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Effectiveness of Opuntia ficus-indica mucilage as a carrier agent in microencapsulation of bioactive compounds of Amaranthus hypochondriacus var. Nutrisol

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Food Bioscience 2023年第2期52卷 468-478页

作者： Danger Tabio-Garcia Francisco Paraguay-Delgado Daniel Lardizabal Gutierrez Armando Quintero-Ramos Carmen O.Melendez-Pizarro luz a.ochoa-martinez Miguel A.Sanchez-Madrigal Martha G.Ruiz-Gutierrez Jose C.Espinoza-Hicks Universidad Autonoma de Chihuahua Facultad de Ciencias QuimicasCircuito Universitario s/nCampus Universitario#2ChihuahuaChihuahuaC.P.31125Mexico Centro de Investigacion en Materiales Avanzados S.C. CIMAVMiguel de Cervantes 120ChihuahuaChihuahuaC.P.31136Mexico Tecnologico Nacional de Mexico/IT de Durango Division de Estudios de Posgrado de InvestigacionBlvdFelipe Pescador 1830 OteColonia Nueva VizcayaC.P.34080DurangoDgoMexico

The effectiveness of maltodextrin(10%)and cactus mucilage(CM)(0%,0.25%,0.50%,0.75%,and 1%)as carrier agents was evaluated in the encapsulation of bioactive amaranth *** drying,an efficient encapsulation method,achieved high yields(62.9%-68%).The increase in CM concentration significantly augmented the water absorption index(WAI),bulk density,and hygroscopicity of the encapsulated amaranth ***,it significantly decreased the moisture content,water activity,and water solubility index(WSI).The glass transition temperatures(>40℃),Hausner ratio(HR),and Carr’s index(CI)values indicated the suitability of powders for handling and ***,no cracks were observed in the microcapsules surface,which favoured the bioactive amaranth compounds retention and ***,low degradation rate constants and long half-life time values were determined for the encapsulated amaranth powders,indicative of its storage *** of 0.75%CM was an efficient concentration to achieve high percentage retention of betacyanins(55.5%),betaxanthins(58%),total polyphenols(73.3%),amaranthine(56.8%),isoamaranthine(62.7%),individual polyphenols(44.6%-81%),and antioxidant activity(79.6%).These results demonstrated the efficiency of CM as an encapsulating agent in the food industry.

关键词： Amaranth Betalains Polyphenols Cactus Mucilage Microencapsulation

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Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis

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World Journal of Gastroenterology 2010年第12期16卷 1500-1505页

作者： Clara luz Sampieri Sol de la Pea Mariana.ochoa-Lara Roberto Zenteno-Cuevas Kenneth León-Córdoba Institute of Public Health Veracruzana University Biomedical Sciences Doctoral Program Institute of Health SciencesVeracruzana University Dr.Miguel Dorantes Mesa Hospital

AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase ***:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain *** was carried out using three different *** were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was moderately ***2 was highly expressed,while MMP9 was not detected or lowly expressed in normal tissues,moderately or highly expressed in gastritis and highly expressed in *** expression of 18SRNA and HPRT-1 showed no significant *** differences in MMP2 and MMP9 were found between cancer and normal tissue,but not between gastritis and normal *** quantification of MMP9 echoed this pattern,but differential expression of MMP2 proved *** by qGZ indicated significant differences between cancer and normal tissue in MMP-2,total MMP-9,250 and 110 kDa ***:MMP9 expression is enhanced in gastric cancer compared to normal mucosa;interpretation of differential expression of MMP2 is difficult to establish.

关键词： Gastric cancer Superficial gastritis Matrix metalloproteinases Quantitative real-time polymerase chain reaction Quantitative zymography

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Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

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World Journal of Gastroenterology 2020年第34期26卷 5101-5117页

作者： David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato Precision Medicine and Metabolism Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160BizkaiaSpain CIBERehd-Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas Madrid 28029Spain Department of Precision Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Liver Disease Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Proteomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain OWL Metabolomics Derio 48160Spain Instituto Biofisika(UPV/EHU CSIC)Leioa 48940SpainDepartamento de Bioquímica y Biología MolecularUniversidad del País VascoLeioa 48940Spain Pre-clinical and Chemistry Manufacturing and ControlsGalmed PharmaceuticalsTel Aviv 6578317Israel Metabolomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of *** a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic *** To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with *** Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 ***,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled *** the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 *** metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related *** Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in *** translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA ***,liver metabolomic analysis showed

关键词： Nonalcoholic fatty liver disease Steatohepatitis Methionine and choline deficient diet Tricarboxylic acid cycle Hemoglobin A1c Stearoyl-CoA desaturase 1

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