检索结果-南通市图书馆

Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 27-32,39页

作者： YAN Xiao-shuai luo chao YANG Fang The Fifth Hospital of Xianmen Xiamen Fujian 361101China

Objective:To construct methotrexate(MTX)-chitosan(CS)-chuanxiongmuizine(TMP)nano-delivery system MTX-CS-TMP-NPs,and to investigate its effect on the telomerase activity of cervical cancer Hela ***:MTX-CS and MTX-CS-TMP-NPs were prepared by amide reaction and ionic gel method,and the encapsulation rate and drug loading rate were *** method and TRAP method were used to detect Hela cells and telomerase activity,and to compare the difference of telomerase activity of MTX,MTX-CS,and MTX-CS-TMP-NPs on cervical cancer Hela ***:In this study,the total amount of TMP was 150μg,of which the amount of free TMP was(26.46±1.72)μg,the encapsulation rate of TMP was(82.36±0.01)%,and the drug loading was(17.62±0.23)*** activity of Hela cells increased with the extension of time,and the OD value of Hela cell activity(1.24±0.05)was lower than that of the other three groups at 72 h of treatment,and the difference was statistically significant(P<0.05).The telomerase activity of He La cells in the MTX-CS-TMP-NPs solution treatment group was(0.23±0.12)%lower than that of the other three groups,with statistically significant difference(P<0.05).Conclusion:MTX-CS-TMP-NPs may effectively reduce the activity and telomerase activity of cervical cancer Hela cells,showing its potential anti-cervical cancer effect.

关键词： cervical cancer(CC) Docetaxel MTX telomerase nano-drug delivery system cell cycle

同方期刊数据库

Quasi-in-situ Observation and SKPFM Studies on Phosphate Protective Film and Surface Micro-Galvanic Corrosion in Biological Mg-3Zn-xNd Alloys

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 648-664页

作者： Zhaochen Yu Kaixuan Feng Shuyun Deng Yang Chen Hong Yan Honggun Song chao luo Zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang330031China Institute for Advanced Study Nanchang UniversityNanchang330031China

The phosphate protective film and micro-galvanic corrosion of biological Mg-3Zn-xNd (x = 0, 0.6, 1.2) alloys were investigated by scanning and transmission electron microscopy, quasi-in-situ observation, scanning Kelvin probe force microscopy (SKPFM) and electrochemical tests. The results revealed the Mg-Zn-Nd phases formed in Mg-3Zn alloy contained with Nd. Adding Nd resulted in a significant decline in the cracks of the phosphate protective film and micro-galvanic corrosion of alloys, which were recorded by quasi-in-situ observation. In addition, the Volta potential difference of Mg-Zn-Nd/α-Mg (~ 188 mV) was lower than MgZn/α-Mg (~ 419 mV) and Zn-rich/α-Mg (~ 260 mV), and the corrosion rates of alloys markedly decreased after the addition of 0.6 wt% Nd. The improvement in corrosion resistance of Nd-containing alloys was mainly attributed to the following: (i) the addition of Nd reduced the Volta potential difference (second phases/α-Mg);(ii) the phosphate protective film containing Nd_(2)O_(3) deposited on the surface of the alloys, effectively preventing the penetration of harmful anions.

关键词： Magnesium alloys Quasi-in-situ observation Phosphate protective film Scanning Kelvin probe force microscopy(SKPFM) Micro-galvanic corrosion

Applications of optical control materials based on localized surface plasmon resonance effect in smart windows

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2024年第4期6卷 711-731页

作者： Na Ta Jing-Yi Huang Shuai He W.Hanggai luo-Meng chao College of Science Inner Mongolia University of Science and Technology Fundamental Aspects of Materials and Energy Faculty of Applied Sciences Delft University of Technology

The increasing energy consumption in buildings due to cooling and heating,accounting for over one-third of the total energy consumption in society,has become a growing ***,reducing building energy consumption has become an urgent issue for countries *** serve as the primary channel for energy exchange between the indoor and the outdoor *** providing natural lighting for occupants,windows are also the weakest link in terms of energy *** recent years,there have been some new and superior coating glass technologies compared to traditional low-emissivity *** coatings utilize various optical functional materials to regulate the incident sunlight,aiming to save cooling and heating energy ***,such as tungsten-based compounds,vanadium dioxide,lanthanum hexaboride,or copper monosulfide,can absorb near-infrared light to effectively control solar radiation by leveraging the localized surface plasmon resonance(LSPR) effect of *** paper mainly introduces the micro-mechanisms of these materials and provides a detailed summary of the latest advancements in coating *** application and effects of these coatings in building energy conservation are ***,the challenges and prospects of LSPRbased smart windows are *** is expected that this review will provide new insights into the application of smart windows in green buildings.

关键词： Copper monosulfide Lanthanum hexaboride Localized surface plasmon resonance (LSPR) Tungsten Tungsten-based compounds Vanadium dioxide

In-situ AFM and quasi-in-situ studies for localized corrosion in Mg-9Al-1Fe-(Gd) alloys under 3.5 wt.% NaCl environment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第3期12卷 1170-1185页

作者： Junping Shen Tao Lai Zheng Yin Yang Chen Kun Wang Hong Yan Honggun Song Ruiliang Liu chao luo Zhi Hu School of Advanced Manufacturing Nanchang UniversityNanchang 330031China Institute for Advanced Study Nanchang UniversityNanchang 330031China Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University60 Nanyang Drive 637751Singapore

Revealing the localized corrosion process of Mg alloy is considered as one of the most significant ways for improving its corrosion *** reliable monitor should be high distinguishability and real-time in liquid ***,Mg-9Al-1Fe and Mg-9Al-1Fe-1Gd alloys were designed to highlight the impact of intermetallic on the corrosion ***-situ AFM with a special electrolyte circulation system and quasi-in-situ SEM observation were used to monitor the corrosion process of the designed ***-EDS and TEM-SAED were applied to identify the intermetallic in the designed alloys,and their volta potentials were measured by *** to the real-time and real-space in-situ AFM monitor,the corrosion process consisted of dissolution of anodicα-Mg phase,accumulation of corrosion products around cathodic phase and shedding of some fine cathodic ***,the localized corrosion process of Mg alloy was revealed combined with the results of the monitor of corrosion process and Volta potential difference.

关键词： Magnesium Localized corrosion In-situ AFM SKPFM Corrosion behaviour.

Magnetocaloric effect and phase transition critical behavior of La0.75Sr0.25Mn0.9Co0.1O3 compound synthesized under the high pressure

在线全文

学校读者我要写书评

暂无评论

Tungsten 2024年第03期6卷 621-632页

作者： Jing Zhao Lei Gao Jian-Jun Zhao Wei Wei Hui-Qin Yun Ru Xing Huai-Jin Ma Xiang Jin luo-Meng chao School of Physical Science and Technology Key Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region Baotou Teachers' College National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Physics and Electronic Information Inner Mongolia Normal University College of Science Inner Mongolia University of Science and Technology

In this study,a novel method is proposed for producing perovskite rare-earth manganese oxide magnetic refrigeration materials that exhibit superior properties compared to similar *** maximum magnetic entropy change values for this sample are 1.44 and 3.75 J·kg-1·K-1for magnetic fields of 2 and 7 T,***,its relative cooling power has been calculated to be 101.96 and 404.78 J·kg-1,indicating good *** results were obtained using the sample synthesized under a pressure of 4 GPa,and the sample has undergone a second phase *** critical behavior of the sample fits well with the mean field *** different magnetic fields,there is a significant overlap between the values of the maximum magnetic entropy change and the temperature-averaged entropy change,indicating that the refrigeration performance of the sample after high pressure can approach its maximum capability.

关键词： High-pressure synthesis Magnetocaloric effect Relative cooling power Magnetic phase transition

Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin LIN Ru-kun LI Chan CHEN Zhi-jie CHEN Yi-fei luo chao-hua MO Zhi-xian LIN Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

“雅颂之音”与“讽谕之鸣”:论礼乐复兴视域下的宋初文学

在线全文

学校读者我要写书评

暂无评论

新疆大学学报（哲学社会科学版） 2024年第1期52卷 131-138页

作者：罗超华山东大学文学院山东济南250100

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化... 详细信息

宋初文坛纷繁复杂,不仅呈现出南北对峙、难以融合的紧张局面,还产生了时文与古文的创作分歧。而于此之外,士人群体内又共同含纳着一股颂美君王功业、宣扬帝国政治的风气。尽管从传统文艺审美的角度看,这种风气催生的文学作品多属程式化的礼仪书写,但若将之置于宋初礼乐复兴视域下进行更深层次解读,则于某些赋颂中可观觇士大夫政治主体意识的觉醒迹象,且雅颂主旋律中讽喻之声的鸣起,又宣示了宋初文人对唐人风雅观的进一步开拓。这些被程式化书写遮蔽的内容,实质是政治与文学的合奏交响,二者间表里经纬的错综关系及由此生成的强力互动,正体现出此间特殊的文学生态。

关键词：礼乐宋代雅颂文学风气儒道

学前教育PPP项目可行性、收益回报与风险评估研究

在线全文

学校读者我要写书评

暂无评论

价格理论与实践 2024年第7期 172-176,224页

作者：罗超王小为华中师范大学教育学院贵州师范学院教育科学学院

PPP模式有利于发挥社会资本的优势,开源节流、取长补短、优化配置,提高服务质量。学前教育领域PPP项目的可行性、收益回报和风险评估关涉项目开展的关键要点,决定了项目实施以及深度合作的可能性。分析可知,整体提升学前教育质量和满足... 详细信息

PPP模式有利于发挥社会资本的优势,开源节流、取长补短、优化配置,提高服务质量。学前教育领域PPP项目的可行性、收益回报和风险评估关涉项目开展的关键要点,决定了项目实施以及深度合作的可能性。分析可知,整体提升学前教育质量和满足农村偏远地区幼儿入园需求需要社会资本参与;与传统建设项目相比,PPP项目能够优化资金使用率,保障社会效益最大化。随着政府支持和社会资本的作用,建设学前教育事业的风险由政府和社会资本共同承担,形成共担共御机制,较好地预防和控制风险,有利于提高学前教育建设水平和幼教质量。

关键词： PPP 社会资本学前教育教育质量

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

智能技术赋能飞秒激光:表征与控制(特邀)

激光与光电子学进展 2024年第1期61卷 223-243页

作者：罗超义理林蒲国庆上海交通大学电子信息与电气工程学院区域光纤通信网与新型光通信系统国家重点实验室上海200240

飞秒激光在学术领域和工业领域都具有极高的应用价值,对飞秒激光进行准确快速的表征与精确控制对其各种应用至关重要。飞秒脉冲的传统表征方法依赖非线性效应且光路结构复杂,而飞秒脉冲的控制则大多采用开环手动调试,无法实现稳定的最... 详细信息

飞秒激光在学术领域和工业领域都具有极高的应用价值,对飞秒激光进行准确快速的表征与精确控制对其各种应用至关重要。飞秒脉冲的传统表征方法依赖非线性效应且光路结构复杂,而飞秒脉冲的控制则大多采用开环手动调试,无法实现稳定的最优调控,极大地限制了飞秒激光的应用。近年来,智能技术的出现给飞秒激光研究提供了新范式,结合智能技术,低能量高重复频率飞秒脉冲序列的单帧全域测量与飞秒脉冲的按需智能调控有望成为现实。

关键词：锁模激光器飞秒脉冲智能表征飞秒脉冲智能调控

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海洋油气央企研发中心发展模式探索与实践

天津科技 2024年第8期51卷 10-12页

作者：罗超海洋石油工程股份有限公司天津300461

创新是维持企业生命力和竞争力的核心要素,研发中心作为企业创新的重要载体,作用日益凸显。研发中心的发展模式从完全委托研究到合作研究,再到开放式创新联合研究,不同的组织模式适应不同的研究类型和不同的发展阶段。以某大型海洋油气... 详细信息

创新是维持企业生命力和竞争力的核心要素,研发中心作为企业创新的重要载体,作用日益凸显。研发中心的发展模式从完全委托研究到合作研究,再到开放式创新联合研究,不同的组织模式适应不同的研究类型和不同的发展阶段。以某大型海洋油气央企研发中心的建设和创新实践为对象,深入分析研发中心在企业发展中的作用。

关键词：研发中心研究类型组织模式