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Cross correlation mediated by distant Majorana zero modes with no overlap

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Chinese Physics B 2022年第1期31卷 561-567页

作者：秦陆培冯伟李新奇 Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300072China

Existing studies via shot noise calculation conclude that the cross correlation between the currents in the two leads connected by a pair of Majorana zero modes(MZMs)vanishes when their coupling energy𝜖∈_(M)→*** by the intrinsic nature of nonlocality of the MZMs,we revisit this important problem and propose an experimental scheme to demonstrate the nonvanishing cross correlation even at the limit𝜖∈_(M)→*** proposed scheme employs the Andreevprocess-associated branch circuit currents,which are theoretically obtained by applying a decomposition analysis for the total currents while are accessible directly in practical *** different bias voltage setup,we find intriguing results of both negative and positive correlations and carry out simple physical understanding using a quantum jump ***,combining together with the evidence of the zero-bias-peak of conductance,the nonlocal cross correlation predicted in this work can help to confirm the existence of the nonlocal MZMs.

关键词： Majorana zero modes cross correlation Andreev currents

Double-dot interferometer for quantum measurement of Majorana qubits and stabilizers

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Chinese Physics B 2021年第1期30卷 142-150页

作者：周凯张程秦陆培李新奇 Department of Physics Beijing Normal UniversityBeijing 100875China Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300072China

Motivated by the need of quantum measurement of Majorana qubits and surface-code stabilizers, we analyze the performance of a double-dot interferometer under the influence of environment noise. The double-dot setup design allows accounting for the full multiple tunneling process between the dots through the Majorana island, within a master equation approach. In the co-tunneling regime, which results in a Majorana-mediated effective coupling between the dots, the master equation approach allows us to obtain analytic solutions for the measurement currents. The measurement quality,characterized by figures of merit such as the visibility of measurement signals, is carried out in regard to the unusual decoherence effect rather than ‘which-path’ dephasing. The results obtained in this work are expected to be useful for future experiments of Majorana qubit and stabilizer measurements.

关键词： Majorana qubits stabilizers quantum measurements

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基于弱值放大的量子精密测量的评估分析

北京师范大学学报（自然科学版） 2022年第3期58卷 387-391页

作者：刘迎新秦陆培李新奇天津大学理学院量子交叉研究中心天津300072

针对弱值放大方案与常规方案相比是否具有优越性这一颇具争议问题,本文对不同情况做了探讨和澄清.利用Fisher信息,分别刻画了meter态为高斯型波函数及光学相干态的计量精度,指出高斯型meter态在弱值放大测量中所包含的Fisher信息最多只... 详细信息

针对弱值放大方案与常规方案相比是否具有优越性这一颇具争议问题,本文对不同情况做了探讨和澄清.利用Fisher信息,分别刻画了meter态为高斯型波函数及光学相干态的计量精度,指出高斯型meter态在弱值放大测量中所包含的Fisher信息最多只能达到与常规标准测量相同的结果;而利用光学相干态作为meter态,基于光子数测量提取编码在相位移动相干态中的Fisher信息,弱值放大测量技术可以明显优于标准测量方案.

关键词：测量精度弱值放大 Fisher信息

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奇异量子弱值的物理根源

北京师范大学学报（自然科学版） 2016年第6期52卷 677-680页

作者：秦陆培李新奇北京师范大学物理学系北京100875

对量子弱值这一重要而又备受争议的量子物理概念,提供了一个简明、直接的理解方法,澄清了引起量子弱值异常的物理根源。我们的分析以施特恩-盖拉赫装置在量子贝叶斯框架下得到的严格结果为数学基础.我们还特别对一项近期工作引起的混乱... 详细信息

对量子弱值这一重要而又备受争议的量子物理概念,提供了一个简明、直接的理解方法,澄清了引起量子弱值异常的物理根源。我们的分析以施特恩-盖拉赫装置在量子贝叶斯框架下得到的严格结果为数学基础.我们还特别对一项近期工作引起的混乱做出了澄清.该工作声称,奇异弱值可以由数据统计引起,而非量子物理特有的本质.

关键词：量子弱值量子贝叶斯公式量子干涉

Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2429-2442页

作者： Dong Liang Chen Yu Zhao Ma Xingye Yang Zhenzhen Li Xuhui Dong Xiaojun qin lupei Du Minyong Li Key Laboratory of Chemical Biology(MOE) School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Head and neck squamous cell carcinoma(HNSCC) is one of the most common human cancers;however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map(cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. In addition, tubulin was identified as a primary target of parbendazole, and the direct binding between them was further verified. Parbendazole was further proved as an effective tubulin polymerization inhibitor, which can block the cell cycle, cause apoptosis and prevent cell migration, and it exhibited reasonable therapeutic effect and low toxicity in the in vivo and in vitro anti-tumor evaluation. Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers.

关键词： HNSCC cMap Bioinformatics Parbendazole Drug repositioning Anti-tumor

First small-molecule PROTACs for G protein-coupled receptors:inducing α1A-adrenergic receptor degradation

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1669-1679页

作者： Zhenzhen Li Yuxing Lin Hui Song Xiaojun qin Zhongxia Yu Zheng Zhang Gaopan Dong Xiang Li Xiaodong Shi lupei Du Wei Zhao Minyong Li Department of Medicinal Chemistry Key Laboratory of Chemical Biology(MOE)School of PharmacyShandong UniversityJinan 250012China Department of Immunology Key Laboratory of Infection and Immunity of Shandong ProvinceSchool of Basic Medical ScienceShandong UniversityJinan 250012China Department of Chemistry University of South FloridaTampaFL 33620USA State Key Laboratory of Microbial Technology Shandong UniversityJinan 250100China

Proteolysis targeting chimeras(PROTACs)are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitinproteasome system(UPS),thereby selectively reducing the target protein level by the ubiquitinproteasome ***,small-molecule PROTACs are gaining popularity as tools to desrade pathogenic ***,we present the first small-molecule PROTACs that can induce the alA-adrenergic receptor(α1 A-AR)degradation,which is also the first small-molecule PROTACs for G proteincoupled receptors(GPCRs)to our *** degradation inducers were developed through conjugation of knownα1-adrenergic receptors(α1-ARs)inhibitor prazosin and cereblon(CRBN)ligand pomalidomide through the different *** representative compound 9 c is proved to inhibit the proliferation of PC-3 cells and result in tumor growth regression,which highlighted the potential of our study as a new therapeutic strategy for prostate cancer.

关键词： Small-molecule PROTACs α1A-Adrenergic receptor Ubiquitylation Degradation Prostate cancer

胸外科专科医师规范化培训制度的国内外对比和试点思考

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中华外科杂志 2022年第8期60卷 742-748页

作者：沈莹冉蔡陆培秦雄王海峰张鹏朱余明陈昶姜格宁戴洁同济大学附属上海市肺科医院胸外科上海200433 皇家斯托克大学医院斯托克ST46QG英国

我国的胸外科专科医师规范化培训在受训者筛选和考核、培训内容设置和出站要求设定等方面尚未形成统一制度。从培训模式、基地认证、对象招收、培训内容、考核标准及科研能力培训六个方面, 对比我国与日本、美国、英国的胸外科专科培训... 详细信息

我国的胸外科专科医师规范化培训在受训者筛选和考核、培训内容设置和出站要求设定等方面尚未形成统一制度。从培训模式、基地认证、对象招收、培训内容、考核标准及科研能力培训六个方面, 对比我国与日本、美国、英国的胸外科专科培训制度后发现, 各国培训体制存在差异, 建立有效的专科培训制度需立足我国的基本国情。应建立住院医师规范化培训和专科医师规范化培训相衔接的培养模式, 逐步打造一体化培训体系, 并针对受训者的需求, 制定不同的培训模式, 提供多样化选择。通过设置全国统一的课程大纲, 严格筛选培训基地, 缩小各省市医院间培养的专科医师在业务能力和学术能力上的差异, 保障培训的同质化。同时需注重科研教学, 提升受训者的创新能力和科研素养, 推动科研型临床人才的建设。建立合理且高效的培训模式, 有望推动我国专科医学教育的进步。

关键词：胸外科学教育专业专科医师住院医师