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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun luqian feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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影响HUS治疗产后Ⅲ~Ⅳ度盆腔脏器脱垂效果的因素分析

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中国妇产科临床杂志 2024年第5期25卷 429-432页

作者：孙畅任露倩杨茜淇冯林侍立峰中国人民解放军联勤保障部队第九〇三医院妇产科杭州310031 中国人民解放军联勤保障部队第九〇三医院健康医学科杭州310031

目的分析影响腹腔镜下高位骶韧带悬吊(HUS)治疗产后Ⅲ~Ⅳ度盆腔脏器脱垂(POP)效果的相关因素。方法从中国人民解放军联勤保障部队第九〇三医院妇产科资料库中调取2019年8月至2022年8月行HUS的产后Ⅲ~Ⅳ度POP患者的病历资料进行回顾性研... 详细信息

目的分析影响腹腔镜下高位骶韧带悬吊(HUS)治疗产后Ⅲ~Ⅳ度盆腔脏器脱垂(POP)效果的相关因素。方法从中国人民解放军联勤保障部队第九〇三医院妇产科资料库中调取2019年8月至2022年8月行HUS的产后Ⅲ~Ⅳ度POP患者的病历资料进行回顾性研究,根据术后1年的临床疗效将患者分为无效组(n=26)和有效组(n=188)。收集两组资料,分析影响HUS治疗产后Ⅲ~Ⅳ度POP效果的因素。结果经单因素、多因素Logistic回归分析显示,阴道分娩史(OR=11.909)、血清松弛素水平异常升高(OR=1.167)、基质金属蛋白酶-1(MMP-1)水平异常升高(OR=11.656)是影响HUS治疗产后Ⅲ~Ⅳ度POP效果的危险因素,而术后规律性生活(OR=0.043)则是保护因素。结论HUS治疗产后Ⅲ~Ⅳ度POP效果受阴道分娩次数、术后规律性生活、血清松弛素及MMP-1水平等综合因素的影响,建议针对性早期宣教及干预性治疗,以提高手术治疗效果。

关键词：盆腔脏器脱垂盆底重建术阴道分娩松弛素

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The Binarity of Early-type Stars from LAMOST medium-resolution Spectroscopic Survey

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Research in Astronomy and Astrophysics 2022年第2期22卷 92-107页

作者： Yanjun Guo Jiao Li Jianping Xiong Jiangdan Li luqian Wang Heran Xiong feng Luo Yonghui Hou Chao Liu Zhanwen Han Xuefei Chen Yunnan Observatories Chinese Academy of SciencesP.O.Box 110Kunming650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Research School of Astronomy and Astrophysics Mount Stromlo ObservatoryThe Australian National UniversityACT 2611Australia Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China School of Astronomy and Space Science University of Chinese Academy of SciencesChina Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China

Massive binaries play significant roles in many *** massive stars,particularly massive binaries,is of great *** this paper,by adopting the technique of measuring the equivalent widths of several spectral lines,we identified 9382 early-type stars from the LAMOST medium-resolution survey and divided the sample into four groups,T1(~O-B4),T2(~B5),T3(~B7)and T4(~B8-A).The relative radial velocities RVrelwere calculated using Maximum Likelihood *** stars with significant changes of RVreland at least larger than 15.57 km s-1 were identified as spectroscopic *** found that the observed spectroscopic binary fractions for the four groups are 24.6%±0.5%,20.8%±0.6%,13.7%±0.3%and 7.4%±0.3%,*** that orbital period(P)and mass ratio(q)have intrinsic distributions as f(P)∝Pπ(1

关键词： early-type stars:statistics (stars:)binaries:spectroscopic catalogs

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碳捕捉新技术清除二氧化碳

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低温与特气 2019年第1期37卷 10-10页

作者：吴鹏赵冰冯鲁迁赵安雷黄丹王波刘毅文酒泉卫星发射中心甘肃酒泉732750

近日,美国能源部橡树岭国家实验室(ORNL)科学家开发出一种可去除燃煤电厂二氧化碳的方法,其原理类似于水肺潜水换气器中碱石灰的工作原理,为碳捕获提供了一种更简单的替代性策略,所需能源比工业基准解决方案减少24%。

关键词：二氧化碳美国能源部技术捕捉国家实验室燃煤电厂工作原理科学家

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