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SIRT7 slows down stem cell aging by preserving heterochromatin:a perspective on the new discovery

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Protein & Cell 2020年第7期11卷 469-471页

作者： luyang sun Weiwei Dang Huffington Center on Aging Baylor College of MedicineHoustonTX 77030USA

Stem cell aging is one of the leading theories of aging and is gaining momentum in recent years with the development of new technologies to study stem cells(Schultz&Sinclair,2016).In the stem cell aging theory,the age-associated physiological changes and functional declines at tissue and organismal levels are atrbuted to changes to various stem cell populations,both in their quantity and ***,one of the pressing questions in the aging research is to understand the molecular mechanisms that preserve stem cell function and delay their aging process.

关键词： aging process. Sinclair

Inffuence of the near field of secondary source and the elasticity of pipe wall on active noise control performance of liquid-filled pipe

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Chinese Journal of Acoustics 2023年第4期42卷 479-496页

作者： GUO Gege sun Hongling sun luyang CAO Shengnan YANG Jun Key Laboratory of Noise and Vibration Institute of AcousticsChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

The numerical models of liquid-filled straight pipe system with active silencers are established. The inffuence of the near field of secondary source in the active silencers and the elasticity of pipe wall on active noise control performance under sound excitation is *** results show that the near field of secondary source is non-uniform, and the active control effect of some frequencies is poor or even the sound pressure level will increase when the error points are located in this region. The noise reduction can be increased by more than 10 d B when the error points are in the region of uniform sound field. The noise reduction of most frequencies can be increased by more than 5 d B by increasing the number of error points. The coupling between secondary source and pipe wall is strong because of the elasticity of pipe wall. Asymmetrically distributed secondary sources tend to excite the pipe wall vibration,which causes the troughs of control effect. The symmetrically distributed secondary sources can significantly improve the control effect. Increasing the number of secondary sources can improve the active-passive hybrid control effect of the system. However, it makes the sound field in the pipe more complex, and the active silencing effect of the models with multiple secondary sources decreases with increasing frequency.

关键词： effect. field. elasticity

Identification of Cytochrome P450 (CYP) Genes in Zhikong Scallop (Chlamys farreri)

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Journal of Ocean University of China 2013年第1期12卷 97-102页

作者： GUO Huihui BAO Zhenmin DU Huixia ZHANG Lingling WANG Shi sun luyang MOU Xiaoyu HU Xiaoli Key Laboratory of Marine Genetics and Breeding (MGB) Ministry of EducationCollege of Marine Life Sciences Ocean University of China

Cytochrome P450 （CYP） superfamily is one of the membership largest and function most diverse protein superfamily recogniozed among living beings. Members of this superfamily were further assigned to different families and subfamilies based on their amino acid similarities. According to their phylogenetic relationships, the CYP genes which likely diverged from common ancestor gene and may share common functions were grouped into one clan. Widely distributing scallops are a group of the most conspicuous bivalve; however the studies on their CYP is acarce. In this study, we searched the genome and expressed sequence tags of Zhikong scallop （Chlamysfarreri） for CYP genes. In total, 88 non-redundant CIfP were identified, which were homed in 13 CYPs gene families. Phylogenetic analysis divided these genes into 4 CYP clans. As in deuterostomes, Clan 2 was the largest, which contained 33 genes belonging to CYP1, CYP2, CYP17 and CYP356 families. Clan 3 contgained 19 genes belonging to CYP3, CYP5 and CYP30 families. Clan 4 contained 23 genes, all belonging to CYP4 family. The mitochondrial CYP clan contained 9 genes belonging to CYPIO and CYP24 families. In comparison, protostomes （C. farreri, D. pluex, D. melanogaster） contained more CYP genes than deuterostomes （S. purpuratus and vertebrates） in Clan 2 but less genes in Clan 3 and Clan 4. Our findings will aid to deciphering CYP function and evolution in scallops and bivalves.

关键词： cytochrome P450 CYP Zhikong scallop Chlamysfarreri phylogenetic analysis

Genome-wide adenine N6-methylation map reveals epigenomic regulation of lipid accumulation in Nannochloropsis

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Plant Communications 2024年第3期5卷 106-122页

作者： Yanhai Gong Qintao Wang Li Wei Wensi Liang Lianhong Wang Nana Lv Xuefeng Du Jiashun Zhang Chen Shen Yi Xin luyang sun Jian Xu Single-Cell Center CAS Key Laboratory of BiofuelsShandong Key Laboratory of Energy GeneticsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdaoChina Shandong Energy Institute QingdaoChina Qingdao New Energy Shandong Laboratory QingdaoChina University of Chinese Academy of Sciences Beijing 100049China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Epigenetic marks on histones and DNA,such as DNA methylation at N6-adenine(6mA),play crucial roles in gene expression and genome maintenance,but their deposition and function in microalgae remain largely ***,we report a genome-wide 6mA map for the model industrial oleaginous microalga Nannochloropsis oceanica produced by single-molecule real-time *** in 0.1%of adenines,6mA sites are mostly enriched at the AGGYV motif,more abundant in transposons and 30 untranslated re-gions,and associated with active ***,6mA gradually increases in abundance along the direction of gene transcription and shows special positional enrichment near splicing donor and transcrip-tion termination *** expressed genes tend to show greater 6mA abundance in the gene body than do poorly expressed genes,indicating a positive interaction between 6mA and general transcription ***,knockout of the putative 6mA methylase NO08G00280 by genome editing leads to changes in methylation patterns that are correlated with changes in the expression of molybdenum cofactor,sulfate transporter,glycosyl transferase,and lipase genes that underlie reductions in biomass and oil *** contrast,knockout of the candidate demethylase NO06G02500 results in increased 6mA levels and reduced *** the epigenomic players and their roles in biomass productivity and lipid metabolism lays a foundation for epigenetic engineering of industrial microalgae.

关键词： adenine N6-methylation industrial oleaginous microalgae Nannochloropsis oceanica transcriptional regulation epigenomics

Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks

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Journal of Molecular Cell Biology 2017年第3期9卷 178-194页

作者： Yongqing Liu Shumeng Liu Shuai Yuan Huajing Yu Yu Zhang Xiaohan Yang Guojia Xie Zhe Chen Wanjin Li Bosen Xu luyang sun Yongfeng Shang Jing Liang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Capital Medical University Beijing 100069 China Tianjin Key Laboratory of Medical Epigenetics Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Tianjin Medical University Tianjin 300070 China

Faithful transmission or restoration of epigenetic information such as repressive histone modifications through generations is crit- ical for the maintenance of cell identity. We report here that chromodomain Y-like protein （CDYL）, a chromodomain-containing transcription corepressor, is physically associated with chromatin assembly factor 1 （CAF-1） and the repiicative heUcase MCM complex. We showed that CDYL bridges CAF-1 and MCM, facilitating histone transfer and deposition during DNA replication. We demonstrated that CDYI. recruits histone-modifying enzymes G9a, SETDB1, and EZH2 to replication forks, leading to the addition of H3Kgme2/3 and H3K27me2/3 on newly deposited histone H3. Significantly, depletion of CDYL impedes early S phase progres- sion and sensitizes cells to DNA damage. Our data indicate that CDYL plays an important role in the transmission/restoration of repressive histone marks, thereby preserving the epigenetic landscape for the maintenance of cell identity.

关键词： epigenetic inheritance histone modification CDYL CAF-1 MCM

电视剧《扫黑风暴》的写实化影像审美与主旋律精神引领

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电影评介 2022年第9期 92-95页

作者：晏妮孙璐杨贵州师范大学历史与政治学学院云南民族大学马克思主义学院贵州师范大学历史与政治学院

影视剧作为当今时代重要的文艺形式之一,是构建主流意识形态的先锋和重要场域。主旋律电视剧《扫黑风暴》以写实的细节增强了观众的情感认同,用光影的直观呈现效果凸显了“正能量”的魅力,并以通俗易懂的台词,提升了主流价值观的温度,... 详细信息

影视剧作为当今时代重要的文艺形式之一,是构建主流意识形态的先锋和重要场域。主旋律电视剧《扫黑风暴》以写实的细节增强了观众的情感认同,用光影的直观呈现效果凸显了“正能量”的魅力,并以通俗易懂的台词,提升了主流价值观的温度,进而强化了主流意识形态的感染力。该剧采用多元的叙事方式与观众多元化的观剧需求相契合,增强了主流意识形态的传播效度,同时以“多线”共进式的叙事结构使剧情更加丰富,一定程度上增强了主流意识形态的说服力。

关键词：主旋律电视剧文艺形式主流价值观情感认同精神引领影视剧叙事结构写实化

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弯管对末端带弹性障板充液管路辐射声能量的影响

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声学学报 2022年第1期47卷 126-138页

作者：黎亚军孙红灵孙陆阳杨军中国科学院噪声与振动重点实验室(声学研究所) 北京100190 中国科学院大学北京100049

基于声固耦合有限元方法建立了末端带弹性障板的充液管路数值模型,重点分析了不同激励下弯管对管口辐射声能量的影响。结果表明:弯管引入的高阶周向模式耦合使结构振动和流体声传播都发生明显改变,以致系统辐射声能量及主要能量贡献源... 详细信息

基于声固耦合有限元方法建立了末端带弹性障板的充液管路数值模型,重点分析了不同激励下弯管对管口辐射声能量的影响。结果表明:弯管引入的高阶周向模式耦合使结构振动和流体声传播都发生明显改变,以致系统辐射声能量及主要能量贡献源也发生转移,并随激励方式和频率而不同。对本文管路模型,平面波激励下弯管系统在低频的结构辐射声能量明显增加,在高频段呈流体声与结构声交替主导的特点。径向力激励下直管系统的总声能量几乎全部来自于弹性障板辐射结构声,而弯管的声固耦合使得管口流体声功率显著增加。在轴向力激励下弯管耦合使系统总辐射声功率显著下降的同时管出口的流体声功率反而增加。

关键词：声功率障板声固耦合有限元方法结构振动模式耦合声能量弯管

The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3666-3683页

作者： Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang luyang sun Yongfeng Shang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Biochemistry and Molecular BiologyDepartment of Laboratory MedicinePeking University Third HospitalSchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Department of Clinical Laboratory Peking University First Hospital100034 BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesHangzhou Normal University311121 HangzhouChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical University100069 BeijingChina Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the *** report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the *** showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in *** propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy *** demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription ***,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation.

关键词： metabolic cycle Together

2219铝合金焊接接头软化模型的建立与应用

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材料导报 2020年第10期34卷 10138-10143页

作者：吴奇李晓延孙鲁阳王小鹏北京工业大学材料科学与工程学院北京100124

通过2219铝合金TIG焊接接头不同区域的微区拉伸试验以及母材在热循环过程中不同温度下的拉伸试验,获得了相应的屈服强度和抗拉强度,建立了基于温度、温度历史及应变强化效应的接头软化模型。将此软化模型应用到TIG焊接接头残余应力的有... 详细信息

通过2219铝合金TIG焊接接头不同区域的微区拉伸试验以及母材在热循环过程中不同温度下的拉伸试验,获得了相应的屈服强度和抗拉强度,建立了基于温度、温度历史及应变强化效应的接头软化模型。将此软化模型应用到TIG焊接接头残余应力的有限元模拟中,并将应力模拟值与X射线衍射应力实测值进行对比。结果表明,与常规模型相比,软化模型中的残余应力分布水平出现了不同程度的降低,此外,残余应力在焊缝附近区域、起弧端与收弧端区域及横向分布上下降幅度较为明显。与实测值相比,应用接头软化模型计算得到的焊接残余应力分布与之更为接近,提高了残余应力的计算精度,验证了接头软化模型的有效性。

关键词： 2219铝合金软化模型焊接残余应力有限元模拟