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维生素D缺乏与产后压力性尿失禁的相关性分析

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实用妇科内分泌电子杂志 2023年第30期10卷 31-33页

作者：吕冰峰张家港市第二人民医院妇产科江苏张家港215631

目的分析维生素D缺乏与产后压力性尿失禁的相关性。方法选取100例阴道分娩产妇,依据分娩前血清25-羟维生素D水平分为维生素D缺乏组(30 ng/ml,25例)。比较两组第二产程时间、产后3个月尿垫试验结果,并统计分析产前、产后1个月、3个月、6... 详细信息

目的分析维生素D缺乏与产后压力性尿失禁的相关性。方法选取100例阴道分娩产妇,依据分娩前血清25-羟维生素D水平分为维生素D缺乏组(30 ng/ml,25例)。比较两组第二产程时间、产后3个月尿垫试验结果,并统计分析产前、产后1个月、3个月、6个月排尿困扰量表(UDI-6)、尿失禁影响问卷简表(ⅡQ-7),分析各指标和产后3个月UDI-6评分、ⅡQ-7评分的相关性。结果维生素D缺乏组产妇的第二产程时间长于维生素D正常组(P<0.05),产后3个月尿垫试验阳性率66.67%(50/75)高于维生素D正常组的36.00%(9/25)(P<0.05)。产后1个月、3个月、6个月,维生素D缺乏组产妇的UDI-6评分、ⅡQ-7评分均高于维生素D正常组(P<0.05)。产妇第二产程时间、新生儿体重和产后3个月UDI-6评分、ⅡQ-7评分均成正相关(P<0.05),血清25(OH)D水平和产后3个月UDI-6评分、ⅡQ-7评分均成负相关(P<0.05)。结论维生素D缺乏会引发产后压力性尿失禁,应加强重视。

关键词：产后压力性尿失禁维生素D缺乏相关性

2-2 Lifetime Measurements of the Low-lying Excited States in 87 Zr and 87 Nb

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IMP & HIRFL Annual Report 2015年第1期 50-51页

作者： Qiang Yunhua Liu Minliang Zhou Xiaohong Wang Jianguo Wang Kailong lv bingfeng Zheng Yong Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Jiang Jian Sun Mingdao 不详

Lifetime measurements of low-lying excited states in 87Zr and 87Nb have been performed via and coincidences. The 124 MeV 32S beam was delivered from the Sector-Focusing Cyclotron (SFC) of the Heavy Ion R-esearch Facility in Lanzhou (HIRFL). The parent nuclei 87Nb and 87Mo were produced by the respective reactions 58Ni (32S, 3p) and 58Ni (32S, 2p1n), at a beam energy 100 MeV through the 8 m Al degrader.

关键词： Low-lying Excited States

右美托咪定对不停跳冠脉旁路移植患者血浆晚期糖基化终末产物受体的影响

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中华实验外科杂志 2020年第12期37卷 2329-2331页

作者：吕冰风胡杰李斌陈兴澎新乡医学院 453003 洛阳市中心医院麻醉科 471009 洛阳市心胸外科疾病临床研究中心 471009 洛阳市中心医院心外科 471009

目的观察右美托咪定对不停跳冠脉旁路移植患者血浆晚期糖基化终末产物受体(RAGE)信号通路的影响。方法30例接受不停跳冠状动脉旁路移植术患者随机均分为右美托咪定组和对照组,两组静脉全身麻醉诱导,以静脉泵入丙泊酚、舒芬太尼麻醉维持... 详细信息

目的观察右美托咪定对不停跳冠脉旁路移植患者血浆晚期糖基化终末产物受体(RAGE)信号通路的影响。方法30例接受不停跳冠状动脉旁路移植术患者随机均分为右美托咪定组和对照组,两组静脉全身麻醉诱导,以静脉泵入丙泊酚、舒芬太尼麻醉维持,间断静脉注射顺阿曲库铵。右美托咪定组于麻醉诱导前静脉泵入右美托咪定1.0μg/(kg·h)10 min后,持续静脉泵入右美托咪定0.5μg/(kg·h)维持,对照组同期给以等量生理盐水,于T1(麻醉诱导后)、T2(吻合血管前)、T3(术后6 h)、T4(术后24 h)、T5(术后48 h)5个时间点采集颈内静脉血3 ml,采用酶联免疫吸附法测定血浆高迁移率族蛋白B1(HMGB1)、白细胞介素-6(IL-6)、RAGE浓度。组间数据比较采用t检验,分类变量比较采用χ^2检验。结果右美托咪定组血浆HMGB1、RAGE水平在T5点低于对照组:HMGB1[(189.81±35.89)pg/ml比(265.92±49.48)pg/ml,P<0.01],RAGE[(230.56±64.84)pg/ml比(316.24±126.73)pg/ml,P<0.05];右美托咪定组血浆IL-6水平在T4点低于对照组[(38.03±6.31)pg/ml比(55.81±21.48)pg/ml,P<0.01]。结论右美托咪定对不停跳冠脉旁路移植术中,通过降低HMGB1、RAGE水平,抑制RAGE介导的核因子-κB(NF-κB)炎症通路,发挥抗炎作用。

关键词：右美托咪定冠脉旁路移植晚期糖基化终末产物受体

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我国化妆品智慧审评技术要点分析

日用化学工业（中英文） 2022年第10期52卷 1113-1120页

作者：苏哲胡康吕冰峰塔娜王钢力路勇中国食品药品检定研究院北京100050

为落实《化妆品监督管理条例》,国家药品监督管理局构建了全新的化妆品法规和技术体系,并组织建设化妆品注册备案信息服务平台,中国食品药品检定研究院积极开展了化妆品智慧审评相关工作。论文在此基础上,以《化妆品监督管理条例》及其... 详细信息

为落实《化妆品监督管理条例》,国家药品监督管理局构建了全新的化妆品法规和技术体系,并组织建设化妆品注册备案信息服务平台,中国食品药品检定研究院积极开展了化妆品智慧审评相关工作。论文在此基础上,以《化妆品监督管理条例》及其配套法规为依据,围绕电子资料内容和技术审评工作要求,对能够通过系统完成一定自动化判定和提示的审评要点进行梳理,对具体实现路径、需整合数据库、判断逻辑等进行分析,并讨论了在技术审评和监管工作中的应用。目前,已成功建立起一系列智慧审评要点,覆盖产品配方和原料使用、产品检验报告、产品标签样稿、产品执行的标准、安全评估报告等审评内容,并研究了功效宣称评价依据摘要的规范化填报和自动形式审核,为化妆品智慧审评和智慧监管工作提供了技术支撑。

关键词：化妆品监督管理条例化妆品智慧申报审评系统智慧审评

miR20a自噬炎症小体在子宫内膜异位组织中表达及意义

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中国计划生育学杂志 2022年第1期30卷 139-142页

作者：吕冰峰秦锦龙江苏省张家港市第二人民医院 215600 同济大学附属上海市第四人民医院

目的:探讨miR20a-自噬-炎症小体通路在子宫内膜异位症(EMs)表达及意义。方法:收集2019年1月-2020年12月就诊于本院妇产科的EMs患者住院病历,从中选择60例子宫内膜组织为EMs异位组,健康女性正常子宫内膜组织60例为对照组,再将EMs异位组分... 详细信息

目的:探讨miR20a-自噬-炎症小体通路在子宫内膜异位症(EMs)表达及意义。方法:收集2019年1月-2020年12月就诊于本院妇产科的EMs患者住院病历,从中选择60例子宫内膜组织为EMs异位组,健康女性正常子宫内膜组织60例为对照组,再将EMs异位组分为:EMs组、脂多糖(LPS)诱导组、LPS+miR-20a转染组各20例。用荧光定量PCR法检测miR20a在Ems不同内膜组织中表达水平;用酶联免疫吸附法检测EMs患者血清和异位组织细胞中白介素-6(IL-6)、C反应蛋白(CRP)、白介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)水平;采用Western blotting法检测半胱天冬氨酸蛋白酶1(Caspase-1)、凋亡相关颗粒样蛋白(ASC)以及自噬蛋白(LC3)表达。结果:EMs异位组组织中miR20a及血清IL-1β、TNF-α、CRP水平均高于对照组,且在EMs组、诱导组、转染组中IL-6、TNF-α、IL-1β和CRP水平依次增加(均P<0.05);EMs组、诱导组、转染组中ASC、Caspase-1、LC3、Beclin-1表达量依次增加(P<0.05)。结论:miR20a在EMs异位细胞中表达上调,提示miR20a可作为EMs预后标志物,miR20a可能通过调控细胞自噬-炎症小体通路参与EMs。

关键词：子宫内膜异位症 miR20a 炎症小体自噬脂多糖通路

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei lv Wei Qin Xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第9期20卷 2556-2570页

作者： Yongting lv Hongfu Li Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Medical Genetics and Center for Rare disease Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Nanhu Brain-Computer Interface Institute HangzhouZhejiang Province

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely *** principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain,brainstem,and spinal cord,as well as abnormal protein deposition in the cytoplasm of neurons and glial *** biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid,blood,and even *** these biomarke rs,neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system,while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and *** light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and ***,there are challenges in using neurofilament light chain to diffe rentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal *** fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment,oxygen saturation,and the glomerular filtration *** DNA-binding protein 43,a pathological protein associated with amyotrophic lateral sclerosis,is emerging as a promising biomarker,particularly with advancements in exosome-related *** is currently lacking for the value of creatinine and creatine kinase as diagnostic markers;however,they show potential in predicting disease *** the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years,the quest for definitive diagnostic and prognostic biomarke rs remains a formidable *** review summarizes the lat

关键词： amyotrophic lateral sclerosis biomarker blood biomarkers diagnosis glial fibrillary acidic protein neurofilament light chain prognosis TAR DNA-binding protein 43

2-3 Lifetime Measurement of the First Excited State in 37S

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IMP & HIRFL Annual Report 2015年第1期 51-52页

作者： Wang Kailong Liu Minliang Wang Jianguo Qiang Yunhua Gao Bingshui Zheng Yong lv bingfeng Zhang Zhiyuan Zhang Wenqiang Zhou Xiaohong Wang Jiansong Yang Yanyun Bai Zhen Ma Peng Jin Shilun Ma Junbing Duan Fangfang Zhang Xing Jiao Lei 不详

We have found that the excited energy from the ground state with 1f7=2 configuration to the first excited state with 2p3=2 configuration in 37S is obviously lower compared with that in nearby N=21 isotones 35Si, 39Ar and 41Ca (see Fig. 1, The insert indicates the relevant single-particle orbits of proton and neutron). This interesting phenomenon may result from the collapse of N=28 closure, which gives the sufficient valence space for collective deformation which can been revealed from the B(E2) value. Therefore, to obtain the B(E2), we perform the experiments for measuring the lifetime of the first excited state in 37S.

关键词： Lifetime Measurement Excited

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing Ning Shi lv Qian Wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury