检索结果-南通市图书馆

Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

引用

World Journal of Hepatology 2022年第4期14卷 719-728页

作者： Milena Lima Rodrigues Tatiane Priscila Santos Rodrigues da luz Caroline Louise Diniz Pereira Andrea Dória Batista Ana Lúcia Coutinho Domingues Ricardo Oliveira Silva Edmundo Pessoa Lopes Programa de Pós-Graduação em Medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em Química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital das Clínicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The evaluation of periportal fibrosis(PPF)is essential for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography,^(1)H-nuclear magnetic resonance(NMR)-based metabonomics has been employed to assess liver fibrosis in some *** To build 1H-NMR-based metabonomics models(MM)to discriminate mild from significant periportal PPF and identify differences in the metabolite *** A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern *** evaluated 41 serum samples from 10 patients with mild PPF(C Niamey pattern)and 31 patients with significant PPF(D/E/F Niamey patterns).MM were built using partial least squares-discriminant analysis(PLS-DA)and orthogonal projections to latent structures discriminant analysis(OPLS-DA)*** PLS-DA and OPLS-DA resulted in discrimination between mild and significant PPF groups with R2 and Q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model,*** OPLS-DA model presented accuracy,sensitivity,and specificity values of 92.7%,90.3%,and 100%to discriminate significant *** metabolites identified as responsible by discrimination were:Nacetylglucosamines,alanine,glycolaldehyde,carbohydrates,and *** MMs discriminated mild from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

关键词： Metabolomics Portal hypertension Schistosoma mansoni Biomarkers Neglected disease Nuclear magnetic resonance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism:WLB-73502,an analgesic with improved efficacy and safety profile compared to strong opioids

引用

Acta Pharmaceutica Sinica B 2023年第1期13卷 82-99页

作者： Alba Vidal-Torres Begoña Fernández-Pastor Mónica García Eva Ayet Anna Cabot Javier Burgueño Xavier Monroy Bertrand Aubel Xavier Codony luz Romero Rosalía Pascual Maria Teresa Serafini Gregorio Encina Carmen Almansa Daniel Zamanillo Manuel Merlos JoséMiguel Vela WeLab Barcelona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids are the most effective painkillers,but their benefit-risk balance often hinder their therapeutic ***-73502 is a dual,bispecific compound that binds sigma-1(S1R)and mu-opioid(MOR)***-73502 is an antagonist at the *** behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificantβ-arrestin-2 recruitment,thus demonstrating low intrinsic efficacy on MOR at both signalling *** its partial MOR agonism,WLB-73502exerted full antinociceptive efficacy,with potency superior to morphine and similar to oxycodone against nociceptive,inflammatory and osteoarthritis pain,and superior to both morphine and oxycodone against neuropathic ***-73502 crosses the blood-brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive *** to morphine and oxycodone,tolerance to its antinociceptive effect did not develop after repeated 4-week ***,contrary to opioid comparators,WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy,and it was devoid of proemetic effect(retching and vomiting)in ferrets at potentially effective ***-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.

关键词： WLB-73502 Sigma-1 receptor Mu-opioid receptor Biased agonist Analgesic activity Chronic pain Neuropathic pain Safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three Uncommon Seaweeds of the Pacific Coast of Mexico

引用

American Journal of Plant Sciences 2015年第19期6卷 3187-3192页

作者： A. Catalina Mendoza-González luz Elena Mateo-Cid Deisy Yazmín García-López Departamento de Botánica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Campus Santo Tomás México City México

This report describes a new record and two unusual and rare species of marine algae collected from Oaxaca, Michoacán, Jalisco and Baja California Sur at Mexican Pacific coast. Boodleopsis verticillata is the first record in the Pacific shore of Mexico, in the case of Melobesia polystromatica, this is the sixth record at tropical Pacific while Litholepis sonorensisis reported for the third time in the Gulf of California. These results suggest that the taxonomic inventory of seaweed in the Pacific coast of Mexico is not yet complete, so attention must be given to the epiphytes, and other small and delicate species that inhabit the coast of Mexico. Morphological descriptions, distributional range, reproductive stage and samples examined are included.

关键词： Bryopsidales Corallinales Distribution New Records Seaweeds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of Solid Acid Catalysts Based on TiO2- SO42-and Pt/TiO2- SO42-Applied in n-Hexane Isomerization

引用

Open Journal of Metal 2013年第3期3卷 34-44页

作者： Juan Manuel Hernández Enríquez luz Aracely Cortez Lajas Ricardo García Alamilla Estefanía ángeles San Martín Pedro García Alamilla Edward Brent Handy Guadalupe Cárdenas Galindo luz Arcelia García Serrano CIEP Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí Av. Dr. Manuel Nava #6 Zona Universitaria 78210 San Luis Potosí San Luis Potosí México Instituto Politécnico Nacional Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo 30 de Junio #1520 Barrio La Laguna Ticomán 07340 México D.F. México Instituto Tecnológico de Cd. Madero División de Estudios de Posgrado e Investigación Juventino Rosas y Jesús Urueta S/N Col. Los Mangos 89440 Cd. Madero Tamaulipas México Universidad Juárez Autónoma de Tabasco División Académica de Ciencias Agropecuarias Avenida Universidad S/N Zona Cultura Colonia Magisterial 86040 Villahermosa Tabasco México

The physicochemical properties and catalytic activity of pure and sulfated titanium oxide (TiO2 and ) is described in this work. Titanium hydroxide synthesized by the sol-gel method was impregnated with a 1 N H2SO4 solution, varying amount of sulfate ions () in the range from 10 to 20 wt%. Pure and modified hydroxides were calcined at 500°C for 3 h and then characterized by TGA-DTG, XRD, BET, FT-IR, potentiometric titration with n-butylamine and 2-propanol dehydration. Catalytic activity of materials was tested in the n-hexane isomerization at 350°C. The results showed that TiO2 and mainly developed anatase phase. All have acceptable specific surface area (95-105 m2/g). Potentiometric titration with n-butylamine revealed that showed higher acidity (430-530 mV) than compared to pure TiO2 (﹣15 mV), indicating that this oxide only has weak acidity. The results showed good relationship between acidity determined by potentiometric titration with n-butylamine and the catalytic activity evaluated by 2-propanol dehydration and n-hexane isomerization. Titanium oxide with 20 wt% ofions was the material that demonstrated the highest catalytic activity for both reactions.

关键词： Acid Catalysts Sulfated Titanium Oxide Physico-Chemical Properties n-Hexane Isomerization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prediction of hepatocellular carcinoma biological behaviorin patient selection for liver transplantation

引用

World Journal of Gastroenterology 2016年第1期22卷 232-252页

作者： Umberto Cillo Tommaso Giuliani Marina Polacco luz Maria Herrero Manley Gino Crivellari Alessandro Vitale Hepatobiliary Surgery and Liver Transplantation Unit Department of General Surgery and Organ TransplantationUniversity Hospital of Padua35128 PadovaItaly UnitàOperativa di Oncologia Medica Istituto Oncologico Veneto(IOV)IRCCS35128 PadovaItaly

Morphological criteria have always been considered the benchmark for selecting hepatocellular carcinoma(HCC)patients for liver transplantation(LT).These criteria,which are often inappropriate to express the tumor’s biological behavior and aggressiveness,offer only a static view of the disease burden and are frequently unable to correctly stratify the tumor recurrence risk after ***-fetoprotein(AFP)and its progression as well as AFP-m RNA,AFP-L3%,des-γ-carboxyprothrombin,inflammatory markers and other serological tests appear to be correlated with post-transplant *** other markers for patient selection including functional imaging studies such as18F-FDG-PET imaging,histological evaluation of tumor grade,tissue-specific biomarkers,and molecular signatures have been outlined in the *** growth rate and response to pre-transplant therapies can further contribute to the transplant evaluation process of HCC *** AFP,its progression,and HCC response to pretransplant therapy have already been used as a part of an integrated prognostic model for selecting patients,the utility of other markers in the transplant setting is still under *** article intends to review the data in the literature concerning predictors that could be included in an integrated LT selection model and to evaluate the importance of biological aggressiveness in the evaluation process of these patients.

关键词： Hepatocellular carcinoma Liver Alphafetoprotein Transplantation Biomarkers Histopathology Recurrence Integrated prognostic tool

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of the Acoustic Impact of Wind Farm Projects: Methodology and Case

引用

Journal of Geoscience and Environment Protection 2018年第1期6卷 99-110页

作者： Jose Molina-Ruiz Mari luz García-Lorenzo María José Martínez-Sánchez Diego Gallego Department of Geography Faculty of Geography University of Murcia Murcia Spain Department of Mineralogy and Petrology Faculty of Geology University Complutense of Madrid Madrid Spain Department of Agricultural Chemistry Geology and Pedology Faculty of Chemistry University of Murcia Murcia Spain Diego Gallego Cambronero Departamento Ecologia Faculty of Sciences University of Alicante Alicante Spain

Wind energy is a clean renewable and its benefits are considered greater than the disadvantages. However, even though wind farms represent environmentally friendly projects, they frequently generate public resistance. Wind turbines are socially controversial because of their visual and acoustic impacts. The aim of this work was to design a methodology for the preliminary evaluation of potential acoustic impact of wind farms. Three steps have been proposed: identification, characterization and assessment of the acoustic impact during the construction, operation and decommissioning phase. Obtained results in the studied area suggested that at a maximum power, at 500 meters of wind turbines, noise level is lower than the reference level established in the legislation. In summary, proposed methodology could help to determine and to evaluate the best location for new wind farm projects. Proposed methodology could help to determine and to evaluate the best location for new wind farm projects. Moreover, this method could be used as a consulting tool for public organizations and private institutions, being quick, concise and clear. Obtained results for the studied wind farm project suggested that almost all the area showed noise levels lower than established background noise level.

关键词： Wind Turbine Environmental Impact Assessment Acoustic Impact Wind Farm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simulaccion Processes of a Mathematical Model to Determine the Growth of Tomato under Plastic Cover

引用

Agricultural Sciences 2015年第12期6卷 1532-1537页

作者： luz Elva Marín Vaca Martha Lilia Domínguez Patino Nadia Lara Ruiz Miguel Aguilar Cortes Centro de Investigacion en Ingenieria y Ciencias Aplicadas Universidad Autonoma del Estado de MorelosCuernavacaMexico Facultad de Ciencias Quimicas e Ingenieria Universidad Autonoma del Estado de MorelosCuernavacaMexico

The tomato is one of the horticultural crops of the greatest economic value;for this reason, flexibility of management is usable. The population density in a crop of vegetables is determined by the distance between the plants and so it is necessary to choose the number of plants per square meter since the saturation of plants will lead to competition between sunlight, nutrients and weed. The objective of this work is to make the appropriate investigation for the use of the model proposed in order to describe the growth of tomato in greenhouse to high density of two plants per container to two bunches per plant, resulting in eight plants per square meter to grow, by means of a simulator of growth by computer. Of this work, it is concluded that it is possible to use the model to describe the growth of plants, and in the near future it will be possible to develop a simulator by computer of the growth of these crops in order to improve their quality and increase their production.

关键词： Simulation Plastic Cover Tomato

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Do Pregnant Teens Have Higher Risk of Intimate Partner Violence than Pregnant Adult Women in Mexico?

引用

Health 2014年第20期6卷 2814-2824页

作者： Rosario Valdez Santiago Mariana Mojarro Iñ iguez Elisa Hidalgo Solorzano Leticia Avila Burgos luz Arenas Monreal WHO Collaborating Centre for Injuries and Violence Research National Institute of Public Health (INSP/Mexico) Cuernavaca Mexico

Objective: The objective of the study is to estimate the prevalence of Intimate Partner Violence (IPV) and identify factors linked to it in pregnant Mexican adult and adolescent women. Methods: Data were gathered by the National Survey of Violence against Women (2006), applied to women between the ages 15-49, users of Mexican public health institutions. Multinomial logistic regression analyses were performed to explore the significant factors associated with IPV against pregnant women. Results: Both adolescent and adult study participating women showed a 24% prevalence of current IPV (during the previous 12 months). The study’s multivariate model for adult women revealed the following as main predictors for IPV: a woman’s agreement with traditional gender roles (OR = 4.35, CI95% = 2.20 - 8.60), and women with a history of childhood sexual abuse (OR = 2.76, CI95% = 1.68 - 4.55). The main predictor of IPV in pregnant adolescents was their partners’ frequency of alcohol consumption: often/usually (OR = 6.49, CI95% = 2.18 - 19.33). Conclusion: To this date, Mexico has not been able to guarantee universal screening methods for IPV as a part of prenatal care protocols. The phenomenon of IPV towards pregnant women neither has been followed-up by further research nor has been identified as a public health problem in spite of the seriousness of its implications for women and their offspring.

关键词： Partner Violence in Pregnancy Adolescents & Adults Mexico

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

把孩子照片画成插画

引用

中外文摘 2017年第9期 I0002-I0003页

作者： Maria Jose Da luz

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxoplasmosis among pregnant women:High seroprevalence and risk factors in Kinshasa,Democratic Republic of Congo

引用

Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 69-74页

作者： Doudou Yobi Renaud Piarroux Coralie L'Ollivier Jacqueline Franck Hypolite Situakibanza Hypolite Muhindo Patrick Mitashi Raquel Andreia Inocencio da luz Marc Van Sprundel Marleen Boelaert Jean-Pierre Van Geertruyden Pascal Lutumba Kinshasa University Democratic Republic of Congo University Hospital of Timone University of Antwerp Institute of Tropical Medicine Institut National de Recherche Biomedicale KinshasaDemocratic Republic of Congo

Objective:To determine the seroprevalence of toxoplasmosis in pregnant women,as well as the proportion of acutely infected and risk factors in the Democratic Republic of ***:Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to *** were interviewed with a structured questionnaire about known risk factors(age,meat consumption,contact with soil,and presence of cat)and a venous blood sample was *** were analysed for total immunoglobulins(Ig)by VIDAS Toxo Competition using Enzyme Linked Fluorescent *** was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG ***:A total of 781 women were *** age was 28 years old(IQR:8.S).And 627women(80.3%;95%CI:77.5-83.1)were found to be positive to total Ig and 17 out of 387(4.4%;95%CI:2.3-6.4)were positive to *** avidity was low for 2(11.8%)women,intermediate for 2(11.8%)and high for 13 women(76.4%).There was no statistically significant association between Toxoplasma gondii infection and any risk factors ***:In Kinshasa,toxoplasmosis endemicity is highly *** woman out of twenty five had a recent toxoplasmosis infection and 20%were not protected against primoinfection,indicating a need for measures to prevent and control toxoplasmosis during pregnancy.

关键词： Seroprevalence Toxoplasmosis Pregnant women Kinshasa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：