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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： Junning Pu Daiwen Chen Gang Tian Jun He Ping Zheng Zhiqing Huang Xiangbing Mao Jie Yu yuheng luo Junqiu luo Hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32 weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(P<0.05).Feeding piglets with 5 and 15 mg/d ATRA also inhibited the increase of serum diamine oxidase(DAO)activ-ity and the decrease of occludin and claudin-1 protein levels in jejunal mucosa induced by TGEV,and maintained intestinal barrier integrity(P<0.05).Meanwhile,5 mg/d ATRA feeding increased the sucrase activity and the expres-sions of nutrient transporter related genes(GLUT2 and SLC7A1)in jejunal mucosa of TGEV-challenged piglets(P<0.05).Furthermore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(P<0.05).Feeding 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,MyD88,TRIF and MAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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五轴混联机构时间最优速度规划及精准插补

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哈尔滨工业大学学报 2024年第8期56卷 112-123页

作者：陈迪赛高健罗于恒张揽宇省部共建精密电子制造技术与装备国家重点实验室(广东工业大学) 广州510006

为提高五轴混联机构对复杂曲面及其特征的加工质量,提出一种准确识别曲率点的时间最优速度规划及精准插补方法。首先,采用向心法生成路径节点参数,作密集化处理生成速度节点参数;其次,用B样条描述速度曲线,通过伪加加速度将三阶约束模... 详细信息

为提高五轴混联机构对复杂曲面及其特征的加工质量,提出一种准确识别曲率点的时间最优速度规划及精准插补方法。首先,采用向心法生成路径节点参数,作密集化处理生成速度节点参数;其次,用B样条描述速度曲线,通过伪加加速度将三阶约束模型转变为线性模型;然后,以速度节点参数为分段点,构造各段路径的时间积分函数,采用自适应辛普森积分法求解;最后,将所得离散点信息输入到运动控制卡进行轨迹加工。实验结果表明:本方法可快速收敛到全局最优,降低曲率点速度并迅速回升其邻域速度;计算所得路径总时间仅有3.5μs的波动,与常规插补方法收敛后的精度一致,且收敛时间更短;位置和角度的最大插补误差分别为0.76×10^(-3) mm和0.9×10^(-3)°,小于编码器分辨率,符合加工需求,特别是极大曲率处相比一般方法降低95.37%。因此,在路径曲线基础上生成的速度节点参数具备更好的曲率识别性,通过构造各段路径的时间积分函数求解路径总时间具备更高的鲁棒性与效率。

关键词：五轴混联机构时间最优速度规划曲率 B样条插补

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甘南地区草地NPP空间分布的估算研究

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山西建筑 2024年第2期50卷 169-172页

作者：闫宏昌罗玉恒甘肃林业职业技术学院甘肃天水741020

通过使用地理信息系统和遥感技术的数据处理方法,对获取的MODIS多时相遥感数据、气象数据和与其密切的植被生态统计资料,对2020年—2022年5月—9月份的甘南草地使用CASA模型进行了估算,并且在估算验证的基础上,分析了甘南草地的NPP空间... 详细信息

通过使用地理信息系统和遥感技术的数据处理方法,对获取的MODIS多时相遥感数据、气象数据和与其密切的植被生态统计资料,对2020年—2022年5月—9月份的甘南草地使用CASA模型进行了估算,并且在估算验证的基础上,分析了甘南草地的NPP空间分布关系和随时间变化的特征,在建立NPP估算模型的研究基础上,重新建立了甘南草地2020年—2022年不同土地覆盖下NPP年内变化的时空序列及演变模式,分析了2020年—2022年甘南NPP时空变化情况及原因。结果表明:3年甘南草地5月—9月的平均NPP为679.675 gC/(m 2·a);甘南草地植被季节性变化比较明显,成长期主要聚集在第173天~第245天;甘南地区植被NPP呈现逐年增长趋向。

关键词： MODIS数据 NPP 甘南草地 CASA模型

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Effect of sialyllactose on growth performance and intestinal epithelium functions in weaned pigs challenged by enterotoxigenic Escherichia Coli

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1151-1162页

作者： Qiming Duan Daiwen Chen Bing Yu Zhiqing Huang yuheng luo Ping Zheng Xiangbing Mao Jie Yu Junqiu luo Hui Yan Jun He Institute of Animal Nutrition Sichuan Agricultural UniversitySichuan ProvinceChengdu 611130People’s Republic of China Key Laboratory of Animal Disease-resistant Nutrition Sichuan ProvinceChengdu 611130People’s Republic of China

Background:Sialyllactose(SL)is one of the most abundant oligosaccharides present in porcine breast ***,little is known about its effect on growth performance and intestinal health in weaned *** study was conducted to explore the protective effect of SL on intestinal epithelium in weaned pigs upon enterotoxigenic Escherichia coli(ETEC)***:Thirty-two pigs were randomly divided into four *** fed with a basal diet or basal diet containing SL(5.0 g/kg)were orally infused with ETEC or culture ***:SL supplementation elevated the average daily gain(ADG)and feed efficiency in the ETEC-challenged pigs(P<0.05).SL also improved the digestibilities of dry matter(DM),gross energy(GE),and ash in non-challenged pigs(P<0.05).Moreover,SL not only elevated serum concentrations of immunoglobulins(IgA,IgG,and IgM),but also significantly decreased the serum concentrations of inflammatory cytokines(TNF-α,IL-1β,and IL-6)upon ETEC challenge(P<0.05).Interestingly,SL increased the villus height,the ratio of villus height to crypt depth(V:C),and the activities of mucosal sucrase and maltase in the jejunum and ileum(P<0.05).SL also elevated the concentrations of microbial metabolites(*** acid,propanoic acid,and butyric acid)and the abundance of Lactobacillus,Bifidobacterium,and Bacillus in the cecum(P<0.05).Importantly,SL significantly elevated the expression levels of jejunal zonula occludins-1(ZO-1),occluding,and fatty acid transport protein-4(FATP4)in the ETEC-challenged pigs(P<0.05).Conclusions:SL can alleviate inflammation and intestinal injury in weaned pigs upon ETEC challenge,which was associated with suppressed secretion of inflammatory cytokines and elevated serum immunoglobulins,as well as improved intestinal epithelium functions and microbiota.

关键词： Immunity Inflammation Intestinal epithelium Sialyllactose Weaned pigs

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Yeast hydrolysate attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage in weaned piglets

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1569-1583页

作者： Runqi Fu Chan Liang Daiwen Chen Gang Tian Ping Zheng Jun He Jie Yu Xiangbing Mao yuheng luo Junqiu luo Bing Yu Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130China Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanChina

Background Intestinal inflammation is the main risk factor causing intestinal barrier dysfunction and lipopolysaccharide(LPS)can trigger inflammatory responses in various eukaryotic *** hydrolysate(YH)possesses multibiological effects and is received remarkable attention as a functional ingredient for improving growth performance and promoting health in ***,there is still inconclusive on the protective effects of dietary YH supplementation on intestinal barrier of *** study was conducted to investigate the attenuate effects of YH supplementation on inflammatory responses and intestinal barrier injury in piglets challenged with *** Twenty-four piglets(with an average body weight of 7.42±0.34 kg)weaned at 21 days of age were randomly assigned to one of two dietary treatments(12 replications with one pig per pen):a basal diet or a basal diet containing YH(5 g/kg).On the 22nd d,6 piglets in each treatment were intraperitoneally injected with LPS at 150μg/kg BW,and the others were injected with the same amount of sterile normal *** hours later,blood samples of each piglet were collected and then piglets were *** Dietary YH supplementation increased average daily feed intake and average daily gain(P<0.01),decreased the ratio of feed intake to gain of piglets(P sponse,evidenced by the increase o=0.048).Lipopolysaccharide(LPS)injection induced systemic inflammatory ref serum concentrations of haptoglobin(HP),adrenocorticotropic hormone(ACTH),cortisol,and interleukin-1β(IL-1β).Furthermore,LPS challenge resulted in inflammatory intestinal damage,by up-regulation of the protein or mRNA abundances of tumor necrosis factor-α(TNF-α),IL-1β,toll-like receptors 4(TLR4)and phosphor-nuclear factor-κB-p65(p-NFκB-p65)(P<0.01),and down-regulation of the jejunal villus height,the protein and mRNA abundances of zonula occludens-1(ZO-1)and occludin(OCC;P<0.05)in jejunal *** YH supplementation decreased the impaired eff

关键词： Inflammatory response Intestinal barrier Lipopolysaccharide Piglets Yeast hydrolysate

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Effects of different starch structures on energy metabolism in pigs

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2474-2482页

作者： Xiaoqian Gao Bing Yu Jie Yu Xiangbing Mao Zhiqing Huang yuheng luo Junqiu luo Ping Zheng Hui Yan Jun He Daiwen Chen Key Laboratory for Animal Disease‑Resistance Nutrition Ministry of EducationInstitute of Animal NutritionSichuan Agricultural UniversityChengdu 611130People’s Republic of China

Background Starch is a major component of carbohydrates and a major energy source for monogastric *** is composed of amylose and amylopectin and has different physiological functions due to its different *** has been shown that the energy supply efficiency of amylose is lower than that of ***,there are few studies on the effect of starch structure on the available energy of *** purpose of this study was to measure the effect of different structures of starch in the diet on the net energy(NE)of pigs using a comparative slaughter method and to establish a prediction equation to estimate the NE of starch with different ***-six barrows(initial BW 10.18±0.11 kg)were used,and they were housed and fed *** were divided into 7 treatments,with 8 replicates for each treatment and 1 pig for each *** of the treatments was randomly selected as the initial slaughter group(ISG).Pigs in the remaining treatments were assigned to 6 diets,fed with basic diet and semi-pure diets with amylose/amylopectin ratio(AR)of 3.09,1.47,0.25,0.15 and 0.12,*** experiment lasted for 28 *** Results showed that compared with the high amylose(AM)groups(AR 3.09 and 1.47),the high amylopectin(AP)group(AR 0.15)significantly increased the final BW,average daily weight gain and average daily feed intake of pigs(P<0.05),but the F:G of the AM group was lower(P<0.01).In addition,AR 0.15 and 0.12 groups have higher(P<0.01)nutrient digestibility of dry matter,crude protein,gross energy and crude ***,compared with other groups,AR 0.15 group has a higher(P<0.05)NE intake and energy retention(RE).The regressive equation for predicting with starch structures was established as RE=1,235.243-48.298AM/AP(R^(2)=0.657,P=0.05).Conclusions In conclusion,NE intake and RE of pigs augmented with the increase of dietary amylopectin content,indicating that diets high in amylopectin were more conducive to promoting the growt

关键词： Amylose Amylopectin Net energy Pigs Starch structure

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Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

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Science China(Life Sciences) 2022年第10期65卷 2062-2075页

作者： Wen Ren Bing Yu Jie Yu Ping Zheng Zhiqing Huang Junqiu luo Xiangbing Mao Jun He Hui Yan Jinlong Wu Daiwen Chen yuheng luo Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-resistant Nutrition of Sichuan Provinceand Animal Nutrition InstituteSichuan Agricultural UniversityChengdu61l130China DSM(China)Animal Nutrition Research Center Co. LtdBazhou 065799China

Growing evidences show a direct link between diarrhea and disorders of gut microbiota in ***,whether there are microbial markers associated with post-weaning diarrhea remains *** the current study,we compared the microbial community,functions and metabolites between healthy weaned piglets(group H,n=7)and piglets with post-weaning diarrhea(group D,n=7),in order to find out diarrhea associated microbial *** of 7 fecal samples was collected from H and D piglets(weaned at 21 d and sampled at 26 d).The metagenomic and untargeted metabolomic analysis revealed that the microbial composition,function and metabolic profile in D pigs was considerably reshaped,including the reduced abundance and number of Bacteroides,which significantly correlated with the diarrhea status of *** carbohydrate metabolism,biosynthesis and metabolism,lipid metabolism,amino acid metabolism,and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H *** significantly changed the metabolic profiles of fecal microbiota,and most of the altered metabolites were negatively or positively correlated with the change in the abundance of *** conclusion,the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.

关键词： post-weaning piglet diarrhea Bacteroides metabolic dysfunction commensal microbiota

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Effect of fermented rapeseed meal on growth performance,nutrient digestibility,and intestinal health in growing pigs

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Animal Nutrition 2023年第4期15卷 420-429页

作者： Changyi Shuai Daiwen Chen Bing Yu yuheng luo Ping Zheng Zhiqing Huang Jie Yu Xiangbing Mao Hui Yan Jun He Institute of Animal Nutrition Sichuan Agricultural UniversitySichuan ProvinceChengdu611130China Key Laboratory of Animal Disease-resistant Nutrition Sichuan ProvinceChengdu611130China

To explore the effects of fermented rapeseed meal(FRSM)on growth performance and intestinal health,a total of 30 growing pigs were randomly allotted to three treatments consisting of corn-soybean meal diet(CSD),rapeseed meal diet(RSD),and fermented rapeseed meal diet(FRSD).Results showed that compared with RSD,FRSD feeding increased the average daily gain and final body weight in pigs(P<0.01).Compared with RSD feeding,FRSD feeding elevated the apparent digestibility of crude protein,acid detergent fiber,and ether extract in pigs(P<0.01).Moreover,the FRSD group exhibited greater apparent ileal digestibility of His,Thr,Lys,and Ser than the RSD group(P<0.01).The digestible energy,metabolic energy,and nitrogen utilization were higher in the FRSD and CSD groups than in the RSD group(P<0.01).As compared to the RSD,FRSD feeding decreased the serum concentration of leptin but significantly increased the concentrations of immunoglobulin(Ig)A,IgG,ghrelin,and enzyme activities of amylase,lipase,and trypsin in the pancreas(P<0.05).Interestingly,the villus height,the ratio of villus height to crypt depth,and the activities of brush border enzymes(e.g.,maltase and sucrase)in the small intestine were higher in the CSD and FRSD groups than in the RSD group(P<0.05).As compared to the RSD,the FRSD feeding not only increased the expression level of the occludin in the small intestinal epithelium(P<0.05)but also elevated the expression levels of claudin-1,MUC1,and PepT1 genes in the duodenum,and elevated the expression levels of SGLT1 and CAT1 genes in the jejunum(P<0.05).Importantly,FRSD feeding significantly decreased the abundance of Escherichia coli,but increased the abundance of Lactobacillus and the content of butyrate in the cecum and colon(P<0.05).These results indicated that compared with rapeseed meal,fermented rapeseed meal exhibited a positive effect on improving the growth performance and intestinal health in growing pigs,and the results may also help develop novel protein

关键词： Fermented rapeseed meal Growing pigs Growth performance Nutrient digestibility Intestinal health

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Dietary lycopene supplementation improves meat quality,antioxidant capacity and skeletal muscle fiber type transformation in finishing pigs

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Animal Nutrition 2022年第1期8卷 256-264页

作者： Wanxue Wen Xiaoling Chen Zhiqing Huang Daiwen Chen Bing Yu Jun He yuheng luo Hui Yan Hong Chen Ping Zheng Jie Yu Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Institute of Animal NutritionSichuan Agricultural UniversityChengduSichuan 611130China College of Food Science Sichuan Agricultural UniversityYa'anSichuan 625014China

This study aimed to investigate effects of dietary lycopene supplementation on meat quality,antioxidant ability and muscle fiber type transformation in finishing *** a 70-day experiment,18 DurocLandraceYorkshire barrows were randomly allocated to 3 dietary treatments including a basal diet supplemented with 0,100 and 200 mg/kg lycopene,*** dietary treatment had 6 replicates with one pig *** showed that dietary 200 mg/kg lycopene supplementation increased muscle redness a^(*)value,intramuscular fat and crude protein contents,and decreased muscle lightness L^(*)and yellowness b^(*)values(P<0.05),suggesting that addition of 200 mg/kg lycopene to the diet of finishing pigs improved color,nutritional value and juiciness of pork after *** also showed that dietary lycopene supplementation enhanced antioxidant capacity of finishing pigs(P<0.05).Moreover,dietary supplementation of 200 mg/kg lycopene significantly increased slow myosin heavy chain(MyHC)protein level and slow-twitch fiber percentage,and decreased fast MyHC protein level and fast-twitch fiber percentage(P<0.05),suggesting that the addition of 200 mg/kg lycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to ***,we provide the first evidence that dietary 200 mg/kg lycopene supplementation improves meat quality,enhances antioxidant capacity and promotes muscle fiber type transformation from fast-twitch to slow-twitch in finishing pigs.

关键词： Lycopene Meat quality Antioxidant capacity Skeletal muscle fiber type transformation Finishing pig

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Effect of different dietary protein levels and amino acids supplementation patterns on growth performance, carcass characteristics and nitrogen excretion in growing-finishing pigs

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Journal of Animal Science and Biotechnology 2020年第1期11卷 111-120页

作者： Yumei Zhao Gang Tian Daiwen Chen Ping Zheng Jie Yu Jun He Xiangbing Mao Zhiqing Huang yuheng luo Junqiu luo Bing Yu Key Laboratory of Animal Disease-Resistance Nutrition Animal Nutrition InstituteSichuan Agricultural University46#Xinkang RoadYucheng DistrictYaan 625014SichuanChina

Background:This study was conducted to determine the effects of different dietary protein levels and amino acids supplementation patterns in low protein diets on the growth performance,carcass characteristics and nitrogen excretion in growing-finishing ***-two barrows(25.00±0.39 kg)were randomly assigned to 7 *** 1:the high crude protein diet with balanced for 10 essential amino acids(EAAs).Diet 2:the medium crude protein diet with 2%(approx)decreased protein level of Diet 1 and balanced 10 *** 3:the low crude protein diet with 4%decreased protein level of Diet 1 and balanced 10 *** protein levels of Diet 4,5,6 and 7 were the same as that of Diet *** 4 was only balanced for lysine(Lys),methionine(Met),threonine(Thr)and tryptophan(Trp);Diet 5 and 6 were further supplemented with extra isoleucine(Ile)or valine(Val),respectively;Diet 7 was further supplemented with extra Ile+***:Over the 112 days trial,the reduction of dietary protein by 2%or 4%with balanced10 EAAs significantly decreased nitrogen excretion(P0.05).In low protein diet,Val supplementation significantly increased body weight gain at 25–50 kg phase(P0.05).The total N excretion of pigs supplemented with only Lys,Met,Thr and Trp was numerically higher than that of pigs fed with extra Ile,or Val,or Ile+Val ***:In low protein diet,Val is more required than Ile in the early growing phage(25–50 kg),while Ile becomes more required in the late growing and finishing phage(75–125 kg).

关键词： Growing-finishing pigs Growth performance Isoleucine Low protein diets Nitrogen excretion Valine

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