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Virus-Host Interactions Drive Contrasting Bacterial Diel Dy.amics in the Ocean

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Research 2024年第2期6卷 389-399页

作者： Xiaowei Chen Chen Hu Wei Wei y.nlan y.ng Markus G.Weinbauer Hongbo Li Shiy.ng Ren Ruije Ma y.ibin Huang Tingwei luo Nianzhi Jiao Rui Zhang State Key.Laboratory.of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102PR China College of the Environment and Ecology Xiamen UniversityXiamen 361102PR China Research Center for Environmental Ecology.and Engineering School of Environmental Ecology and Biological EngineeringWuhan Institute of TechnologyWuhan 430205PR China Sorbonne Universités UPMCUniversitéParis 06CNRSLaboratoire d'Oceanographie de Villefranche(LOV)Villefranche-sur-Mer 06230France National Marine Environmental Monitoring Center Ministry of Ecological EnvironmentDalian 116023PR China Department of Ocean Sciences University of CaliforniaSanta CruzCAUSA NOAA/OAR Pacific Marine Environmental Laboratory SeattleWAUSA Institute for Advanced Study Shenzhen UniversityShenzhen 518055PR China

Marine organisms perform a sea of diel *** diel dy.amics have been shown to be driven by.light,energy.resources,circadian rhy.hms,and the coordinated coupling of photoautotrophs and heterotrophic ***,we explore the diel fluctuation of viral production and decay.and their impact on the total and active bacterial community.in the coastal and open seawaters of the South China *** results showed that the night-production diel pattern of ly.ic viral production was concurrent with the lower viral decay.at night,contributing to the accumulation of the viral population size during the night for surface *** diel variations in bacterial activity.community.composition,and diversity.were found highly.affected by.viral *** was revealed by.the finding that bacterial community.diversity.was positively.correlated to ly.ic viral production in the euphotic zone of the open ocean but was negatively.related to ly.ogenic viral production in the coastal *** distinct but contrasting correlations suggest that viral life strategies can not only.contribute to diversify.ng bacterial community.but also potentially.piggy.ack their host to dominate bacterial community.suggesting the tightly.sy.chronized depth-dependent and habitat-specific diel patterns of virus-host *** further implies that viruses serve as an ecologically.important driver of bacterial diel dy.amics across the ocean,highlighting the viral roles in bacterial ecological and biogeochemical processes in the ocean.

关键词： coastal ocean Marine

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du y.hua y.n Juehua y. Tailin Zhu Chu-Chung Huang Lingli Zhang Xingy.e Shan Ren Li y.an Dai Hui LV Xiao-y.ng Zhang Jianfeng Feng Wei-Guang Li Qiang luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key.Laboratory.of Medical Neurobiology.and Ministry.of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key.Laboratory.of Brain Functional Genomics(Ministry.of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical y.t challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study. we performed a genome-wide association study.using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity.risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underly.ng the association between fluid intelligence and body.metabolism. Surprisingly. we demonstrated that SH2B1 variation influenced fluid intelligence independently.of its effects on metabolism but partially.mediated its association with bilateral hippocampal volume. Consistently. selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly.in inhibitory.neurons, but not in excitatory.neurons, significantly.impaired working memory. short-term novel object recognition memory. and behavioral flexibility. but not spatial learning and memory. mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathway. revealed that Sh2b1 deletion resulted in aberrantly.enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study.thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy.and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen y.an-Hang Ma Qi-Fa luo y.n-Bo Li y.ng y.ng Dan Ma Department of General Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Natural orifice specimen extraction surgery.NOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy.LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy.and safety.of NOSES for GC surgery.is *** study.aimed to compare the safety.and feasibility.in addition to postoperative complications of NOSES and *** Dual circular staplers were used in Roux-en-y.digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study.was conducted from May.2018 to September 2020,and patients were categorized into the NOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analy.ed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay.the length of abdominal incision,difference in tumor ty.e,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay.length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(Py.and length of abdominal incision were significantly.shorter than those in the LATG *** in the NOSES group had faster postoperative recovery.and achieved abdominal minimally.invasive incision that met aesthetic *** were no significant differences in gender,age,tumor ty.e,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-y.digestive tract reconstruction combined with NOSES gastrectomy.is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler Natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

作为方法的创意写作:融媒体视域下的当代文学研究转型

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南京社会科学 2024年第9期 125-134页

作者：罗长青广东外语外贸大学中国语言文化学院广州510420

创意写作通常被视为艺术表达,而不是学术路径。作为一种探究思维或研究视角,创意写作能够推动当代文学的研究转型,促使研究者重新审视融媒体背景下的文学创作、文学理论、文学批评和文学史。创意写作倡导创新、创造和创意精神,打破了传... 详细信息

创意写作通常被视为艺术表达,而不是学术路径。作为一种探究思维或研究视角,创意写作能够推动当代文学的研究转型,促使研究者重新审视融媒体背景下的文学创作、文学理论、文学批评和文学史。创意写作倡导创新、创造和创意精神,打破了传统文类、学科和媒介之间的壁垒,呈现出跨文体、跨学科和跨媒介的特征,促成了“跨界”作品的生成。创意写作将精英文学创作引入大众文创领域,拓展了融媒体的叙事路径,凸显了文学的动态性,重塑了作品的审美价值,推动了当代文学理论的发展。创意写作增强了文学批评的活力,促进了学院批评、学者批评和专业批评对文创产业的关注。创意写作还为当代文学史编纂指明了新的道路,通过更新编纂理论和结构体例,将跨文体、跨媒介和跨领域的创作纳入文学史的叙述,使其更具时代感和前瞻性。

关键词：创意写作文学转型文创产业新文科非虚构

贵州高原典型喀斯特县域生境质量时空演变及定量归因

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环境科学 2024年第5期45卷 2793-2805页

作者：李月冯霞吴路华罗光杰罗红芬贵州财经大学公共管理学院贵阳550025 铜仁学院经济管理学院铜仁554300 贵州师范学院贵州省流域地理国情监测重点实验室贵阳550018

揭示贵州高原喀斯特县域生境质量时空演变规律及其驱动因素,为平衡喀斯特区域生态保护和可持续发展提供科学依据.利用1989年、2003年、2010年和2020年4期土地利用数据、DEM数据、气象数据和社会经济数据,采用InVEST模型阐明普定县近30... 详细信息

揭示贵州高原喀斯特县域生境质量时空演变规律及其驱动因素,为平衡喀斯特区域生态保护和可持续发展提供科学依据.利用1989年、2003年、2010年和2020年4期土地利用数据、DEM数据、气象数据和社会经济数据,采用InVEST模型阐明普定县近30年生境质量时空分布格局及演变特征,并对其空间分异的驱动力进行了定量探测.结果表明:①耕地和林地是普定县的主要土地利用类型,构成了地表覆盖景观基质.2003~2010年土地利用变化最显著,其中林地的增幅最大,达86.42%,耕地是流失最严重的土地利用类型,面积减少157.57 km^(2),主要流向林地和建设用地;②1989~2020年普定县生境质量指数平均值由0.60上升至0.73,空间上由东北部向西南部大体呈现出“高-低-高”的分布格局,生境质量高值区主要分布在东北部林地和草地区,低值区集中在中部和南部的建设用地,生境质量等级上升的区域主要集中在东部及西北部的大部分地区;③土地利用类型是影响生境质量时空分布的首要因素,解释程度为91.00%.在交互作用探测中,任意两种影响因素的交互作用大于单个因素的单独作用,土地利用类型和年均降水量的交互作用最强,达到96.00%,其与岩性因子的交互作用达到94.00%,自然与人文因素共同主导生境质量的时空变化.1989~2020年普定县生境质量总体较好,土地利用类型变化与生境质量关系密切,优化土地利用结构、减小人类活动的影响对提高普定县生境质量具有重要意义.

关键词：贵州喀斯特 InVEST模型生境质量地理探测器驱动因子

Insights into reservoir-triggered landslides development and its influence factors in the Three Gorges Reservoir area， China

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Journal of Earth Science 2024年

作者： Shi-lin luo Da Huang Jian-bing Peng Zhou-zhou Xie Zhi-y. y.ng Roberto Tomás College of Civil Engineering， Changsha University College of Civil Engineering and Geomatics， Chang'an University Hunan Provincial Key.Laboratory.for Big Data Smart Application of Natural Disaster Risks Survey.of Highway.Engineering School of Civil Engineering， Central South University Dpto.de Ingeniería Civil.Escuela Politécnica Superior de Alicante.Universidad de Alicante.

More than 5000 landslides or potential landslides have been triggered in the Three Gorges Reservoir （TGR） area since the impoundment in 2003. Aimed at investigating the reservoir-induced landslides spatiotemporal and size distribution and its influence factors in the TGR by.taking 790 landslides as statistical samples. The landslides exhibit significant regional and sub-regional differences in spatially. and numerous landslides occurred at the initial three impoundment stages and the corresponding following 2–3 cy.les of reservoir operations， but the landslide frequency.decreased dramatically.after 2010 in temporally. The relationship between landslide development and topographical， geological as well as hy.rological factors were analy.ed qualitatively. The reservoir-induced landslides in TGR area exhibit self-organized criticality.and the rollover is nearly.2.5×104m2， which could not attribute to the data missing but the coupled influences imposed by.affecting factors. Both the double Pareto and inverse gamma functions are more suitable than the power-law function to present the landslide size characteristics. In term of the fitting precious， the adaptability.of the inverse gamma function is better if the landslide inventories are limited. The research results provide foundation for the landslide susceptibility.maps and hazard risk assessment.

关键词：

D-ty.e neuropeptide decorated AIEgen/RENP hy.rid nanoprobes with light-driven ROS generation ability.for NIR-Ⅱ fluorescence imaging-guided through-skull photody.amic therapy.of gliomas

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Aggregate

Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He y.an luo y.ny.ng Li y.anbo Pan Ry.n T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key.Laboratory.of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key.Laboratory.of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous sy.tem,leading high mortality.rates in ***-induced emission(AIE)photosensitizers-based photody.amic therapy.PDT)has emerged as a promising therapeutic strategy.for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly.penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability.which greatly.limited the clinical practice of AIE photosensitizers for especially.deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hy.rid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/y./Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-ty.e neuropeptide DNPy.for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxy.en species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dty.e neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-ty.e neuropeptide glioma photody.amic therapy rare-earth doping nanoparticles

Erratum:"HI in High Gas-phase Metallicity.Dwarf Galaxy.WISEA J230615.06+143927.9"(2024,RAA,24,015024)

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Research in Astronomy.and Astrophy.ics 2024年第7期24卷 272-272页

作者： y.n Guo C.Sengupta T.C.Scott P.Lagos y.luo Puy.le Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy.and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophy.ics and Space Sciences(IA Porto) Rua das Estrelas4150-762.PortoPortugal

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生物活性材料与牙周组织再生

生物工程学报 2024年第2期40卷 378-390页

作者：陈紫琴罗岚骆凯许雄程福建医科大学附属口腔医院福建医科大学口腔组织工程研究中心福建省高校口腔医学重点实验室福建省口腔疾病研究重点实验室福建福州350002

生物活性材料是一类经由材料表面或界面产生特殊生物或化学反应,从而影响组织和材料间的结合、诱发细胞活性或引导组织再生的生物材料。近年来,生物活性材料已广泛应用于牙周组织再生。本文对不同类型生物活性材料的特点及其在牙周组织... 详细信息

生物活性材料是一类经由材料表面或界面产生特殊生物或化学反应,从而影响组织和材料间的结合、诱发细胞活性或引导组织再生的生物材料。近年来,生物活性材料已广泛应用于牙周组织再生。本文对不同类型生物活性材料的特点及其在牙周组织再生中的作用进行综述,为推动其在牙周组织再生领域中的应用提供参考。

关键词：生物活性材料牙周组织再生组织工程