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常染色体隐性遗传性羊毛状发伴少毛症两家系基因突变分析

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中国麻风皮肤病杂志 2024年第4期40卷 234-238页

作者：赵安琪曹巧玉郑璐瑶刘庆梅李明吴文育赵敬军上海交通大学医学院附属新华医院皮肤科上海200092 上海交通大学医学院皮肤病研究所上海200092 复旦大学附属儿科医院皮肤科上海201102 安徽省儿童医院皮肤科安徽合肥230022 复旦大学附属华山医院皮肤科上海200040

目的:检测常染色体隐性遗传性羊毛状发伴少毛患者家系的致病基因。方法:收集2例中国汉族常染色体隐性遗传性羊毛状发伴少毛家系患者及其父母外周血标本,应用二代皮肤靶向测序包检测血样中DNA的基因突变,Sanger测序进行家系验证,Minigen... 详细信息

目的:检测常染色体隐性遗传性羊毛状发伴少毛患者家系的致病基因。方法:收集2例中国汉族常染色体隐性遗传性羊毛状发伴少毛家系患者及其父母外周血标本,应用二代皮肤靶向测序包检测血样中DNA的基因突变,Sanger测序进行家系验证,Minigene验证剪切突变致病性。结果:先证者1的LIPH基因检测到c.742C>A(***248Asn)和c.982+12A>G的复合杂合突变。先证者2的LIPH基因检测到c.629-1_629delinsTT和c.686delAinsGTAGAACCCAACCTGGCT的复合杂合突变。一代测序验证显示复合杂合突变分别来自母亲和父亲。LIPH c.982+12A>G和c.629-1_629delinsTT尚未报道过,Minigene验证发现,剪切突变c.982+12A>G会导致内含子滞留;剪切突变c.629-1_629delinsTT会导致外显子跳跃和外显子缺失。结论:本文报道了LIPH的两个新剪切突变,通过家系验证和Minigene验证了剪切突变的致病性,丰富了LIPH导致常染色体隐性羊毛状发伴少毛的突变谱。

关键词：常染色体隐性遗传性羊毛状发 LIPH基因剪切突变

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猴痘患者41例的临床特征分析

中华传染病杂志 2024年第4期42卷 210-213页

作者：张美彭芳阎本永房媛贾琳贾寒郑璐瑶刘志英汪雯黄晓婕张彤首都医科大学附属北京佑安医院感染与免疫医学科北京100069 宜春学院第二附属医院感染肝炎结核科宜春336000

目的分析总结猴痘患者的临床特征,提高临床医师对重症猴痘的认识,为临床诊治提供依据。方法回顾性分析2023年6月至11月收治于首都医科大学附属北京佑安医院41例猴痘患者的临床特征。根据患者临床表现分为轻症和重症,比较两组患者的实验... 详细信息

目的分析总结猴痘患者的临床特征,提高临床医师对重症猴痘的认识,为临床诊治提供依据。方法回顾性分析2023年6月至11月收治于首都医科大学附属北京佑安医院41例猴痘患者的临床特征。根据患者临床表现分为轻症和重症,比较两组患者的实验室检查结果。统计学分析采用曼-惠特尼U检验。结果41例猴痘患者的临床表现主要包括发热、皮疹和淋巴结肿大,5例重症猴痘患者可出现严重合并症,包括细菌性肺炎、Ⅰ型呼吸衰竭、真菌感染、阴茎或肛周干性坏疽、阴茎软组织水肿、肠梗阻、脓毒症休克、肛周脓肿和坏死性筋膜炎。重症猴痘患者的白细胞计数、中性粒细胞计数、C反应蛋白均明显高于轻症组患者[14.60(9.92,24.08)×10^(9)/L比6.41(5.64,8.37)×10^(9)/L,12.43(7.02,21.15)×10^(9)/L比3.35(2.46,5.03)×10^(9)/L,108.20(56.20,124.10)mg/L比16.6(6.25,49.98)mg/L];白蛋白、CD4+T淋巴细胞计数则明显低于轻症组患者[31.80(22.90,35.15)g/L比44.70(42.90,47.40)g/L,24.00(12.00,81.50)/μL比606.00(414.50,767.50)/μL],差异均有统计学意义(U=2.81、3.02、2.98、3.56、3.26,均P<0.01)。结论临床治疗中,如果猴痘患者的白细胞计数和C反应蛋白明显升高,CD4+T淋巴细胞计数明显下降,或出现严重合并症时,需警惕猴痘重症感染。

关键词：猴痘重症临床特征

Cellular Cd^(2+)fluxes in roots confirm increased Cd availability to rice(Oryza sativa L.)induced by soil acidifications

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Journal of Environmental Sciences 2024年第5期139卷 516-526页

作者： Xiaoyi Sun Meng Wang luyao Qin Lei Yu Jing Wang Han zheng Wenneng Zhou Shibao Chen State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds School of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China

Soil acidifications become one of the main causes restricting the sustainable development of agriculture and causing issues of agricultural product *** order to explore the effect of different acidification on soil cadmium(Cd)availability,soil pot culture and hydroponic(soil potting solution extraction)were applied,and non-invasive micro-test technique(NMT)was *** three different soil acidification processes were simulated,including direct acidification by adding sulfuric acid(AP1),acid rain acidification(AP2)by adding artificial simulated acid rain and excessive fertilization acidification by adding(NH_(4))_(2)SO_(4)(AP3).The results showed that for direct acidification(AP1),DTPA-Cd concentration in field soils in Liaoning(S1)and Zhejiang(S2)increased by 0.167-0.217 mg/kg and 0.181-0.346 mg/kg,respectively,compared with control *** soil pH decreased by 0.45 units in S1,the Cd content of rice stems,leaves and roots increased by 0.48 to 6.04 mg/kg and 2.58 to 12.84mg/kg,respectively,When the pH value of soil S1 and S2 decreased by 0.20 units,the average velocity of Cd^(2+)at 200μm increased by 10.03-33.11 pmol/cm~2/sec and 21.33-52.86pmol/cm^(2)/sec,respectively,and followed the order of AP3>AP2>*** summary,different acidification measures would improve the effectiveness of Cd,under the same pH reduction condition,fertilization acidification increased Cd availability most significantly.

关键词： Soil acidification Cadmium Non-invasive micro-test technique Bioavailability

Evolution and Prospects of Foundation Models: From Large Language Models to Large Multimodal Models

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Computers, Materials & Continua 2024年第8期80卷 1753-1808页

作者： Zheyi Chen Liuchang Xu Hongting zheng luyao Chen Amr Tolba Liang Zhao Keping Yu Hailin Feng College of Mathematics and Computer Science Zhejiang A&F UniversityHangzhou311300China Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Mathematics and Computer Science Department Faculty of ScienceMenofia UniversityShebin El KomMenoufia Governorate32511Egypt School of Computer Science Shenyang Aerospace UniversityShenyang110136China Graduate School of Science and Engineering Hosei UniversityTokyo184-8584Japan

Since the 1950s,when the Turing Test was introduced,there has been notable progress in machine language *** modeling,crucial for AI development,has evolved from statistical to neural models over the last two ***,transformer-based Pre-trained Language Models(PLM)have excelled in Natural Language Processing(NLP)tasks by leveraging large-scale training *** the scale of these models enhances performance significantly,introducing abilities like context learning that smaller models *** advancement in Large Language Models,exemplified by the development of ChatGPT,has made significant impacts both academically and industrially,capturing widespread societal *** survey provides an overview of the development and prospects from Large Language Models(LLM)to Large Multimodal Models(LMM).It first discusses the contributions and technological advancements of LLMs in the field of natural language processing,especially in text generation and language ***,it turns to the discussion of LMMs,which integrates various data modalities such as text,images,and sound,demonstrating advanced capabilities in understanding and generating cross-modal content,paving new pathways for the adaptability and flexibility of AI ***,the survey highlights the prospects of LMMs in terms of technological development and application potential,while also pointing out challenges in data integration,cross-modal understanding accuracy,providing a comprehensive perspective on the latest developments in this field.

关键词： Artificial intelligence large language models large multimodal models foundation models

Insights into the enhancement of food flavor perception:strategies,mechanism and emulsion applications

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Food Science and Human Wellness 2024年第5期13卷 2410-2424页

作者： luyao Huang Yujie Dai Fan Zhang Longtao Zhang Baodong zheng Yi Zhang Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition Ministry of EducationFuzhou 350002China College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China

The core drivers of the modern food industry are meeting consumer demand for tasty and healthy *** application of food flavor perception enhancement can help to achieve the goals of salt-and sugar-reduction,without compromising the sensory quality of the original food,and this has attracted increasing research *** analysis of bibliometric results from 2002 to 2022 reveals that present flavor perception enhancement strategies(changing ingredient formulations,adding salt/sugar substitutes,emulsion delivery systems)are mainly carry out based on sweetness,saltiness and *** systems is becoming a novel research foci and development trends of international food flavor perception-enhancement *** structured design of food emulsions,by using interface engineering technology,can effectively control,or enhance the release of flavor ***,this review systematically summarizes strategies,the application of emulsion systems and the mechanisms of action of food flavor perception-enhancement technologies,based on odor-taste cross-modal interaction(OTCMI),to provide insights into the further structural design and application of emulsion systems in this field.

关键词： Food flavor perception Emulsion Mechanism Bibliometric

Silicon lithium-ion battery anode with enhanced performance： Multiple effects of silver nanoparticles

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Journal of Materials Science & Technology 2018年第10期34卷 1902-1911页

作者： Shanshan Yin Qing Jia Xiuxia Zuo Shuang Xie Kai Fang Yonggao Xia Jinlong Li Bao Qiu Meimei Wang Jianzhen Ban Xiaoyan Wang Yi Zhang Ying Xiao luyao zheng Suzhe Liang Zhaoping Liu Cundong Wang Ya-Jun Cheng Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 China North University of China Taiyuan 030051 China The University of Nottingham Ningbo China Ningbo 315100 China Nano Science and Technology Institute University of Science and Technology of China Suzhou 215123 China Department of Materials University of Oxford Parks Rd. OX1 3PH Oxford UK

Silicon has been regarded as one of the most promising next generation lithium-ion battery anode. How- ever, the poor cyclic stability of the Si based anode has severely limited its practical applications, which is even worse with high mass loading density （〉1 mg cm^-2 ）. A new concept has been developed to enhance the electrochemical performance of the Si nanoparticle anode. Silver nanoparticles are composited with the silicon nanoparticles in a facile way for the first time. It is found that the mechanical properties of the Si electrode have been significantly improved by the incorporation of the silver nanoparticles, leading to enhanced cyclic performance. With the Si/Ag mass ratio of 4：1, the reversible specific discharge capacity is retained as l 156 mA h g^-1 after 100 cycles at 200 mAg^-1, which is more than three times higher than that of the bare silicon （318 mA h g^-1 ）. The rate performance has been effectively improved as well due to excellent electron conductivity of the silver nanoparticles.

关键词： Silicon Silver Nanoparticles Nanocomposite Lithium-ion battery Anode

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燃料电池供电系统用新型升压变换器的研究

低压电器 2011年第8期 12-16页

作者：陆治国郑路遥重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044

提出了一种新颖的适用于燃料电池供电系统的升压变换器——开关电容交错并联高增益Boost变换器,并对其工作原理进行了详细分析,给出了控制框图。与传统两相交错并联Boost变换器相比,新拓扑结构不仅输入电流纹波减小,而且在相同的占空比... 详细信息

提出了一种新颖的适用于燃料电池供电系统的升压变换器——开关电容交错并联高增益Boost变换器,并对其工作原理进行了详细分析,给出了控制框图。与传统两相交错并联Boost变换器相比,新拓扑结构不仅输入电流纹波减小,而且在相同的占空比下实现了更高的电压增益,开关器件的电压应力得以减小。因此,新拓扑结构非常适合应用于低压输入、高压输出的场合,如燃料电池供电等系统。最后,进行了动态仿真和分析,验证了理论分析的正确性。

关键词：燃料电池供电系统升压变换器电压应力

一种新型无源交错并联Boost软开关变换器

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低压电器 2011年第12期 56-60,63页

作者：陆治国郑路遥重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044

给出了一种新型无源交错并联Boost软开关变换器的拓扑结构,对其工作原理进行了详细分析。该拓扑结构简单,在传统交错并联Boost变换器中加入了一个对称的无源辅助电路,实现了开关管的零电压开通和关断。分析了该变换器各阶段工作模态的... 详细信息

给出了一种新型无源交错并联Boost软开关变换器的拓扑结构,对其工作原理进行了详细分析。该拓扑结构简单,在传统交错并联Boost变换器中加入了一个对称的无源辅助电路,实现了开关管的零电压开通和关断。分析了该变换器各阶段工作模态的等效电路和实现软开关的条件,给出了辅助谐振电路的设计,并对主电路进行了仿真研究,仿真结果验证了电路分析的正确性和可行性。

关键词：无源软开关交错并联升压变换器电流纹波

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新型双输入Boost变换器

电力自动化设备 2010年第9期30卷 42-45页

作者：陆治国刘捷丰郑路遥秦煜森重庆大学输配电装备及系统安全与新技术国家重点实验室重庆400044

针对传统的多输入变换器(MIC)具有电路结构复杂、电压增益低或开关器件电压应力高的问题,提出了一种新型双输入Boost变换器拓扑结构,该拓扑由2个完全一致的基本Boost变换器子拓扑构成,每个基本Boost变换器的功率开关管分别并联一个功率... 详细信息

针对传统的多输入变换器(MIC)具有电路结构复杂、电压增益低或开关器件电压应力高的问题,提出了一种新型双输入Boost变换器拓扑结构,该拓扑由2个完全一致的基本Boost变换器子拓扑构成,每个基本Boost变换器的功率开关管分别并联一个功率二极管,在单输入状态时一个始终导通,另一个始终关断;在双输入状态时,2个功率二极管全部关断。分析了2种输入状态下的工作原理及各个阶段的工作模态,结果表明该变换器适合工作在双输入状态,且在此状态时可以实现2种不同性质的电源输入,具有电压增益高、开关器件电压应力低等优点。研制了一台输出功率为240 W的双输入Boost变换器原理样机,通过实验验证了理论分析的正确性。

关键词：多输入变换器双输入Boost变换器电压增益电压应力工作模态