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COVID-19感知易感性对健康风险感知、风险规避和出游意愿的影响:政府信任的调节作用(英文)

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Journal of Resources and Ecology 2024年第3期15卷 733-744页

作者：周彬王璐婷王灵恩 CHRIS Ryan 刘思怡熊启昊王玉欣宁波大学旅游系浙江宁波315211 中国科学院地理科学与资源研究所北京100101 怀卡托大学中国-新西兰旅游研究中心新西兰哈密尔顿3240 科廷大学商学与法学院管理与营销系澳大利亚珀斯6102

本研究考察了COVID-19感知易感性、健康风险感知、风险规避与出游意愿之间的关系,并探讨了政府信任的调节作用。研究数据通过腾讯问卷(113)和实地调研(507)两种方法收集。研究发现:感知易感性显著影响健康风险感知和风险规避,这2个变量... 详细信息

本研究考察了COVID-19感知易感性、健康风险感知、风险规避与出游意愿之间的关系,并探讨了政府信任的调节作用。研究数据通过腾讯问卷(113)和实地调研(507)两种方法收集。研究发现:感知易感性显著影响健康风险感知和风险规避,这2个变量又显著影响游客的出游意愿。健康风险感知和风险规避分别在感知易感性影响出游意愿发挥部分中介作用,它们之间的链式中介关系也得到支持。政府信任在感知易感性影响健康风险感知,以及健康风险感知和出游意愿之间有显著的调节作用。本研究对全球公共卫生危机游客出游意愿的影响因素提供了新的见解,有助于后疫情时代旅游经济复苏和目的地的营销策略制定。

关键词：感知易感性健康风险感知风险规避出游意愿政府信任

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软体机器人离子/电响应驱动材料与结构进展

机器人 2024年第2期46卷 178-194页

作者：吴佳祥邱林涛王吕婷赵雨开张凯航石烨杨栩旭李铁风浙江大学浙江杭州310013

介电弹性体和水凝胶这些软材料具有特殊的物理和化学特性,能够对外界刺激做出良好响应,使其成为新型软驱动器、可穿戴设备、医疗保健设备和人机交互机器人的重要组成部分。本文首先探讨了电子型电活性聚合物(介电弹性体材料)的应用前景... 详细信息

介电弹性体和水凝胶这些软材料具有特殊的物理和化学特性,能够对外界刺激做出良好响应,使其成为新型软驱动器、可穿戴设备、医疗保健设备和人机交互机器人的重要组成部分。本文首先探讨了电子型电活性聚合物(介电弹性体材料)的应用前景和改良路径。讨论了硅橡胶类、聚氨酯类和丙烯酸酯类介电弹性体的性能和优缺点,阐述了该类材料在人工肌肉中的应用前景及局限性。进而提出了利用瓶刷式介电弹性体(BBE)以及互穿型网络结构(IPN)改良材料性能等解决方案。其次,介绍了电磁响应型、渗透压响应型以及光响应型水凝胶驱动器,并对其各自的工作原理和应用进行了全面的阐述。最后,总结了介电弹性体和水凝胶两类驱动材料与结构对软体机器人性能的影响,展示了这两大类驱动器在软体机器人、人工肌肉和智能传感器等领域的应用可能性,并提出了未来的一些研究方向。

关键词：介电弹性体多功能材料水凝胶驱动器软体机器人

为学生的未来发展而教:引导式教学法的课堂实践

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创新人才教育 2024年第3期 6-12页

作者：刘灿杨咏梅王露婷教育科学出版社北京100101 贵阳市尚义路小学贵州贵阳550007 贵阳市南明区教育局贵州贵阳550007

引导式教学法以全人教育、建构主义、多元智能等为理论支撑,开展教学实践活动。它强调课前进行精心的教学设计与充分的教学准备,课中重视教学设计的实现度,并对现场生成保持开放,课后重视反思和持续迭代改进。贵阳市尚义路小学成为引导... 详细信息

引导式教学法以全人教育、建构主义、多元智能等为理论支撑,开展教学实践活动。它强调课前进行精心的教学设计与充分的教学准备,课中重视教学设计的实现度,并对现场生成保持开放,课后重视反思和持续迭代改进。贵阳市尚义路小学成为引导式教学法试点学校后,项目组以“引导型教师行动学习项目”为研修载体,加强教师培训,深化课堂教学改革,促进学习真实发生,提升了学生核心素养。

关键词：基础教育教学改革引导式教学课堂实践

The intragastrointestinal fate of paclitaxel-loaded micelles:Implications on oral drug delivery

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Chinese Chemical Letters 2021年第4期32卷 1545-1549页

作者： Iqbal Zoya Haisheng He luting wang Jianping Qi Yi Lu Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan University.Shanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China

The goal of the present study is to elucidate the intragastrointestinal fate of micellar delivery systems by monitoring fluorescently labeled different micelles and the model drug paclitaxel(PTX).Both in vitro and ex vivo leakage studies showed fast PTX release in fluids while micelles remained intact,except in fedstate simulated intestinal fluid and fasted-state pig intestinal fluid,thus referring to the intact absorption of micelles and PTX leakage in the gastrointestinal tract with D-a-tocopherol polyethylene glycol 1000 succinate(TPGS)micelles showing higher stability than other *** groups of micelles were absorbed intact in Caco-2 and Caco-2/HT29-MTX cell models and the absorption of TPGS micelles was found to be higher than other *** transport of the micelles across Caco-2/Raji(1.6%-3.5%),Caco-2(0.8%-1%),and Caco-2/HT29-MTX(0.58%-1%)cell monolayers further verified the absorption of micelles and their subsequent transport;however,more TPGS micelles transported across cell monolayers than other ***,the histological examination also confirmed that micelles ente red the enterocytes and were transported to basolateral tissues and TPGS showed the stronger ability of penetration than other ***,these results are succinctly presenting the absorption of intact micelles in GIT confirmed by imaging evidence with prior leakage of the drug,upta ke by enterocytes and the transport of micelles that survive the digestion by enterocytes and mainly by microfold cells in material nature dependent way with TPGS showing better results than other *** conclusion,these results identify the mechanism by which the gastrointestinal tract processes micelles and point to the likely use of this approach in the design of micelles-based therapies.

关键词： Drug delivery Oral Micelles Paclitaxel In vivo fate

The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2479-2493页

作者： Wufa Fan Haixia Peng Zhou Yu luting wang Haisheng He Yuhua Ma Jianping Qi Yi Lu Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province School of PharmacyQinghai Nationalities UniversityXining 810007China

The long-circulating effect is revisited by simultaneous monitoring of the drug payloads and nanocarriers following intravenous administration of doxorubicin(DOX)-loaded methoxy polyethylene glycol-polycaprolactone(mPEG-PCL) nanoparticles. Comparison of the kinetic profiles of both DOX and nanocarriers verifies the long-circulating effect, though of limited degree, as a result of pegylation. The nanocarrier profiles display fast clearance from the blood despite dense PEG decoration;DOX is cleared faster than the nanocarriers. The nanocarriers circulate longer than DOX in the blood, suggesting possible leakage of DOX from the nanocarriers. Hepatic accumulation is the highest among all organs and tissues investigated, which however is reversely proportionate to blood circulation time. Pegylation and reduction in particle size prove to extend circulation of drug nanocarriers in the blood with simultaneous decrease in uptake by various organs of the mononuclear phagocytic system. It is concluded that the long-circulating effect of mPEG-PCL nanoparticles is reconfirmed by monitoring of either DOX or the nanocarriers, but the faster clearance of DOX suggests possible leakage of a fraction of the payloads. The findings of this study are of potential translational significance in design of nanocarriers towards optimization of both therapeutic and toxic effects.

关键词： Long-circulating In vivo fate Aggregation-caused quenching Nanoparticles mPEG-PCL Doxorubicin Drug delivery Pharmacokinetics

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国外网页资源归档的协同采集模式及其启示

档案学研究 2022年第2期 69-76页

作者：王璐婷东南大学档案馆南京210096

立足网页资源归档协同采集模式旨在推动我国网页资源归档项目可持续开展。本文通过生命周期模型对人类和机器协同工作环节进行解析,通过国外网页资源归档项目案例分析对多机构协作采集模式的实现展开讨论,最终为我国网页资源归档实践开... 详细信息

立足网页资源归档协同采集模式旨在推动我国网页资源归档项目可持续开展。本文通过生命周期模型对人类和机器协同工作环节进行解析,通过国外网页资源归档项目案例分析对多机构协作采集模式的实现展开讨论,最终为我国网页资源归档实践开展提出四点建议。

关键词：网页资源归档生命周期模型协同采集

Band structures of strained kagome lattices

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Chinese Physics B 2024年第2期33卷 456-463页

作者：徐露婷杨帆 Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300354China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology Department of PhysicsTianjin UniversityTianjin 300354China

Materials with kagome lattices have attracted significant research attention due to their nontrivial features in energy *** theoretically investigate the evolution of electronic band structures of kagome lattices in response to uniaxial strain using both a tight-binding model and an antidot model based on a periodic muffin-tin *** is found that the Dirac points move with applied ***,the flat band of unstrained kagome lattices is found to develop into a highly anisotropic shape under a stretching strain along y direction,forming a partially flat band with a region dispersionless along ky direction while dispersive along kx *** results shed light on the possibility of engineering the electronic band structures of kagome materials by mechanical strain.

关键词： kagome lattice strain band structure engineering

A novel preimplantation genetic testing strategy for a subtelomeric genetic disorder:A case study

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Genes & Diseases 2024年第4期11卷 13-15页

作者： Songchang Chen Li Wanng luting Chen Weihui Shi Junyu Zhang Yuting Hu Yinyu wang Li Jin Jianzhong Sheng Feng Zhang Yanting Wu Hefeng Huang Chenming Xu Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200090China The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Research Units of Embryo Original Diseases Chinese Academy of Medical SciencesShanghai 200030China Key Laboratory of Reproductive Genetics(Ministry of Education) Department of Reproductive EndocrinologyWomen's HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China Shanghai First Maternity and Infant Hospital Tongji University School of MedicineShanghai 200030China

Preimplantation genetic testing(PGT)is a precise and effective technique for detecting inherited pathogenic mutations to prevent birth ***,there are few reports on PGT for pseudo-autosomal genetic diseases.

关键词： implantation testing precise

Bioactive chemical constituents from the marine-derived fungus Cladosporium ***-5

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Journal of Oceanology and Limnology 2024年第3期42卷 905-914页

作者： luting DAI Qingyi XIE Jiaocen GUO Qingyun MA Li YANG Jingzhe YUAN Haofu DAI Zhifang YU Youxing ZHAO College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Hainan Academy of Tropical Agricultural ResourceHaikou 571101China

A new isochromanone,cladosporinisochromanone(1),accompanied by 15 known compounds(2–16)were obtained from secondary metabolites produced by marine-derived fungus Cladosporium *** and HRESIMS spectra elucidation determined the planar structure of *** electronic circular dichroism(ECD)experiment assigned the absolute configuration of *** 1,2,4–6,and 10 displayed different degrees of neuroprotective activities on human neuroblastoma cells *** compounds(1,3–5,and 13)emerged resistance to protein tyrosine phosphatase 1B(PTP1B),further kinetic analysis and molecular docking study indicated that the most potent compound 13(IC50value of 10.74±0.61μmol/L)was found as a noncompetitive inhibitor for *** plasmon resonance(SPR)and molecular docking studies also demonstrated the interaction between compound 12 and Niemann-Pick C1 Like 1(NPC1L1),which has been identified as significant therapeutic target for *** addition,compounds 3,6,and 14 showed attractive inhibitory activity against the phytopathogenic fungi:Colletotrichum ***,library of Cladosporium metabolites is enriched and new active uses of known compounds are explored.

关键词： Cladosporium sp. marine-derived fungus neuroprotective effects protein tyrosine phosphatase 1B(PTP1B) Niemann-Pick C1 Like 1(NPC1L1) antifungal activity