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Prediction of hepatocellular carcinoma biological behaviorin patient selection for liver transplantation

World Journal of Gastroenterology 2016年第1期22卷 232-252页

作者： Umberto Cillo Tommaso Giuliani Marina Polacco luz maria herrero manley Gino Crivellari Alessandro Vitale Hepatobiliary Surgery and Liver Transplantation Unit Department of General Surgery and Organ TransplantationUniversity Hospital of Padua35128 PadovaItaly UnitàOperativa di Oncologia Medica Istituto Oncologico Veneto(IOV)IRCCS35128 PadovaItaly

Morphological criteria have always been considered the benchmark for selecting hepatocellular carcinoma(HCC)patients for liver transplantation(LT).These criteria,which are often inappropriate to express the tumor’s biological behavior and aggressiveness,offer only a static view of the disease burden and are frequently unable to correctly stratify the tumor recurrence risk after ***-fetoprotein(AFP)and its progression as well as AFP-m RNA,AFP-L3%,des-γ-carboxyprothrombin,inflammatory markers and other serological tests appear to be correlated with post-transplant *** other markers for patient selection including functional imaging studies such as18F-FDG-PET imaging,histological evaluation of tumor grade,tissue-specific biomarkers,and molecular signatures have been outlined in the *** growth rate and response to pre-transplant therapies can further contribute to the transplant evaluation process of HCC *** AFP,its progression,and HCC response to pretransplant therapy have already been used as a part of an integrated prognostic model for selecting patients,the utility of other markers in the transplant setting is still under *** article intends to review the data in the literature concerning predictors that could be included in an integrated LT selection model and to evaluate the importance of biological aggressiveness in the evaluation process of these patients.

关键词： Hepatocellular carcinoma Liver Alphafetoprotein Transplantation Biomarkers Histopathology Recurrence Integrated prognostic tool

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Genetic variation at the p53 locus of two ecologically divergent Microtus pine voles:identification of molecular markers for species assignment

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Integrative Zoology 2022年第6期17卷 1179-1192页

作者： Ana Sofia QUINA João Paulo TAVANEZ maria da luz MATHIAS CESAM-Centro de Estudos do Ambiente e do Mar Departamento de BiologiaUniversidade de AveiroAveiroPortugal CESAM-Centro de Estudos do Ambiente e do Mar Faculdade de CiênciasUniversidade de LisboaLisboaPortugal Departamento de Biologia Animal Faculdade de CiênciasUniversidade de LisboaLisboaPortugal Global Health and Tropical Medicine(GHTM) Instituto de Higiene e Medicina Tropical(IHMT)Universidade NOVA de Lisboa(UNL)Portugal

The Lusitanian(Microtus lusitanicus)and the Mediterranean(Microtus duodecimcostatus)pine voles are recently diverged sister species endemic of the Iberian Peninsula that can be identiﬁed with ecological and morphological characters,but in areas where the 2 species co-occur,species designation may be difﬁ*** discrimination between *** and *** has not been achieved yet possibly because of their estimated re-cent split and an evolutionary history that includes inter-species geneﬂ*** our previous observations on exons 5–7 of the p53 gene,here we analyze the potential use of the p53 genomic region as a discrimination marker of these species by extending our analyses to several kb upstream and downstream of the p53 gene and charac-terizing the degree of genetic differentiation in 7 markers within this ***,we fully sequenced the P53 protein of both *** observed:(i)generally high differentiation in this region;(ii)*** showed in general higher values of nucleotide and haplotype diversities;(iii)the concatenated phylogenetic tree separates the 2 species;(iv)the 2 P53 proteins only differ in 1 amino acid;(v)4 of the markers,2 in p53,one in Atp1b2,and another in Wrap53,contain species-speciﬁc genetic variation thus allowing a reliable discrimination between specimens from both species,irrespective of sampling location or introgression *** provide ad-ditional data on the putative role of p53 in the evolution of these species and present researchers with a fast and cost-effective resource for *** and *** identiﬁcation.

关键词： ecological stress genetic variation Microtus molecular marker p53

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Using presence signs to discriminate between similar species

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Integrative Zoology 2009年第3期4卷 258-264页

作者： Sara M.SANTOS António P.MIRA maria luz MATHIAS Centre of Environmental Biology Department of Animal BiologyUniversity of LisbonLisbonPortugal and Institute of Mediterranean Agricultural Sciences Department of BiologyUniversity ofévoraévoraPortugal

The Lusitanian and the Mediterranean pine voles(Microtus lusitanicus Gerbe,1879 and Microtus duodecimcostatus de Selys-Longchamps,1839)are fossorial sister species and have an allopatric pattern of distribution in Portugal,which includes a potential sympatry area in the centre of the *** present study aimed to determine the validity of using presence signs in the field for discrimination of the two species in an area of sympatry(Northern Alentejo)and the characteristics that achieve the best classification accuracy.A total of 175 trapping plots were sampled across the study *** to the set up of traps,ten presence signs were randomly selected for measure-ments of four variables:proportion of soil mounds,mean diameter of mounds,proportion of burrow openings and mean diameter of burrow *** the basis of a classification tree analysis,results showed that presence signs can be used to discriminate plots inhabited by one or the other species in the studied sympatry *** character-istic that most accurately enables species identification is the proportion of burrow openings:for every ten pres-ence signs found in a plot,if more than eight have an opening,then it is inhabited by ***(*** burrow openings with few or no mounds present);if eight or fewer have an opening,*** is present(*** mounds with few or no burrow openings).

关键词： Microtus duodecimcostatus Microtus lusitanicus presence signs species identification.

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Optimization of the future remnant liver:review of the current strategies in Europe

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 350-363页

作者： Riccardo Memeo maria Conticchio Emmanuel Deshayes Silvio Nadalin Astrid herrero Boris Guiu Fabrizio Panaro Division of Hepato-Pancreato-Biliary Surgery Department of Surgery“F.Miulli”General HospitalAcquaviva delle FontiBariItaly Policlinico di Bari Aldo Moro UniversityBariItaly Department of Nuclear Medicine Institute du Cancer de Montpellier(ICM)MontpellierFrance INSERM U1194 Montpellier Cancer Research InstituteMontpellier UniversityMontpellierFrance Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenGermany Department of Surgery Division of HBP Surgery and Liver TransplantationSt-Eloi University HospitalMontpellierFrance Department of Radiology St-Eloi University HospitalMontpellierFrance

Liver resection still represent the treatment of choice for liver malignancies,but in some cases inadequate future remnant liver(FRL)can lead to post hepatectomy liver failure(PHLF)that still represents the most common cause of death after *** strategies in recent era have been developed in order to generate a compensatory hypertrophy of the FRL,reducing the risk of post hepatectomy liver *** vein embolization,portal vein ligation,and ALLPS are the most popular techniques historically adopted up to *** liver venous deprivation and the radio-embolization are the most recent promising *** even more precise tools to calculate the relationship among volume and function,such as scintigraphy with^(99m)Tc-mebrofenin(HBS),no consensus is still available to define which of the above mentioned augmentation strategy is more adequate in terms of kind of surgery,complexity of the pathology and quality of liver *** aim of this article is to analyse these different strategies to achieve sufficient FRL.

关键词： Liver resection future remnant liver(FRL) liver failure liver volume liver function hypertrophy

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A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility

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Asian Journal of Andrology 2021年第3期23卷 306-313页

作者： Julio Bunay luz-maria Gallardo Jorge Luis Torres-Fuentes M Veronica Aguirre-Arias Renan Orellana Nestor Sepulveda Ricardo D Moreno Physiology Department Faculty of Biological SciencesPontificia Universidad Cat6lica de Chile(PUC)Santiago 8331150Chile Department of Chemistry and Biological Sciences Health Sciences FacultyUniversidad Bernardo 0 HigginsSantiago 8370854Chile Center of Excellence in Biotechnology of Reproduction Universidad de la FronteraTemuco 4780000Chile.

Obesity is a major worldwide health problem that is related to most chronic diseases,including male *** to its wide impact on health,mechanisms underlying obesity-related infertility remain *** this study,we report that mice fed a high-fat diet(HFD)for over 2 months showed reduced fertility rates and increased germ cell apoptosis,seminiferous tubule degeneration,and decreased intratesticular estradiol(E2)and E2-to-testosterone ***,we also detected a decrease in testicular fatty acid levels,behenic acid(C22:0),and docosahexaenoic acid(DHA,22:6n-3),which may be related to the production of dysfunctional ***,we did not detect any changes in the frequency of seminiferous tubule stages,sperm count,or rate of in vitro ***,there was an increase in spontaneous and progesterone-induced acrosomal exocytosis(acrosome reaction)in spermatozoa from HFD-fed *** data suggest that a decrease in E2 and fatty acid levels influences spermatogenesis and some steps of acrosome biogenesis that will have consequences for ***,our results add new evidence about the adverse effect of obesity in male reproduction and suggest that the acrosomal reaction can also be affected under this condition.

关键词： cholesterol estradiol fat acid testis testosterone

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Retrograde intrarenal surgery:An expanding role in treatment of urolithiasis

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Asian Journal of Urology 2018年第4期5卷 264-273页

作者： maria Rodriguez-Monsalve herrero Steeve Doizi Etienne Xavier Keller Vincent De Coninck Olivier Traxer Department of Urology Tenon HospitalAssistance-Publique Hopitaux de ParisParisFrance

During the past 3 decades,the surgical management of kidney stones has undergone many technological advances and one is the development of the flexible *** development of this instrument as well as ancillary equipment such as baskets,graspers,and others,and improvements in lithotripsy with Holmium:YAG laser have led to expand its indications with diagnostic and therapeutic management of medical issues of the upper urinary tract such as urolithiasis and urothelial *** objective of this review is to describe its indications and results in the different scenarios for the treatment of urinary stones.

关键词： Ureteroscopy Retrograde intrarenal surgery Endourology Urolithiasis

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Effects of the allelopathic plant Artemisia herba-alba Asso on the soil seed bank of a semi-arid plant community

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Journal of Plant Ecology 2017年第6期10卷 927-936页

作者： Antonio I.Arroyo Yolanda Pueyo Ramón Reiné maria luz Giner Concepción L.Alados Instituto Pirenaico de Ecología(CSIC) Av.Montañana 1005P.O.Box 13.034Zaragoza 50080Spain Escuela Politécnica Superior(Universidad de Zaragoza) Ctra.Cuarte s/nHuesca 22071Spain

Aims Seed bank strongly influences composition and structure of above-ground *** attention has been paid to the role of allel-opathy driving soil seed bank dynamics,even though allelochemicals released by allelopathic plants might determine whether a species can or cannot germinate from the soil seed bank and,therefore,to co-exist in the neighborhood of the allelopathic ***,the effects of allelopathic plants on community organization through the effects of allelochemicals on soil seed bank remain largely *** this study,we assessed spatial heterogeneities in soil seed bank caused by the presence of allelopathic plants,and evaluated allelo-pathic effects on seed bank germination and seedling *** We examined the effects of the allelopathic shrub Artemisia herba-alba Asso on the spatial structure(in terms of species richness and seed density)of the soil seed bank of a semi-arid ecosystem in NE ***,we evaluated seed bank richness and density at three microsites:under the canopy of ***-alba individuals,under the canopy of Salsola vermiculata L.(a non-allelopathic shrub)individuals,and in bare *** addition,we assessed the effects of aqueous extract of ***-alba on soil seed bank germination(seed-ling emergence and emergence timing)and seedling *** Findings We found that seed bank richness and density were higher under shrub canopy than they were in bare ***-alba and *** microsites had similar seed bank ***,seed bank density was higher under ***-alba because of the high abundance of ***-alba *** extract reduced seedling emergence from the seed bank by 50%,and affected mortality of some emerged *** the other hand,aqueous extract did not influence the emergence timing of *** conclude that,although the presence of allelo-pathic plants does not cause relevant changes in seed bank struc-ture relative to similar non-allelopathi

关键词： allelopathic shrub aqueous extract Middle Ebro Valley seed bank inhibition seed bank density seedling emergence

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INFLUENCE OF THE THERMAL AND LIGHTING PERFORMANCE IN CLASSROOMS ON THE COGNITIVE PRODUCTIVITY OF STUDENTS IN COLOMBIA

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Journal of Green Building 2021年第4期16卷 135-164页

作者： Lucas Arango-Díaz Olga Lucía Montoya Flórez Laura Rendón Gaviria luz Magnolia Tilano Vega Carla maria Zapata Rueda Facultad de Artes Integradas.University of San Buenaventura Medellín Facultad de Arquitectura Arte y Diseño.University of San BuenaventuraCali Facultad de Psicología.University of San Buenaventura Medellín

This paper examines the influence of the thermal and lighting performance in classrooms on the cognitive productivity of students attending public schools in the principal three cities of Colombia:Bogota,Medellin and *** methodology used involves the application of cognitive performance tests and thermal and visual perception surveys,along with measurements of climatic parameters in 34 classrooms of 14 schools in 2017 and *** results were analyzed using transversal correlational *** the conclusions,this study found that the operative temperature turned out to be the most conclusive variable explaining cognitive performance relationships.

关键词： school classrooms environmental comfort thermal performance lighting performance cognitive performance and productivity

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Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

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World Journal of Gastroenterology 2012年第2期18卷 188-191页

作者： Roberto J Carvalho-Filho Janaína luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon maria Lucia G Ferraz Antonio Eduardo B Silva Division of Gastroenterology Hepatitis SectionFederal University of Sao Paulo04037-003 Sao PauloBrazil

Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected ***,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative *** describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without *** improvement was observed after antiviral *** discuss the spectrum of neurological manifestations of HCV infection and review the literature.

关键词： Hepatitis C Central nervous system Poly-neuropathy Interferon-α

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Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan Marcos Caram Costa Marina maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira Silva Marcel Silva luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

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