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Gut liver brain axis in diseases:the implications for therapeutic interventions

Signal Transduction and Targeted Therapy 2024年第1期9卷 79-104页

作者： Mengyao yan Shuli Man Benyue Sun Long Ma Lanping Guo luqi Huang Wenyuan Gao State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&Technology300457 TianjinChina National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences100700 BeijingChina Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityWeijin Road300072 TianjinChina

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract,liver,and nervous *** the past few decades,breakthrough progress has been made in the gut liver brain axis,mainly through understanding its formation mechanism and increasing treatment *** this review,we discuss various complex networks including barrier permeability,gut hormones,gut microbial metabolites,vagus nerve,neurotransmitters,immunity,brain toxic metabolites,β-amyloid(Aβ)metabolism,and epigenetic regulation in the gut-liver-brain *** therapies containing antibiotics,probiotics,prebiotics,synbiotics,fecal microbiota transplantation(FMT),polyphenols,low FODMAP diet and nanotechnology application regulate the gut liver brain ***,some special treatments targeting gut-liver axis include farnesoid X receptor(FXR)agonists,takeda G protein-coupled receptor 5(TGR5)agonists,glucagon-like peptide-1(GLP-1)receptor antagonists and fibroblast growth factor 19(FGF19)*** gut-brain axis embraces cognitive behavioral therapy(CBT),antidepressants and tryptophan metabolism-related *** liver-brain axis contains epigenetic regulation and Aβmetabolism-related *** the future,a better understanding of gut-liver-brain axis interactions will promote the development of novel preventative strategies and the discovery of precise therapeutic targets in multiple diseases.

关键词： metabolism therapeutic immunity

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Centrifuge modeling of unreinforced and multi-row stabilizing piles reinforced landslides subjected to reservoir water level fluctuation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1600-1614页

作者： Chenyang Zhang Yueping Yin Hui yan Sainan Zhu Ming Zhang luqi Wang Department of Civil Engineering The University of Hong KongHong KongChina China Institute of Geo-environment Monitoring BeijingChina Chongqing 107 Municipal Construction Engineering Co. Ltd.ChongqingChina Faculty of Engineering China University of GeosciencesWuhanChina School of Civil Engineering Chongqing UniversityChongqingChina

With the construction of the Three Gorges Reservoir dam,frequent reservoir landslide events have been *** recent years,multi-row stabilizing piles(MRSPs)have been used to stabilize massive reservoir landslides in *** this study,two centrifuge model tests were carried out to study the unreinforced and MRSP-reinforced slopes subjected to reservoir water level(RWL)operation,using the Taping landslide as a *** results indicate that the RWL rising can provide lateral support within the submerged zone and then produce the inward seepage force,eventually strengthening the slope ***,a rapid RWL drawdown may induce outward seepage forces and a sudden debuttressing effect,consequently reducing the effective soil normal stress and triggering partial pre-failure within the RWL fluctuation ***,partial deformation and subsequent soil structure damage generate excess pore water pressures,ultimately leading to the overall failure of the reservoir *** study also reveals that a rapid increase in the downslope driving force due to RWL drawdown significantly intensifies the lateral earth pressures exerted on the ***,the MRSPs possess a considerable reinforcement effect on the reservoir landslide,transforming the overall failure into a partial deformation and failure situated above and in front of the *** mechanical transfer behavior observed in the MRSPs demonstrates a progressive alteration in relation to RWL *** the RWL rises,the mechanical states among MRSPs exhibit a growing *** shear force transfer factor(*** ratio of shear forces on pile of the n th row to that of the first row)increases significantly with the RWL *** indicates that the mechanical states among MRSPs tend toward an enhanced *** insights gained from this study contribute to a more comprehensive understanding of the failure mechanisms of reservoir landslides and the mechanical behavior of M

关键词： Reservoir landslide Failure mechanism Multi-row stabilizing piles Mechanical behavior

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Sentiment Analysis of Short Texts Based on Parallel DenseNet

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Computers, Materials & Continua 2021年第10期69卷 51-65页

作者： luqi yan Jin Han Yishi Yue Liu Zhang yannan Qian Nanjing University of Information Science&Technology Nanjing210044China State Grid Hunan Electric Power Company Limited Research Institute Changsha410007China Waterford Institute of Technology WaterfordX91 K0EKIreland

Text sentiment analysis is a common problem in the field of natural language processing that is often resolved by using convolutional neural networks(CNNs).However,most of these CNN models focus only on learning local features while ignoring global *** this paper,based on traditional densely connected convolutional networks(DenseNet),a parallel DenseNet is proposed to realize sentiment analysis of short ***,this paper proposes two novel feature extraction blocks that are based on DenseNet and a multiscale convolutional neural ***,this paper solves the problem of ignoring global features in traditional CNN models by combining the original features with features extracted by the parallel feature extraction block,and then sending the combined features into the final ***,a model based on parallel DenseNet that is capable of simultaneously learning both local and global features of short texts and shows better performance on six different databases compared to other basic models is proposed.

关键词： Sentiment analysis short texts parallel DenseNet

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Study on the four Qi of Pfaffia glomerata based on the metabolomics technology and comparison of Dangshen(Radix Codonopsis) in the equivalent substitution prescription

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Journal of Traditional Chinese Medicine 2024年第4期44卷 713-721页

作者： SONG Zhenguang yanG Bin WANG Fei yan Dongmei ZHOU Xiaoqing HUANG Liping GAO Xuemei LI Bin HUANG luqi Academician Workstation Jiangxi University of Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China School of PharmacyChengdu University of Traditional Chinese Medicine National Resource Center for Chinese Materia Medica Chinese Academy of Chinese Medical Sciences(CACMS)

OBJECTIVE: To explore the four Qi of Pfaffia glomerata(PG) and endow this foreign folk herb with the properties of Chinese medicine, make it Chinese medicinal and localized, and could be used as a Chinese medicine. METHODS: The normal group, six cold herb groups, six hot herb groups, six cool herb groups, PG prescription group(PGPG), and Dangshen(Radix Codonopsis) prescription group(CPPG) were prepared with corresponding concentrations of water extracts, these herb extracts were administered by gavage to SpragueDawley rats, and the 12 h urine at night on the 29th day of the SD rats in each group were collected, Liquid Chromatograph Mass Spectrometer system was used to analyze them, the best discriminant models for the medicinal properties of cold-hot and cold-cool were set up, so as to the medicinal properties of PGPG, CPPG and PG were predicted. Based on the Progenesis QI, Human Metabolome Database, Kyoto Encyclopedia of Genes and Genomes, MetaboAnalyst 5.0 database, we enriched metabolic pathway and classification mechanism of medicinal properties of cold-cool Chinese herbs and the molecular mechanism of PG prescription. RESULTS: We established a best model of cold-hot herbal discrimination in the positive ion mode, then the probability that PGPG was predicted cold property was 88.9%. Furthermore, a model of cold-cool herbal discrimination was established, then the probability of PGPG containing the cool property was 77.8%. In addition, typical cold and cool herbs mainly affected nine biomarkers such as tyrosine-proline,(R)-3',7-Dihydroxy-2',4'-dimethoxyisoflavane in rats. The regulation trend of PGPG on markers was basically as same as the cool herbs and mainly involved in regulating the two pathways of cytochrome P450 and purine metabolism. CONCLUSION: The results showed PGPG had a cool medicinal property as same as CPPG, and the regulation trend of PGPG on markers was consistent with cool herbs. Therefore, the medicine properties PG and CP should be consistent,

关键词： Pfaffia glomerata equivalent substitution medicinal properties of Chinese medicine metabolomics molecular mechanism

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海洋微生物源抗菌肽对鲜榨黄瓜汁贮藏品质的影响

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食品工业科技 2023年第18期44卷 398-406页

作者：鄢陆琪谭明辉李昆太广东海洋大学食品科技学院广东省水产品加工与安全重点实验室广东省海洋食品工程技术研究中心广东省海洋生物制品工程实验室水产品深加工广东普通高等学校重点实验室广东湛江524088 海洋食品精深加工关键技术省部共建协同创新中心大连工业大学辽宁大连116034

探究不同浓度海洋枯草芽孢杆菌抗菌肽对鲜榨黄瓜汁常温贮藏期内(5 d)品质的影响。采用感官评价、理化分析(pH、稳定系数、总糖含量、菌落总数)及电子鼻技术(主成分分析、雷达图、主要风味成分传感器相应值)综合评价保鲜作用效果。结果表... 详细信息

探究不同浓度海洋枯草芽孢杆菌抗菌肽对鲜榨黄瓜汁常温贮藏期内(5 d)品质的影响。采用感官评价、理化分析(pH、稳定系数、总糖含量、菌落总数)及电子鼻技术(主成分分析、雷达图、主要风味成分传感器相应值)综合评价保鲜作用效果。结果表明,抗菌肽浓度与各项理化指标呈正相关,2×MIC浓度抗菌肽作用效果最优,感官评分(7.03)、pH(4.97)、稳定系数(32.86%)、总糖含量(5.11 mg/mL)最高,抑菌效果最佳(0.88 log CFU/mL)。主成分分析(principal component analysis,PCA)表明各抗菌肽处理组黄瓜汁的风味特征相似,对照组与山磷酸钾处理组黄瓜汁的风味特征相似;雷达图揭示各抗菌肽处理组黄瓜汁的风味物质在贮藏后期(第5 d)有所增加,对照组与山梨酸钾处理组黄瓜汁的风味物质在贮藏期内基本不变;主要风味成分传感器响应值分析表明枯草芽孢杆菌BBW1542抗菌肽对鲜榨黄瓜汁中挥发性风味物质产生了一定的影响。综上所述,枯草芽孢杆菌BBW1542抗菌肽的保鲜效果均显著优于化学保鲜剂组(P<0.05)。本研究可为鲜榨黄瓜汁短期贮藏品质保障及海洋微生物源保鲜剂的开发应用提供理论依据。

关键词：鲜榨黄瓜汁保鲜效果海洋微生物源抗菌肽枯草芽孢杆菌风味

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一株拮抗柑橘绿霉病海洋微生物的分离筛选鉴定及其所产活性物质稳定性研究

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江西农业大学学报 2022年第6期44卷 1529-1537页

作者：凌晓宁鄢陆琪张荣章启慧李昆太江西农业大学生物科学与工程学院/江西省农业微生物资源开发与利用工程实验室江西南昌330045 广东海洋大学食品科技学院广东湛江524088

【目的】筛选对柑橘绿霉病菌指状青霉(Penicillium digitatum)具有拮抗作用的海洋源微生物,以期为柑橘绿霉病的生物防治提供新的菌种资源。【方法】采用平板稀释涂布法,从广东湛江海域的5个海底淤泥样品中分离微生物;以指状青霉为指示菌... 详细信息

【目的】筛选对柑橘绿霉病菌指状青霉(Penicillium digitatum)具有拮抗作用的海洋源微生物,以期为柑橘绿霉病的生物防治提供新的菌种资源。【方法】采用平板稀释涂布法,从广东湛江海域的5个海底淤泥样品中分离微生物;以指状青霉为指示菌,利用平板对峙法对分离的海洋微生物进行初筛,管碟法进行复筛。对复筛获得的菌株HY 2-1进行形态学观察、生理生化检测、16S rDNA序列分析及分类学鉴定,并测定该菌对不同盐浓度的耐受性。通过紫外照射、热、酸碱及酶等手段处理无菌发酵上清液(CFS),初步探究菌株HY 2-1所产活性物质的稳定性。【结果】筛选出一株对指状青霉有较好拮抗作用的细菌,其抑菌圈直径达到(21.88±0.19)mm,该菌鉴定为解淀粉芽孢杆菌(Bacillus amyloliquefaciens)。培养基盐质量浓度在20 g/L范围内对菌株HY2-1生长具有促进作用,且该菌对盐的耐受性高达130 g/L。菌株HY 2-1的CFS在短时间紫外照射下稳定性较好,60℃以内热稳定性较好,在pH值3~9的范围内抑菌活性稳定,但经胃蛋白酶、胰蛋白酶、蛋白酶K等酶处理后,抑菌活性显著降低(P<0.05)。【结论】来源于广东省湛江市北部湾海域的解淀粉芽孢杆菌HY 2-1(*** HY 2-1),具有耐受高盐的特性,且其发酵上清液抑菌活性物质的稳定性较好,可为柑橘采后病害生防制剂的开发奠定基础。

关键词：解淀粉芽孢杆菌筛选鉴定指状青霉稳定性

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当代国画没骨画的美学构成及现代设计应用研究

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鞋类工艺与设计 2024年第7期4卷 70-72页

作者：王雁王露琦西京学院设计艺术学院陕西西安710123

国画没骨画兼具工笔与写意的优点,但又和这些风格存在差异,凭借着独特的性质备受民众的青睐,该中国传统绘画形式传承价值是非常高的。时代不断发展的过程中,赋予没骨画更为丰富的风格,尤其是新元素的加入使其具有创新性。没骨画的美学... 详细信息

国画没骨画兼具工笔与写意的优点,但又和这些风格存在差异,凭借着独特的性质备受民众的青睐,该中国传统绘画形式传承价值是非常高的。时代不断发展的过程中,赋予没骨画更为丰富的风格,尤其是新元素的加入使其具有创新性。没骨画的美学构成使其美感更为丰富,提升观赏者的审美体验,从而吸引更多学者开展相关研究工作。基于此,本文对没骨画的表现形式进行分析,并探究没骨画的美学构成,提出其在现代设计的应用策略。

关键词：没骨画美学构成现代设计

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瘟疫与中医:我们为什么要关注?

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Science Bulletin 2024年第11期69卷 1617-1622页

作者：熊一白鲍琳琳马艳张玲秦川黄璐琦 NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Changping National Laboratory(CPNL) Beijing 102206China National Center for Technology and Innovation of Animal Model Beijing 100021China

Wen-Yi refers to an acute infectious disease that is highly contagious and can cause widespread *** known as“Yi”or“Li”in the Chinese medicine(CM)literature,Wen-Yi diseases,such as corona virus disease 2019(COVID-1... 详细信息

关键词： acute diseases tuberculosis

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重组枯草芽孢杆菌产角蛋白酶的发酵培养基及发酵条件优化

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中国饲料 2023年第19期 29-36页

作者：利刚慧刘俊杰彭帅英梁颖茵鄢陆琪李昆太广东海洋大学食品科技学院广东湛江524088 江西农业大学生物科学与工程学院江西南昌330045

角蛋白是潜在的优良饲用蛋白资源,其中角蛋白酶作为可特异性降解角蛋白的酶类,在角蛋白饲料化领域展现出广泛的应用潜力和价值。本研究以自主构建的重组角蛋白酶工程菌枯草芽孢杆菌WB600-pMA5-kerJY-23为研究对象,利用单因素和二次通用... 详细信息

角蛋白是潜在的优良饲用蛋白资源,其中角蛋白酶作为可特异性降解角蛋白的酶类,在角蛋白饲料化领域展现出广泛的应用潜力和价值。本研究以自主构建的重组角蛋白酶工程菌枯草芽孢杆菌WB600-pMA5-kerJY-23为研究对象,利用单因素和二次通用旋转组合设计试验对其摇瓶发酵产角蛋白酶的发酵培养基和发酵条件进行优化。结果表明:该菌株最佳发酵产酶条件为:葡萄糖25 g/L,蔗糖25 g/L,酵母浸膏20 g/L,硫酸铵10 g/L,磷酸氢二钾1.5 g/L,氯化钠0.3 g/L,氯化钙0.025 g/L,硫酸镁0.025 g/L,硫酸亚铁0.015 g/L,氯化锰0.05 g/L,初始pH 8,装液量45 mL/250 mL三角瓶,接种量6%,培养温度37℃,摇床转速200 r/min,发酵周期36 h。在该优化条件下,重组枯草芽孢杆菌WB600发酵产角蛋白酶的酶活达到(2110±15.011)U/mL,较优化前提高了5.10倍(P<0.05),为该酶在角蛋白降解及资源化利用领域的应用提供了理论依据与研究基础。

关键词：角蛋白酶重组枯草芽孢杆菌WB600 发酵培养基发酵条件优化

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客观性、原则性、灵活性——容积率“值域化”在石嘴山星海湖新区控规中的实践探索

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规划师 2014年第12期30卷 59-64页

作者：黄明华鄢鹿其王阳王琛西安建筑科技大学建筑学院西安建大城市规划设计研究院西安建筑科技大学

容积率"值域化"是由容积率影响因子与容积率之间的数理模型推导出的一个(容积率)区间值。研究以既有容积率"值域化"研究为基础,针对石嘴山星海湖新区内容积率确定过程中存在科学依据不足、价值取向模糊和"刚弹"适应欠缺的现实问题,结合... 详细信息

容积率"值域化"是由容积率影响因子与容积率之间的数理模型推导出的一个(容积率)区间值。研究以既有容积率"值域化"研究为基础,针对石嘴山星海湖新区内容积率确定过程中存在科学依据不足、价值取向模糊和"刚弹"适应欠缺的现实问题,结合新区内具有商业开发性的居住用地和商业服务业设施用地,运用"值域区间(控制性指标)—引导数值(引导性指标)—调整区间"的控制方法,对"值域化"的实践进行探讨,从而最终实现容积率"值域化"控制。

关键词：容积率“值域化” 星海湖新区新区控规

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