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Asian Journal of Andrology 2021年第3期23卷 306-313页

作者： Julio Bunay luz-m.ria gallardo Jorge Luis Torres-Fuentes m Veronica Aguirre-Arias Renan Orellana Nestor Sepulveda Ricardo D moreno Physiology Department Faculty of Biological SciencesPontificia Universidad Cat6lica de Chile(PUC)Santiago 8331150Chile Department of Chemistry and Biological Sciences Health Sciences FacultyUniversidad Bernardo 0 HigginsSantiago 8370854Chile Center of Excellence in Biotechnology of Reproduction Universidad de la FronteraTemuco 4780000Chile.

Obesity is a major worldwide health problem that is related to most chronic diseases,including male *** to its wide impact on health,mechanisms underlying obesity-related infertility remain *** this study,we report that mice fed a high-fat diet(HFD)for over 2 months showed reduced fertility rates and increased germ cell apoptosis,seminiferous tubule degeneration,and decreased intratesticular estradiol(E2)and E2-to-testosterone ***,we also detected a decrease in testicular fatty acid levels,behenic acid(C22:0),and docosahexaenoic acid(DHA,22:6n-3),which may be related to the production of dysfunctional ***,we did not detect any changes in the frequency of seminiferous tubule stages,sperm count,or rate of in vitro ***,there was an increase in spontaneous and progesterone-induced acrosomal exocytosis(acrosome reaction)in spermatozoa from HFD-fed *** data suggest that a decrease in E2 and fatty acid levels influences spermatogenesis and some steps of acrosome biogenesis that will have consequences for ***,our results add new evidence about the adverse effect of obesity in male reproduction and suggest that the acrosomal reaction can also be affected under this condition.

关键词： cholesterol estradiol fat acid testis testosterone

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

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World Journal of Hepatology 2022年第4期14卷 719-728页

作者： milena Lima Rodrigues Tatiane Priscila Santos Rodrigues da luz Caroline Louise Diniz Pereira Andrea Dória Batista Ana Lúcia Coutinho Domingues Ricardo Oliveira Silva Edmundo Pessoa Lopes Programa de Pós-Graduação em medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital das Clínicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The evaluation of periportal fibrosis(PPF)is essential for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography,^(1)H-nuclear magnetic resonance(NmR)-based metabonomics has been employed to assess liver fibrosis in some *** To build 1H-NmR-based metabonomics models(mm)to discriminate mild from significant periportal PPF and identify differences in the metabolite *** A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern *** evaluated 41 serum samples from 10 patients with mild PPF(C Niamey pattern)and 31 patients with significant PPF(D/E/F Niamey patterns).mm were built using partial least squares-discriminant analysis(PLS-DA)and orthogonal projections to latent structures discriminant analysis(OPLS-DA)*** PLS-DA and OPLS-DA resulted in discrimination between mild and significant PPF groups with R2 and Q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model,*** OPLS-DA model presented accuracy,sensitivity,and specificity values of 92.7%,90.3%,and 100%to discriminate significant *** metabolites identified as responsible by discrimination were:Nacetylglucosamines,alanine,glycolaldehyde,carbohydrates,and *** mms discriminated mild from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

关键词： metabolomics Portal hypertension Schistosoma mansoni Biomarkers Neglected disease Nuclear magnetic resonance

Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors

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World Journal of Clinical Cases 2022年第31期10卷 11283-11291页

作者： Fabrício Freire de melo Hanna Santos marques Fabian Fellipe Bueno Lemos marcel Silva luz Samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza márcio Vasconcelos Oliveira Institution multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene *** function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory RNAs Nickel-regulated small RNA Virulence factors Cytotoxin associated antigen A Gastric cancer

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro m.riana Santos Calmon marcel Silva luz Samuel Luca Rocha Pinheiro Clara Faria Souza mendes dos Santos Gabriel Lima Correa Santos Hanna Santos marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza márcio Vasconcelos Oliveira Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(mALT)lymphoma(GmL)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GmL,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GmL following bacterial *** We performed independent,computer-assisted literature searches using the Pubmed/mEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GmL following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-mA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GmL patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

Influence of Helicobacter pylori oncoprotein CagA in gastric cancer:A critical-reflective analysis

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World Journal of Clinical Oncology 2022年第11期13卷 866-879页

作者： Fabrício Freire de melo Hanna Santos marques Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos marcel Silva luz Kádima Nayara Teixeira Cláudio Lima Souza márcio Vasconcelos Oliveira Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094Brazil Campus Toledo Universidade Federal do ParanáToledo 85919899Brazil

Gastric cancer is the fifth most common malignancy and third leading cancerrelated cause of death *** pylori is a Gram-negative bacterium that inhabits the gastric environment of 60.3%of the world’s population and represents the main risk factor for the onset of gastric *** is the most important virulence factor in ***,and is a translocated oncoprotein that induces morphofunctional modifications in gastric epithelial cells and a chronic inflammatory response that increases the risk of developing precancerous *** translocation and tyrosine phosphorylation,CagA moves to the cell membrane and acts as a pathological scaffold protein that simultaneously interacts with multiple intracellular signaling pathways,thereby disrupting cell proliferation,differentiation and *** these alterations in cell biology increase the risk of damaged cells acquiring pro-oncogenic genetic *** this sense,once gastric cancer sets in,its perpetuation is independent of the presence of the oncoprotein,characterizing a“hit-and-run”carcinogenic ***,this review aims to describe ***-and CagA-related oncogenic mechanisms,to update readers and discuss the novelties and perspectives in this field.

关键词： Helicobacter pylori Virulence factors CagA Gastric cancer EPIYA motifs Hit-and-run carcinogenesis

From Helicobacter pylori infection to gastric cancer:Current evidence on the immune response

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World Journal of Clinical Oncology 2022年第3期13卷 186-199页

作者： Vinícius Lima de Souza Gonçalves m.ria Luísa Cordeiro Santos marcel Silva luz Hanna Santos marques Breno Bittencourt de Brito Filipe Antônio França da Silva Cláudio Lima Souza márcio Vasconcelos Oliveira Fabrício Freire de melo Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil Universidade Federal da Bahia Instituto Multidisciplinar em SaúdeVitória da Conquista 45029-094BahiaBrazil

Gastric cancer(GC)is the result of a multifactorial process whose main components are infection by Helicobacter pylori(***),bacterial virulence factors,host immune response and environmental *** development of the neoplastic microenvironment also depends on genetic and epigenetic changes in oncogenes and tumor suppressor genes,which results in deregulation of cell signaling pathways and apoptosis *** review summarizes the main aspects of the pathogenesis of GC and the immune response involved in chronic inflammation generated by ***.

关键词： Gastric cancer Helicobacter pylori Chronic inflammation Host immune response

Correction to“Performance of a serological Igm and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de melo Lilian martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos Dantas miranda Dórea Breno Bittencourt de Brito Hanna Santos marques Fabian Fellipe Bueno Lemos marcel Silva luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene m.ria de magalhães Queiroz Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de melo F,martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDm,de Brito BB,marques HS,Lemos FFB,Silva luz m,Rocha Pinheiro SL,de magalhães Queiroz *** of a serological Igm and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** J Exp med 2022;12(5):100-103[PmID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

molecular and serology methods in the diagnosis of COVID-19: An overview

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World Journal of methodology 2022年第3期12卷 83-91页

作者： marcel Silva luz Ronaldo Teixeira da Silva Júnior Gabriella Almeida Santos de Santana Gabriela SantosRodrigues Henrique de Lima Crivellaro m.riana Santos Calmon Clara Faria Souza mendes dos Santos LuisGuilherme de Oliveira Silva Qesya Rodrigues Ferreira Guilherme Rabelo mota Heloísa Heim Filipe AntônioFrança da Silva Breno Bittencourt de Brito Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease-19(COVID-19)has become a pandemic,being a global health concern since December 2019 when the first cases were *** acute respiratory syndrome coronavirus 2,the COVID-19 causal agent,is aβ-coronavirus that has on its surface the spike protein,which helps in its virulence and pathogenicity towards the ***,effective and applicable diagnostic methods to this disease come as an important tool for the management of the *** use of the molecular technique PCR,which allows the detection of the viral RNA through nasopharyngeal swabs,is considered the gold standard test for the diagnosis of ***,serological methods,such as enzyme-linked immunosorbent assays and rapid tests,are able to detect severe acute respiratory syndrome coronavirus 2-specific immunoglobulin A,immunoglobulin m,and immunoglobulin G in positive patients,being important alternative techniques for the diagnostic establishment and epidemiological *** the other hand,reverse transcription loop-mediated isothermal amplification also proved to be a useful diagnostic method for the infection,mainly because it does not require a sophisticated laboratory apparatus and has similar specificity and sensitivity to ***,imaging exams provide findings of typical pneumonia,such as the ground-glass opacity radiological pattern on chest computed tomography scanning,which along with laboratory tests assist in the diagnosis of COVID-19.

关键词： COVID-19 Pandemic Diagnosis Polymerase chain reaction molecular biology Serology