检索结果-南通市图书馆

Sickle Crisis Precipitated by Pneumonia: A Diagnostic and Therapeutic Challenge

Journal of Biosciences and Medicines 2025年第1期13卷 255-263页

作者： David Fernando Ortiz-Pérez Luisa mar.a Petro-Noriega mar.arita Rosa Burgos-Peña marlon José Rosado-Mendoza Santiago Sánchez-rojas Cristina De Jesús Portillo-Monterrosa Daniel de Jesús González-Villarreal Juan Pablo de la Ossa Díaz John Sebastián Osorio-Muñoz Manuel Esteban Ortiz Pérez Ana mar.a García-Suárez Department of Internal Medicine Cartagena del Mar Medical Center Cartagena Colombia Internal Medicine Program Universidad del Sin Cartagena Colombia Faculty of General Medicine Universidad del Sin Cartagena Colombia Faculty of General Medicine Universidad Surcolombiana Neiva Colombia Faculty of General Medicine Universidad de Sucre Sincelejo Colombia Faculty of General Medicine Universidad Libre Barranquilla Colombia Faculty of General Medicine Fundacin Universitaria Navarra Neiva Colombia Faculty of General Medicine Universidad de Cartagena Cartagena Colombia

Sickle cell anemia (SCA) is a prevalent genetic disorder primarily affecting individuals of African descent and populations in malaria-endemic regions, with significant global public health implications. Sickle cell crises are their most common acute complication, characterized by episodes of intense pain and systemic manifestations that impair quality of life and impose a high healthcare burden. We present the case of a 19-year-old male diagnosed with SCA since the age of two, who developed a sickle cell crisis precipitated by right basal pneumonia. The patient exhibited sudden-onset, cyclic lumbar pain with progressive dyspnea. Initial management included multimodal pain control, volume optimization, and targeted antimicrobial therapy to achieve clinical stabilization. This case underscores the importance of a comprehensive approach to managing sickle cell crises, addressing both symptomatic relief and the prevention and treatment of complications. It also highlights the need for public health strategies promoting early diagnosis, access to disease-modifying therapies such as hydroxyurea, and interdisciplinary follow-up to mitigate the socioeconomic and clinical impact of SCA.

关键词： Sickle Cell Anemia Sickle Cell Crisis Pain Management Pneumonia Hydroxyurea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Periodic Solutions in Unbounded Domains for the Boussinesq System

引用

Acta Mathematica Sinica,English Series 2010年第5期26卷 837-862页

作者： Elder Jesús VILLAMIZAR-ROA mar.a ngeles RODRíGUEZ-BELLIDO marko Antonio rojas-MEDAR Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Special Case on the Stability and Accuracy for the 1D Heat Equation Using 3-Level and <i>θ</i>-Schemes

引用

Applied Mathematics 2015年第3期6卷 476-483页

作者： Pedro Pablo Cárdenas Alzate José Gerardo Cardona luz mar.a rojas Department of Mathematics Universidad Tecnol&oacute gica de Pereira Pereira Colombia Fundació n Universitaria del Area Andina Pereira Colombia

We establish the conditions for the compute of the stability restriction and local accuracy on the time step and we prove the consistency and local truncation error by using θ-scheme and 3-level scheme for Heat Equat... 详细信息

关键词： Global Truncation Local Accuracy Stability Restriction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

引用

World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： Jaime Toral-Lopez luz mar.a González Huerta Olga Messina-Baas Sergio A Cuevas-Covarrubias Departamento de Genética Medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México Departamento de Biología Molecular Hospital General de MéxicoCuauhtémoc 06720México Departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUMmarY The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary manifestations in inflammatory bowel disease: The gut,the drugs and the liver

引用

World Journal of Gastroenterology 2013年第42期19卷 7327-7340页

作者： mar.a rojas-Feria Manuel Castro Emilio Suárez Javier Ampuero Manuel Romero-Gómez Unit for Medical and Surgical Management of Digestive Diseases and CIBERehd Valme University HospitalUniversity of SevilleE-41014 SevillaSpain

Abnormal liver biochemical tests are present in up to30%of patients with inflammatory bowel disease(IBD),and therefore become a diagnostic *** and biliary tract diseases are common extraintestinal manifestations for both Crohn’s disease and ulcerative colitis(UC),and typically do not correlate with intestinal *** sclerosing cholangitis(PSC)is the most common hepatobiliary manifestation of IBD,and is more prevalent in *** 5%of patients with UC develop PSC,with the prevalence reaching up to 90%.Cholangiocarcinoma and colon cancer risks are increased in these *** common disorders include autoimmune hepatitis/PSC overlap syndrome,IgG4-associated cholangiopathy,primary biliary cirrhosis,hepatic amyloidosis,granulomatous hepatitis,cholelithiasis,portal vein thrombosis,liver abscess,and non-alcoholic fatty liver *** B reactivation during immunosuppressive therapy is a major concern,with screening and vaccination being recommended in serologically negative cases for patients with *** prophylaxis with entecavir or tenofovir for 6to 12 mo after the end of immunosuppressive therapy is mandatory in patients showing as hepatitis B surface antigen(HBsAg)positive,independently from viral *** negative and anti-HBc positive patients,with or without anti-HBs,should be closely monitored,measuring alanine aminotransferase and hepatitis B virus DNA within 12 mo after the end of therapy,and should be treated if the viral load *** the other hand,immunosuppressive therapy does not seem to promote reactivation of hepatitis C,and hepatitis C antiviral treatment does not influence IBD natural history *** of the drugs used for IBD treatment may induce hepatotoxicity,although the incidence of serious adverse events is *** in liver biochemical tests associated with aminosalicylates are uncommon and are usually not clinically *** hepatotoxicity has been describ

关键词： Inflammatory bowel disease Hepatobiliary disorders Extraintestinal manifestations Primary sclerosing cholangitis Drug-induced liver injury Hepatotoxicity Hepatitis B Hepatitis C

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

引用

Journal of Clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela rojas mar.a Rosario García-Lozano Antonio Gil-Gómez Manuel Romero-Gómez Javier Ampuero Department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain SeLiver group at the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Institute of HealthMadridSpain De-partment of Organic and Medicinal Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HSC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HSCs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC *** mechanisms are plausible antifibrotic targets in NASH,as the activation of HSCs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease Cirrhosis Fibrosis Glutaminoly-sis Ammonia Urea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inflammatory bowel disease and celiac disease:Overlaps and differences

引用

World Journal of Gastroenterology 2014年第17期20卷 4846-4856页

作者： Virginia Pascual Romina Dieli-Crimi Natalia López-Palacios Andrés Bodas luz mar.a Medrano Concepción Nú?ez UGC de Inmunología Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Servicio de Digestivo Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Servicio de Pediatría Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain

Recent findings demonstrate the common genetic basis for many immune-mediated diseases, and consequently, the partially shared pathogenesis. We collected these findings and reviewed the extension of these overlaps to other disease characteristics. Two autoimmune diseases were selected that also share the specific target organ, the bowel. The etiology and immunopathogenesis of both conditions characterized by chronic intestinal inflammation, inflammatory bowel disease (IBD) and celiac disease (CeD), are not completely understood. Both are complex diseases with genetics and environment contributing to dysregulation of innate and adaptive immune responses, leading to chronic inflammation and disease. CeD constitutes a particular disease because the main environmental and genetic triggers are largely known. IBD comprises two main clinical forms, Crohn’s disease and ulcerative colitis, which most likely involve a complex interplay between some components of the commensal microbiota and other environmental factors in their origin. These multifactorial diseases encompass a broad spectrum of clinical phenotypes and ages of onset, although the clinical presentation often differs depending on childhood or adult onset, with greater heterogeneity commonly observed in adults.

关键词： Disease susceptibility Gene-environment interaction Immune system Inflammation Microbiota Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Role of Mutual Support Groups for the Control of Diabetes in a Mexican City: Achievements and Limitations from the Patients’ Perspective

引用

Health 2014年第15期6卷 1984-1993页

作者： luz mar.a Tejada-Tayabas mar.a Judith Rios Lugo Faculty of Nursing Autonomus University of San Luis Potosi San Luis Potosí México

Background: Mutual Support Groups (MSG) provides to the patient, the ability to effective self-management behaviors, such as taking prescribed medications, following diet and exercise regimens, self-monitoring, and coping emotionally with the rigors of living with diabetes. Physicians, nurses and health promoters from public primary Health Care Centers (HCC) are responsible for providing follow-up care through MSGs. However, although the MSG program has been carried out, in the last decade Mexico presents the most alarming statistics in the prevalence and complications of Diabetes Mellitus type II (DM-II), suggesting a low impact of MSG in the strategy to support the effective control of the disease. Objetive: The aim of this work was to assess whether knowledge or benefits of effective management to control of DM-II, also to identify strengths and limitations of MSGs, in six different Health Care Centers (HCC), in San Luis Potosi, Mexico. This research provides an overview of patients’ perception, and significant issues that demand to adjust MGSs strategies, with the goal of exceed the expectations of current health statistics. Methods: A qualitative evaluation was carried out, with an ethnographic approach design. The study included 28 diabetic persons, (21 women and 7 men from ruraland urban carecenters). Semi-structured interviews, non-participant observation, and structured content analysis were used. Results: Support groups give patients a way to address emotional issues, and learn about their disease and self-care, although some patients consider participation an inconvenient obligation. Support group users mention barriers such as lack of continuity in support group activities, inconvenient meeting times, and the difficulty of commuting to attend group sessions. They also mention that overworked health care workers find it difficult to provide leadership to keep the group going. These issues have multiple implications for the success of strategies to control

关键词： Mutual Support Group Diabetes Mellitus Qualitative Research Health Care Services Mexico

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards curative therapy in gastric cancer:Faraway, so close!

引用

World Journal of Gastroenterology 2015年第41期21卷 11609-11620页

作者： marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo luz Carolina Palmela mar.a Santos Fábio Lopes Rui Maio Gastroenterology Department Surgery and Oncology ClinicsHospital Beatriz Angelo

Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments.

关键词： Gastric cancer Multidisciplinary treatment Therapeutic strategies Curative surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feynman integrals and hypergeometric functions

引用

International Journal of Modeling, Simulation, and Scientific Computing 2014年第S1期5卷 1-13页

作者： Héctor Luna García luz mar.a García Departamento de Ciencias Básicas UAM-Azcapotzalco Av.San Pablo 18002200MéxicoD.F.México

We review Davydychev method for calculating Feynman integrals for massive and no massive propagators,by employing Mellin-Barnes transformation and the dimensional regularization scheme,same that lead to hypergeometric... 详细信息

关键词： Quantum field theory propagators dimensional regularization Mellin-Barnes integrals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：