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CD9 negatively regulates collective electrotaxis of the epidermal monolayer by controlling and coordinating the polarization of leader cells

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Burns & Trauma 2023年第1期11卷 361-374页

作者： Xiaoqiang liu Jinrui Yang Meng Kong Min Jiang luojia liu Jinghong Zhang Ying Chen Xu Chen Ze Zhang Chao Wu Xupin Jiang Jie liu Jiaping Zhang Department of Plastic Surgery State Key Laboratory of TraumaBurns and Combined InjurySouthwest HospitalThird Military Medical University(Army Medical University)29 Gaotan Yan StreetShapingba400038 ChongqingChina

Background:Endogenous electric fields(EFs)play an essential role in guiding the coordinated collective migration of epidermal cells to the wound centre during wound *** polarization of leadercells is essential for collective migration,the signal mechanisms responsible for the EF-induced polarization of leader cells under electrotactic collective migration remain *** study aims to determine how the leader cells are polarized and coordinated during EF-guided collective migration of epidermal cell ***:Collective migration of the human epidermal monolayer(human immortalized ker-atinocytes HaCaT)under EFs was observed via time-lapse *** involvement of tetraspanin-29(CD9)in EF-induced fibrous actin(F-actin)polarization of leader cells as well as electrotactic migration of the epidermal monolayer was evaluated by genetic ***,rescue and co-culture experiments were conducted to explore the downstream signalling of ***:EFs guided the coordinated collective migration of the epithelial monolayer to the anode,with dynamic formation of pseudopodia in leader cells at the front edge of the monolayer along the direction of migration.F-actin polarization,as expected,played an essential role in pseudopod formation in leader cells under *** confocal microscopy,we found that CD9 was colocalized with F-actin on the cell surface and was particularly downregulated in leader cells by ***,genetic overexpression of CD9 abolished EF-induced F-actin polarization in leader cells as well as collective migration in the epidermal ***,CD9 determined the polarization of F-actin in leader cells by downregulating a disintegrin and metalloprotease 17/heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor(ADAM17/HB-EGF/EGFR)*** abolished polarization of leader cells due to CD9 overex-pression could be restored in a co-culture monolayer where normal c

关键词： CD9 Electric fields Collective migration Wound healing F-actin polarization leader cells

基于三生融合理念的既有厂区景观设计方法探索

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城市建筑 2024年第13期21卷 194-198页

作者：刘荦珈郜鹏宋志永中国兵器工业集团北方工程设计研究院有限公司

随着生态景观逐步受到关注,工业厂区景观不再是以往单纯的工厂绿化设计。目前我国多数既有厂区都存在生态景观可持续性不足、空间组成单一、企业文化体现不完善等问题。基于生态、生产、生活的三生融合理念,采用“保留、提升、舍弃”的... 详细信息

随着生态景观逐步受到关注,工业厂区景观不再是以往单纯的工厂绿化设计。目前我国多数既有厂区都存在生态景观可持续性不足、空间组成单一、企业文化体现不完善等问题。基于生态、生产、生活的三生融合理念,采用“保留、提升、舍弃”的设计方法对既有厂区现存主要景观资源进行了详细甄别。以山西新华化工厂为例,从生态环境、生产融合、生活人文等方面探索性地提出了既有厂区景观设计的新策略,以期实现既有厂区景观的优化提升和三生融合发展的目标。

关键词：工业更新工业厂区生态环境景观设计三生融合

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稚鳖养殖水体中异养细菌及自养细菌的初步研究

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同济医科大学学报 2000年第5期29卷 397-399页

作者：运珞珈李谷刘志伟唐非刘红艳同济医科大学环境医学研究所武汉4300302 中国水产科学研究院长江水产研究所荆州434020

对 D湖水产养殖场 ,室内养鳖池水体和底泥中的异养细菌及自养细菌种类、数量进行了初步测定分析。结果表明水中异养细菌总数为 5 .3× 10 5 ～ 17.0× 10 5 CFU / ml,底泥中异养细菌总数为 1.6 6× 10 6～ 2 .2 4× 10 6CFU / m l(湿重 ... 详细信息

对 D湖水产养殖场 ,室内养鳖池水体和底泥中的异养细菌及自养细菌种类、数量进行了初步测定分析。结果表明水中异养细菌总数为 5 .3× 10 5 ～ 17.0× 10 5 CFU / ml,底泥中异养细菌总数为 1.6 6× 10 6～ 2 .2 4× 10 6CFU / m l(湿重 )。三种自养细菌的总数 (用最大可能数 MPN法测得 )分别为 8.5 MPN / ml,0 .4MPN / ml,2 .45 MPN/ ml。自养细菌的数量明显低于异养细菌。试验稚鳖池水中共分离出 2 1株异养细菌 ,其中优势菌为假单胞杆菌属细菌(Pseudom onas) ;底泥中共分离出 2 5株异养细菌 ,其中优势菌为芽胞杆菌属细菌 (Bacillus) ,微球菌属细菌(Micrococcus)假单胞菌属细菌 (Pseudomonas) ,三种自养细菌分别为具有氧化硫化氢、元素硫或硫化亚铁的硫细菌 ;具有氧化氨为亚硝酸的亚硝化细菌和能将亚硝酸进一步转化成硝酸的硝化细菌。测定稚鳖养殖池水体的化学指标其中BOD5 ,NH3 - N,大大超过渔业水质标准及参考标准。 S2 -指标虽未超标但也接近标准的上限值。

关键词：稚鳖养殖水体异养细菌自养细菌水体污染

Aggregation-induced emission:recent applications in infectious diseases

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Science China Chemistry 2023年第11期66卷 2986-3005页

作者： Meijia Gu luojia Chen Rui Hu Qingrong Chen Jianbo liu Lianrong Wang Shi Chen Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug DiscoveryTaiKang Center for Life and Medical SciencesZhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Respiratory Diseases The Research and Application Center of Precision MedicineThe Second Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450014China

Infectious diseases are caused by various pathogenic microorganisms that break through the human immune barrier,then reproduce and mutate in human cells,thus causing invasive *** many recent scientific and technological advances in fields,such as genetics,chemistry,and protein engineering,and in the efficiency of drug research and development,the discovery and development of novel and potent anti-infectious disease agents have still lagged *** is often challenging to keep up with the emergence and mutation of new pathogenic microorganisms,which leads to the emergence of more resistant pathogenic *** emergence of aggregation-induced emission(AIE)fluorogens with high luminescence yields and high reactive oxygen species(ROS)production rates provides scientists with a new strategy for the prevention and treatment of pathogenic *** to their advantages in terms of brightness,biocompatibility,photostability,and positive correlation,AIE fluorogens(AIEgens)have great potential in biological *** review presents a systemic overview of recent progress in AIEgen-based platforms for the photodynamic therapy(PDT)of infectious diseases,which has emerged as a promising noninvasive alternative to traditional antibiotics for combating the drug resistance of infectious *** review is mainly divided into two parts according to the type of pathogenic microorganisms:a section on bacterial and fungal infections(e.g.,eye,skin,oral cavity,and blood infections),and a section on viral *** future prospects and potential clinical applications of AIEgens are also discussed in *** addition to motivating further interest in this field,this review is intended to promote ideas for the further exploration of AIEgens and the development of more advanced AIEgens in a broader range of biomedical and clinical applications.

关键词： aggregation-induced emission infectious diseases photosensitizers photodynamic therapy pathogenic microorganisms

Aggregation-induced emission shining in the biomedical field:From bench to bedside

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Engineered Regeneration 2021年第1期2卷 206-218页

作者： Yishen liu Qingrong Chen Yidan Sun luojia Chen Yuncong Yuan Meijia Gu Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationSchool of Pharmaceutical SciencesWuhan UniversityWuhanHubei 430071China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Type Culture Collection Wuhan UniversityWuhanHubei 430072China

Fluorogens with aggregation-induced emission characteristics(AIEgens)have been developed in an unprece-dented manner in the biomedical field over the past decade,which is ascribable to their superior fluorescence quantum yields,photosensitivities,as well as their“turn-on”characteristics in their aggregate *** delib-erately engineering their molecular structures and nanocarriers,the input energies of AIEgens can be channeled into specific forms,thereby enabling bioimaging,phototherapy,and even synergetic ***,multiple targeting strategies have been tailored for nidus and pathogen localization that subsequently guide therapeutic *** review integrates application-oriented design strategies for AIEgens,demonstrating how microscopic imaging,bioimaging,and theranostics can be developed to combat tumors,pathogens,and other diseases,and critically discusses challenges and perspectives for clinical translation.

关键词： Aggregation-induced emission(AIE) Biomedical field Microscopic imaging Bioimaging Theranostics

Direct extraction of topological Zak phase with the synthetic dimension

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Light(Science & Applications) 2023年第4期12卷 671-679页

作者： Guangzhen Li luojia Wang Rui Ye Yuanlin Zheng Da-Wei Wang Xiong-Jun liu Avik Dutt Luqi Yuan Xianfeng Chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Interdisciplinary Center for Quantum Information and Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityHangzhou 310027China InternationalCenter for Quantum Materials and School of Physics Peking UniversityBeijing 100871China International Quantum Academy Shenzhen 518048China Department of Mechanical Engineering Institute for Physical Science and TechnologyUniversity of MarylandCollege ParkMD 20742USA Collaborative Innovation Center of Light Manipulation and Applications Shandong Normal UniversityJinan 250358China

Measuring topological invariants is an essential task in characterizing topological phases of *** are usually obtained from the number of edge states due to the bulk-edge correspondence or from interference since they are integrals of the geometric phases in the energy *** is commonly believed that the bulk band structures could not be directly used to obtain the topological ***,we implement the experimental extraction of Zak phase from the bulk band structures of a Su-Schrieffer-Heeger(SSH)model in the synthetic frequency *** synthetic SSH lattices are constructed in the frequency axis of light,by controlling the coupling strengths between the symmetric and antisymmetric supermodes of two bichromatically driven *** measure the transmission spectra and obtain the projection of the time-resolved band structure on lattice sites,where a strong contrast between the non-trivial and trivial topological phases is *** topological Zak phase is naturally encoded in the bulk band structures of the synthetic SSH lattices,which can hence be experimentally extracted from the transmission spectra in a fiber-based modulated ring platform using a laser with telecom *** method of extracting topological phases from the bulk band structure can be further extended to characterize topological invariants in higher dimensions,while the exhibited trivial and non-trivial transmission spectra from the topological transition may find future applications in optical communications.

关键词： topological trivial synthetic

鼠伤寒沙门氏菌/微粒体试验(Ames试验)对9种化学物质致突变性的测定

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武汉医学院学报 1980年第4期 35-38页

作者：王家玲运珞珈吕维善刘红艳林海蔡宏道武汉医学院卫生系环境卫生学教研室

Ames试验是利用鼠伤寒沙门氏菌的营养缺陷型菌株,在有微粒体酶系统参与活化的条件下发生回复突变的性能来检测化学物质致突变性的一种测试方法。资料表明,用Ames法测得的致突变物之90％亦为致癌物。由于该法具有快速、简易、经济、尤其... 详细信息

Ames试验是利用鼠伤寒沙门氏菌的营养缺陷型菌株,在有微粒体酶系统参与活化的条件下发生回复突变的性能来检测化学物质致突变性的一种测试方法。资料表明,用Ames法测得的致突变物之90％亦为致癌物。由于该法具有快速、简易、经济、尤其是准确度高等特点,可作为初步筛选潜在致癌物的一种方法,用于检测人类

关键词：致突变性鼠伤寒沙门氏菌 Ames 回复突变反突变醋酸棉酚化学物质

点阵CO_(2)激光联合其他非手术方式治疗痤疮瘢痕安全性的网状Meta分析

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中国美容整形外科杂志 2024年第8期35卷 465-470,I0006,I0007页

作者：蒋敏夏录凡张警泓陈煦刘骆家张泽刘小强武潮江旭品陈颖张家平陆军军医大学(第三军医大学)第一附属医院整形外科(创伤与化学中毒国家重点实验室) 重庆400038

目的系统评价点阵CO_(2)激光联合其他非手术方式治疗痤疮瘢痕的安全性.方法陆军军医大学(第三军医大学)第一附属医院整形外科通过检索Pubmed、Embase、Cochrane Library、Wanfang Data和CNKI数据库,搜索有关点阵CO_(2)激光和点阵CO_(2)... 详细信息

目的系统评价点阵CO_(2)激光联合其他非手术方式治疗痤疮瘢痕的安全性.方法陆军军医大学(第三军医大学)第一附属医院整形外科通过检索Pubmed、Embase、Cochrane Library、Wanfang Data和CNKI数据库,搜索有关点阵CO_(2)激光和点阵CO_(2)激光联合其他非手术方式治疗痤疮瘢痕安全性的随机对照试验(RCT),检索时限均为建库至2023年6月.由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 16.0软件进行网状Meta分析.结果共纳入55个RCT,包括4779例患者.网状Meta分析结果显示,在色素沉着发生率方面,最佳累积概率排序为:点阵CO_(2)激光+富血小板血浆(platelet-rich plasma,PRP;79.9%)>点阵CO_(2)激光+表皮生长因子凝胶(70.2%)>点阵CO_(2)激光+硅酮凝胶(64.3%)>点阵CO_(2)激光+胶原贴敷料(58.0%)>点阵CO_(2)激光+透明质酸敷料(56.6%)>点阵CO_(2)激光+重组碱性成纤维细胞生长因子(55.6%)>点阵CO_(2)激光+积雪苷霜(51.8%)>点阵CO_(2)激光+果酸(38.8%)>点阵CO_(2)激光+微针(23.4%)>点阵CO_(2)激光(1.3%).在误工时间方面,最佳累积概率排序为:点阵CO_(2)激光+PRP(97.0%)>点阵CO_(2)激光+表皮生长因子凝胶(72.8%)>点阵CO_(2)激光+硅酮凝胶(68.7%)>点阵CO_(2)激光+积雪苷霜(40.7%)>点阵CO_(2)激光+胶原贴敷料(20.7%)>点阵CO_(2)激光(0).在水肿发生率方面,最佳累积概率排序为:点阵CO_(2)激光+PRP(73.5%)>点阵CO_(2)激光+表皮生长因子凝胶(70.4%)>点阵CO_(2)激光+胶原贴敷料(68.8%)>点阵CO_(2)激光+透明质酸敷料(63.8%)>点阵CO_(2)激光+果酸(51.0%)>点阵CO_(2)激光+硅酮凝胶(36.0%)>点阵CO_(2)激光(19.9%)>点阵CO_(2)激光+重组碱性成纤维细胞生长因子(16.4%).在感染发生率方面,最佳累积概率排序为:点阵CO_(2)激光+PRP(75.6%)>点阵CO_(2)激光+表皮生长因子凝胶(71.7%)>点阵CO_(2)激光(33.3%)>点阵CO_(2)激光+微针(19.4%).结论点阵CO_(2)激光联合PRP可能是点阵CO_(2)激光联合其他非手术方式治疗痤疮瘢痕中最安全的治疗方式,可以有效降低单用点阵CO_(2)激光治疗痤疮瘢痕过程中的色素沉着发生率、误工时间、水肿和感染发生率,增加患者的依从性.

关键词：痤疮瘢痕点阵CO_(2)激光安全性网状Meta分析

Observation of flat-band and band transition in the synthetic space

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Advanced Photonics 2022年第3期4卷 114-121页

作者： Guangzhen Li luojia Wang Rui Ye Shijie liu Yuanlin Zheng Luqi Yuan Xianfeng Chen Shanghai Jiao Tong University School of Physics and AstronomyState Key Laboratory of Advanced Optical Communication Systems and NetworksShanghaiChina Shanghai Research Center for Quantum Sciences ShanghaiChina Shandong Normal University Collaborative Innovation Center of Light Manipulation and ApplicationsJinanChina

.Constructions of synthetic lattices in modulated ring resonators attract growing attention to interesting physics beyond the geometric dimensionality,where complicated connectivities between resonant frequency modes are explored in many theoretical *** implement experimental demonstration of generating a stub lattice along the frequency axis of light,in two coupled ring resonators of different lengths,with the longer one dynamically *** a synthetic photonic structure intrinsically exhibits the physics of flat *** show that the time-resolved band structure read-out from the drop-port output of the excited ring is the intensity projection of the band structure onto a specific resonant mode in the synthetic momentum space,where gapped flat band,mode localization effect,and flat-to-nonflat band transition are observed in experiments and verified by *** work provides evidence for constructing a synthetic stub lattice using two different rings,which,hence,makes a solid step toward experimentally constructing complicated lattices in multiple rings associated with synthetic frequency dimensions.

关键词： synthetic dimensions ring resonators dynamic modulation flat band.