Zhihua YU Mingming School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266003China Key Laboratory of Glycoscience&Glycotechnology of Shandong Province Qingdao 266003China Key Laboratory of Marine Drugs Ministry of Education of ChinaQingdao 266003China

Fish oil is a popular nutritional product consumed in China. The beneficial effects of fish oil have been attributed to docosahexaenoic acid(DHA) and eicosapentaenoic acid(EPA). Hence, it is crucial to develop a rapid and precise method to determine the contents of EPA and DHA in fish oil. In this study, a rapid and accurate proton nuclear magnetic resonance method for the quantification of DHA and EPA was developed. Dimethyl terephthalate was selected as an internal standard, and the signals at 2.391 ppm for DHA and at 1.697 ppm for EPA were chosen for the quantification. Validation of the method was performed in terms of specificity, precision, and stability. The results indicated that the method was precise and in line with the China Food and Drug Administration guidance. The method has been successfully applied to characterize fish oil capsules obtained from four pharmaceutical companies. This study indicated that the rapid ~1H NMR method is suitable for the quality control of fish oil.

关键词： ^1H NMR EPA DHA fish oil quality control

Embedding Derivatives and Integration Operators on Hardy Type Tent Spaces

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Acta Mathematica Sinica,English Series 2022年第6期38卷 1069-1093页

作者： Mao Fa WANG lv ZHOU School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we completely characterize the positive Borel measuresμon the unit ball B_(n)such that the differential type operator R^(m)of order m∈N is bounded from Hardy type tent space HT_(q,α)^(p)(B_(n))into L^(s)(μ)for full range of p,q,s,α.Subsequently,the corresponding compact description of differential type operator R^(m)is also *** an application,we obtain the boundedness and compactness of integration operator J_(g)from HT_(q,α)^(p)(B_(n))toHT_(s,β)^(t)(B_(n)),and the methods used here are adaptable to the Hardy spaces.

关键词： Embedding derivative integration operator Hardy type tent space Carleson measure

Control of chiral-optical activities by magnetic field based on the transformation of achiral binary crystals into chiral ternary crystals

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Science China Chemistry 2024年第7期67卷 2300-2305页

作者： Zhiyan Chen Yan lv Wei Qin College of Physics Qingdao UniversityQingdao 266071China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Linuo Photovoltaic Hi-Tech Co. Ltd.Jinan 250100China

Multicomponent self-assembled chiral systems have attracted great attention due to their promising application in the area of spin-photonics and *** this work,through introducing an achiral third component into an achiral binary crystal,a chiral organic ternary crystal is fabricated,where both pronounced chiral-optical coupling and magnetic field dependence of chiral-optical activities are *** transformation of achiral structure into chiral structure generates a significant effect on the polarized state of light and the electron spin resonance ***,the coupling between circularly polarized photon and spin is observed in chiral ternary crystal with pronounced chiral orbit,where obvious magnetic field-transmissivity loop is ***,temperature could increase the magnitude of lattice parameters to lead to a larger helix radius to increase the chiral orbit ***,this work indicates that the further exploration of photon-chiral orbit-spin interactions in organic chiral ternary crystals is promising.

关键词： organic chiral ternary crystals chiral orbit chiral-optical activities magnetic field

Multiple magnetic topologies in flux transfer events: THEMIS measurements

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Science China(Technological Sciences) 2016年第8期59卷 1283-1293页

作者： lv LeiQi PU ZuYin XIE Lun School of Earth and Space Science Peking University Beijing 100871 China PKU/UCLA Joint Research Institute in Science and Engineering Peking University Beijing 100871 China

Flux transfer events （FTEs） are local transient magnetic reconnections at the magnetopause （MP） that provide channels for transport of solar wind energy and plasma into the magnetosphere （MSP）. All current theoretical models suggest that FTEs are open-flux ropes; however, global simulations show that they contain both open and closed magnetic fields. To clarify this to- pology, we analyzed 441 events observed by THEMIS and investigated their magnetic topologies. Only one type of open field line was detected in most magnetosheath （MSH） FTEs, independent of the polarity of the Bn bipolar signatures. Newly formed MSH field lines were also observed. In the all MP boundary layers FTEs and most MSP FTEs, multiple types of topologies were observed, irrelevant to the Bn bipolar polarity. Closed field lines were found in all MP boundary layers and MSP FTEs. Meanwhile very few boundary FTEs contained the newly formed MSH flux. In some situations, only closed field lines were seen in MSP FTEs, which are referred to as the fossil FTEs. These results, which largely differ from the traditional view, demonstrate the existence of complex magnetic topologies in FTEs. Based on these results, we propose a new 3D FTE picture to modify the current FTE models.

关键词： flux transfer events magnetic flux rope magnetic field topology magnetopause