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The gene expression of adenosine receptors in the processes of contrast induced nephropathy in mouse kidney

World Journal of Cardiovascular Diseases 2013年第9期3卷 561-568页

作者： luyu yao Cynthia Zhao Xin Gu Gopi K. Kolluru Christopher G. Kevil Wayne W. Zhang Department of Pathology Louisiana State University Health Sciences Center Shreveport USA Department of Surgery Louisiana State University Health Sciences Center Shreveport USA

Objective: Contrast induced nephropathy (CIN) is the third leading cause of hospital acquired renal failure. The mechanism of CIN is not fully understood. The objectives of this study were to investigate the expression changes of the four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, and A3AR) following administration of contrast media in mice. Methods: C57BL/6J mice were randomized into treatment and control groups. Iodixanol (IDX) was administered to two treatment groups through retroorbital injection at two different dosages, 0.75 gI/kg and 2.75 gI/kg. Phosphate buffered saline (PBS) was given to the control group. Mice kidneys were harvested at day 3 and day 7 after Iodixanol administration. Kidney injuries and function were evaluated according to Hematoxylin and eosin stain, Ki67 protein expression, and TUNEL assay of paraffin embedded kidney sections, and plasma creatinine assay. RNA and protein were extracted from the kidney specimens. A1AR, A2AAR, A2BAR, and A3AR RNA and protein level of the samples were assessed using qRT-PCR and Western blotting, with GAPDH as an endogenous control. Results: H&E staining showed no significant histopathology injuries after Iodixanol administration. No evidence of kidney injury and functional impairment was found. However, there was an increased number of A1AR, A2AAR, A2BAR, and A3AR RNA transcripts detected in the kidney 3 days after Iodixanol injection. The RNA levels in all the four subtypes of adenosine receptors were increased 2-3 fold in the day 3 specimens and back to normal at day 7. Western blot demonstrated that A1AR, A2AAR, and A3AR expression increased 1.5 to 2 fold at day 3 and day 7 following Iodixanol injection. A2BAR baseline expression was low in normal physiological conditions and no significant change was detected by Western blot. Conclusions: Iodixanol significantly increases adenosine receptors gene expression in mice. This suggests that adenosine receptors may play a role in the development of CI

关键词： Contrast Induced Nephropathy Adenosine Receptor Iodixanol

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高斯激光非准直性对激光会聚铬原子沉积的影响

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光学学报 2015年第6期35卷 13-17页

作者：张宝武姚芦鹬陈君王道档中国计量学院计量测试工程学院浙江杭州310018 中国计量学院光学与电子科技学院浙江杭州310018

通过数值计算,仿真研究了高斯激光情况下基片表面不同位置处激光会聚铬原子沉积条纹结构的一致性.研究结果显示高斯激光束构成的光学势阱沿激光中轴线和垂直于激光中轴线两个方向相对于准直高斯激光都有独特的分布结构.这种独特的结构... 详细信息

通过数值计算,仿真研究了高斯激光情况下基片表面不同位置处激光会聚铬原子沉积条纹结构的一致性.研究结果显示高斯激光束构成的光学势阱沿激光中轴线和垂直于激光中轴线两个方向相对于准直高斯激光都有独特的分布结构.这种独特的结构导致铬原子运动轨迹相对于波节位置对称性的破坏,进而导致沉积条纹结构发生变化:在沿激光中轴线方向上,x0从0 mm变化到-50 mm过程中,铬原子的运动轨迹最终的聚集区域相对于波节慢慢失去对称性,并且向x0绝对值较小的一边偏离波节位置;铬原子沉积条纹的半峰全宽、中心峰值和中心线相对于波节的偏移量都随x0的变化而趋向线性变化.其中,半峰全宽约有8 nm的增宽,中心峰值约有50个单位的减少量,中心线相对于波节的偏移量约有15 nm的增大量.

关键词：高斯激光激光会聚铬原子

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几种OCT图像散斑降噪算法的研究与比较

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中国计量学院学报 2015年第3期26卷 336-340页

作者：姚芦鹬余桂英张宝武毕凯王毅中国计量学院计量测试工程学院浙江杭州310018

为了探究光学相干层析技术(optical coherence tomography,OCT)中图像散斑的降噪处理方法,以提高图像质量,于是采用猪胃和泡沫塑料管为对象,对比研究了中值滤波、维纳滤波、小波滤波和各向异性扩散法对OCT图像散斑的降噪效果,并且通过... 详细信息

为了探究光学相干层析技术(optical coherence tomography,OCT)中图像散斑的降噪处理方法,以提高图像质量,于是采用猪胃和泡沫塑料管为对象,对比研究了中值滤波、维纳滤波、小波滤波和各向异性扩散法对OCT图像散斑的降噪效果,并且通过信噪比(SNR)、等效视数(ENL)和散斑指数(Speckle-index)三个指标评价去噪效果,以此来弥补视觉对比的不足.结果表明,各向异性扩散算法不仅对OCT图像的散斑噪声具有最好的降噪效果,而且也较有效地保持了图像边缘信息.

关键词：光学相干层析技术散斑噪声降噪算法

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基于VirtualLab Fusion的TDOCT系统合成光源仿真

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中国计量大学学报 2016年第4期27卷 452-457页

作者：张宝武霍剑锋张明月刘媛媛余桂英姚芦鹬中国计量大学计量测试工程学院浙江杭州310018 比萨大学物理系意大利比萨56127

基于VirtualLab Fusion构建了时域光学相干层析技术(time domain optical coherence tomography,TDOCT)光路系统,导入不同颗数发光二极管(light emitting diode,LED)的合成光谱,从参考镜的位置变化中获得干涉信号,以此分析出合成光源的... 详细信息

基于VirtualLab Fusion构建了时域光学相干层析技术(time domain optical coherence tomography,TDOCT)光路系统,导入不同颗数发光二极管(light emitting diode,LED)的合成光谱,从参考镜的位置变化中获得干涉信号,以此分析出合成光源的半高宽和相干度,以及对应TDOCT的纵向分辨率.结果表明,合成光源的最大强度值随着LED颗数从1到10的增加先增加后趋向不变;而半高宽随之不断增加;TDOCT系统的纵向分辨率随之不断提高.当LED增加至3颗的时候,合成光源已经可以使TDOCT系统纵向分辨率提高至9.8μm,这与一颗超辐射发光二极管(super luminescent light-emitting diode,SLD)给出的分辨率级别相当.

关键词：光学相干层析技术 VirtualLab Fusion软件发光二极管合成光源

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电极电势的三种可视化方法辨析

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广州化工 2024年第19期52卷 11-13,47页

作者：王学琳韩威杨瑶黄婵田璐瑜邹光龙贵州民族大学数据科学与信息工程学院贵州贵阳550025 贵州民族大学化学工程学院贵州贵阳550025

电极电势作为衡量物质氧化还原能力强弱的依据,其数值的大小则反映了电对(氧化型/还原型)中得失电子的能力,它表征的是元素氧化数的相对稳定性以及是否发生歧化反应等。然而,传统的列表式电极电势无法全面了解某一种元素的相关氧化态,... 详细信息

电极电势作为衡量物质氧化还原能力强弱的依据,其数值的大小则反映了电对(氧化型/还原型)中得失电子的能力,它表征的是元素氧化数的相对稳定性以及是否发生歧化反应等。然而,传统的列表式电极电势无法全面了解某一种元素的相关氧化态,而用图解法讨论与某元素相关的电极电势不仅能克服上述的不便,而且会提供元素及其化合物的更多信息。从电极电势的三种主要可视化方法(元素电势图、电势-pH图和自由能(电势)-氧化数图)出发,系统全面地了解电势与浓度、温度和溶液酸度之间的关联情况,并举例介绍了它们的一些应用。

关键词：电极电势可视化元素电势图电势-pH图电势-氧化数图

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Numerical investigation on effects of side curtain opening behavior on indoor climate of naturally ventilated dairy buildings

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International Journal of Agricultural and Biological Engineering 2020年第5期13卷 63-72页

作者： Qifeng Li Chuanxia yao luyu Ding Ligen Yu Weihong Ma Ronghua Gao Wengang Zheng Beijing Research Center for Information Technology in Agriculture Beijing 100097China Beijing Research Center of Intelligent Equipment for Agriculture Beijing 100097China Beijing Academy of Agriculture and Forestry Sciences Beijing 100097China

The side-curtain is popular in cattle buildings to regulate indoor climates and ventilation rates by adjusting the opening *** normally had three different adjusting strategies relate to the position of rollers,*** roller(S1),top roller(S2)and bottom roller(S3),which result in different opening behaviors to generate the same opening ratio but different opening positions in the side wall for a full-curtain *** simulations were conducted using computational fluid dynamics(CFD)to investigate the effects of the eight potential opening behaviors of side curtains on the indoor climates and airflow rates in winter for a typical naturally ventilated dairy house in China when the opening ratio were 8.5%and 17%.Airflow patterns,wind chilled temperature(WCT)and age of air were analyzed in the animal occupied zone(AOZ)by taking reference *** at the very bottom of side walls had more efficient ventilation due to the younger air age,more effective air disturbing,more uniformly distributed indicators in ***,it will result in a lower WCT in AOZ although a lower ventilation rate was observed in this *** on the very top of side wall would generate a better thermal comfort in AOZ but with very poor air quality and nonuniformly distributed airflows in the dairy house.S1 was not recommended to the practical application due to the poor indoor climate and the higher cost of the mechanical *** on the comprehensive evaluations of the analytic hierarchy process,the most satisfaction opening positions were at the bottom of the side curtains and the optimized adjusting strategy is S2.

关键词： thermal comfort age of air ventilation rate computational fluid dynamics analytic hierarchy process

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Potential roles of the rectum keystone microbiota in modulating the microbial community and growth performance in goat model

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2048-2062页

作者： Dangdang Wang Guangfu Tang Lichao Zhao Mengya Wang luyu Chen Congcong Zhao Ziqi Liang Jie Chen Yangchun Cao Junhu yao College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiChina

Background Ruminal microbiota in early life plays critical roles in the life-time health and productivity of ruminant ***,understanding of the relationship between gut microbiota and ruminant phenotypes is very ***,the relationship between the rectum microbiota,their primary metabolites,and growth rate of a total of 76 young dairy goats(6-month-old)were analyzed,and then 10 goats with the highest or lowest growth rates respectively were further compared for the differences in the rectum microbiota,metabolites,and animal’s immune parameters,to investigate the potential mechanisms by which the rectum microbiota contributes to the health and growth *** The analysis of Spearman correlation and microbial co-occurrence network indicated that some keystone rectum microbiota,including unclassified Prevotellaceae,Faecalibacterium and Succinivibrio,were the key modulators to shape the rectum microbiota and closely correlated with the rectum SCFA production and serum IgG,which contribute to the health and growth rate of young *** addition,random forest machine learning analysis suggested that six bacterial taxa in feces could be used as potential biomarkers for differentiating high or low growth rate goats,with 98.3%accuracy of ***,the rectum microbiota played more important roles in gut fermentation in early life(6-month-old)than in adulthood stage(19-month-old)of *** We concluded that the rectum microbiota was associated with the health and growth rate of young goats,and can be a focus on the design of the early-life gut microbial intervention.

关键词： Early life Goat Growth performance Rectum microbiota SCFA

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Rumen bacterial cluster identification and its influence on rumen metabolites and growth performance of young goats

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Animal Nutrition 2023年第4期15卷 34-44页

作者： Dangdang Wang Guangfu Tang Yannan Wang Junjian Yu luyu Chen Jie Chen Yanbo Wu Yuanjie Zhang Yangchun Cao Junhu yao College of Animal Science and Technology Northwest A&F UniversityYangling712100ShaanxiChina Key Laboratory of Livestock Biology Northwest A&F UniversityYangling712100ShaanxiChina

Enterotypes,which are defined as bacterial clusters in the gut microbiome,have been found to have a close relationship to host metabolism and ***,this concept has never been used in the rumen,and little is known about the complex biological relationships between ruminants and their rumen bacterial *** this study,we used young goats(n=99)as a model,fed them the same diet,and analyzed their rumen microbiome and corresponding bacterial *** relationships between the bacterial clusters and rumen fermentation and growth performance in the goats were further *** bacterial clusters were identified in all goats:the P-cluster(dominated by genus Prevotella,n=38)and R-cluster(dominated by Ruminococcus,n=61).Compared with P-cluster goats,Rcluster goats had greater growth rates,concentrations of propionate,butyrate,and 18 free amino acids)and proportion of unsaturated fatty acids,but lower acetate molar percentage,acetate to propionate ratio,and several odd and branched chain and saturated fatty acids in rumen fluid(P<0.05).Several members of Firmicutes,including Ruminococcus,Oscillospiraceae NK4A214 group,and Christensenellaceae R-7 group were significantly higher in the R-cluster,whereas Prevotellaceae members,such as Prevotella and Prevotellaceae UCG-003,were significantly higher in P-cluster(P<0.01).Co-occurrence networks showed that R-cluster enriched bacteria had significant negative correlations with P-cluster enriched bacteria(P<0.05).Moreover,we found the concentrations of propionate,butyrate and free amino acids,and the proportions of unsaturated fatty acids were positively correlated with R-cluster enriched bacteria(P<0.05).The concentrations of acetate,acetate to propionate ratio,and the proportion of odd and branched chain and saturated fatty acids were positively correlated with P-cluster enriched bacteria(P<0.05).Overall,our results indicated that rumen bacterial clusters can influence rumen fermentation and growth performan

关键词： Rumen microbiota Bacterial cluster Rumen fermentation Growth performance Goat

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Estimating the air exchange rates in naturally ventilated cattle houses using Bayesian-optimized GBDT

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International Journal of Agricultural and Biological Engineering 2023年第1期16卷 73-80页

作者： luyu Ding Lei E Yang Lyu Chunxia yao Qifeng Li Shiwei Huang Weihong Ma Ligen Yu Ronghua Gao Information Technology Research Center Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China National Innovation Center of Digital Technology in Animal Husbandry Beijing 100097China Beijing Technology Innovation Strategic Alliance for Intelligence Internet of Things Industry in Agriculture Beijing 100097China Department of Agricultural Structure and Bioenvironmental Engineering College of Water Resources and Civil EngineeringChina Agricultural UniversityBeijing 100083China

It is challenging to estimate the air exchange rate(AER)dynamically in naturally ventilated livestock buildings such as dairy houses due to the influence of complex and variable outdoor environmental factors,large opening ratios,and the confusion of inflow and outflow at *** makes it difficult to efficiently regulate the opening ratio to meet the ventilation requirements in naturally ventilated livestock *** this study,the air exchange rates of naturally ventilated cattle houses(NVCHs)in different seasons and opening ratios were obtained through field measurements and computational fluid dynamics(CFD)simulations.A fast and efficient machine learning framework was proposed and examined to predict AER based on the gradient boosting decision tree(GBDT)combined with Bayesian *** with commonly used machine learning models such as multilayer perceptrons(MLPs)and support vector machines(SVMs),the proposed GBDT model has higher prediction accuracy and can avoid falling easily into local *** with the existing mechanical model based on the Bernoulli equation,the proposed GBDT model showed a slightly higher prediction than the mechanistic model and was much easier to use in AER estimation when inputting easily collected environmental factors in practical *** Bayesian optimization could dramatically reduce the computing time when determining the optimal hyperparameter for establishing the GBDT model,dramatically saving on computing *** on the Bayesian optimized GBDT model,the desirable opening ratio of the side curtain can be determined for automatically regulating the AER of cattle houses in future applications.

关键词： natural ventilation Bayesian GBDT air exchange rate cattle house

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灸法辅助治疗勃起功能障碍的临床疗效与安全性Meta分析

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中国性科学 2024年第7期33卷 103-108页

作者：李鲁豫琚保军李霄生旺张永涛马苗苗姚均超河南中医药大学第一临床医学院郑州450000 河南中医药大学第一附属医院男科郑州450000

目的系统评价灸法辅助治疗勃起功能障碍(ED)的临床疗效与安全性,为灸法的临床应用提供循证医学证据。方法计算机检索中国知网、万方、维普、SinoMed、PubMed、Embase和Cochrane数据库,搜索灸法辅助治疗ED的随机对照试验研究,检索时限从... 详细信息

目的系统评价灸法辅助治疗勃起功能障碍(ED)的临床疗效与安全性,为灸法的临床应用提供循证医学证据。方法计算机检索中国知网、万方、维普、SinoMed、PubMed、Embase和Cochrane数据库,搜索灸法辅助治疗ED的随机对照试验研究,检索时限从建库至2023年3月。由两位研究者独立进行文献筛选、资料提取和质量评价工作,采用RevMan 5.4软件进行Meta分析。结果最终纳入13个研究,共1175例研究对象。Meta分析结果显示:灸法辅助治疗ED与常规疗法相比,治疗总有效率提升(RR=1.23,95%CI:1.16~1.31,P<0.00001);国际勃起功能指数-5(IIEF-5)评分增加(MD=2.75,95%CI:2.38~3.12,P<0.00001);勃起硬度(EHS)评分增加,勃起硬度改善(MD=0.44,95%CI:0.30~0.58,P<0.00001);睾酮水平升高(MD=0.87,95%CI:0.66~1.08,P<0.00001);不良反应率显著降低(RR=0.41,95%CI:0.17~0.95,P=0.04)。结论灸法辅助常规疗法治疗ED,能有效提高治疗总有效率、IIEF-5评分、EHS评分及睾酮水平,降低不良反应率。

关键词：灸法勃起功能障碍阳痿 Meta分析

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