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Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population

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Chinese Medical Journal 2014年第4期127卷 638-644页

作者： Xu RY Ye P luo lm Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH Department of Geriatric Cardiology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China Department of Geriatric Cardiology Navy General Hospital Beijing 100048 China Department of Geriatric Cardiology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China

Background N-terminal pro-B-type natriuretic peptide （NT-proBNP） and high-sensitivity cardiac troponin T （hs-cTnT） are excellent biomarkers for detecting heart failure and subclinical myocardial ***,it remains unclear whether subclinical myocardial injury is associated with NT-proBNP elevation in a community based *** In a community based study,levels of hs-cTnT and of NT-proBNP were determined in 1 497 participants older than 45 *** lower detection limit of the hs-cTnT assay used in the present study was 0.003 ng/*** association of hs-cTnT levels and NT-proBNP levels was *** When the subjects with undetectable （〈0.003 ng/ml）,intermediate （0.003-0.014 ng/ml）,and elevated （≥0.014 ng/ml） levels of hs-cTnT were compared （r=0.175,P 〈0.001）,a strong association between the hs-cTnT levels and NT-proBNP levels was observed （β=-0.206,P 〈0.001; β=-0.118,P 〈0.001,respectively）.In multivariable analyses,older age and hs-cTnT were positively and independently associated with NT-proBNP levels （β=0.341,P 〈0.001; β=0.143,P 〈0.001,respectively）,and male gender and the levels of eGFR were inversely and independently associated with NT-proBNP *** the subjects with normal or elevated NT-proBNP were analyzed separately,the hs-cTnT level was not an independent predictor for the NT-proBNP level in the normal NT-proBNP group,whereas the hs-cTnT level was the only independent predictor for NT-proBNP level in the elevated NT-proBNP group （β=0.399,P 〈0.01）.Conclusions In this community based population,NT-proBNP elevation was *** addition to female gender and older age,subclinical myocardial injury indicated by the hs-cTnT level was another important factor in NT-proBNP elevation.

关键词： N-terminal pro-brain natriuretic peptide cardiac troponin T myocardial injury

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Levenberg-Marquardt based artificial physics method for mobile robot oscillation alleviation

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Science China(Physics,Mechanics & Astronomy) 2014年第9期57卷 1771-1777页

作者： ZHANG XiangYin DUAN HaiBin luo QiNan State Key Laboratory of Virtual Reality Technology and Systems Beihang University Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical Engineering Beihang University

This paper proposed a modified artificial physics(AP)method to solve the autonomous navigation problem for mobile robots in complex *** basic AP method tends to cause oscillations in the presence of obstacles and in narrow passages,which can result in time *** alleviate oscillation,we modified the AP method using the Levenbery-Marquardt(lm)*** the modified AP method,we altered the original directions of AP forces to the Newton direction,and adjust the parameter by the lm algorithm.A series of comparative experimental results show that the modified AP method can achieve smoother trajectories with less time *** demonstrates the feasibility and effectiveness of our proposed approach.

关键词： artificial physics(physicomimetics) Levenbery-Marquardt(lm) algorithm autonomous navigation obstacle avoidance

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Performance-weighted-voting model:An ensemble machine learning method for cancer type classification using whole-exome sequencing mutation

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Quantitative Biology 2020年第4期8卷 347-358页

作者： Yawei Li Yuan luo Department of Preventive Medicine Northwestern UniversityFeinberg School of MedicineChicagoIL 60611USA

Background:With improvements in next-generation DNA sequencing technology,lower cost is needed to collect genetic *** machine learning techniques can be used to help with cancer analysis and ***:We developed an ensemble machine learning system named performance-weighted-voting model for cancer type classification in 6,249 samples across 14 cancer *** ensemble system consists of five weak classifiers(logistic regression,SVM,random forest,XGBoost and neural networks).We first used cross-validation to get the predicted results for the five *** weights of the five weak classifiers can be obtained based on their predictive performance by solving linear regression *** final predicted probability of the performance-weighted-voting model for a cancer type can be determined by the summation of each classifier's weight multiplied by its predicted ***:Using the somatic mutation count of each gene as the input feature,the overall accuracy of the performance-weighted-voting model reached 71.46%,which was significantly higher than the five weak classifiers and two other ensemble models:the hard-voting model and the soft-voting *** addition,by analyzing the predictive pattern of the performance-weighted-voting model,we found that in most cancer types,higher tumor mutational burden can improve overall ***:This study has important clinical significance for identifying the origin of cancer,especially for those where the primary cannot be *** addition,our model presents a good strategy for using ensemble systems for cancer type classification.

关键词： cancer type classification ensemble method performance-weighted-voting model linear regression single-nucleotide polymorphism

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The development of silicate matrix phosphors with broad excitation band for phosphor-convered white LED

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Chinese Science Bulletin 2008年第19期53卷 2923-2930页

作者： luo XiXian CAO WangHe SUN Fei Optoelectronic Technology Institute Department of Physics Dalian Maritime University Dalian 116026 China

This paper briefly reviews the recent progress in alkaline earth silicate host luminescent materials with broad excitation band for phosphor-convered white LED. Among them, the Sr-rich binary phases (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ are excellent phosphors for blue LED chip white LED. They have very broad excitation bands and exhibit strong absorption of blue radiation in the range of 450―480 nm. And they exhibit green and yellow-orange emission under the InGaN blue LED chip radiation, respectively. The luminous efficiency of InGaN-based (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ is about 70-80 lm/W, about 95%―105% that of the InGaN-based YAG:Ce, while the correlated color temperature is between 4600―11000 K. Trinary alkaline earth silicate host luminescent materials MO(M=Sr, Ca, Ba)-Mg(Zn)O-SiO2 show strong absorption of deep blue/near-ultraviolet radia- tion in the range of 370―440 nm. They can convert the deep blue/near-ultraviolet radiation into blue, green, and red emissions to generate white light. The realization of high-performance white-light LEDs by this approach presents excellent chromaticity and high color rendering index, and the application disadvantages caused by the mixture of various matrixes can be avoided. Moreover, the application prospects and the trends of research and development of alkaline earth silicate phosphors are also discussed.

关键词：发光二极管白色宽激励带硅酸盐

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Forehead sEMG signal based HMI for hands-free control

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The Journal of China Universities of Posts and Telecommunications 2014年第3期21卷 98-105页

作者： ZHANG Yi ZHU Xiang DAI Ling-ling luo Yuan National Engineering Research and Development Center for Information Accessibility Chongqing University of Posts and Telecommunications

A hands-free method is proposed to control an electric powered wheelchair （EPW） based on surface electromyography （sEMG） signals. A CyberLink device is deployed to obtain and analyze forehead sEMG signals generated by the facial movements. The autoregressive （AR） model is used to extract sEMG features. Then, the back-propagation artificial neural network （BPANN） is proposed to recognize different facial movement patterns and improved by Bayesian regularization and Levenberg-Marquardt （lm） algorithm. A sEMG based human-machine interface （HMI） is designed to map facial movement patterns into corresponding control commands. The experimental results show that the method is simple, real-time and have a high recognition rate.

关键词： intelligent wheelchair sEMG HMI AR model BP artificial neural network

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Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs

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World Journal of Gastroenterology 2010年第9期16卷 1076-1085页

作者： Zhu, Jie Chen, Ling Xia, Hong luo, He-Sheng Wuhan Univ Renmin Hosp Dept Gastroenterol Wuhan 430060 Hubei Province Peoples R China Wuhan Univ Res Ctr Struct Biol Wuhan 430060 Hubei Province Peoples R China

AIM:To investigate the effects of sulfated cholecystokinin octapeptide (CCK-8S) on the contractile activity of guinea-pig proximal ***:Proximal colonic smooth muscle (PCSM) strips were obtained from adult female guinea pigs and contractile response of PCSM strips was recorded using a *** cells were isolated by enzymatic *** potential (RP),action potential (AP),large conductance potassium channel currents (IBKCa) and L-type calcium currents (ICa-L) were recorded by patch-clamp ***:(1) CCK-8S (10-7 mol/L) enhanced the mean contractile amplitude of colonic circular muscle and longitudinal muscle (lm) strips by 56.53% ± 11.92%(P=0.038) and 65.93% ± 12.98% (P=0.019),respectively,as well as the mean frequency of lm by 31.69% ± 13.58% (P=0.023),which were significantly attenuated by pretreating strips with devazepide,nifedipine,iberiotoxin,thapsigargin (TG) and BAPTA-AM (BA) respectively;(2) CCK-8S (10-7 mol/L) increased the AP amplitude by 38.6% ± 3.2% (P=0.015),decreased AP duration by 36.9% ± 8.7% (P=0.026),and depolarized the RP from-61.3 ± 2.7 mV to-29.8 ± 5.9 mV (P=0.032);and (3) Compared with the normal control group,CCK-8S (10-7 mol/L) enhanced the peak current of IBKCa by 18.7% ± 2.1% (from 916 ± 183 pA to 1088 ± 226 pA;at +60 mV;P=0.029),which was inhibited by respective pretreatment with iberiotoxin and ***,CCK-8S (10-7 mol/L) intensif ied the peak current of ICa-L by 40% (from 60 ± 8 pA to 84 ± 11 pA;at +10 mV;P=0.012),compared to the normal control group,which was apparently suppressed by respective pretreatment with nifedipine,devazepide,TG and *** the respective presence of heparin and staurosporine,CCK-8S did not signif icantly enhance IBKCa and ***:The results suggest that CCK-8S promotes guinea-pig proximal colon contraction by CCK1 receptors,following activation of the inositol triphosphate-protein kinase C signal transduction pathway.

关键词： Muscle contraction Potassium channels Calcium channels Colon Cholecystokinin octapeptide

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Quasicrystal dissolution and performance of isothermally heat-treated Mg–Zn–Y alloy

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Rare Metals 2015年第7期34卷 452-456页

作者： Di-Qing Wan Xian luo Ya-Juan Liu Tian Yu Key Laboratory of Ministry of Education for Conveyance and Equipment East China Jiaotong University State Key Laboratory of Solidification Processing Northwestern Polytechnical University School of Materials Science Northwestern Polytechnical University

Conventional casting method was employed to prepare Mg–Zn–Y alloy only with a-Mg+I-phase; however, the grain size of quasicrystal is quite large in the ascast ***, isothermal treatment was applied to refine the quasicrystal *** result shows that after the Mg–Zn–Y alloy was isothermally treated at 500 °C for several hours, the coarse quasicrystal can be gradually dissolved and thus ***, the dissolving processes of quasicrystal are slow first and then accelerate;after isothermally treated with 8 h at 500 °C, the quasicrystal is almost completely dissolved into the matrix only with 1–5 lm tiny quasicrystals *** of quasicrystal can markedly reduce the wear resistance, but increase the corrosion resistance.

关键词： Magnesium alloy Quasicrystal Isothermal treatment

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Machine Learning for Lung Cancer Diagnosis,Treatment,and Prognosis

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 850-866页

作者： Yawei Li Xin Wu Ping Yang Guoqian Jiang Yuan luo Department of Preventive Medicine Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Department of Medicine University of Illinois at ChicagoChicagoIL 60612USA Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905/ScottsdaleAZ 85259USA Department of Artificial Intelligence and Informatics Mayo ClinicRochesterMN 55905USA

The recent development of imaging and sequencing technologies enables systematic advances in the clinical study of lung ***,the human mind is limited in effectively handling and fully utilizing the accumulation of such enormous amounts of *** learningbased approaches play a critical role in integrating and analyzing these large and complex datasets,which have extensively characterized lung cancer through the use of different perspectives from these accrued *** this review,we provide an overview of machine learning-based approaches that strengthen the varying aspects of lung cancer diagnosis and therapy,including early detection,auxiliary diagnosis,prognosis prediction,and immunotherapy ***,we highlight the challenges and opportunities for future applications of machine learning in lung cancer.

关键词： Omics dataset Imaging dataset Feature extraction Prediction Immunotherapy

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Preparation and characterization of TiO_2/acrylic resin composite coatings on sintered NdFeB permanent magnets by electrochemical deposition

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Rare Metals 2014年第6期33卷 703-708页

作者： Zhen-Chen Zhong Ji-Lin Xu Zheng-Xian Huang Jun-Ming luo School of Materials Science and Engineering Nanchang Hangkong University

The sintered Nd Fe B permanent magnets are widely used in various industries because of their excellent magnetic and comprehensive properties. However, they are seriously hindered to further developments and applications owing to its poor corrosion resistance. In this paper,TiO2/acrylic resin composite coatings were successfully prepared on the sintered Nd Fe B permanent magnets by electrochemical deposition for the first time, and the corrosion behaviors were investigated by using immersion testing and potentiodynamic polarization tests. It is found that the coating is a composite, being composed of polymerized acrylic resin as the matrix and nano-rutile TiO2particles（-200 nm） as the reinforcements. It is about25 lm in thickness and its surface and cross-section exhibit uniform and smooth with no pores, cracks, and other defects. Compared with those of the uncoated Nd Fe B magnets, the weight loss of the coated samples immersed in H2SO4 solution reduces by two orders of magnitude,corrosion current density decreases by four orders of magnitude, and the corrosion potential of the coated sample is shifted in the noble direction by 400 m V. The mechanisms of corrosive resistance enhancement were discussed.

关键词： NdFeB magnets Nano-TiO2 Acrylic resin Electrophoretic deposition Corrosion resistance

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Fluidic Ga–In liquid metal-modified cathode with improved cyclic performance and capacity of Li–O2 batteries

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Rare Metals 2022年第7期41卷 2223-2229页

作者： Ao-Hua Chai Chen-Hao Ji Dong Yuan Lian-Kun Yin Yan-Song Zhang Xiang-Qun Zhuge Zhi-Hong luo Yi-Bing Li Kun luo Guangxi Key Laboratory of Optical and Electronic Materials and Devices College of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China Jiangsu Province Engineering Research Center of Intelligent Manufacturing Technology for the New Energy Vehicle Power Battery School of Materials Science and EngineeringChangzhou UniversityChangzhou 213164China

The cathode passivation induced by the accumulated solid products is a serious issue which impede the application of Li-O_(2) ***,we applied Ga-In liquid metal(Ga-In lm)functionalized cathode to alleviate the cathode passivation by using the fluidity and self-healing surface of Ga-In lm microdrops,which could hardly be covered by the solid discharge products,such as Li_(2)O_(2) and LiOH during charge/discharge cycles.

关键词： cathode hardly healing

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