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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Research ethics:a safeguard for advanced technologies

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National Science Review 2020年第11期7卷 1787-1792页

作者： Hepeng jia Soochow University

With the fast development of cutting-edge technologies and their greater integration into human life, more ethical challenges emerge. The problem became more salient when the world’s first genetically edited babies were born in China in violation of existing ethical rules. Although the responsible researcher He jiankui was sentenced for imprisonment for three years last December,

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Agriculture: science and technology safeguard sustainability

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National Science Review 2019年第3期6卷 595-600页

作者： Hepeng jia Freelance science writer based in Ithaca New York USA and Beijing China

China has traditionally placed tremendous importance on agricultural research. Meanwhile, in recent years,sustainable agriculture has been increasingly highlighted in both policy agenda and the capital market. However... 详细信息

关键词： China science and technology safeguard sustainability Agriculture

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Joint Bayesian and Greedy Recovery for Compressive Sensing

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Chinese Journal of Electronics 2020年第5期29卷 945-951页

作者： LI jia China Electronics Technology Group Corporation 54th Research Institute Hebei Key Laboratory of Electromagnetic Spectrum Cognition and Control

Greedy algorithms are widely used for sparse recovery in compressive sensing. Conventional greedy algorithms employ the inner product vector of signal residual and sensing matrix to determine the support, which is based on the assumption that the indexes of the larger-magnitude entries of the inner product vector are more likely to be contained in the correct ***, this assumption may be not valid when the number of measurements is not sufficient, leading to the selection of an incorrect support. To improve the accuracy of greedy recovery, we propose a novel greedy algorithm to recover sparse signals from incomplete *** entries of a sparse signal are modelled by the type-II Laplacian prior, such that the k indexes of the correct support are indicated by the largest k variance hyperparameters of the entries. Based on the proposed model, the supports can be recovered by approximately estimating the hyperparameters via the maximum a posteriori process. Simulation results demonstrate that the proposed algorithm outperforms the conventional greedy algorithms in terms of recovery accuracy, and it exhibits satisfactory recovery speed.

关键词： Sparse recovery Compressive sensing Greedy algorithm Laplacian prior

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干细胞的趋电性迁移及机制

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中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

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光交联复合水凝胶支架中人牙髓干细胞的成骨/成牙分化能力

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中国组织工程研究 2025年第19期29卷 4022-4028页

作者：杨杜娟程梦可刘佳新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆维吾尔自治区乌鲁木齐市830054 新疆维吾尔自治区口腔医学研究所新疆维吾尔自治区乌鲁木齐市830054

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TDM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的... 详细信息

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TDM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的牙髓再生提供了新的思路和方法。目的:探究1∶2质量比Gel-MA/TDM复合光交联水凝胶支架对人牙髓干细胞增殖能力及成骨/成牙本质分化能力的影响。方法:将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TDM复合水凝胶支架中,采用CCK-8实验检测人牙髓干细胞在复合水凝胶支架中的增殖能力。将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TDM复合水凝胶支架中并进行成骨诱导,采用碱性磷酸酶染色及茜素红染色观察矿化结节的形成情况,采用RT-PCR检测成牙相关因子(牙本质基质蛋白1、牙本质涎磷蛋白)和成骨相关因子(骨钙素、Runt相关转录因子2)的基因表达。结果与结论:①CCK-8检测结果显示,前7 d的牙髓干细胞增殖能力明显升高,第10天时速度减缓;②碱性磷酸酶染色及茜素红染色结果显示,Gel-MA/TDM复合水凝胶组牙髓干细胞的碱性磷酸酶活性及矿化结节生成强于单纯Gel-MA水凝胶组(P<0.05);③RT-PCR结果显示,Gel-MA/TDM复合水凝胶组牙髓干细胞中牙本质基质蛋白1、牙本质涎磷蛋白、骨钙素、Runt相关转录因子2的基因表达量明显高于单纯Gel-MA水凝胶组(P<0.05),且14 d基因表达量明显高于7 d(P<0.05)。结果表明,培养在1∶2 Gel-MA/TDM复合水凝胶支架上的牙髓干细胞表现出较好的增殖能力,能够强化牙髓干细胞的成骨、成牙本质分化能力。

关键词：牙髓再生甲基丙烯酸酐改性明胶牙本质基质复合支架牙髓干细胞成骨成牙本质

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Nano-scale pore distribution characterisation of coal using small angle X-ray scattering

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Particuology 2023年第10期81卷 73-85页

作者： Peng jia Jinzhang jia Sadegh Nadimi College of Safety Science and Engineering Liaoning Technical UniversityFuxinLiaoning123000China School of Engineering Newcastle UniversityNE17RUUK

In the process of coal seam fracturing with liquid nitrogen(LN_(2)),the change of coal pore structure has an important influence on the efficiency of coalbed methane(CBM)*** nano-scale pore size distribution(PSD)in coal particles before and after freezing with LN_(2) are experimentally studied in this *** samples are collected from four coal mines,where coal and gas outburst accidents have *** angle X-ray scattering technology(SAXS)and scanning electron microscopy(SEM)are used to study the pore structure changes of coal samples quantitatively and *** is found that the scattering intensity of coal samples increases after *** PSD of all samples significantly changes in the range of 0.8–7 nm,showing new pore spaces in 0.8–4 nm and fewer pores in the 4–7 nm *** the pore fractal dimension and the radius of gyration of coal samples increase after freezing and are mainly affected by the changes in pores and the anisotropy of the coal *** expansion and pore connections are observed in the surface structure of the coal sample using *** study provides a better understanding of the nano-scale mechanism of coal seam fracturing with LN_(2) for the prevention of coal and gas outbursts.

关键词： Coalbed methane Small angle X-ray scattering LN2 freezing Pore size distribution(PSD) Particle characterisation Fractal dimension

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An Experimental Investigation on Heat Transfer Performance of Nanofluid Pulsating Heat Pipe

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Journal of Thermal Science 2013年第5期22卷 484-490页

作者： Hongwei jia Li jia Zetao Tan Institute of Thermal Energy Engineering School of Mechanical Electronic and Control EngineeringBeijing Jiaotong University jiangsu Key Laboratory of Process Enhancement & New Energy Equipment Technology Nanjing University of Technology

The effect of SiO2 particles on heat transfer performance of a pulsating heat pipe （PHP） was investigated experi- mentally. DI water was used as the base fluid and contrast medium for the PHP. In order to study and measure the character, there are SiO2/H20 nanofluids with different concentration and applying with various heating powers during the experiment investigation. According to the experimental result, the high fraction of SiO2/H20 will de- teriorate the performance of PHP compared with DI water, i.e. the thermal resistance and the temperature of evaporation section increases. It is in contrary in the case of low fraction of SiO2/H20. Finally, the comparison of the thermal performances between the normal operation system and the static settlement system is given. It is found that both the thermal resistance of nanofluid PHP and the temperature of the evaporation section increase after standing for a period, and it is the same trend for the temperature fluctuation at the identical heating power for PHP.

关键词： Nanofluid Pulsating heat pipe Heat transfer characteristics Suspension characteristics

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Mechanical Properties of Interlocked-ring Polymers: A Molecular Dynamics Simulation Study

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Chinese Journal of Polymer Science 2019年第12期37卷 1298-1304,I0008页

作者： Zheng-Tao Wu jia-jia Zhou College of Engineering Zhejiang Normal UniversityJinhua 321004China School of Chemistry Beihang UniversityBeijing 100191China

Interlocked-ring polymers,also known as polycatenanes,possess an interesting molecular *** polymers are composed of many interlocked rings in a linear *** topological constrain between neighboring rings distinguishes the interlockedring polymer from its linear *** we present extensive molecular dynamic simulations on the interlocked-ring polymers and analyze the static properties of the *** applying external forces to the polymer,we also study the force-extension curves of the polymer,which provides rich information about the mechanical properties of the interlockedring polymers.

关键词： Poly catenanes Molecular dynamics simulation Force-extension Entanglement

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