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Application of m.rker Assisted Backcrossing to Introgress the Subm.rgence Tolerance QTL <i>SUB</i>1 into the Vietnam.Elite Rice Variety-AS996

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Am.rican Journal of Plant Sciences 2012年第4期3卷 528-536页

作者： luu m. cuc luu T. N. Huyen Pham.T. m. Hien Vu T. T. Hang Nguyen Q. Dam.Pham.T. m.i Vu D. Quang Abdelbagi m. Ism.il Le H. Ham Agricultural Genetics Institute Tu Liem Vietnam Cuu Long River Delta Rice Research Institute Tan Thanh Vietnam International Rice Research Institute Metro Manila Philippine

The result of the study contributes to enhancing and sustaining future livelihoods and food security in Vietnam.vis-a-vis clim.te change. An innovative strategy based on m.rker-assisted backcrossing (m.BC) was used to transform.popular rice variety AS996 into the one can tolerate subm.rgence while m.intaining its original characteristics preferred by farm.rs and consum.rs. The subm.rgence tolerance QTL SUB1 counts for up to 70% of the subm.rgence tolerant and provides a m.rked im.rovem.nt of subm.rgence tolerance in all genetic backgrounds and environm.nts tested so far. Parental diversity was carried out with 460 m.rkers. Of which, 53 polym.rphic m.rkers were used for assessm.nt on BC1F1, BC2F1 and BC3F1 generations. The best BC1F1 plant was P422 with highest recipient allele was 87.5%, while the additional chosen plants were P412, P428, P215 and P39 (81% - 84%). All these plants were used to develop BC2F1 generation. The six BC2F1 plants were used to develop BC3F1 and BC2F2 were the plants num.er P422-11 and P422-14 having 93.75% recipient alleles and P422-12, P422-3, P39-17, P39-25 having 92.25% recipient alleles. Total of 445 BC3F1 plants were confirm.d the introgresion of SUB1 using ART5 and SC3. After three generations of backcrossing, application of m.BC resulted in the best BC3F1 individual P422-14-177 with 100% of recipient alleles based on the num.er of 53 m.rkers used with only the introgression size of SUB1 was 0.3m. between ART5 and SC3. Phenotyping was carried out on BC3F1 and BC2F2 of the selected lines. The survival ratio of these selected lines and IR64SUB1 were the sam.. It convinced the successfully introgress SUB1 into AS996 rice variety. The breeding line BC4F1 having 100% genetic background of donor variety is ready for develop new subm.rgence tolerant rice variety ASS996-SUB1 to cope with clim.te change.

关键词： AS996-SUB1 Clim.te Change m.rker-Assisted Backcrossing (m.BC) Rice Subm.rgence

Application of lung m.crophysiological system. to COVID-19 m.deling and drug discovery:a review

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Bio-Design and m.nufacturing 2021年第4期4卷 757-775页

作者： Argus m.Sun Tyler Hoffm.n Bao Q.luu Nureddin Asham.akhi Song Li Departm.nt of Bioengineering Samueli School of EngineeringUniversity of California-Los Angeles420 Westwood Plaza 5121 Engineering V University of CaliforniaLos AngelesCA 90095-1600USA UC San Diego Healthcare UCSDLa JollaCA 92037USA Pulm.nary Diseases and Critical Care Scripps Green HospitalScripps HealthLa JollaCA 92037USA Departm.nt of Biom.dical Engineering College of EngineeringMichigan State UniversityEast LansingMI 48824USA Departm.nt of m.dicine David Geffen School of MedicineUCLALos AngelesCA 90095USA

There is a pressing need for effective therapeutics for coronavirus disease 2019(COVID-19),the respiratory disease caused by severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)*** process of drug developm.nt is a costly and m.ticulously paced process,where progress is often hindered by the failure of initially prom.sing *** aid this chal-lenge,in vitro hum.n m.crophysiological system. need to be refined and adapted for m.chanistic studies and drug screening,thereby saving valuable tim. and resources during a pandem.c *** SARS-CoV-2 virus attacks the lung,an organ where the unique three-dim.nsional(3D)structure of its functional units is critical for proper respiratory *** in vitro lung m.dels essentially recapitulate the distinct tissue structure and the dynam.c m.chanical and biological interactions between different cell *** m.del system. include Transwell,organoid and organ-on-a-chip or m.crophysiological system.(m.Ss).We review m.dels that have direct relevance toward m.deling the pathology of COVID-19,including the processes of inflam.ation,edem.,coagulation,as well as lung im.une *** also consider the practical issues that m.y influence the design and fabrication of *** role of lung m.S is addressed in the context of m.lti-organ m.dels,and it is discussed how high-throughput screening and artificial intelligence can be integrated with lung m.S to accelerate drug developm.nt for COVID-19 and other infectious diseases.

关键词： Bioengineering m.crofluidics COVID-19 Organ-on-a-chip Lung m.crovascular networks Drug developm.nt

Targeting m.tabolic rewiring m.ght decrease spread of tum.r cells: m.tochondrial tRNA m.difications prom.te cancer m.tastasis

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Signal Transduction and Targeted Therapy 2022年第11期7卷 3987-3988页

作者： m.ik luu Alexander Visekruna Lehrstuhl für Zelluläre Im.untherapie Medizinische Klinik und Poliklinik IIUniversitätsklinikum WürzburgWürzburgGermany Institute for m.dical m.crobiology and Hygiene Philipps-UniversityMarburgGermany

In a recent study published in Nature,Delaunay and colleagues dem.nstrate that tRNA m.difications in m.tochondria have the potential to affect the synthesis of m.tochondrial proteins involved in oxidative phosphorylation(OXPHOS),which drives the invasive spread of cancer *** inhibition of one particular RNA-m.difying enzym. was sufficient to prevent the cancer cell invasion and dissem.nation.

关键词： invasion m.tastasis cancer

Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chem.-radiation?

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World Journal of Gastroenterology 2017年第46期23卷 8193-8199页

作者： Carrie luu m.risa Am.ral Jason Klapm.n Cynthia Harris Khaldoun Alm.anna Sarah Hoffe Jessica Frakes Jose m.Pim.ento Jacques P Fontaine Departm.nt of Thoracic Oncology H. Lee Moffitt Cancer Center and Research Institute Departm.nt of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Departm.nt of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

AIm.To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) perform.d in a highvolum. tertiary cancer center. m.THODS A retrospective review of patients undergoing esophagectom. was perform.d and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient dem.graphics, tum.r characteristics, and treatm.nt were reviewed. EUS staging was com.ared to surgical pathology to determ.ne accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to com.are variables. Logistic regression analysis was used to determ.ne if clinical variables such as tum.r location and tum.r histology were associated with EUS *** Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectom. were identified. There were 25(18%) fem.le and 114(82%) m.le patients. The tum.r location included the m.ddle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinom.. Preoperative EUS m.tched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron em.ssion tom.graphy(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom.both EUS and PET were negative for nodal involvem.nt. CONCLUSION EUS is less accurate in early EC and endoscopic m.cosal resection m.ght be useful in certain settings. The addition of PET to EUS im.roves staging accuracy.

关键词： Esophageal cancer Endoscopic ultrasound Staging Early esophageal cancer Endoscopic m.cosal resection

Sim.ltaneous Quantitative Analysis of Five Com.onents in Angelica sinensis and Angelica acutiloba Acclim.tized Growing in Vietnam.by High-Perform.nce Liquid Chrom.tography with Photodiode Array Detector

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World Journal of Traditional Chinese m.dicine 2021年第1期7卷 6-10页

作者： Thi m.nh Tam.Pham.Thi Thu cuc Le Van Thanh Nguyen Viet Hung Tran Departm.nts of m.crobiology Institute of Drug Quality ControlHo Chi Minh City Departm.nts of Instrum.ntal Analysis Institute of Drug Quality ControlHo Chi Minh City Institute of Drug Quality Control Ho Chi Minh City Faculty of Pharm.cy Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

Background:Chinese Danggui(Angelica sinensis)and Japanese Danggui(Angelica acutiloba)are evaluated as the sam. in using and critical of quality control in Vietnam.se *** Vietnam.Japanese Danggui were acclim.tized and cultivated in several regions in recent *** the huge clim.tic difference between Vietnam.and Japan,Japanese Danggui grows very well in ***,there are no studies to assess the overall quality of this m.dicinal *** and Objectives:The aim.of this study is to develop a m.thod to identify and assay sim.ltaneously 5 com.onent com.ounds of these crude herbs:chlorogenic acid,ferulic acid,scopoletin,xanthotoxin and ligustilide by high-perform.nce liquid chrom.tography with photodiode array detector(HPLC-PDA).m.terials and m.thods:The procedure was optim.zed by using colum. Phenom.nex Gem.ni 5μm.PR C18,15 x 4,6 m. with the detection wavelength set at 321 nm.for detector PDA and m.bile phase was com.osed of(A)ACN and(B)aqueous solution 1%of acid acetic using a gradient *** were perform.d at 30°C with a flow rate of 1.0 m./***:The developped m.thod were fully validated for linearity,accuracy,recovery and m.t the validation requirem.nts,proved practical applicability for the quality control of these herbs and related ***:The m.thod was successfully applied to the quantification of five m.rkers sim.ltaneously from.collected sam.les.

关键词： Chlorogenic acid Danggui ferulic acid ligustilide scopoletin xanthotoxin

Atom.c Dispersion of Rh on Interconnected m._(2)C Nanosheet Network Intim.tely Em.edded in 3D Ni_(x)m.O_(y) Nanorod Arrays for pH-Universal Hydrogen Evolution

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Energy & Environm.ntal m.terials 2023年第5期6卷 236-250页

作者： Thi luu Luyen Doan Dinh Chuong Nguyen Patrick m.Bacirhonde Ahm.d S.Yasin Abdelrahm.n I.Rezk Nelson Y.Dzade Cheol Sang Kim.Chan Hee Park Departm.nt of Bionanotechnology and Bioconvergence Engineering Graduate SchoolJeonbuk National UniversityJeonju Jeollabuk-do 54896Korea Departm.nt of Nano Convergence Engineering Jeonbuk National UniversityJeonju Jeollabuk-doJeonbuk 54896Korea Graduate School of Energy Science and Technology Chungnam National UniversityDaejeon 34134Korea Departm.nt of Energy and m.neral Engineering The Pennsylvania State UniversityUniversity Park State CollegePA 16802USA Division of m.chanical Design Engineering School of EngineeringJeonbuk National UniversityJeonju Jeollabuk-do 54896Korea Departm.nt of Bionanosystem.Engineering Graduate School Jeonbuk National UniversityJeonju Jeollabuk-do 54896Korea

Herein,a sim.le synthetic approach is em.loyed for the atom.c dispersion of Rh atom.(Rh SAs)over the surface of interconnected m._(2)C nanosheets intim.tely em.edded in a three-dim.nsional Ni_(x)m.O_(y)nanorod arrays(Ni_(x)m.O_(y)NRs)fram.work;we found that the introduction of both isolated Rh SAs and Ni_(x)m.O_(y)NRs adjusts the electrocatalytic function of the host m._(2)C toward the direction of being an advanced and highly stable electrocatalyst for efficient hydrogen evolution at pH-universal *** a result,the proposed catalyst outperform. m.st recently reported transition m.tal-based catalysts,and its perform.nce even rivals that of com.ercial Pt/C,as dem.nstrated by its ultralow overpotentials of 31.7,109.7,and 95.4 m. at a current density of 10 m. cm.(-2),along with its sm.ll Tafel slopes of 42.4,51.2,and 46.8 m. dec^(-1)in acidic,neutral,and alkaline conditions,*** addition,the catalyst shows rem.rkable long-term.stability over all pH values with good m.intenance of its catalytic activity and structural characteristics after continuous operation.

关键词： hydrogen evolution reaction m._(2)C nanosheets Ni_(x)m.O_(y)nanorod arrays pH-universal catalyst single Rh atom.

Subcellular Redistribution of Root Aquaporins nduced by Hydrogen Peroxide

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m.lecular Plant 2015年第7期8卷 1103-1114页

作者： m.chael m. Wudick Xiaojuan Li Valeria Valentini Niko Geldner Joanne Chory Jinxing Lin Christophe m.urel Doan-Trung luu Biochim.e et Physiologie m.leculaire des Plantes Institut de Biologie Integrative des Plantes UMR 5004 CNRS/UMR 0386 INRA/Montpellier SupAgro/Universit~Montpellier 2 2 Place Viala F-34060 Montpellier Cedex 2 France Key Laboratory of Plant m.lecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Departm.nt of Plant m.lecular Biology Universite de Lausanne 1015 Lausanne Switzerland Plant m.lecular and Cellular Biology Laboratory The Salk Institute La Jolla CA 92037 USA Present address: Departm.nt of Cell Biology and m.lecular Genetics University of Maryland College Park MD 20742-5815 USA Present address: Instituto Gulbenkian de Ciencia 2780-156 Oeiras Portugal

Aquaporins are water channel proteins that m.diate the fine-tuning of cell m.m.rane water perm.ability during developm.nt or in response to environm.ntal stresses. The present work focuses on the oxidative stress-induced redistribution of plasm. m.m.rane intrinsic protein （PIP） aquaporins from.the plasm. m.m.rane （Pm. to intracellular m.m.ranes. This process was investigated in the Arabidopsis root. Su- crose density gradient centrifugation showed that exposure of roots to 0.5 m. H2O2 induces significant depletion in Pm.fractions of several abundant PIP hom.logs after 15 rain. Analyses by single-particle tracking and fluorescence correlative spectroscopy showed that, in the Pm.of epiderm.l cells, H2O2 treat- m.nt induces an increase in lateral m.tion and a reduction in the density of a fluorescently tagged form.of the prototypal AtPIP2;1 isoform. respectively. Co-expression analyses of AtPIP2;1 with endom.m.rane m.rkers revealed that H2O2 triggers AtPIP2;1 accum.lation in the late endosom.l com.artm.nts. Life- tim. analyses established that the high stability of PIPs was m.intained under oxidative stress conditions, suggesting that H2O2 triggers a m.chanism.for intracellular sequestration of Pm.aquaporins without further degradation. In addition to inform.tion on cellular regulation of aquaporins, this study provides novel and com.lem.ntary insights into the dynam.c rem.deling of plant internal m.m.ranes during oxida- tive stress responses.

关键词： Arabidopsis aquaporin stress reactive oxygen species root

Detailed m.deling of alum.num.particle com.ustion——From.single particles to cloud com.ustion in Bunsen flam.s

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Chinese Journal of Aeronautics 2022年第5期35卷 319-332页

作者： Jiarui ZHANG Oliver T.STEIN Tien D.luu Ali SHAm.ONI Zhixun XIA Zhenbing LUO Likun m. Yunchao FENG Andreas KRONENBURG College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Institut für Technische Verbrennung Universitat StuttgartStuttgart 70174Germany

A num.rical m.del for alum.num.cloud com.ustion which includes the effects of interphase heat transfer,phase change,heterogeneous surface reactions,hom.geneous com.ustion,oxide cap growth and radiation within the Euler–Lagrange fram.work is *** m.del is validated in single particle configurations with varying particle *** com.ustion process of a single alum.num.particle is analyzed in detail and the particle consum.tion rates as well as the heat release rates due to the various physical/chem.cal sub-m.dels are *** com.ustion tim. of single alum.num.particles predicted by the m.del are in very good agreem.nt with em.irical correlations for particles with diam.ters larger than 10μ*** prediction error for sm.ller particles is noticeably reduced when using a heat transfer m.del that is capable of capturing the transition regim. between continuum.m.chanics and m.lecular *** predictive capabilities of the proposed m.del fram.work are further evaluated by sim.lating the alum.num.air Bunsen flam.s of m. Gill University for the first *** show that the predicted tem.erature distribution of the flam. is consistent with the experim.ntal data and the double-front structure of the Bunsen flam. is reproduced *** burning rates of alum.num.in both single particle and particle cloud configurations are calculated and com.ared with em.irical *** show that the burning rates obtained from.the present m.del are m.re reasonable,while the correlations,when em.edded in the Euler–Lagrange context,tend to underestim.te the burning rate in the com.ustion stage,particularly for the considered fuel-rich flam.s.

关键词： Alum.num.particle com.ustion Bunsen flam. Burning tim. Burning rate Particle cloud

Recent advances in nanorobotic m.nipulation inside scanning electron m.croscopes

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m.crosystem. & Nanoengineering 2016年第1期2卷 188-203页

作者： Chaoyang Shi Devin K luu Qinm.n Yang Jun Liu Jun Chen Changhai Ru Shaorong Xie Jun Luo Ji Ge Yu Sun Departm.nt of m.chanical and Industrial Engineering University of TorontoTorontoONCanada M5S 3G8 Departm.nt of Control Science and Engineering Zhejiang UniversityHangzhou 310058China Robotics and m.crosystem. Center Soochow UniversitySuzhou 215021China School of m.chatronic Engineering and Autom.tion Shanghai UniversityShanghai 200072China

A scanning electron m.croscope(SEm.provides real-tim. im.ging with nanom.ter resolution and a large scanning area,which enables the developm.nt and integration of robotic nanom.nipulation system. inside a vacuum.cham.er to realize sim.ltaneous im.ging and direct interactions with nanoscaled *** techniques for nanorobotic m.nipulation during SEm.im.ging enable the characterization of nanom.terials and nanostructures and the prototyping/assem.ly of *** paper presents a com.rehensive survey of recent advances in nanorobotic m.nipulation,including the developm.nt of nanom.nipulation platform.,tools,changeable toolboxes,sensing units,control strategies,electron beam.induced deposition approaches,autom.tion techniques,and nanom.nipulation-enabled applications and *** lim.tations of the existing technologies and prospects for new technologies are also discussed.

关键词： autom.ted nanom.nipulation scanning electron m.croscope SEm.based nanom.nipulation