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Highly fluorescence Ta_(4)C_(3) MXene quantum dots as fluorescent nanoprobe for heavy ion detection and stress monitoring of fluorescent hydrogels

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Chinese Chemical Letters 2022年第4期33卷 1850-1854页

作者： Shouzhen Li Junfei Ma Xuelin Zhao Peide Zhu Meng Xu Yingchun Niu dixian luo Quan Xu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development National Energy Shale Oil Research and Development CenterChina University of Petroleum(Beijing)Beijing 102249China Department of Musculoskeletal Tumor Senior Department of Orthopedicsthe Fourth Medical Center of PLA General HospitalBeijing 100142China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518000China

Compared with other transition metal Mxene derived quantum dots(MQD_(S)),Ta-based Mxene quantum dots have good functionality,but Ta-based Mxene quantum dots and their applications have not been studied so *** this paper,we report for the first time the synthesis of high fluorescence quantum yield(QY) N-doped Ta_(4)C_(3) quantum dots(N-MQDs) using Ta_(4)C_(3) quantum dots in acid reflux damaged Ta_(4)C_(3) nanosheets as precursors and ethylenediamine as nitrogen *** prepared N-MQDs have excellent blue photoluminescence(PL) properties,particle size is only 2.60 nm,QY is up to 23.4%,and good *** addition,it has been reported that N-MQDs can be used as fluorescent probe for detection of Fe;and remote force sensing analysis In liquid ion sensing,N-MQDS shows a unique selective quenching of Fe;with a detection limit as low as 2 μmol/L,and has great potential as a fast and super-sensitive fluorescent probe for the detection of heavy *** importantly,in solid mechanics sensing,the introduction of N-MQDs into self-healing hydrogels can be developed into a fluorescent hydrogel that can be used for accurate remote force measurement and applied in the field of mechanical sensing ***,Ta-based N-MQDs show excellent potential in the field of fluorescence sensing,which provides a door for multi-dimensional sensing of new materials in the future.

关键词： MXene quantum dots Fluorescent probe Fluorescent hydrogel Hydrothermal method Quantum yield

MOPCS: next-generation nucleic acid molecular biosensor

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National Science Review 2022年第9期9卷 139-141页

作者： Quan Liu Shang Chen Li Wang Zhaojun Duan Fuquan Xie Guojun Zhao Yunde Hou dixian luo Laboratory Medicine Center Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital) Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Shenzhen University Health Science Center National Institute for Viral Disease Control and Prevention China Center for Disease Control and Prevention Department of Laboratory Medicine Shenzhen Children's Hospital The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan City People's Hospital

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a huge impact on the world, causing millions of deaths and a serious blow to the global economy. SARS-CoV-2 can aack most body tissues with devastating consequences [1].e current global SARS-CoV-2 outbreak has exposed our shortcomings in the prevention and control of infectious diseases,

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Integrating of lipophilic platinum(IV) prodrug into liposomes for cancer therapy on patient-derived xenograft model

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Chinese Chemical Letters 2022年第4期33卷 1875-1879页

作者： Zibo Li Qing Xu Xuefeng Lin Kunyi Yu Ling Lin Yangjia Liu Zhiqiang Yu Tiancai Liu dixian luo Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518000China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China School of Laboratory Medicine and Biotechnology Institute of Antibody EngineeringSouthern Medical UniversityGuangzhou 510515China

Platinum-based anticancer agents such as cisplatin and its analogues are widely used for treating multiple cancers. However, due to the inferior water-solubility, chemoresistance and consequent adverse side effects, their clinical applications are limited. Herein, choles Pt(IV), a lipophilic platinum(IV) prodrug was synthesized for manufacture of Choles Pt(IV)-Liposomes aiming to resolve the predefined obstacles encountered by platinum drugs. Following systematic screening, Choles Pt(IV)-Liposomes showed a small particle size(105.6 nm), the rapid release of platinum(Pt) ions, and notable apoptosis of cancer *** addition, according to the fluidity and safety results of animal experiments in mice, Choles Pt(IV)-Liposomes also showed better therapeutic effect, which significantly inhibited the growth of patientderived xenograft tumors of hepatocellular carcinoma with an inhibition ratio of 80.7%, and effectively alleviated the drug toxicity brought by traditional platinum drugs. Overall, this study provides a promising route to enhance the therapeutic efficiency of platinum drugs in cancer treatment.

关键词： Lipophilic platinum(IV)prodrug Liposome Cancer therapy Drug delivery Patient-derived xenograft

Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

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Chinese Chemical Letters 2024年第4期35卷 414-419页

作者： Peide Zhu Yangjia Liu Yaoyao Tang Siqi Zhu Xinyang Liu Lei Yin Quan Liu Zhiqiang Yu Quan Xu dixian luo Juncheng Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Institute of Stomatology First Medical CenterChinese PLA General HospitalBeijing 100853China

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped ***/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关键词： Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration

β-Cyclodextrin derived full-spectrum fluorescent carbon dots: The formation process investigation and biological applications

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Chinese Chemical Letters 2023年第10期34卷 215-222页

作者： Peide Zhu Wenjing Li Yuqi Zhang Qiang Sun Yi Lin Ailin Qiu Xinyi Chen Yujin Zhou Guangfu Wu Yifan Li Zhiqiang Yu Quan Xu dixian luo Lulu Cai State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523018China

Carbon dots(CDs), a new building unit, have been revolutionizing the fields of biomedicine, bioimaging, and optoelectronics with their excellent physical, chemical, and biological properties. However, the difficulty of preparing excitation-dependent full-spectrum fluorescent CDs has seriously hindered their further research in fluorescence emission mechanisms and biomedicine. Here, we report full-spectrum fluorescent CDs that exhibit controlled emission changes from purple(380 nm) to red(613 nm) at room temperature by changing the excitation wavelength, and the excitation dependence was closely related to the regulation of sp2 and sp3 hybrid carbon structures by β-cyclodextrin-related groups. In addition,by regulating the content of β-cyclodextrin, the optimal quantum yields of full-spectrum fluorescent CDs were 8.97%, 8.35%, 7.90%, 9.69% and 17.4% at the excitation wavelengths of 340, 350, 390, 410 and 540 nm,respectively. Due to their excellent biocompatibility and color tunability, full-spectrum fluorescent CDs emitted bright and steady purple, blue, green, yellow, and red fluorescence in MCF-7 cells. Moreover, we optimized the imaging conditions of CDs and mitochondrial-specific dyes;and realized the mitochondrialtargeted co-localization imaging of purple, blue and green fluorescence. After that, we also explored the effect of full-spectrum fluorescent CDs in vivo fluorescence imaging through the intratumorally, subcutaneously, and caudal vein, and found that full-spectrum fluorescent CDs had good fluorescence imaging ability in vivo.

关键词： Carbon dots Multi-emission Fluorescence mechanism Mitochondrial targeting Color tenability Fluorescence imaging

Target on wide type nucleic acid with CRISPR/Cas9 to increase the sensitivity of ctDNA detection based on NGS technology

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Target on wide type nucleic acid with CRISPR/Cas9 to increas...

AKR1B10 participates in radiotherapy resistance viaFFA/TLR4/NF-κB signaling pathway in nasopharyngeal carcinoma

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Wang,li luo,dixian Hu,Zheng The Hospital of Chenzhou Affiliated to University of Southern Medical University National & Local Joint Engineering Laboratory for High-throughput Molecular Diagnosis Technology Affiliated to The First People’s Hospital of Chenzhou

The detection of circulating cell-free DNA(cfDNA) is a powerful tool in monitoring tumor burden of multiple cancer types because of circulating tumor DNA(ctDNA) providing the genetic information of cancer ***,the ctDNA presented in the blood is low concentration with more abundant wide type nucleic *** an increasing sequencing platforms have been recently developed to detect mutations,they have own limitations in the sensitivity of detection,especially at advanced stage.

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AKR1B10 participates in radiotherapy resistance viaFFA/TLR4/...

A novel molecular marker in thyroid cancer: AKR1B10

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： liu,Xiangting Qu,Jiayao Li,Jia Gong,Ke luo,dixian University of South China The First People’s Hospital of Chenzhou University of South China

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) is a member of the aldehyde ketone reductase superfamily,which can reduce aldehydes and ketones to the corresponding alcohols,protecting cells from toxic damage of carbonyl groups,and promote FFA synthesis by stably synthesizing the rate-limiting enzyme acetyl CoA Carboxylase-α(ACCα).NF-κB is an important downstream factor in TLR4.

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A novel molecular marker in thyroid cancer: AKR1B10

Exploring practical methods for detecting k-nonseparability in multipartite quantum states

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者：郭远薇 Yu Wang Wangli Wei Jia Li Xiaojie Li Huiqiu Cao dixian luo Translational Medicine Institute and National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis TechnologyAffiliated the First People’s Hospital of ChenzhouUniversity of South China Center for Clinical Pathology Affiliated the First People’s Hospital of ChenzhouUniversity of South China E.N.T.Department the First People’s Hospital of Chenzhou

Objective: To investigate the expression of AKR1 B10 in papillary thyroid carcinoma and the correlation between the expression levels and clinicopathological characteristics Materials and methods: Specimens and clinical data were obtained from patients with thyroid disease at the First People’s Hospital of Chenzhou from January 2013 to July 2015. There were 117 cases of thyroid papillary carcinoma(PTC), 40 cases of nodular goiter, 40 cases of follicular adenoma of thyroid, 40 cases of Hashimoto thyroiditis and 13 cases of normal thyroid tissue. The expression levels of AKR1 B10 were measured by immunohistochemistry. SPSS 18.0 statistical software was used to analyze the data. Results: 1. AKR1 B10 were detected mainly in the cytoplasm and occasionally in the nucleus. The positive rates of AKR1 B10 expression were higher in papillary thyroid carcinoma(88.0%) and hashimoto thyroiditis(82.5%) than that in nodular goiter(22.5%), thyroid follicular adenoma(32.5%),para-carcinoma tissue(28.6%)and normal thyroid tissue(38.5%). 2. The expression levels of AKR1 B10 were not significantly different between PTC and hashimoto thyroiditis(p>0.05). However, the difference of AKR1 B10 expression between PTC and other four type of begin tissues was statistically significant(p<0.05). 3. The levels of AKR1 B10 expression in PTC were positively associated with tumor size and node metastasis(p<0.05) and negatively correlated with the level of serum TSH(p<0.05). However, the expression level of AKR1 B10 in PTC was not correlated with gender, age, infiltration to adjacent tissue, site and TNM stage. Conclusion: AKR1 B10 overexpression was positively correlated with tumor size, lymph node metastasis, but negatively correlated with the level of serum TSH. AKR1 B10 might be involved in regulating the proliferation and migration of tumor cells. Therefore, AKR1 B10 might become a novel biomarker for diagnosis of treatment of PTC.

关键词： AKR1B10 thyroid papillary carcinoma metastasis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 255-256页

作者： Shunlong luo Academy of Mathematics and Systems Science Chinese Academy of Sciences

Quantum entanglement, referred to as “spooky action at a distance” by Einstein, is not only an intriguing and fascinating feature of quantum theory challenging our classical intuitions about locality and correlations, but also has practical and profound implications for quantum technologies. Initially described by Einstein, Podolsky and Rosen, as well as by Schro¨dinger, entanglement now has become a basic and crucial ingredient for both foundational and experimental investigations of the quantum world.

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