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基于“大创”项目的医学生科研能力培养的实践与探索

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创新创业理论研究与实践 2024年第1期7卷 71-74页

作者：何志凯钟萍罗超沈力贺细菊湖北医药学院基础医学院基础医学研究所湖北十堰422000

在医学教育中,医学本科生科研能力的培养显得越来越重要。为适应现代医学教育的要求,湖北医药学院基于大学生创新创业训练计划项目(简称“大创”项目)开展科研训练,该文以基础医学研究所科研平台为依托,以“大创”项目主要参与成员和指... 详细信息

在医学教育中,医学本科生科研能力的培养显得越来越重要。为适应现代医学教育的要求,湖北医药学院基于大学生创新创业训练计划项目(简称“大创”项目)开展科研训练,该文以基础医学研究所科研平台为依托,以“大创”项目主要参与成员和指导教师为主体,结合“大创”项目的开展和实施,为建立科学有效的医学本科生科研能力培养体系进行了实践与探索。

关键词：医学教育大学生创新创业训练计划科研平台医学本科生科研能力培养

公共交通可达性提升规划研究及实践——以重庆市中心城区为例

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城市公共交通 2024年第8期 47-51页

作者：王世能温馨罗超夏宇翔重庆市交通规划研究院重庆400020 重庆通拓交通规划设计有限公司重庆400020 南京市市政设计研究院有限责任公司重庆分公司重庆400020

重庆作为超大型山地城市,组团式发展布局对公共交通发展提出更高的要求。由于山地城市地势落差大,对公共交通站点步行可达性、时效性保障的挑战更高,有必要研究公共交通与其他交通方式无缝衔接,以增强公共交通客流分担能力。本文借助交... 详细信息

重庆作为超大型山地城市,组团式发展布局对公共交通发展提出更高的要求。由于山地城市地势落差大,对公共交通站点步行可达性、时效性保障的挑战更高,有必要研究公共交通与其他交通方式无缝衔接,以增强公共交通客流分担能力。本文借助交通大数据、重庆市交通综合信息平台,辅以网络问卷调查,量化评估现状轨道交通站点和公交站点对城市人口的服务覆盖率,识别问题成因,精准提出改造提升方案,切实解决人民群众出行难题,提升公共交通服务水平。

关键词：公共交通可达性交通大数据服务水平

Ultrathin and Air-Stable Lithium Metal Anodes with Superlong Cycling Life in Ether/Ester-Based Electrolytes

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Energy & Environmental Materials 2023年第4期6卷 289-296页

作者： chao luo Zihuan Tang Miaomiao Zhang Xiaoyu Feng Rongjie luo Qifei Guo Xuming Zhang Biao Gao Zhao Ding Yang Zheng Kaifu Huo The State Key Laboratory of Refractories and Metallurgy Institute of Advanced Materials and NanotechnologyWuhan University of Science and TechnologyWuhan 430081China Wuhan National Laboratory for Optoelectronics(WNLO) School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China

Ultrathin and air-stable Li metal anodes hold great promise toward high-energy and high-safety Li metal batteries(LMBs).However,the application of LMBs is technically impeded by existing Li metal anodes with large thickness,high reactivity,and poor ***,we developed a novel and scalable approach for the construction of a 10-μm-thick flexible and air-stable Li metal anode by conformally encapsulating Li within a multifunctional VN ***,the highly lithiophilic VN layer guides a uniform deposition of Li,while abundant and multilevel pores arising from assembly of ultrathin nanosheets enable a spatially confined immersion of metallic Li,thus ensuring an ultrathin and sandwiched Li *** impressively,the strong hydrophobicity of VN surface can effectively improve the stability of anode to humid air,whereas the highly conductive framework greatly boosts charge transfer dynamics and enhances Li utilization and high-rate *** from such fascinating features,the constructed Li-VN anode exhibits ultrastable cycling stability in both ether(2500 h)and carbonate(900 h)electrolytes,***,even exposed to ambient air for 12 h,the anode still can retain~78%capacity,demonstrating excellent air-defendable *** work affords a promising strategy for fabricating high-performance,high-safety,and low-cost LMBs.

关键词： air stable highly lithiophilic lithium metal anodes ultrathin VN

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空间站舱段平转式转位方案设计与验证

航天器工程 2024年第1期33卷 19-25页

作者：罗超罗文成刘冬雨史纪鑫北京空间飞行器总体设计部北京100094

根据我国空间站实验舱在转位前后对天/地指向不变的任务需求,提出舱段平转式转位方案,设计基于转位机构的舱段转位实现方案。转位期间,空间站组合体采用重力梯度被动稳定姿态飞行,解决姿态主动停控时空间站稳定指向的难题。通过设计选... 详细信息

根据我国空间站实验舱在转位前后对天/地指向不变的任务需求,提出舱段平转式转位方案,设计基于转位机构的舱段转位实现方案。转位期间,空间站组合体采用重力梯度被动稳定姿态飞行,解决姿态主动停控时空间站稳定指向的难题。通过设计选取合适的转位任务窗口,确保转位全程测控链路畅通、光照充足,以提高任务安全性和可靠性。地面试验和在轨实验舱转位任务实施,全面验证了空间站舱段平转式转位方案的正确性。

关键词：空间站组装建造平转式转位机构

Text Detection and Recognition for Natural Scene Images Using Deep Convolutional Neural Networks

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Computers, Materials & Continua 2019年第7期61卷 289-300页

作者： Xianyu Wu chao luo Qian Zhang Jiliu Zhou Hao Yang Yulian Li School of Computer Science Chengdu University of Information TechnologyChengdu610225China School of Computer Science University of Nottingham Jubilee CampusNG81BBUK School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu610054China

Words are the most indispensable information in human *** is very important to analyze and understand the meaning of *** with the general visual elements,the text conveys rich and high-level moral information,which enables the computer to better understand the semantic content of the *** the rapid development of computer technology,great achievements have been made in text information detection and ***,when dealing with text characters in natural scene images,there are still some limitations in the detection and recognition of natural scene *** natural scene image has more interference and complexity than text,these factors make the detection and recognition of natural scene image text face many *** solve this problem,a new text detection and recognition method based on depth convolution neural network is proposed for natural scene image in this *** text detection,this method obtains high-level visual features from the bottom pixels by ResNet network,and extracts the context features from character sequences by BLSTM layer,then introduce to the idea of faster R-CNN vertical anchor point to find the bounding box of the detected text,which effectively improves the effect of text object *** addition,in text recognition task,DenseNet model is used to construct character recognition based on ***,the output of Softmax is used to classify each *** method can replace the artificially defined features with automatic learning and context-based *** improves the efficiency and accuracy of recognition,and realizes text detection and recognition of natural scene *** on the PAC2018 competition platform,the experimental results have achieved good results.

关键词： Detection recognition resnet blstm faster R-CNN densenet

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

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Neuroscience Bulletin 2019年第3期35卷 561-580页

作者： chao luo Junyan Liu Xu Wang Xiaoyuan Mao Honghao Zhou Zhaoqian Liu Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha 41000& China Hunan Key Laboratory of Pharmacogenetics Institute of Clinical PharmacologyCentral South UniversityChangsha 41007& China School of Life Sciences Central South UniversityChangsha 41007& China Department of Orthopaedics The First Affiliated Hospital of the University of South ChinaHengyang 421001. China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 41000& China

Antipsychotic-induced weight gain(AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that [ 25 single-nucleotide polymorphisms in19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2 C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not beenincluded in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population,genome-wide association studies and multiple-center, standard, unified, and large samples are needed.

关键词： Pharmacogenetic Antipsychotic Weight gain Single nucleotide polymorphism Schizophrenia

顶空固相微萃取/气相色谱-质谱法测定血液中15种挥发性有机物

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分析测试学报 2024年第9期43卷 1442-1449页

作者：李昊洋张文骥韩祺瑞丁海媛于汇川罗颖超中国刑事警察学院刑事科学技术学院辽宁沈阳110854

该研究使用人工合成模拟血液标准添加溶液,采用部分因子实验、单因素实验、响应曲面法优化萃取条件,建立了顶空固相微萃取/气相色谱-质谱联用(HS-SPME/GC-MS)测定血液中常见挥发性有机物(VOCs)的分析方法。取2.0 mL血液样品,使用65μm... 详细信息

该研究使用人工合成模拟血液标准添加溶液,采用部分因子实验、单因素实验、响应曲面法优化萃取条件,建立了顶空固相微萃取/气相色谱-质谱联用(HS-SPME/GC-MS)测定血液中常见挥发性有机物(VOCs)的分析方法。取2.0 mL血液样品,使用65μm聚二甲基硅氧烷/二乙烯基苯(PDMS/DVB)萃取纤维,在萃取温度57℃,萃取时间45 min,搅拌转速1000 r/min,解吸温度280℃、解吸时间5 min、氯化钠含量为0条件下进行萃取,以内标法定量。结果表明,15种VOCs在0.4~4、4~40、40~400 ng/mL质量浓度范围内线性良好(r2>0.99),方法检出限为0.03~0.1 ng/mL,定量下限为0.1~0.3 ng/mL。15种VOCs在2.0、20、200ng/mL加标水平下的平均回收率为71.1%~122%,相对标准偏差(n=6)为7.5%~16%。使用该方法测定新鲜人体血液样品和标准添加样品进行基质效应差异性评价,结果表明模拟血液和真实血液在基质效应方面无显著差异(p>0.05)。该方法线性范围广、检出限和定量下限低、前处理方便、检测门槛低,适用于血液中多种VOCs的检测。

关键词：响应曲面法顶空固相微萃取气相色谱-质谱联用挥发性有机物血液

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荧光定量PCR仪校准技术指标及结果分析

上海计量测试 2024年第2期51卷 2-5页

作者：梁文霍银波杨镇州罗超李妍上海市计量测试技术研究院

根据不同荧光定量PCR仪器品牌的市场占有率挑选了不同型号、不同工作频率和使用年限的仪器进行校准和质量风险分析,重点针对温度示值误差、温度均匀度、样本重复性和样本线性四个技术指标作了检测和比较,探讨了这四个技术指标出现偏差... 详细信息

根据不同荧光定量PCR仪器品牌的市场占有率挑选了不同型号、不同工作频率和使用年限的仪器进行校准和质量风险分析,重点针对温度示值误差、温度均匀度、样本重复性和样本线性四个技术指标作了检测和比较,探讨了这四个技术指标出现偏差可能造成的检测结果失准的风险,并对仪器生产厂商和仪器使用者提出了建议。通过分析评估得出了该类仪器应该重点关注的技术参数指标和技术难点,为仪器使用者了解该产品的质量状况及相关政策措施的制定提供了参考依据。

关键词：荧光定量PCR仪计量测试风险评估

Identification of two Monilia species from apricot in China

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Journal of Integrative Agriculture 2017年第11期16卷 2496-2503页

作者： YIN Liang-fen CAI Ming-li DU Sheng-fang luo chao-xi Experimental Teaching Center of Crop Science College of Plant Science & Technology Huazhong Agricultural University Wuhan 430070 P.R.China Key Laboratory of Crop Disease Monitoring & Safety Control of Hubei Province~College of Plant Science & Technology Huazhong Agricultural University Wuhan 430070 P.R. China

Monilinia fructicola, Monilia mumecola and Monilia yunnanensis have been reported as the causal agents of brown rot disease on stone fruits in China. Up to date, these species have been identified from peach and plum, and M. mumecola has also been reported on apricot recently. To investigate whether M. fructicola and M. yunnanensis can cause brown rot disease on apricot in China, 37 isolates were collected from four orchards in Chongqing and Beijing municipalities in 2014. These isolates were divided into two phenotypes according to their distinct colony appearances. Two representative isolates of each phenotype and reference species of M. mumecola from apricot were selected for further analysis. Based on the morphological characterization and molecular identification, the two phenotypes of isolates were identified as M. fructicola and M. yunnanensis, respectively.

关键词： brown rot apricot Monilinia fructicola Monilia yunnanensis