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Acta Epileptologica 2022年第2期5卷 78-87页

作者： Shen Wang Juan Yang Nian wei Wenbo lv Zhigang Jiang Hao Huang Jun Zhang Ping Xu Chang Yin Yu Zucai Xu Department of Neurology Affliated Hospital of Zunyi Medical UniversityZunyi 563000China. Zunyi Medical University Zunyi 563000China.

Background:This study was aimed to investigate whether patients with epilepsy(PWE)have higher depression and anxiety levels than the normal population in low-risk areas for coronavirus disease 2019(COVID-19)in the northern part of Guizhou Province,China,during the COVID-19 epidemic,to evaluate their knowledge on COVID-19,and to analyze related factors for the psychological distress of PWE at this special ***:The survey was conducted online from February 28,2020 to March 7,2020 via a *** from the outpatient clinic of epilepsy of the Aflited Hospital of Zunyi Medical University,and healthy people matched for age and sex,participated in this *** health was assessed via a generalized anxiety self-rating scale(GAD-7)and the self-rating depression scale(PHQ-9).The knowledge of COVID-19 in both groups was ***:There were no significant differences in the general demographics between the PWE and healthy control *** scores of PHQ-9(P0.05).PWE knew less about some of the prevention and control measures of COVID-19 than healthy ***:During the COVID-19 epidemic,excessive attention to the epidemic an

关键词： COVID-19 Epilepsy Anxiety Depression Knowledge of epidemic prevention and control

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“团带式”商业规划模式的构建与实证

中国流通经济 2011年第2期25卷 86-90页

作者：吕波魏国辰北京物资学院商学院北京市101149

本文在分析"商圈理论"和"组团理论"等基础上,提出了"团带式"商业规划模式,并以北京市平谷区"十二五"商业发展规划为研究对象,提出了该模式应用的六个支撑要素,即一个区域在具备交通干线、经济发展、招商引资、辐射区域、商业人才和商业... 详细信息

本文在分析"商圈理论"和"组团理论"等基础上,提出了"团带式"商业规划模式,并以北京市平谷区"十二五"商业发展规划为研究对象,提出了该模式应用的六个支撑要素,即一个区域在具备交通干线、经济发展、招商引资、辐射区域、商业人才和商业项目等六方面要素的有力支撑时,可以应用该模式进行商业规划。利用"团带式"商业规划模式可以有效解决区域跨越式发展所带来的负面效应影响,引导区域商业由中心式分布向均衡式分布过渡,改变在组团核心地带商业过于密集和人口过于拥挤的现状,并预防其交通过于拥堵、生活环境趋于恶化等问题。该研究对于科学制定区域性的商业发展规划,提高城市商业的服务功能,提供了一种理论和实践模式。

关键词：团带式商业规划商业布局商业模式

Tacrolimus dosage requirements in living donor liver transplant recipients with small-for-size grafts

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World Journal of Gastroenterology 2009年第31期15卷 3931-3936页

作者： Fei Liu Ya Li Xiang Lan Yong-Gang wei Bo Li lv-Nan Yan Tian-Fu Wen Ji-Chun Zhao Ming-Qing Xu Wen-Tao Wang Jia-Yin Yang Department of Liver and-Vascular Surgery Center of Liver Transplantation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China West China School of Clinical Medicine Sichuan University Chengdu 610041 Sichuan Province China

AIM： To investigate the tacrolimus dosage requirements and blood concentrations in adult-to-adult right lobe living donor liver transplantation （AALDLT） recipients with small-for-size （SFS） grafts. METHODS： During January 2007 and October 2008, a total of 54 cases of AALDLT with an observation period of 6 mo were enrolled in this study. The 54 patients were divided into two groups according to graftrecipient body weight ratio （GRBW）： SFS grafts group （Group S, GRBW 〈 0.8%, n = 8） and non-SFS grafts group （Group N, GRBW ≥ 0.8%, n = 46）. Tacrolimus 12-hour blood levels and doses were recorded during weeks 1, 2, 3 and 4 and months 2, 3, 4, 5 and 6 in group S and group N. Meanwhile, acute rejection rates, liver and renal function test results, and the number of potentially interacting medications were determined at each interval in the two groups. A comparison of tacrolimus dosage requirements and blood levels were made weekly in the first month post-surgery, and monthly from months 2 to 6. RESULTS： There were no differences in the demo-graphic characteristics, acute rejection rates, liver and renal function test results, or the number of potentially interacting medications administered between the two groups. The tacrolimus dosage requirements in group S were significantly lower than group N at 2 wk （2.8 ± 0.4 mg/d vs 3.6 ± 0.7 mg/d, P = 0.006）, 3 wk （2.9± 0.7 mg/d vs 3.9±0.8 rag/d, P = 0.008）, 4 wk （2.9 ± 0.8 mg/d vs 3.9 ± 1.0 mg/d, P = 0.023） and 2 mo （2.8 ±0.7 mg/d vs 3.8±1.1 mg/d, P = 0.033）. Tacrolimus 12-h trough concentrations were similar between the two groups at all times except for 2 wk post-transplantation, when the concentrations were significantly greater in group S recipients than in group N recipients （11.3 ± 4.8 ng/mL vs 7.0 ± 3.8 ng/mL, P = 0.026）. CONCLUSION： SFS grafts recipients have significantly decreased tacrolimus dosage requirements compared with non-SFS grafts recipients in AALDLT during the first 2 mo post-surgery.

关键词： Blood concentration Liver transplantation Living donor Small-for-size graft Tacrolimus

Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and covaccination as an effective method of prevention of COVID-19 and influenza

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1876-1883页

作者： Linlin Bao wei Deng Feifei Qi Qi lv Zhiqi Song Jiangning Liu Hong Gao Qiang wei Pin Yu Yanfeng Xu Yajin Qu Fengdi Li Jing Xue Shuran Gong Mingya Liu Guanpeng Wang Shunyi Wang Binbin Zhao Bin Cong Chuan Qin Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Hebei Medical University ShijiazhuangChina

Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus,leading to more serious respiratory diseases during this ***,the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the host remains *** a mammalian model,sequential infection was performed in ferrets and in K18-MCE2 mice,with SARS-CoV-2 infection following *** found that co-infection with H1N1 and SARS-CoV-2 extended the duration of clinical manifestation of COVID-19,and enhanced pulmonary damage,but reduced viral shedding of throat swabs and viral loads in the lungs of ***,mortality was increased in sequentially infected mice compared with single-infection *** with singlevaccine inoculation,co-inoculation of PiCoVacc(a SARS-CoV-2 vaccine)and the flu vaccine showed no significant differences in neutralizing antibody titers or virus-specific immune *** immunization effectively protected K18-MCE2 mice against both H1N1 and SARS-CoV-2 *** findings indicated the development of systematic models of co-infection of H1N1 and SARS-CoV-2,which together notably enhanced pneumonia in ferrets and mice,as well as demonstrated that simultaneous vaccination against HINT and SARS-CoV-2 may be an effective prevention strategy for the coming winter.

关键词： prevention H1N1 influenza

Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

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Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： guo-Jing Tang Xiao-Dong Chen Lu Sun Chao-Heng guo Meng-Yu Li Zhong-Tao Tian Hou-Hong Chen Hong-wei Wang Qi-Yao Sun Ying-Di Pan Xin-Tao He Yi-Kai Su Jian-Wen Dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive

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地面目标红外立体特征

红外与激光工程 2014年第9期43卷 2810-2814页

作者：吕相银金伟杨莉电子工程学院红外与低温等离子体安徽省重点实验室安徽合肥230037 脉冲功率激光技术国家重点实验室安徽合肥230037

研究地面目标的红外立体特征,有助于全面掌握目标红外特性的细节,对红外热像的模拟、红外目标识别以及红外隐身设计等都有着重要的意义。文中通过对影响目标温度因素的定量分析,建立了地面目标表面温度的一般数学模型。以一维导热微分... 详细信息

研究地面目标的红外立体特征,有助于全面掌握目标红外特性的细节,对红外热像的模拟、红外目标识别以及红外隐身设计等都有着重要的意义。文中通过对影响目标温度因素的定量分析,建立了地面目标表面温度的一般数学模型。以一维导热微分方程为例,计算了某建筑物墙壁不同方位的外表面温度在一天中随时间的变化关系,并与实际测量值进行了比较。在此基础上,最后对建筑物的红外辐射进行了理论计算和讨论。结果表明地面目标的红外立体特征在白天非常显著,在晚上的立体特征则没有白天显著。

关键词：地面目标温度红外辐射立体特征

Small extracellular vesicles in combination with sleep-related circRNA3503:A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis

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Bioactive Materials 2021年第12期6卷 4455-4469页

作者： Shi-Cong Tao Ji-Yan Huang Yuan Gao Zi-Xiang Li Zhan-Ying wei Helen Dawes Shang-Chun guo Department of Orthopaedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghai200233China Institute of Microsurgery on Extremities Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghai200233China Department of Stomatology Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine185 Pu’an RoadShanghai200021China School of Medicine Shanghai Jiao Tong University227 South Chongqing RoadShanghai200025China Medical College of Soochow University Soochow UniversityChangzhou215123JiangsuChina Shanghai Clinical Research Centre of Bone Diseases Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Faculty of Health and Life Science Oxford Brookes UniversityHeadington RoadOxfordOX30BPUK

Osteoarthritis(OA),characterized by chondrocyte apoptosis and disturbance of the balance between catabolism and anabolism of the extracellular matrix(ECM),is the most common age-related degenerative joint disease *** sleep has been found to be beneficial for cartilage repair,and circular RNAs(circRNAs)have been demonstrated to be involved in the pathogenesis of OA,we performed RNA sequencing(RNA-seq),and found circRNA3503 was significantly increased after melatonin(MT)-induced cell *** of circRNA3503 expression completely rescued the effects of interleukin-1β(IL-1β),which was used to simulate OA,on apoptosis,ECM degradation-and synthesis-related ***,circRNA3503 acted as a sponge of hsa-miR-181c-3p and ***,as we previously showed that small extracellular vesicles(sEVs)derived from synovium mesenchymal stem cells(SMSCs)can not only successfully deliver nucleic acids to chondrocytes,but also effectively promote chondrocyte proliferation and migration,we assessed the feasibility of sEVs in combination with sleep-related circRNA3503 as an OA *** successfully produced and isolated circRNA3503-loaded sEVs(circRNA3503-OE-sEVs)from ***,poly(D,L-lactide)-b-poly(ethylene glycol)-b-poly(D,L-lactide)(PDLLA-PEG-PDLLA,PLEL)triblock copolymer gels were used as carriers of *** in vivo and in vitro experiments,PLEL@circRNA3503-OE-sEVs were shown to be a highly-effective therapeutic strategy to prevent OA *** multiple pathways,circRNA3503-OE-sEVs alleviated inflammation-induced apoptosis and the imbalance between ECM synthesis and ECM degradation by acting as a sponge of hsa-miR-181c-3p and *** addition,circRNA3503-OE-sEVs promoted chondrocyte renewal to alleviate the progressive loss of *** results highlight the potential of PLEL@circRNA3503-OE-sEVs for preventing OA progression.

关键词： Extracellular vesicles Exosomes Circular RNAs PDLLA-PEG-PDLLA

Electrochemical biosensors represent promising detection tools in medicalﬁeld

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Advanced Sensor and Energy Materials

Advanced Sensor and Energy Materials 2023年第4期2卷 40-55页

作者： Li Zhang Wenqiang guo Chenrui lv Xiaomeng Liu Mei Yang Meng guo Qiuyue Fu Huazhong Agricultural University Wuhan 430070PR China Southwest University of Science and Technology Mianyang 621000PR China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046PR China

In recent years,there has been a growing demand for rapid detection methods,leading to the proliferation of biosensors,particularly electrochemical biosensors,which have garnered substantial attention from *** fusion of biosensors with advanced electrochemical sensing technology has given rise to a diverse array of electrochemical biosensors characterized by their rapid detection capabilities and heightened ***,an imperative exists to comprehensively recapitulate recent advances in electrochemical biosensors,especially within the realm of clinical *** review aims to elucidate the applications of electrochemical biosensors and delineate future development prospects,facilitating a more profound comprehension and further progression of thisﬁ***ﬁcally,we will examine the utilization of electrochemical biosensors in clinical medicine,encompassing their roles in point-of-care testing,disease diagnosis,and therapeutic ***,we will spotlight emerging trends and prospective innovations,such as the evolution of nanostructured sensors and portable *** providing a comprehensive overview of the advances and potential applications of electrochemical biosensors in clinical medicine,this review will signiﬁcantly contribute to the advancement of thisﬁeld and serve as a catalyst for further research into innovative detection tools.

关键词： Biosensors Electrochemical techniques Detection Medical Classiﬁcation

Correlation of restenosis after rabbit carotid endarterectomy and inflammatory cytokines

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 231-236页

作者： Jun-Jun Liang wei Xue Li-Zhi Lou Cheng Liu Zhao-Fen Wang Qing-guo Li Shao-Hua Huang Department of Cardiovascular Thoracic Surgery.Anqiu People's Hospital Department of Medical Service Anqiu People's Hospital Tianjin Cerebral Hospital Department of Neurosurgery.Anqiu People's Hospital

Objective:To establish rabbit model of restenosis after carotid endartereclomy surgery,and to study tissue inflammatory cytokines(TNF-α,IL-61 involved in ***:A total of 32 rabbits were randomly divided into two groups:model group and control *** right common carotid artery in rabbits was damaged by carotid endar terectomy in model *** tissues were harvested at different time points respectively,the pathological changes of the vascular wall after operation were observed at different time *** changes of expression of tissue vascular wall inflammatory cytokines(TNF-α.IL-6)at different lime points after the surgery was observed by RT-PCR,and the changes of serum inflammatory cytokines(TNT-α,IL-6)were detected by ***:The new intima appeared after 7 days of the injury and reached the peak on 28 d which is uneven and significantly thicker than the control group(Plv increased after the rabbit common carotid artery injury,which was significant difference compared with normal control group(P<0.05).Conclusions:The tissue inflammatory factors significantly increase after the rabbit carotid artery injury,which suggests the mutual concurrent effects of inflammatory cytokines can result in the proliferation of vascular restenosis.

关键词： Inflammatory factors Carotid endarterectomy Restenosis after angioplasty

Late-onset multiple acyl-CoA dehydrogenase deficiency with cardiac syncope: A case report

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World Journal of Clinical Cases 2020年第5期8卷 995-1001页

作者： Xue-Qi Pan Xue-Li Chang wei Zhang Hua-Xing Meng Jing Zhang Jia-Ying Shi Jun-Hong guo Department of Neurology Frist Hospital of Shanxi Medical University

BACKGROUND Multiple acyl-CoA dehydrogenase deficiency(MADD)is an uncommon autosomal recessive disorder of mitochondrial fatty acid *** is a transient loss of consciousness due to acute global cerebral ***-onset MADD with syncope has not been reported *** SUMMARY We report a 17-year-old girl with exercise intolerance and muscle *** felt palpitation and shortness of breath after short bouts of *** also suffered from a transient loss of consciousness many *** biopsy showed lipid *** mutation analysis indicated a compound heterozygous mutation c.250G>A(p.A84T)and c.872T>G(p.V291G)in the ETFDH *** results of Holter electrocardiogram monitoring showed supraventricular tachycardia when the patient experienced a loss of *** treatment with riboflavin and carnitine,muscle weakness and palpitation symptoms improved *** loss of consciousness occurred,and the Holter electrocardiogram monitoring was *** Late-onset MADD with supraventricular tachycardia can cause cardiac *** and riboflavin supplement were beneficial for treating the late-onset MADD with cardiac *** should be paid to the prevention of cardiac syncope when diagnosing late-onset MADD.

关键词： Late-onset multiple acyl-CoA dehydrogenase deficiency ETFDH Cardiac syncope Supraventricular tachycardia Mitochondrion Carnitine Case report