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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-yan Feng Li-na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(Pnal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(Pnal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer

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World Journal of Gastroenterology 2024年第16期30卷 2195-2208页

作者： Xiao-Jun Zhang yan Yu He-Ping Zhao Lei Guo Kun Dai Jing lv Department of Clinical Laboratory Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Spinal Surgery Honghui HospitalXi’an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Department of Clinical Laboratory Yanliang Railway Hospital of Xi’anXi’an 710089Shaanxi ProvinceChina

As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in *** to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still *** addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor *** aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of ***,personalized treatments could be developed to maximize the advantages of immunotherapy.

关键词： Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Tumor immune microenvironment Immunosuppression Immunotherapy

Removal of a guide-wire sliding into abdominal cavity via transgastric natural orifice transluminal endoscopic surgery: A case report

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World Journal of Clinical Cases 2024年第3期12卷 596-600页

作者： Shi-Ju Chen Da-Ya Zhang yan-Ting lv Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical University570216 HaikouHainan ProvinceChina Department of Gastroenterology Clinical Medical Center of Hainan ProvinceHaikou 570216Hainan ProvinceChina

BACKGROUND Guidewire slippage into the peritoneal cavity during clinical operations is extremely ***,this paper aims to report a successful case of guidewire removal using transgastric natural orifice transluminal endoscopic surgery(NOTES).The goal is to enhance physicians'understanding of the management plan for this unique scenario and provide a valuable reference for clinical *** SUMMARY A 64-year-old man presented with abdominal distension and was diagnosed with cirrhosis combined with massive *** proceed with treatment,the patient underwent ultrasound-guided peritoneal puncture and underwent catheterization and ***,a 0.035-inch guidewire slipped into the abdominal cavity during the *** a comprehensive evaluation and consultation by a multidisciplinary team,the guidewire was successfully removed using *** This case highlights the potential consideration of transgastric NOTES removal when encountering a foreign body,such as a guidewire,within the abdominal cavity.

关键词： Guidewire Abdominal cavity natural orifice transluminal endoscopic surgery Cirrhosis Massive ascites Case report

Investigation of the Effect of the Force Arm on the Bending Capability of Prestressed Glulam Beam

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Structural Durability & Health Monitoring 2024年第5期18卷 641-661页

作者： yan Zhao Yuanyuan Wu Shengliang He Zhenglu Gao Ziyan Huang Chenzheng lv Department of Civil Engineering and Architecture Wuyi UniversityWuyishan354300China Experimental Forest Farm in Qingyuan County Lishui323000China Fujian Zhuanghe Bamboo Industry Technology Co. Ltd.Nanping353000China Fujian Liuzheng New Materials Technology Co. Ltd.Nanping353000China

Prestress enables the Glulam beam could make full use of the compression strength,and then increase the span,but it still could not reduce all drawbacks,such as cross-section weakening and small force *** avoid slotting and ensure suitable tension and compression couple,one kind of novel anchor has been proposed,which could meet the bearing capacity *** then the bending test of prestressed Glulam beams with a geometric scale ratio of 1:2 was simulated,to investigate the effect of the force arm on bending capacities,failure modes,and deformation *** show that increasing the force arm could improve the ultimate bending per-formance of the beam signiﬁcantly,and the anchor arm length has a certain effect on the performance,but it is not ***,based on Finite element method analysis,the practice design suggestions have been offered.

关键词： Force arm prestressed Glulam beam ﬁnite element method bearing capacity

Cascade reaction of 3-formylchromones:Highly selective synthesis of 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 94-101页

作者： Ying lv Li Chen Xinghan Yun Kun Li Shengjiao yan Key Laboratory of Medicinal Chemistry for natural Resource(Yunnan University) Ministry of EducationSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091China

A novel method for the preparation of highly functionalized 4-oxo-3-(1H-pyrrol-3-yl)-4H-chromenes(OPCMs)from 3-formylchromones andα-isocyanoacetates via an unprecedented three-component[1+1+3]cycloaddition reaction in one pot was *** three-component cascade reaction was enabled by refluxing a mixture of the substrates in 1,4-dioxane in the presence of Ag_(2)CO_(3) as a Lewis acid *** a result,a series of functionalized pyrroles(OPCMs,3),was prepared regioselectively and in high yields(80%-88%)through the formation of three *** protocol can be used in the synthesis of OPCMs rather than through conventional,multi-step reactions and is suitable for both combinatorial and parallel syntheses of pyrroles.

关键词： 4-Oxo-3-(1H-pyrrol-3-yl)-4H-chromenes Three-component Cascade reaction [1+1+3]cycloaddition 3-Formylchromones

Tuning the membrane rejection behavior by surface wettability engineering for an effective water-in-oil emulsion separation

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Chinese Chemical Letters 2024年第6期35卷 480-485页

作者： yan Zou Yin-Shuang Hu Deng-Hui Tian Hong Wu Xiaoshu lv Guangming Jiang Yu-Xi Huang Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Technology and Business UniversityChongqing 400067China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology(Sun Yat-sen University) Guangzhou 510275China

Membrane-based separation is a promising technology to eliminate water impurities from the oil ***,it remains a great challenge to separate water from highly emulsified viscous oil owing to the high stability of the water droplets in *** we report a surface wettability engineering on an alumina ceramic membrane to achieve an efficient separation of a water-in-oil(W/O)*** with different carbon chain lengths and fluorinated status were introduced to endow the alumina membrane with different surface *** all the modified membranes exhibited excellent separation of the W/O without Span 80(surfactant),the one with amphiphobic wettability and lowest surface energy failed to separate the Span 80 stabilized W/*** presence of Span 80 reduced the interfacial tension of water droplets,making them easier to deform and penetrate the modified membrane with the lowest surface *** reveals that engineering proper surface wettability is the key to separating the oil and water ***,the modified membranes maintained decent separation performance and stability under long-term run separation of the emulsified W/O.

关键词： Water-in-oil emulsion Ceramic membrane Membrane separation Surface wettability

Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence

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World Journal of Clinical Cases 2024年第2期12卷 293-301页

作者： yan-Xia He yang lv Ting-Ting Lan Fang Deng Yuan-Yuan Zhang Department of Obstetrics and Gynecology Wuhan Children’s HospitalWuhan 430015Hubei ProvinceChina Center for Reproductive Medicine Department of Obstetrics and GynecologySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for *** has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and *** To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with *** A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May *** cases were divided into two groups,namely the observation group and the control group,with 40 cases in each *** nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior *** study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both *** After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control *** The integration of timing theory and behavior

关键词： Timing theory Behavior change Primipara Bad mood Quality of life

Interface sites on vanadia-based catalysts are highly active for NO_(x) removal under realistic conditions

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Journal of Environmental Sciences 2024年第2期136卷 523-536页

作者： Zhihui lv Guangzhi He Wenshuo Zhang Jingjing Liu Zhihua Lian yang yang Zidi yan Guangyan Xu Wenpo Shan Yunbo Yu Hong He State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Regional Atmospheric Environment and Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China Ningbo Research Center for Urban Environment Chinese Academy of SciencesNingbo 315800China

TiO_(2)-supported V_(2)O_(5)catalysts are commonly used in NO_(x)reduction with ammonia due to their robust catalytic *** these catalysts,it is generally considered that the active species are mainly derived from the vanadia species rather than the intrinsic structure of V-O-Ti entities,namely the interface *** reveal the role of V-O-Ti entities in NH_(3)-SCR,herein,we prepared TiO_(2)/V_(2)O_(5)catalysts and demonstrated that V-O-Ti entities were more active for NO_(x)reduction under wet conditions than the V sites(V=O)working *** the V-O-Ti entities,kinetic measurements and first principles calculations revealed that NH_(3)activation exhibited a much lower energy barrier than that on V=O *** wet conditions,the V-O-Ti interface significantly inhibited the transformation of V=O to V-OH sites thus benefiting NH_(3)*** wet conditions,meanwhile,the migration of NH_(4)^(+)from Ti site neighboring the V-O-Ti interface to Ti site of the V-O-Ti interface was exothermic;thus,V-O-Ti entities together with neighboring Ti sites could serve as channels linking NH_(3)pool and active centers for activation of NH_(4)^(+).This finding reveals that the V-O-Ti interface sites on V-based catalysts play a crucial role in NO_(x)removal under realistic conditions,providing a new perspective on NH_(3)-SCR mechanism.

关键词： NO_(x)removal Vanadia-based catalysts V-O-Ti entities Interface sites Reaction mechanism

Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1482-1484页

作者： Shi-yan Zhang Xiong-Jian Ma Xue-Xia Zhu na Cai Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This letter to the editor addresses the study titled“Predictive value of NLR,Fib4,and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma”by Kuang et al in the World Journal of Gastrointestinal *** study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient *** letter recommends prospective studies for validation and considers the influence of confounding *** finding underscores the significance of this study in improving hepatocellular carcinoma management.

关键词： Neutrophil-to-lymphocyte ratio Hepatocellular carcinoma Liver failure Hepatectomy Letter to the Editor Commentary