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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： Mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig lutz trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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Anti-angiogenesis in hepatocellular carcinoma treatment: Current evidence and future perspectives

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World Journal of Gastroenterology 2011年第26期17卷 3075-3081页

作者： Martin-Walter Welker Joerg trojan Medizinische Klinik 1 Klinikum der Johann Wolfgang Goethe-Universitt

Hepatocellular carcinoma(HCC) is among the most common cancer diseases *** hypervascularisation is an essential step for HCC tumorigenesis and can be targeted by transarterial chemoembolization(TACE).This interventional method is the standard treatment for patients with intermediate stage HCC,but is also applied as "bridging" therapy for patients awaiting liver transplantation in many centers *** the devascularization effect induced by TACE is transient,consequently resulting in repeated cycles of TACE every 4-8 *** documented survival benefits,TACE can also induce the up-regulation of proangiogenic and growth factors,which might contribute to accelerated progression in patients with incomplete *** 2007,sorafenib,a multi-tyrosine kinase and angiogenesis inhibitor,was approved as the first systemic treatment for advanced stage *** active targeted compounds,either inhibitors of angiogenesis and/or growth factors,are currently being investigated in numerous clinical *** overcome revascularisation or tumor progression under TACE treatment it seems therefore attractive to combine TACE with systemic targeted agents,which might theoretically block the effects of proangiogenic and growth *** the last 12 mo,several retrospec-tive or prospective cohort studies combining TACE and sorafenib have been ***,robust results of the efficacy and tolerability of such combination strategies as proven by randomized,controlled trials are awaited in the next two years.

关键词：抗血管生成治疗肝癌血管生成抑制剂证据生长因子肿瘤发生血管形成

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A methodology for coffee price forecasting based on extreme learning machines

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Information Processing in Agriculture 2022年第4期9卷 556-565页

作者： Carolina Deina Matheus Henrique do Amaral Prates Carlos Henrique Rodrigues Alves Marcella Scoczynski Ribeiro Martins Flavio trojan Sergio Luiz Stevan Jr Hugo Valadares Siqueira Department of Production Engineering Federal University of Rio Grande do Sul90.035-190Brazil Department of Electronics Federal University of TechnologyParana 84017-220Brazil Graduate Program in Production Engineering Federal University of TechnologyParana 84017-220Brazil

This work introduces a methodology to estimate coffee prices based on the use of Extreme Learning *** process is initiated by identifying the presence of nonstationary components,like seasonality and *** components are withdrawn if they are ***,the temporal lags are selected based on the response of the Partial Autocorre-lation Function *** predictors,we address the following models:Exponential Smooth-ing(ES),Autoregressive(AR)and Autoregressive Integrated and Moving Average(ARIMA)models,Multilayer Perceptron(MLP)and Extreme Learning Machines(ELMs)neural *** computational results based on three error metrics and two coffee types(Ara-bica and Robusta)showed that the neural networks,especially the ELM,can reach higher performance levels than the other *** methodology,which presents preprocess-ing stages,lag selection,and use of ELM,is a novelty that contributes to the coffee prices forecasting field.

关键词： Coffee price forecasting Linear models Artificial neural networks Computational intelligence

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Tracing mechanism of optically and thermally stimulated luminescence in Lu2O3:Tb,M（M=Hf,Zr,Ti）ceramic storage phosphors

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Journal of Rare Earths 2019年第11期37卷 1170-1175页

作者： Malgorzata Sojka Dagmara Kulesza Paulina Bolek Joanna trojan-Piegza Eugeniusz Zych Faculty of Chemistry University of Wroclaw

A series of energy storage phosphors,Lu2O3:Tb,M(M=Hf,Zr,Ti),were investigated by means of photoand thermoluminescence techniques to compare the effect of the co-dopant from the same group of periodic table of elements on charge carriers trapping capability and trap *** of the investigated processes were tracked individually for the Tb3+in the two different metal sites offered by the Lu2O3 host-noncentrosymmetric C2 and centrosymmetric *** is proved that both Tb3+ions participate in hole trapping and electrons are immobilized in traps whose depths are defined by the *** traps,~1.79 eV,appear upon Ti addition,while Zr and Hf generate traps of very similar,~1.40-1.44 eV,*** stored energy may be released not only by means of thermal stimulation but also upon the impact of optical *** from the 390-430 nm range of wavelengths was found the most efficient in the latter *** deep red radiation of 780 nm releases most of the trapped electrons in Zr/Hf co-doped ceramics but is much less effective in the case of Tb,Ti *** scheme of electronic levels engaged in charge carriers trapping and subsequent generation of thermoand optically stimulated luminescence was constructed.

关键词： Storage phosphors Lu2O3 Thermoluminescence Optically stimulated luminescence Rare earths

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Optimum Heating of Thick-Walled Pressure Components Assuming a Quasi-steady State of Temperature Distribution

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Journal of Thermal Science 2016年第4期25卷 380-388页

作者： Piotr Dzierwa Marcin trojan Dawid Taler Katarzyna Kamińska Jan Taler Institute of Thermal Power Engineering Cracow University of Technology Institute of Thermal Engineering and Air Protection Faculty of Environmental Engineering Department of Hydraulic Engineering and Geotechnics Agricultural University of Cracow

As a result of the development of wind farms,the gas- steam blocks,which shall quickly ensure energy supply in case the wind velocity is too low,are introduced to the energy *** shorten the start-up time of the gas-steam and conventional blocks,the structure of the basic components of the blocks are changed,*** reducing the diameter of the boiler,the thickness of its wall is also *** attempts were also made to revise the currently binding TRD 301 regulations,replacing them by the EN 12952-3 European Standard,to reduce the allowable heating and cooling rates of thick walled boiler *** basic assumption,on which the boiler regulations allowing to calculate the allowable temperature change rates of pressure components were based,was the quasi- steady state of the temperature field in the simple shaped component,such as a slab,cylindrical or spherical wall.

关键词：准稳态温度分布加热组件压力厚壁燃气-蒸汽锅炉部件

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Portal vein thrombosis and arterioportal shunts:Effects on tumor response after chemoembolization of hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第10期17卷 1267-1275页

作者： Thomas J Vogl Nour-Eldin Nour-Eldin Sally Emad-Eldin Nagy NN Naguib Joerg trojan Hans Ackermann Omar Abdelaziz Institute for Diagnostic and Interventional Radiology Johan Wolfgang Goethe University Hospital Diagnostic and Interventional Radiology Department Cairo University Hospital

AIM: To evaluate the effect of portal vein thrombosis and arterioportal shunts on local tumor response in advanced cases of unresectable hepatocellular carcinoma treated by transarterial chemoembolization. METHODS: A retrospective study included 39 patients (mean age: 66.4 years, range: 45-79 years, SD: 7) with unresectable hepatocellular carcinoma (HCC) who were treated with repetitive transarterial chemoembolization (TACE) in the period between March 2006 and October 2009. The effect of portal vein thrombosis (PVT) (in 19 out of 39 patients), the presence of arterioportal shunt (APS) (in 7 out of 39), the underlying liver pathology,Child-Pugh score, initial tumor volume, number of tumors and tumor margin definition on imaging were correlated with the local tumor response after TACE. The initial and end therapy local tumor responses were evaluated according to the response evaluation criteria in solid tumors (RECIST) and magnetic resonance imaging volumetric measurements. RESULTS: The treatment protocols were well tolerated by all patients with no major complications. Local tumor response for all patients according to RECIST criteria were partial response in one patient (2.6%), stable disease in 34 patients (87.1%), and progressive disease in 4 patients (10.2%). The MR volumetric measurements showed that the PVT, APS, underlying liver pathology and tumor margin definition were statistically significant prognostic factors for the local tumor response (P = 0.018, P = 0.008, P = 0.034 and P = 0.001, respectively). The overall 6-, 12- and 18-mo survival rates from the initial TACE were 79.5%, 37.5% and 21%, respectively. CONCLUSION: TACE may be exploited safely for palliative tumor control in patients with advanced unresectable HCC; however, tumor response is significantly affected by the presence or absence of PVT and APS.

关键词：血栓形成门静脉肿瘤反应肝癌栓塞分流动脉

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Current understanding of thermo(dys)regulation in severe burn injury and the pathophysiological influence of hypermetabolism,adrenergic stress and hypothalamic regulation-a systematic review

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Burns & Trauma 2022年第1期10卷 272-282页

作者： Viktoria Mertin Patrick Most Martin Busch Stefan trojan Christian Tapking Valentin Haug Ulrich Kneser Gabriel Hundeshagen Department of Hand Plastic and Reconstructive SurgeryBurn Trauma CenterBG Trauma Center LudwigshafenUniversity of Heidelberg67071 Ludwigshafen am RheinGermany Division of Molecular and Translational Cardi-ology Department of Internal MedicineⅢUniversity Hospital Heidelberg69120 HeidelbergGermany Deutsches Zentrum für Herz-und Kreislaufforschung(GCCR) Partner site Heidelberg/MannheimGermany Department of Anesthesiology and Intensive Care Medicine Merheim Medical CenterHospitals of CologneUniversity of Witten/Herdecke51109 CologneGermany

Background:In this systematic review,we summarize the aetiology as well as the current knowl-edge regarding thermo(dys)regulation and hypothermia after severe burn trauma and aim to present key concepts of pathophysiology and treatment *** burn injuries with>20%total body surface area(TBSA)affected commonly leave the patient requiring several surgical procedures,prolonged hospital stays and cause substantial changes to body composition and metabolism in the acute and long-term *** in severely burned patients,the loss of intact skin and the dysregulation of peripheral and central thermoregulatory processes may lead to substantial ***:A systematic and protocol-based search for suitable publications was conducted fol-lowing the PRISMA *** were screened and included if deemed *** encompasses animal-based in vivo studies as well as clinical studies examining the control-loops of thermoregulation and metabolic stability within burn patients Results:Both experimental animal studies and clinical studies examining thermoregulation and metabolic functions within burn patients have produced a general understanding of core concepts which are,nonetheless,lacking in *** describe the wide range of pathophysiological alterations observed after severe burn trauma and highlight the association between thermoregulation and hypermetabolism as well as the interactions between nearly all organ ***,the current clinical standards of mitigating the negative effects of thermodysregulation and hypothermia are summarized,as a comprehensive understanding and implementation of the key concepts is critical for patient survival and long-term ***:The available in vivo animal models have provided many insights into the interwoven pathophysiology of severe burn injury,especially concerning *** offer an outlook on concepts of altered central thermoregulation from non-burn research

关键词： Animal model Burn shock Hypothermia Thermoregulation Temperature management Burn injury Hypermetabolism

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Immunotherapy of Malignant Tumors Using Antisense Anti-IGF-I Approach: Case of Glioblastoma

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Journal of Cancer Therapy 2014年第7期5卷 685-705页

作者： Annabelle trojan Lina M. Jay Heliodor Kasprzak Donald D. Anthony Jerzy trojan Department of General Medical Sciences Case Western Reserve University Cleveland USA Department of Investigation National Institute of Health—INS Bogota Colombia Department of Neurosurgery CM Nicolas Copernic University Bydgoszcz Poland Faculty of Medicine CURN University Cartagena de Indias Colombia

The review article describes the criteria established for methodology of antisense anti IGF-I therapy of malignant tumors, particularly of glioblastoma. The cancer patients, after classical therapy of surgery, radiotherapy and chemotherapy, have undergone the injection of genetically modified autologous malignant cells—transfected by IGF-I antisense/triple helix expression vectors. For all cancer patients supervised for up to 19 months, the period corresponding to minimum survival of glioblastoma patients, the following common immune criteria for “anti IGF-I” strategy were admitted: 1) characteristics of cell “vaccines”—absence of IGF-I and expression of MHC-I in cloned transfected cells;2) the peripheral blood lymphocytes, PBL cells, removed after every of two successive vaccinations, demonstrate an increasing level of CD8+ and CD8+28+ molecules (with a switch from CD8+11b+ to CD8+11b-).

关键词： Immunogene Therapy Malignant Tumors Glioblastoma IGF-I Antisense

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以煤粉作橡胶填料的新观点

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煤炭综合利用译丛 1991年第2期14卷 89-95页

作者： M.J.trojan 张秀英化工部炭黑工业研究设计所

0 前言目前,人们正加紧改进胶料性能、减轻重量和降低成本。这种趋势,在汽车用橡胶制品和工业制品领域显得格外重要。它导致了重新研究从研磨的煤粉作为功能填料,以减轻制品重量并改进某些使用性能。本文将通过研磨煤粉和其他常用填料... 详细信息

0 前言目前,人们正加紧改进胶料性能、减轻重量和降低成本。这种趋势,在汽车用橡胶制品和工业制品领域显得格外重要。它导致了重新研究从研磨的煤粉作为功能填料,以减轻制品重量并改进某些使用性能。本文将通过研磨煤粉和其他常用填料的对比,讨论降低胶料比重的基本原理。

关键词：煤粉橡胶填料

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使用IoT协议的无线双体船

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单片机与嵌入式系统应用 2020年第3期20卷 1-4页

作者： [德国]Walter trojan 透镜(译) 不详

学习IoT软硬件最新技术的最好方法莫过于做一个有趣的东西。在这个项目中,我给孙子们做了一个远程控制模型船。在建造的过程中,孩子们不仅学到了技术,而且获得了很多的乐趣。这艘模型船用到了一些空饮料瓶和两个旧电脑风扇,使用一些小... 详细信息

学习IoT软硬件最新技术的最好方法莫过于做一个有趣的东西。在这个项目中,我给孙子们做了一个远程控制模型船。在建造的过程中,孩子们不仅学到了技术,而且获得了很多的乐趣。这艘模型船用到了一些空饮料瓶和两个旧电脑风扇,使用一些小型控制板(如ESP8266)来控制程序,设置WiFi网络和提供MQTT代理服务器。

关键词：远程控制双体船饮料瓶控制板模型船控制程序电脑风扇

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