检索结果-南通市图书馆

Nano Research 2018年第3期11卷 1262-1273页

作者： Xiaojing Liu luting Liu Xiujie Hu Shuyun zhou Rinat Ankri Dror Fixler Zheng Xie Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Faculty of Engineering and Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan 52900 Israel

Advanced biocompatible and robust platforms equipped with diverse properties are highly required in biomedical imaging applications for the early detection of atherosclerotic vascular disease and cancers. Designing nanohybrids composed of noble metals and fluorescent materials is a new way to perform multimodal imaging to overcome the limitations of single-modality counterparts. Herein, we propose the novel design of a multimodal contrast agent; namely, an enhanced nanohybrid comprising gold nanorods （GNRs） and carbon dots （CDs） with silica （SiO2） as a bridge. The nanohybrid （GNR@SiO2@CD） construction is based on covalent bonding between SiO2 and the silane-functionalized CDs, which links the GNRs with the CDs to form typical core-shell units. The novel structure not only retains and even highly improves the optical properties of the GNRs and CDs, but also possesses superior imaging performance in both diffusion reflection （DR） and fluorescence lifetime imaging microscopy （FLIM） measurements compared with bare GNRs or fluorescence dyes and CDs. The superior bioimaging properties of the GNR@SiOa@CD nanohybrids were successfully exploited for in vitro DR and FLIM measurements of macrophages within tissue-like phantoms, paving the way toward a theranostic contrast agent for atherosclerosis and cancer.

关键词： nanohybrids multimodal imagingcontrast agent diffusion reflection fluorescence lifetimeimaging atherosclerosis macrophages

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

固-液界面接触角测定实验的课程思政设计

大学化学 2024年第2期39卷 28-33页

作者：戴春爱韩永生颜鲁婷李振曹莹泽北京交通大学物理科学与工程学院北京100044 中国科学院大学化学工程学院北京100049 中国航天科技创新研究院北京100088 中国空间技术研究院北京100094

固液界面接触角的测定是一个重要的物理化学实验,本案例结合特殊润湿性材料可处理含油废水这一科研进展,将其改进为一个融入课程思政元素的综合创新实验,不仅能提升学生的学习兴趣,还能引导学生学会理论联系实际,利用所学专业知识来保... 详细信息

固液界面接触角的测定是一个重要的物理化学实验,本案例结合特殊润湿性材料可处理含油废水这一科研进展,将其改进为一个融入课程思政元素的综合创新实验,不仅能提升学生的学习兴趣,还能引导学生学会理论联系实际,利用所学专业知识来保护自然、治理环境,培养学生的社会责任感和专业自豪感,有助于达成创新型人才培养目标。

关键词：接触角测定物理化学实验特殊润湿性含油废水处理课程思政

超疏水表面的制备及其在含油废水处理中的应用——一个物理化学综合创新实验

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

大学化学 2024年第2期39卷 34-40页

以较前沿的科研成果为基础设计了一个物理化学综合创新实验。通过该实验,学生不仅可以了解油污染水环境问题,加深对润湿性一般理论的理解,还可以掌握超疏水材料的制备、接触角表征以及超疏水/超亲油材料对含油废水进行处理的操作和方法... 详细信息

以较前沿的科研成果为基础设计了一个物理化学综合创新实验。通过该实验,学生不仅可以了解油污染水环境问题,加深对润湿性一般理论的理解,还可以掌握超疏水材料的制备、接触角表征以及超疏水/超亲油材料对含油废水进行处理的操作和方法。实验融入了较多的课程思政元素,通过引导学生利用课堂学习的表面化学理论知识解决含油废水处理问题,培养学生的社会责任感、专业自豪感、严谨的科学思维和创新能力。

关键词：超疏水表面含油废水处理综合创新实验课程思政

Genomes and evolutionary genomics of animals

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2013年第1期59卷 87-98页

作者： luting SONG Wen WANG State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kun-ming Yunnan 650223 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

Alongside recent advances and booming applications of DNA sequencing technologies, a great number of complete genome sequences for animal species are available to researchers. Hundreds of animals have been involved in whole genome sequencing, and at least 87 non-human animal species’ complete or draft genome sequences have been published since 1998. Based on these technological advances and the subsequent accumulation of large quantity of genomic data, evolutionary genomics has become one of the most rapidly advancing disciplines in biology. Scientists now can perform a number of comparative and evolutionary genomic studies for animals, to identify conserved genes or other functional elements among species, genomic elements that confer animals their own specific characteristics and new phenotypes for adaptation. This review deals with the current ge-nomic and evolutionary research on non-human animals, and displays a comprehensive landscape of genomes and the evolutionary genomics of non-human animals. It is very helpful to a better understanding of the biology and evolution of the myriad forms within the animal kingdom.

关键词：进化基因组学动物物种全基因组序列 DNA测序技术全基因组测序生物学科研究人员技术进步

The effect of urbanization and exposure to multiple environmental factors on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2022年第3期13卷 301-310页

作者： Yanyan Zhao Emilio Pagani-Nú~nez Yu Liu Xiaoying Xing Zhiqiang Zhang Guangji Pan luting Song Xiang Li Zhuoya zhou Yanqiu Chen Donglai Li Yang Liu Rebecca J.Safran State Key Laboratory of Biocontrol School of EcologySun Yat-sen UniversityGuangzhou510006China Institute of Eco-Environmental Research Guangxi Academy of SciencesNanning530007China Department of Health and Environmental Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215028China Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijing100091China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin150006China Institute of Wildlife Conservation Central South University of Forestry and TechnologyChangsha410004China College of Life Science Liaoning UniversityShenyang110036China Department of Ecology and Evolutionary Biology University of ColoradoBoulderUSA

In addition to landscape changes,urbanization also brings about changes in environmental factors that can affect *** the common referral in the published literature to multiple environmental factors such as light and noise pollution,there is a gap in knowledge about their combined *** developed a multidimensional environmental framework to assess the effect of urbanization and multiple environmental factors(light,noise,and temperature)on life-history traits and breeding success of Barn Swallows(Hirundo rustica)across rural to urban gradients in four locations spanning over 2500 km from North to South *** a single breeding season,we measured these environmental factors nearby nests and quantified landscape urbanization over a 1km~*** then analysed the relationships between these multiple environmental factors through a principal component analysis and conducted spatially explicit linear-mixed effects models to assess their effect on lifehistory traits and breeding *** were particularly interested in understanding whether and how Barn Swallows were able to adapt to such environmental conditions associated with *** results show that there is significant variation in the exposure to environmental conditions experienced by Barn Swallows breeding across urbanization gradients in *** changes and their effects are complex due to the behavioural responses ameliorating potential negative effects by selecting nesting sites that minimize exposure to environmental ***,significant relationships between landscape urbanization,exposure to environmental factors,and life-history traits such as laying date and clutch size were ***,the impact on breeding success was,at least in our sample,negligible,suggesting that Barn Swallows are extremely adaptable to a wide range of environmental features.

关键词： Fitness Heat-island effect Latitude Light pollution Noise pollution Parental investment

Survivin和Bcl-2蛋白在胃癌细胞中的表达及其与化疗药物耐药性关系的研究

在线全文

学校读者我要写书评

暂无评论

现代肿瘤医学 2014年第7期22卷 1627-1629页

作者：周露婷王翠翠景洪标李培峰耿明济南军区总医院病理科山东济南250031

目的:检测Survivin和Bcl-2蛋白在胃癌组织中的表达,探讨Survivin和Bcl-2基因与胃癌化疗药物耐药性的关系。方法:取新鲜胃癌手术标本98例,免疫组化检测Survivin和Bcl-2蛋白在胃癌组织中的表达。同时进行原代胃癌细胞培养,MTT比色法检测... 详细信息

目的:检测Survivin和Bcl-2蛋白在胃癌组织中的表达,探讨Survivin和Bcl-2基因与胃癌化疗药物耐药性的关系。方法:取新鲜胃癌手术标本98例,免疫组化检测Survivin和Bcl-2蛋白在胃癌组织中的表达。同时进行原代胃癌细胞培养,MTT比色法检测原代培养细胞对化疗药物HCPT、CDDP、5-FU、ADM和MMC的敏感性。结果:胃癌组织中Survivin和Bcl-2蛋白的阳性率分别为74.5%和70.4%。Survivin阳性表达者对5-FU和ADM的耐药性显著高于阴性者,差异有统计学意义(P<0.05)。5-FU、ADM和MMC三种药物对Bcl-2阳性表达者的抑制率显著低于Bcl-2阴性表达者(P<0.05),其阳性表达与5-FU、ADM及MMC的体外耐药相关。结论:Survivin和Bcl-2基因与胃癌对化疗药物敏感性相关,Survivin与胃癌细胞原发性化疗耐受有关,检测其表达对选择化疗药物有实用价值。Bcl-2可能参与介导胃癌细胞的耐药,其高表达可能是胃癌多药耐药产生的原因之一。

关键词：胃肿瘤免疫组织化学 Survivin Bcl-2 化疗药物耐药性

Direct conversion of methane to methanol by electrochemical methods

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2022年第6期7卷 1132-1142页

作者： Haomin Jiang luting Zhang Zhiwei Han Yang Tang Yanzhi Sun Pingyu Wan Yongmei Chen Morris D.Argyle Maohong Fan Institute of Applied Electrochemistry College of ChemistryBeijing University of Chemical TechnologyBeijing100029China Department of Chemical Engineering Brigham Young UniversityProvoUT84602USA College of Engineering and Applied Sciences School of Energy ResourcesUniversity of WyomingLaramieWY82071USA

A convenient method for methane(CH_(4))direct conversion to methanol(CH_(3)OH)is of great significance to use methane-rich resources,especially clathrates and stranded shale gas resources located in remote ***,the activation of CH_(4) and the selectivity to the CH_(3)OH product are challenging due to the extreme stability of CH_(4) and relatively high reactivity of CH_(3)*** state-of-the-art‘methane reforming-methanol synthesis’process adopts a two-step strategy to avoid the further reaction of CH_(3)OH under the harsh conditions required for CH_(4) *** the electrochemical field,researchers are trying to develop conversion pathways under mild *** have found suitable catalysts to activate the C–H bonds in methane with the help of external charge and have designed the electrode reactions to continuously generate certain active oxygen *** active oxygen species attack the activated methane and convert it to CH_(3)OH,with the benefit of avoiding over-oxidation of CH_(3)OH,and thus obtain a high conversion efficiency of CH_(4) to CH_(3)*** mini-review focuses on the advantages and challenges of electrochemical conversion of CH4 to CH_(3)OH,especially the strategies for supplying electro-generated active oxygen species in-situ to react with the activated methane.

关键词： Methane Methanol Direct conversion Electrochemical methods Active oxygen species

不同内镜逆行胰胆管造影术复杂度分级量表在内镜医师培训中的效用比较

在线全文

学校读者我要写书评

暂无评论

中国内镜杂志 2024年第2期30卷 24-32页

作者：蔡小泥邵金海邱晨张诚杨玉龙章鲁艇绍兴市上虞人民医院(浙江大学医学院附属第二医院上虞分院)普外科浙江绍兴312300 绍兴市上虞人民医院(浙江大学医学院附属第二医院上虞分院)重症医学科浙江绍兴312300 同济大学附属东方医院胆石病中心上海200120

目的探讨不同内镜逆行胰胆管造影术(ERCP)的复杂度分级,在内镜医师培训中的效用。方法收集2022年2月-2023年2月华东地区两家医院由进修培训医师完成ERCP治疗的237例患者的临床资料。所有ERCP病例均使用已提出的复杂度分级量表进行分类,... 详细信息

目的探讨不同内镜逆行胰胆管造影术(ERCP)的复杂度分级,在内镜医师培训中的效用。方法收集2022年2月-2023年2月华东地区两家医院由进修培训医师完成ERCP治疗的237例患者的临床资料。所有ERCP病例均使用已提出的复杂度分级量表进行分类,包括:美国消化内镜学会(ASGE)分级量表、Morriston分级量表和HOUSE分级量表,并与肝胰壶腹解剖特征分类进行比较。记录患者插管成功率、手术治疗成功率和48 h内并发症发生率。结果在每一分级中,按严重程度分为亚组,3种不同分级中,亚组组间插管成功率比较,差异有统计学意义(P=0.000),亚组组间治疗成功率比较,差异有统计学意义(P=0.000);并发症发生率与ASGE分级(P=0.361)、Morriston分级(P=0.332)、HOUSE分级(P=0.586)之间没有相关性。当只考虑具有原始乳头的病例时,新加入肝胰壶腹解剖特征分类,插管成功率取决于复杂度分级。ASGE组中,亚组间插管成功率比较,差异有统计学意义(P=0.004);Morriston组中,亚组间插管成功率比较,差异有统计学意义(P=0.002);HOUSE组中,亚组间插管成功率比较,差异有统计学意义(P=0.000);肝胰壶腹特征组中,亚组间插管成功率比较,差异有统计学意义(P=0.000);治疗成功率与插管成功率亦有相似的发现(P=0.000);并发症发生率与ASGE分级(P=0.586)、Morriston分级(P=0.443)、HOUSE分级(P=0.306)和肝胰壶腹特征分类(P=0.350)之间没有相关性。结论使用肝胰壶腹解剖特征,作为胆管插管复杂度分类是可行的,其可以成为一种替代或附加手段,来预测胆管插管和手术治疗是否成功,未来也可用于评估内镜医师培训学习进度和技术水准。

关键词：内镜逆行胰胆管造影术内镜医师培训分级量表肝胰壶腹

维普期刊数据库博看期刊

Wnt-5a在原发性肝细胞癌发生中的表达及临床意义

在线全文

学校读者我要写书评

暂无评论

中国医师杂志 2014年第5期16卷 588-591页

作者：李培峰刘晓红曹永成王翠翠周露婷耿明济南军区总医院病理科济南250031

目的检测Wnt-5a基因和基因产物在原发性肝细胞癌中的表达,探讨Wnt-5a基因在肝癌发生过程中的作用和临床意义.方法采用实时定量PCR技术,检测Wnt-5a mRNA在26例新鲜肝细胞癌和癌旁组织中的含量;用免疫组化法观察Wnt-5a蛋白在85例肝细胞... 详细信息

目的检测Wnt-5a基因和基因产物在原发性肝细胞癌中的表达,探讨Wnt-5a基因在肝癌发生过程中的作用和临床意义.方法采用实时定量PCR技术,检测Wnt-5a mRNA在26例新鲜肝细胞癌和癌旁组织中的含量;用免疫组化法观察Wnt-5a蛋白在85例肝细胞癌和癌旁组织、15例肝硬化组织中的表达.结果 Wnt-5a mRNA在肝癌及癌旁组织中的相对含量分别为0.102 127±0.158 620和0.020 106±0.022 075,两者间差异有统计学意义（P＜0.05）;Wnt-5a蛋白在肝细胞癌、癌旁组织和肝硬化中的阳性率分别为21.2％（18/85）、81.26％（69/85）和86.7％（13/15）,Wnt-5a在肝癌组织中的阳性表达显著低于肝硬化和癌旁组织,差异有统计学意义（P ＜0.01）;Wnt-5a蛋白在肝癌中的表达与肿瘤的TNM分期和血清甲胎蛋白（AFP）含量有关（P＜0.05）.结论 Wnt-5a基因在HCC基因转录中呈上调表达,而在蛋白水平显示为缺失和下调表达,提示肿瘤细胞是在蛋白翻译水平而不是转录水平干扰了Wnt-5a基因功能.

关键词：癌,肝细胞遗传学原癌基因聚合酶链反应免疫组织化学

在线全文

学校读者我要写书评

暂无评论

抓住本质性内涵发展

北京教育（高教） 2024年第1期 30-30页

作者：马陆亭中国高等教育学会学术发展咨询委员会中国教育科学研究院

年轮新启,万物有本,本即我是我。做好自己,才能更好贡献客观世界。新时代发展的主题是高质量,高质量的核心在内涵。内涵是一事物区别于它事物的本质属性,是事物“类”的差异所在及核心竞争力的体现。在过去不具备条件的时候或尚未到高... 详细信息

年轮新启,万物有本,本即我是我。做好自己,才能更好贡献客观世界。新时代发展的主题是高质量,高质量的核心在内涵。内涵是一事物区别于它事物的本质属性,是事物“类”的差异所在及核心竞争力的体现。在过去不具备条件的时候或尚未到高质量发展阶段,我们可以围绕着核心内涵在外围创造条件谋发展,而一旦进入到高质量发展的新时代就必须牢牢抓住本质属性来发展,以保证发展不跑偏。否则,就是没抓准主责主业,甚至发生“荒自己的田”。

关键词：核心竞争力谋发展具备条件核心内涵主责主业本质属性本质性