检索结果-南通市图书馆

The competing mini-dumbbell mechanism:new insights into CCTG repeat expansion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2016年第1期1卷 21-26页

作者： pei guo Sik Lok Lam Department of Chemistry The Chinese University of Hong KongShatinHong Kong

CCTG repeat expansions in intron 1 of the cellular nucleic acid-binding protein gene are associated with myotonic dystrophy type ***,we have reported a novel mini-dumbbell(MDB)structure formed by two CCTG or TTTA repeats,which potentially has a critical role in repeat *** we present a mechanism,called the competing MDB mechanism,to explain how the formation of MDB can lead to efficient mismatch repair(MMR)escape and thus CCTG repeat expansions during DNA *** a long tract of CCTG repeats,two competing MDBs can be formed in any segment of three *** exchange between these MDBs will make the commonly occupied repeat behave like a *** participations of the 5′-or 3′-flanking repeat in forming competing MDBs will make the mini-loop shift in the 5′-or 3′-direction,thereby providing a pathway for the mini-loop to escape from *** avoid the complications due to the formation of hairpin conformers in longer CCTG repeats,we made use of TTTA repeats as model sequences to demonstrate the formation of competing MDBs and shifting of mini-loop in a long tract of repeating sequence.

关键词： mechanism competing expansion

Chinese herbal medicine for subacute thyroiditis:a systematic review of randomized controlled trials

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2014年第3期34卷 243-253页

作者： Hui luo Meng Lü Xiaohua pei Zhongyuan Xia Institute for Tibetan Medicine ChinaTibetology ResearchCenter Sino-Japanese Friendship Clinical School of Medicine Beijing University of Chinese Medicine Department of Surgery Third Affiliated Hospital Beijing University of Chinese Medicine Department of Surgery of Traditional Chinese Medicine China-Japan Friendship Hospital

OBJECTIVE:To evaluate the effectiveness and safety of Chinese herbal medicine(CHM) in the ***: Randomized controlled trials found in PubMed, Cochrane Library, and three Chinese databases were selected. RevMan 5.2 software was used to analyze the data with relative risk or mean difference, expressed with 95% of confidence interval. The quality of trials was assessed and gradedthe quality of evidence with GRADE profiler ***: Twenty one studies were included. CHM was superior to Western Medicine(include prednisone and NSAIDs) in abating fever, relieving thyroid pain, recovering blood sedimentation, improving thyroid function, and preventing hypothyroidism(P0.05) were found in recovering blood sedimentation and improving thyroid function. The incidence of adverse reactions in treatment group was lower than that in control group(relative risk was 0.12 and 95% confidence interval was 0.03-0.51). The methodological quality of trials is generally poor with a high risk of ***: CHM(particularly CHM combined withWestern Medicine) used to treat subacute thyroiditis may improve clinical symptoms and signs,reduce relapse rate, and alleviate the side effects of hormones. Due to poor methodological quality of included trials, further more high-quality studies are warranted to confirm the effectiveness and safety of CHM.

关键词： Drugs, Chinese herbal Thyroiditis, sub-acute Randomized controlled trial Review, system-atic

Crop residue incorporation and nitrogen fertilizer effects on greenhouse gas emissions from a subtropical rice system in Southwest China

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2018年第9期15卷 1972-1986页

作者： WANG Xiao-guo luo Yong Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and Environment Chinese Academy of Sciences Key laboratory of Geological Spatial information Technology of Ministry of Land and Resource Chengdu University of Technology

Crop residue incorporation has been widely accepted as a way to increase soil carbon(C) sequestration and sustain soil fertility in agroecosystems. However, effect of crop residue incorporation on greenhouse gas(GHG) emissions in rice paddy soils remains uncertain. A field experiment was conducted to quantify emissions of CH_4 and N_2O and soil heterotrophic respiration(RH) from a paddy rice field under five different crop residue treatments(i.e., 150 kg N ha^(-1) of synthetic N fertilizer application only [NF], 150kg N ha^(-1) of synthetic N fertilizer plus 5.3 Mg ha^(-1) wheat residue [NF-WR1], 150 kg N ha^(-1) of synthetic N fertilizer plus 10.6 Mg ha^(-1) wheat residue [NF-WR2], 75 kg N ha^(-1) of synthetic N fertilizer plus 10.6 Mg ha^(-1) wheat residue [50%NF-WR2] and 150 kg N ha^(-1) of synthetic N fertilizer plus 21.2 Mg ha^(-1) wheat residue [NF-WR3]) in southwest China. Our results showed that crop residue incorporation treatments(NF-WR1, NF-WR2, 50%NF-WR2, NF-WR3) significantly increased CH_4 emissions by at least 60%, but N_2O emissions were not enhanced and even suppressed by 25% in the NF-WR3 treatment as compared to the NF treatment. Soil RH emissions were comparable among experimental treatments, while crop residue incorporation treatments significantly increased soil carbon sequestrations relative to the NF treatment. Overall, CH_4 emissions dominated total global warming potentials(GWP) across all experimental treatments. The average yieldscaled GWPs for the NF and NF-WR1 treatments were significantly lower than for the NF-WR2, 50%NFWR2 and NF-WR3 treatments. Given the comparable yield-scaled GWPs between the NF and NF-WR1 treatments, the NF-WR1 treatment could gain net carbon sequestration as compared with the NF treatment with net soil carbon loss. Our findings suggest that the NF-WR1 treatment should be an effective option to sustain rice production while mitigating GHG emissions from the rice field in China.

关键词： Methane Nitrous oxide Crop residueSoil carbon sequestration Global warming potentialPaddy field

Surface modification of natural cellulose substances:toward functional materials and applications

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2014年第12期57卷 1672-1682页

作者： luo Yan HUANG Jian guo Department of Chemistry Zhejiang University

Combining various synthetic chemical processes and biological assemblies provides a promising strategy for the design and fabrication of functional materials with tailored structures and *** unique multilevel structures and morphologies of natural cellulose substances such as ordinary commercial laboratory filter paper make them ideal platforms for the self-assemblies of various functional guest molecules that are to be deposited on the surfaces of their fine structures,and the resulting composite matters show significant potentials for various *** surface sol-gel process was employed to deposit ultrathin metal-oxide(e.g.,titania and zirconia)gel films to coat the cellulose nanofibers in bulk filter papers;thereafter,monolayers of specific guest substrates were immobilized onto the surfaces of the metal-oxide gel *** selective,sensitive,and reversible chemosensors based on the surface modification of filter paper were obtained toward the fluorescence and colorimetric detection of various analytes such as heavy-metal ions,inorganic anions,amino acids,and *** composite materials with superhydrophobic,antibacterial,or luminescent properties were fabricated by self-assembly approaches toward practical applications.

关键词： cellulose self-assembly thin films surface modification

Experimental Investigation on the Flow-induced Noise under Variable Conditions for Centrifugal Pumps

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2012年第3期25卷 456-462页

作者： YUAN Shouqi YANG Jun YUAN Jianping luo Yin pei Ji Research Center of Fluid Machinery Engineering and Technology Jiangsu UniversityZhenjiang 212013China

With extensively using of centrifugal pumps,noise generation in these pumps is increasingly receiving research attention in recent *** noise sources in centrifugal pumps are mainly composed of mechanical noise and flow-induced *** the study of flow-induced noise has become a hotspot and important domain in the *** flow-induced noise closely related to the inner pressure pulses and vibration of volute in pumps,therefore,it is necessary to research the interaction and mechanism among *** investigate the relationships,a test system is designed which includes a test loop and a measurement *** hydrophones and pressure sensors are installed on the outlet of the pump and vibration acceleration sensors are disposed on the pump *** these instruments,the signals of noise,pressure pulses and vibration are collected and *** results show that the level of flow-induced noise becomes smaller as the flow increment during low flow rate operations,and it is steadily close to the design point,then it increases with the growing of flow rate in high flow rate ***,there are some similar peak points in the power spectrum charts of noise,pressure pulses and *** broadband noise at low flow rate is mostly focused on the region of 0-40 times shaft frequency,which is mostly made by rotating stall and vortex;while the noise at high flow rate conditions is focused on the region of 60-100 times shaft frequency,which may be mostly made by *** proposed research is of practical and academic significance to the study of noise reduction for centrifugal pumps.

关键词： centrifugal pump flow-induced noise pressure pulses vibration of volute

Effect of rapid quenching on the microstructure and electrochemical characteristics of La_(0.6)Ce_(0.4)Ni_(3.6)Co_(0.65)Mn_(0.4)Al_(0.2)Ti_(0.05_(FeB)_(0.1) hydrogen storage alloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2010年第6期29卷 593-596页

作者： ZHANG peilong SONG Xiping WANG Xiuli pei pei luo Guiping TU Jiangping CHEN guoliang State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 000China Whole Win(Beijing) Materials Sci.& Tech.Co. Ltd.Beijing 100083China Department of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China

In order to improve the cycling stability of AB5 type alloy electrodes,rapid quenching technology and new alloy composition design were employed.A hydrogen storage alloy with nominal composition La0.6Ce0.4Ni3.6Co0.65Mn0.4Al0.2Ti0.05（FeB）0.1 was prepared by vacuum magnetic levitation melting under high purity argon atmosphere,followed by rapid quenching at different cooling *** results show that all alloys exhibit the single-phase CaCu5-type *** tests indicate that rapid quenching can slightly improve the cycling life of the ***,the high-rate dischargeability of the quenched alloys is lower than that of the as-cast alloy.

关键词： hydrogen storage alloys electrochemical properties rapid quenching microstructure

Cytological Evaluation and Karyotype Analysis in Plant Germplasms of Elytrigia Desv.

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2010年第11期9卷 1553-1560页

作者： MAO pei-sheng HUANG Ying WANG Xin-guo MENG Lin MAO pei-cbun ZHANG guo-fang Forage Seed Laboratory China Agricultural University Beijing 100193 P.R. China Beijing Research and Development Center for Grass and Environment Beijing Academy of Agriculture and Forestry Beijing 100097 P.R.China

Elytrigia Desv. is widely distributed throughout the world and is represented with species of various levels of ploidy including diploids, tetraploids, hexaploids, octaploids, and decaploids. The distribution pattern of these ploidy levels, however, is not well-defined. In this study, the levels of ploidy for 64 accessions of Elytrigia from 25 countries were determined with microscopic procedures. The results showed that accessions of E. intermedia and E. repens were grouped into three distinct levels of ploidy including diploids, tetraploids and hexaploids. For E. elongata, E. pontica, and E. caespitosa, it was found that two ploidy levels presented, and only one ploidy level was in those of E. hybrid, E. pycnantha, E. pungens, E. juncea, and E. alatavica. Karyotype analysis indicated that the karyotype formula of diploid, tetraploid and hexaploid of E. intermedia was 2n = 2x = 14 = 6m ＋ 6sm ＋ 2st, 2n = 4x = 28 = 2M ＋ 10m ＋ 16sm and 2n = 6x = 42 = 4M ＋ 18m ＋ 20sin, respectively. Furthermore, the karyotype formula of three germplasms in tetraploid of E. intermedia was 2n=4x=28 =2M＋ 10m＋ 16sm, 2n=4x=28=4M＋22m （sat）＋2sm and 2n=4x=28 =4M＋ 12m＋ 12sm （sat）, which were not completely uniform. Therefore, it could be suggested that the studies about chromosome constitution would be helpful for the detail understanding of the diversity of germplasm resource in Elytrigia and promoting the utilization in the crop molecular breeding.

关键词： Elytrigia Desv. ploidy evaluation karyotype analysis

In situ generation of oxyanions-decorated cobalt(nickel)oxyhydroxide catalyst with high corrosion resistance for stable and efficient seawater oxidation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第7期94卷 508-516页

作者： Fengting luo pei Yu Jueting Xiang Junjie Jiang Shijian Chen Chongqing Key Laboratory of Interface Physics in Energy Conversion College of PhysicsChongqing UniversityChongqing 401331China Center of Modern Physics Institute for Smart City of Chongqing University in LiyangLiyang 213300JiangsuChina

The development of efficient and robust anode materials for stable alkaline seawater electrolysis is severely limited by chlorine evolution reaction and chloride ***,the sulfur-doped cobalt-nickel bimetallic phosphides(CoNiPS)are specifically designed as a pre-catalyst for navigating a surface reconstruction to fabricate the anions(PO^(3-)_(4) and SO^(2-)_(4))-decorated Co(Ni)OOH catalyst(R-CoNiPS)with exceptional durability and high activity for stable alkaline seawater oxidation(ASO).Various experiment techniques together with theoretical simulations both demonstrate that the in situ-generated PO^(3-)_(4) and SO^(2-)_(4) anions on catalyst surface can improve the oxygen evolution reaction(OER)activity,regulating and stabilizing the catalytic active species Co(Ni)OOH,as well as make a critical role in inhibiting the adsorp-tion of chloride ions and extending the service life of ***,this R-CoNiPS electrode exhi-bits superb OER activity toward AsO and stands out among the non-precious ASO electrocatalysts reported recently,requiring low overpotentials of 420 and 440 mV to attain large current densities of 500 and 1000 mA cm^(-2) in an alkaline natural seawater electrolyte,***,the catalyst displays a negligible chloride corrosion at room temperature during ASO operation(>200 h)at 500 mA cm^(-2).This work opens up a new viewpoint for designing high-activity and durable electrocata-lystsforseawaterelectrolysis.

关键词： Seawater electrolysis Anions Oxygen evolution reaction Chloride corrosion

Homoclinic Solutions for a Class of Perturbed Fractional Hamiltonian Systems with Subquadratic Conditions

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第5期40卷 1177-1196页

作者： Ying luo Fei guo Yan LIU School of Mathematics Tianjin UniversityTianjin 300354P.R.China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin300354P.R.China

In this paper,we consider the following perturbed fractional Hamiltonian systems{tD_(∞)^(α)(_(-∞)D_(t)^(α)u(t))+L(t)u(t)=■_(u)W(t,u(t))+■(u)G(t,u(t)),t∈R,u∈H^(α)(R,R^(N)),whereα∈(1/2,1],L∈C(R,R^(N×N))is symmetric and not necessarily required to be positive definite,W∈C1(R×R^(N,R))is locally subquadratic and locally even near the origin,and perturbed term G∈C1(R×R^(N,R))maybe has no parity in *** the perturbed method improved by the authors,a sequence of nontrivial homo clinic solutions is obtained,which generalizes previous results.

关键词： Perturbed fractional Hamiltonian systems subquadratic condition perturbed method homoclinic solutions multiplicity